Spontaneous Coronary Artery DissectionNCT07178509
A Study of SCAD Using Stress Contrast Echocardiography
An observational study of Spontaneous Coronary Artery Dissection, run by Mayo Clinic at 1 site in United States.
Trial summary
This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Spontaneous Coronary Artery Dissection
- What is being tested?
- Stress Echocardiography with Contrast
- Type of treatment
- Surgery or procedure
- How many people
- 50 participants
- Where
- 1 siteUnited States
- Study dates
- 25 Nov 2025to Sep 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Patients will be recruited from the clinic and community.
Who may be able to join
- Adult >18 years old
- Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history
Who cannot join
- Unable to give consent
- Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
- Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
- Pregnant.
- Unable to interrupt breastfeeding.
- Within 3 months of a heart attack.
- Severe aortic stenosis.
- Severe, uncontrolled hypertension (>200/110 mmHg at baseline).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Mayo Clinic
Rochester, Minnesota, 55905
Pamela Engrav, 507-255-6938, engrav.pamela@mayo.edu
Marysia S Tweet, M.D., M.S.
About this study
Official title: Myocardial Perfusion in Spontaneous Coronary Artery Dissection Using Stress Contrast Echocardiography
This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.
- Conditions
- Spontaneous Coronary Artery Dissection
- Being tested
- Stress Echocardiography with Contrast
- Medical subject headings
- Coronary Artery Dissection, Spontaneous
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Stress Echocardiography with ContrastProcedure or surgery
Stress Echocardiography with Contrast will be used to assess heart function and blood flow response to stressors.
| Study group | Role | What they receive |
|---|---|---|
| Spontaneous coronary artery dissection (SCAD) | Subject has a history of spontaneous coronary artery dissection (SCAD) Receives: Procedure: Stress Echocardiography with Contrast | |
| Healthy Subjects | Subjects are healthy with no significant medical history Receives: Procedure: Stress Echocardiography with Contrast |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Microvascular Function
Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation.
Measured: Baseline, immediately after the Stress Echocardiography
Change in Blood Pressure
Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg).
Measured: Baseline, immediately after the Stress Echocardiography
Change in Heart Rate
Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute).
Measured: Baseline, immediately after the Stress Echocardiography
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Sep 2025
- Study start25 Nov 2025
- Primary completionSep 2027 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Spontaneous Coronary Artery DissectionStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Collaborators
- National Heart, Lung, and Blood Institute (NHLBI)
- Responsible party
- Principal investigator, Marysia Tweet, Mayo Clinic
- Investigators
- Marysia Tweet, M.D., M.S., Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07178509
- Sponsor's protocol ID
- 24-002318
- Other IDs
- 1K23HL155506
- Status last verified
- Jan 2026
- First submitted
- 2 Sep 2025
- Last updated
- 7 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Myocardial Perfusion in Spontaneous Coronary Artery Dissection Using Stress Contrast Echocardiography
- ClinicalTrials.gov ID
- NCT07178509
- Acronym / sponsor ID
- 24-002318
- Conditions
- Spontaneous Coronary Artery Dissection
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Collaborators
- National Heart, Lung, and Blood Institute (NHLBI)
- Study start
- 25 Nov 2025 (actual)
- Primary completion
- Sep 2027 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 17 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Spontaneous coronary artery dissection (SCAD) | – | Procedure: Stress Echocardiography with ContrastSubject has a history of spontaneous coronary artery dissection (SCAD) |
| Healthy Subjects | – | Procedure: Stress Echocardiography with ContrastSubjects are healthy with no significant medical history |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Patients will be recruited from the clinic and community.
Key inclusion criteria (2 listed)
- Adult >18 years old
- Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history
Key exclusion criteria (8 listed)
- Unable to give consent
- Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
- Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
- Pregnant.
- Unable to interrupt breastfeeding.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Stress Echocardiography with ContrastStress Echocardiography with Contrast will be used to assess heart function and blood flow response to stressors. | Procedure or surgery | Healthy Subjects, Spontaneous coronary artery dissection (SCAD) |
Primary outcome
Change in Microvascular Function
Time frame: Baseline, immediately after the Stress Echocardiography
Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation.
Change in Blood Pressure
Time frame: Baseline, immediately after the Stress Echocardiography
Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg).
Change in Heart Rate
Time frame: Baseline, immediately after the Stress Echocardiography
Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Marysia Tweet, M.D., M.S. principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Spontaneous Coronary Artery Dissection, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Pamela Engrav (507-255-6938, engrav.pamela@mayo.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Microvascular Function (time frame: Baseline, immediately after the Stress Echocardiography). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jan 2026.