Clinical trials: Spontaneous Coronary Artery Dissection
Spontaneous Coronary Artery Dissection, SCAD
Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause spontaneous coronary artery dissection (SCAD), in other words, spontaneous tears in blood vessels that supply the heart.
- Trial name
- NCT01427179
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Spontaneous Coronary Artery Dissection
Randomized Study of Beta-Blockers and Antiplatelets in Patients With Spontaneous Coronary Artery Dissection
Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndrome (ACS). Most patients are treated with beta-blockers (BB) and antiplatelet drugs (AP) on empiric basis.
- Trial name
- BA-SCAD (NCT04850417)
- Testing
- Beta blocker, aspirin, clopidogrel
- Volunteers
- 600 people
- Sponsor
- Spanish Society of Cardiology
Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection
Defining the Basis of Fibromuscular Dysplasia (FMD)
The purpose of this study has evolved and expanded since its inception. Originally the intent was to establish the functional, molecular and genetic profile of fibroblasts from Fibromuscular Dysplasia (FMD) patients as compared…
- Conditions
- Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection, Cervical Artery Dissection
- Trial name
- DEFINE (NCT01967511)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spontaneous Coronary Artery Dissection
Spontaneous Coronary Artery Dissection (SCAD) Avatar Study
The purpose of this study is to evaluate patient satisfaction, comfort, and trust in interacting with an avatar compared with speaking to a human clinician during a pre clinical visit.
- Trial name
- NCT07497633
- Testing
- Video Avatar Interview, Voice-Only Avatar Interview, Human Interview
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Cardiac Rehabilitation Program Following the Management of ACS in Patients Presenting With SCAD
Modalities And Safety Of Cardiac Rehabilitation In A Population Managed For Spontaneous Hematoma Or Coronary Disruption
Spontaneous Coronary Artery Dissection (SCAD) is a rare and often misdiagnosed cause of Acute Coronary Syndrome (ACS) affecting predominantly young women without cardiovascular risk factors.
- Trial name
- READAPT-DISCO (NCT05744947)
- Testing
- Data collection
- Where
- 29 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bordeaux
Spontaneous Coronary Artery Dissection
Angiographic and Psychosocial Evaluation of Peripartum vs. Non: SCAD
This multi-site international clinical research project is a collaboration between investigators from multiple institutions in the USA, Canada, and Europe.
- Trial name
- SCAD (NCT03390998)
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Katharine Sears Edwards
Spontaneous Coronary Artery Dissection
Canadian SCAD Study
SCAD (Spontaneous coronary artery dissection - tear in the arterial wall that is not related to trauma) is an under-diagnosed and poorly understood condition that mostly affects young women without common cardiovascular risk…
- Trial name
- NCT02188069
- Where
- 20 sites in United States, Canada
- Volunteers
- 750 people
- Sponsor
- Cardiology Research UBC
Spontaneous Coronary Artery Dissection
Spontaneous Coronary Artery Dissection Registry (DIssezioni Spontanee COronariche ITalian-SPAnish)
The study will investigate the clinical features, acute management and follow up of patients affected by spontaneous coronary artery dissection
- Trial name
- DISCO-IT/SPA (NCT04415762)
- Volunteers
- 314 people
- Sponsor
- San Luigi Gonzaga Hospital
SCAD, Myocardial Infarction (MI)
Norwegian Spontaneous Coronary Artery Dissection Study
The Norwegian Spontaneous Coronary Artery Dissection Study (NOR-SCAD) is a national, multicenter prospective observational study conducted at major hospitals in Norway.
- Conditions
- SCAD, Myocardial Infarction (MI), Women
- Trial name
- NOR-SCAD (NCT07317323)
- Where
- 3 sites in Norway
- Volunteers
- 300 people
- Sponsor
- Oslo University Hospital
Spontaneous Coronary Artery Dissection
Spontaneous Coronary Artery Dissection National Swiss Registry
Spontaneous coronary artery dissection (SCAD), is an underdiagnosed pathology, affecting predominantly young women without traditional cardiovascular risk factors and is associated with major adverse outcomes including myocardial…
- Trial name
- SwissSCAD (NCT04457544)
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- Dr. Sophie Degrauwe
Spontaneous Coronary Artery Dissection
Exercise Support and Rehabilitation for Patients After Spontaneous Coronary Artery Dissection
The study aims to examine the feasibility of a remote exercise program in women recovering from spontaneous coronary artery dissection (SCAD) events (heart attacks).
