AzTrials
AzTrials

Chronic Neck PainNCT07179133

Additional Effects of Semispinalis Cervicis Strengthening With Craniocervical Flexion Training on Chronic Neck Pain

A study testing Craniocervical Flexion Training alone and Semispinalis Cervicis strengthening with Craniocervical Flexion Training: in people with Chronic Neck Pain, run by Foundation University Islamabad at 1 site in Pakistan.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Sites and contacts
Official record
Search all trials

Trial summary

Chronic neck pain affects 30-50% of individuals annually and is a leading cause of disability, often linked to muscle imbalances and compensatory over activation of superficial muscles. Read more about this study

Who is it for?
Ages 18 to 35 years
Conditions the study is for
Chronic Neck Pain
What is being tested?
Craniocervical Flexion Training alone and Semispinalis Cervicis strengthening with Craniocervical Flexion Training:
Type of treatment
Surgery or procedure
Could I receive a placebo?
No, everyone receives an active treatment
How many people
42 participants
Where
1 sitePakistan
Study dates
30 Sep 2025to 1 Nov 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 35 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Adults aged 18 to 35.
  • Chronic nonspecific Neck Pain persisting for more than 3 months.
  • Willingness to participate and and signed an informed consent form.
  • Self reported neck pain intensity greater than and equal to 3 on 11 point numerical pain scale.

Who cannot join

  • Recent neck injuries and surgeries.
  • Several medical conditions like Hypertension, RA and Cardiovascular Diseases.
  • Significant psychiatric disorders.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Andleeb Zahra, DPT contact

+923319532499

zandleeb13@gmail.com

Muhammad Furqan Yaqoob, MS-MSKPT contact

+923465333101

furqan.yaqoob@fui.edu.pk

Pakistan1 site
  • Foundation University Islamabad

    Islamabad, Punjab Province, 46000

Other trials in Pakistan

About this study

Chronic neck pain affects 30-50% of individuals annually and is a leading cause of disability, often linked to muscle imbalances and compensatory over activation of superficial muscles. While craniocervical flexion trainning (CCFT) improves neuromuscular control and reduces pain, limited researches has examined the additional benefits of semispinalis cervicis strengthening. This randomized controlled trial, conducted at Fauji Foundation Hospital and Foundation University College of Physical Therapy will assess the effects of combining semispinalis cervicis strengthening with CCFT on pain, cervical erange of motion, muscle strength and functional disability. Participants will be randomly assigned to either CCFT alone or CCFT with semispinalis cervicis strengthening, performed three times per week for four weeks. Data will be collected at baseline, mid study (week 2) and end of study (week 4) using the Numeric pain rating scale, Goniometer, Sphygmomanometer and Nexk disability index. This study addresses a research gap by exploring deep cervical extensors strengthening alongside CCFT, potentially improving rehabilitation strategies for pain relief, cervical stability and functional recovery.

Read the detailed description

Detailed Description:

Chronic neck pain is persistent discomfort in the neck lasting over three months, often caused by poor posture, injury or degenerative conditions. It is the fourth-leading cause of disability worldwide, affecting 30-50% of people annually. Chronic neck pain significantly impacts quality of life, as well as physical and mental function, making it a leading cause of disability that is often challenging to manage. Common clinical symptoms include persistent neck pain, restricted neck movement, pain in the shoulders or upper limbs, migraines, muscle imbalances, and irregular breathing patterns. Chronic neck pain is often associated with a decline in the strength and endurance of deep neck muscles, particularly the deep cervical flexors (DCF) like the longus colli and longus capitis. These muscles are crucial for maintaining proper neck posture and stability. When they weaken, it can lead to poor posture and increased pain. Likewise deep neck flexors, deep cervical extensor muscles, which include the multifidus and semispinalis cervicis are also weakened in chronic neck pain patient's leading to increase pain and reduced ROMs. In response to the weakness of the deep neck muscles, the body activates superficial flexors and extensors to compensate for the loss of stability and strength. This compensatory activation is a natural response to maintain neck function and posture. However, relying on these superficial muscles can lead to over-activation, which is not ideal for long-term neck health. Exercise is essential for managing neck pain, with recent research highlighting the benefits of deep cervical muscle training. Craniocervical flexor exercises improve neuromuscular control, reduce pain, and enhance muscle activation. Likewise, deep cervical extensors like the semispinalis and multifidus play a key role in stabilization and should be targeted in rehabilitation.

Thavatchai et.al, conducted a study that shows Semispinalis cervicis strengthening outcomes benefits over usual-care outcomes for pain, cervical ROMs and functional disability.

Isha Sikka et al, conducted a study that Craniocervical Flexion training effectively reduces Neck Pain and improves functional status.

A study conducted by Ahmad H. Alghadir et.al, concluded that combining deep cervical flexor (DCF) training with conventional exercises significantly reduces pain and forward head posture (FHP) in school teachers.

Johannes Blomgren et.al, conducted a study found that applying manual resistance to the C2 vertebral arch resulted in the most selective activation of the semispinalis cervicis muscle (measured at C3) compared to resistance at the occiput or C5 level.

Jochen Schomacher et.al, concluded that targeting the semispinalis cervicis muscle through specific exercises, such as manual resistance in extension, can enhance its activation and potentially reduce neck pain.

Gorajiya et.al concludes that craniocervical flexion exercises are superior to isometric exercises, scapulothoracic exercises and transcutaneous electrical nerve stimulation alone in managing chronic neck pain.

Interventions Description:

Both groups will receive a 10-minute hot pack treatment before starting the protocol. Three sessions per week for 4 weeks.

Group A: Craniocervical Flexion Training protocol Group B: Semispinalis Cervicis strengthening in addition to the Craniocervical Flexion Training protocol.

Group A: Craniocervical Flexion Training alone

Week 1: Muscle Activation Goal:

Activate deep cervical flexors with the sphygmomanometer device.

Exercise:

  • Perform in supine with a sphygmomanometer device.
  • Nod head gently as if saying "yes," aiming for 20-22 mmHg.
  • Hold for 5-10 seconds. Sets/Reps: 3 sets of 5 repetitions. Focus: Avoid activation of superficial neck muscles (e.g., sternocleidomastoid).

Week 2: Endurance Training Goal:

Increase holding time and precision.

Exercise:

  • Maintain the contraction at 24-26 mmHg on the device.
  • Hold for 10-15 seconds.
  • Sets/Reps: 3 sets of 6-8 repetitions.

Week 3: Strength and Postural Training Goal:

Improve muscle strength and integrate postural control.

Exercise:

  • Perform CCFT in sitting or standing.
  • Progress to 28-30 mmHg and hold for 15 seconds.
  • Sets/Reps: 3 sets of 8-10 repetitions.

Week 4: Functional Integration Goal:

Incorporate CCFT into daily activities.

Exercise:

  • Maintain contraction during functional tasks (e.g., desk work).
  • Hold for 15-20 seconds.
  • Sets/Reps: 3 sets of 8-12 repetitions.

Group B: Semispinalis Cervicis strengthening with Craniocervical Flexion Training:

Craniocervical flexion training will be same as given to group A.

Week 1: Semispinalis Cervicis Activation:

  • Patient sits upright with neutral spine.
  • Therapist applies gentle manual resistance at C2 vertebra while the patient resists backward motion.
  • Hold for 3-5 seconds, then relax.
  • Reps/Sets: 2 sets of 6 reps. Focus: Avoid compensatory movements and maintain smooth activation

Week 2: Progressive Activation with Increased Resistance:

  • Apply moderate manual resistance at C2.
  • Hold for 5 seconds, focusing on controlled movement.
  • Reps/Sets: 3 sets of 8 reps.
  • Focus: Proper engagement of both semispinalis cervicis and deep cervical flexors.

Week 3: Strength and Functional Coordination with Dynamic Resistance:

  • Introduce light movement (e.g., slight backward head tilt) under resistance.
  • Therapist adjusts resistance dynamically. Reps/Sets: 3 sets of 10 reps

Week 4: Advanced Endurance and Functional Integration with Functional Movements:

  • Combine resistance training with controlled head rotations or slight lateral flexion.
  • Maintain resistance and stability.
  • Reps/Sets: 3-4 sets of 12 reps. Focus: Smooth, coordinated and pain-free execution
Being tested
Craniocervical Flexion Training alone, Semispinalis Cervicis strengthening with Craniocervical Flexion Training:

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Craniocervical Flexion Training aloneProcedure or surgery

    10-minute hot pack treatment before starting the protocol. Week 1: Muscle Activation, • Hold for 5-10 seconds.

    • Perform in supine with a sphygmomanometer device.
    • Nod head gently as if saying "yes," aiming for 20-22 mmHg. Week 2: Endurance Training Goal: • Hold for 10-15 seconds. Increase holding time and precision.

    Exercise:

    • Maintain the contraction at 24-26 mmHg on the device. Week 3: Strength and Postural Training •Hold for 15 seconds.

    Exercise:

    • Perform CCFT in sitting or standing. Week 4: Functional Integration
    • Maintain contraction during functional tasks (e.g., desk work).
    • Hold for 15-20 seconds.
    • Sets/Reps: 3 sets of 8-12 repetitions.
  • Semispinalis Cervicis strengthening with Craniocervical Flexion Training:Procedure or surgery

    Craniocervical flexion training will be same as given to group A.

    Week 1: Semispinalis Cervicis Activation:

    • Patient sits upright with neutral spine.
    • Therapist applies gentle manual resistance at C2 vertebra while the patient resists backward motion.
    • Hold for 3-5 seconds, then relax.

    Week 2: Progressive Activation with Increased Resistance:

    • Apply moderate manual resistance at C2.
    • Hold for 5 seconds, focusing on controlled movement.

    Week 3: Strength and Functional Coordination with Dynamic Resistance:

    • Introduce light movement (e.g., slight backward head tilt) under resistance.
    • Therapist adjusts resistance dynamically.

    Week 4: Advanced Endurance and Functional Integration with Functional Movements:

    • Combine resistance training with controlled head rotations or slight lateral flexion.
    • Maintain resistance and stability.
    • Reps/Sets: 3-4 sets of 12 reps.
Study groups in NCT07179133
Study groupRoleWhat they receive
Craniocervical Flexion TrainingActive comparatorDetailed components of Craniocervical Flexion (CCF) Training
Receives: Procedure: Craniocervical Flexion Training alone
Semispinalis Cervicis Strengthening with CCF TrainingActive comparatorDetailed components of Semispinalis Cervicis Strengthening and Craniocervical Flexion (CCF) Training
Receives: Procedure: Semispinalis Cervicis strengthening with Craniocervical Flexion Training:

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Chronic Neck Pain

    Chronic Neck Pain will be measured using Numeric Pain Rating Scale, minimum value is 0 and maximum value is 10.

    Measured: 4 weeks

  2. Neck Range of Motion

    Neck Range of Motion will be measured using Goniometer, minimum and maximum value depends on movement.

    Measured: 4 weeks

  3. Neck Muscle Strength

    Neck Muscle Strength will be measured with Sphygmomanometer, minimum and maximm value depends on hold time of 20mmHg.

    Measured: 4 weeks

  4. Neck Functional Disability

    Neck Disability Index will be used to measure Neck Functional Disability, 0 to 50 is range.

    Measured: 4 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted17 Sep 2025
  2. Study start30 Sep 2025 (estimated)
  3. Primary completion1 Oct 2026 (estimated)
  4. Study completion1 Nov 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
42 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07179133
Sponsor's protocol ID
FUI/CTR/2025/02
Status last verified
Sep 2025
First submitted
11 Sep 2025
Last updated
23 Sep 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A study testing Craniocervical Flexion Training alone and Semispinalis Cervicis strengthening with Craniocervical Flexion Training: in people with Chronic Neck Pain, run by Foundation University Islamabad at 1 site in Pakistan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: opening soon, as of the sponsor's last update on 23 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Andleeb Zahra, DPT (+923319532499, zandleeb13@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Chronic Neck Pain (time frame: 4 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Sep 2025.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in