- Trial name
- EXERCISE-SCAD (NCT06955663)
- Testing
- Exercise training
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Leicester
Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection
A Study Of Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia
The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance exercise in people with Spontaneous Coronary Artery Dissection (SCAD)…
- Trial name
- NCT07526766
- Testing
- Aerobic and resistance exercises
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
SCAD, ACS (Acute Coronary Syndrome)
Spontaneous Coronary Artery Dissection - AntipLatelet Therapy Intensity in Guided coNservative Management (SCAD-ALIGN) Trial
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome in which blood flow to the heart muscle is reduced or interrupted.
- Trial name
- SCAD-ALIGN (NCT07683923)
- Testing
- Acetylsalicylic acid ASA, ASA plus Clopidogrel
- Where
- 5 sites in Canada, Germany and 3 more
- Volunteers
- 3,518 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Fibromuscular Dysplasia of Arteries, Fibromuscular Dysplasia
Survey on Physical Activity and Qualify of Life in Fibromuscular Dysplasia
Fibromuscular dysplasia (FMD) is a disease of the arteries that is not due to plaque build-up or inflammation. While some patients with FMD are health, some may experience heart attacks, strokes, aneurysms or blood vessel…
- Conditions
- Fibromuscular Dysplasia of Arteries, Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection
- Trial name
- NCT07529691
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Vanderbilt University Medical Center
Myocardial Infarction With Non-Obstructive Coronary Artery, Myocarditis Acute
Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA and MINOCA-mimics
This clinical study examines patients presenting with acute myocardial infarction and no significant coronary artery disease on coronary angiography (MINOCA) and patients with MINOCA-mimics with advanced CMR.
- Conditions
- Myocardial Infarction With Non-Obstructive Coronary Artery, Myocarditis Acute, Takotsubo Cardiomyopathy, Spontaneous Coronary Artery Dissection
- Trial name
- COPE-CMR (NCT06323811)
- Testing
- CMR
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Spontaneous Coronary Artery Dissection
Genetics of Spontaneous Coronary Artery Dissection (SCAD-INSPIRE Genetics)
Spontaneous coronary artery dissection (SCAD) is a rare cause of coronary ischemia and infarction where a tear in blood vessel wall either restricts the flow of blood or the blood becomes trapped in between the layers of the…
- Trial name
- SCAD-INSPIRE (NCT03876847)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Spontaneous Coronary Artery Dissection
A Study of SCAD Using Stress Contrast Echocardiography
This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.
- Trial name
- NCT07178509
- Testing
- Stress Echocardiography with Contrast
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Spontaneous Coronary Artery Dissection, Myocardial Infarction (MI)
Norwegian Danish Spontaneous Coronary Artery Dissection Exercise Study
The goal of this randomized clinical trial is to determine whether a supervised high-intensity interval training (HIIT) program can safely improve cardiorespiratory fitness and overall health in adults who have previously had…
- Conditions
- Spontaneous Coronary Artery Dissection, Myocardial Infarction (MI), High Intensity Interval Training
- Trial name
- NorDen-SCAD Ex (NCT07785765)
- Testing
- High intensity interval training (HIIT)
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Spontaneous Coronary Artery Dissection
International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry
The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center…
- Trial name
- NCT04496687
- Where
- 31 sites in United States, Australia
- Volunteers
- 2,000 people
- Sponsor
- SCAD Alliance
Fibromuscular Dysplasia of Arteries, Segmental Arterial Mediolysis
Using Ultrasonography, Shear Wave Elastography, Strain Imaging, and 3-D Volume Ultrasonography on Cardiovascular Disease
The researchers are trying to see whether contrast-enhanced ultrasonography, shear wave elastography, strain imaging, and 3-D volume ultrasonography improves arterial wall visualization and identifies arterial elastic properties…
- Conditions
- Fibromuscular Dysplasia of Arteries, Segmental Arterial Mediolysis, Spontaneous Coronary Artery Dissection, Atherosclerosis of Artery
- Trial name
- NCT03335020
- Testing
- Shear Wave Elastography, Pulse Wave Imaging, Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic