Healthy VolunteersBFR-LUMBEXNCT07182812
Effects of Blood Flow Restriction Exercises on Lumbar Muscle Endurance and Balance in Healthy Young Adults
A study testing Blood Flow Restriction Sit-to-Stand Exercise and Sit-to-Stand Exercise without Blood Flow Restriction in people with Healthy Volunteers and Low Back Pain, run by Mehmet Akif Guler at 1 site in Turkey (Türkiye).
Trial summary
This study aims to examine the effects of blood flow restriction (BFR) exercises on back muscle endurance and balance in healthy young adults. BFR is a training method that involves applying controlled pressure to the limbs with a cuff while performing simple exercises. Read more about this study
- Who is it for?
- Ages 20 to 25 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Volunteers, Low Back Pain, Postural Balance
- What is being tested?
- Blood Flow Restriction Sit-to-Stand Exercise and Sit-to-Stand Exercise without Blood Flow Restriction
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 70 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 29 Sep 2025to 30 Nov 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 25 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between 20 and 25 years
- Healthy, without musculoskeletal disorders
- No chronic neurological or systemic disease
- No regular exercise program in the last 3 months
- Voluntary participation with signed informed consent
Who cannot join
- History of musculoskeletal disease, injury, or chronic low back pain
- Neurological conditions or regular use of medications affecting balance or cardiovascular function
- Pregnancy
- Participation in regular lumbar or core exercise programs within the last 3 months
- Any symptoms during exercise (e.g., excessive fatigue, dizziness, abnormal blood pressure changes) that may pose health risks
- Withdrawal of consent or inability to comply with study protocol
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Selçuk University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation
Konya, Konya, 42130
Mehmet Akif Güler, PhD, PT, +90 542 464 42 09, makif.guler@selcuk.edu.tr
About this study
Official title: Effects of Blood Flow Restriction Sit-to-Stand Exercises on Lumbar Extensor Muscle Endurance, Balance, and Physiological Parameters in Healthy Young Adults: A Randomized Controlled Trial
This study aims to examine the effects of blood flow restriction (BFR) exercises on back muscle endurance and balance in healthy young adults. BFR is a training method that involves applying controlled pressure to the limbs with a cuff while performing simple exercises. It has been shown to improve muscle strength and endurance even at low exercise loads, reducing stress on the joints.
In this study, participants aged 20 to 25 years will be randomly assigned to two groups. One group will perform sit-to-stand (STS) exercises combined with BFR, while the other group will perform the same exercises without BFR. The exercise program will last 6 weeks, with 2 sessions per week.
Read more
Before and after the program, participants will be assessed for:
Lumbar extensor muscle endurance (using the Biering-Sørensen test)
Balance performance (using a computerized balance platform)
Physiological responses such as oxygen saturation, heart rate, and blood pressure
The purpose of this research is to determine whether BFR exercises improve spinal muscle endurance and balance more effectively than standard sit-to-stand exercises. The results may provide new insights into the use of BFR training as a safe and practical strategy for improving posture, preventing back problems, and enhancing physical performance in young adults.
Read the detailed description
Detailed Description:
Low back muscle endurance and postural balance are essential components of physical health, functional capacity, and injury prevention. Weakness or fatigue in lumbar extensor muscles is associated with spinal instability, poor posture, and an increased risk of low back pain. Similarly, reduced balance control may impair daily activities and athletic performance. Sedentary lifestyles and prolonged sitting are known to negatively affect these functions in young adults.
Blood flow restriction (BFR) training is an innovative exercise method in which a cuff is applied to partially restrict blood flow in the exercising limb during low-load resistance or functional exercises. This technique has been shown to enhance muscle strength, hypertrophy, and endurance with relatively low mechanical stress, thereby reducing the potential risks associated with high-intensity training. While BFR has been studied extensively in the context of lower-limb strength training, its effects on spinal musculature and balance performance are not well understood.
The present randomized controlled trial is designed to investigate the effects of BFR applied during sit-to-stand (STS) exercises on lumbar extensor muscle endurance and balance performance in healthy young adults. Participants will be randomly assigned to one of two groups:
BFR Exercise Group: STS exercises performed with BFR applied to the thigh.
Control Group: STS exercises performed without BFR.
The intervention will last six weeks, with two supervised exercise sessions per week. The BFR cuff pressure will be set at 60-80% of the individual's systolic blood pressure and monitored to ensure participant safety.
Assessments will be conducted at baseline and after the six-week training program. The primary outcomes are lumbar extensor endurance, measured with the Biering-Sørensen test, and postural balance, assessed using a computerized balance platform. Secondary outcomes include oxygen saturation, heart rate, and blood pressure responses before and after exercise sessions.
The study hypothesizes that participants in the BFR exercise group will show greater improvements in lumbar muscle endurance and balance compared to the control group. Findings from this trial will help clarify whether BFR-based functional training can be considered a safe and effective method not only for enhancing muscle performance but also for improving postural stability in healthy individuals. This may have future applications in sports performance, preventive strategies for low back disorders, and rehabilitation programs for populations with musculoskeletal impairments.
- Conditions
- Healthy Volunteers, Low Back Pain, Postural Balance, Muscle Fatigue, Endurance
- Being tested
- Blood Flow Restriction Sit-to-Stand Exercise, Sit-to-Stand Exercise without Blood Flow Restriction
- Keywords
- Blood Flow Restriction Exercise, Sit-to-Stand Exercise, Lumbar Extensor Muscles, Muscle Endurance, Postural Balance, Physiological Parameters (Oxygen Saturation, Heart Rate, Blood Pressure), Young Adults, Randomized Controlled Trial
- Medical subject headings
- Low Back Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Blood Flow Restriction Sit-to-Stand ExerciseBehavioural
Participants perform sit-to-stand (STS) exercises with blood flow restriction applied using a pneumatic cuff placed on the thigh. Cuff pressure is set at 60-80% of the participant's systolic blood pressure. Sessions are supervised by a physiotherapist twice per week for six weeks.
Sit-to-Stand Exercise without Blood Flow RestrictionBehavioural
Participants perform the same sit-to-stand (STS) exercise protocol as the experimental group, but without blood flow restriction. Sessions are supervised twice weekly for six weeks, and outcomes are assessed before and after the program.
| Study group | Role | What they receive |
|---|---|---|
| Blood Flow Restriction Exercise Group | Experimental | Participants in this arm will perform sit-to-stand exercises combined with blood flow restriction (BFR) using a pneumatic cuff applied to the thigh. The cuff pressure will be set to 60-80% of the participant's systolic blood pressure. The program will be conducted for 6 weeks, with 2 sessions per week, supervised by a physiotherapist. Receives: Behavioral: Blood Flow Restriction Sit-to-Stand Exercise |
| Control Exercise Group | Active comparator | Participants in this arm will perform the same sit-to-stand exercise protocol as the experimental group, but without blood flow restriction. Sessions will also be supervised twice weekly for 6 weeks, and assessments will be performed before and after the intervention. Receives: Behavioral: Sit-to-Stand Exercise without Blood Flow Restriction |
What is being measured
The primary outcome is the main question the study is designed to answer.
Lumbar Extensor Muscle Endurance
Endurance of the lumbar extensor muscles will be assessed using the Biering-Sørensen Test. Participants maintain the upper body in a horizontal position while lying prone with the pelvis stabilized. The test duration (in seconds) until trunk decline >5-10° will be recorded.
Measured: Baseline and after 6 weeks of intervention
Postural Balance Performance
Balance performance will be evaluated using a computerized balance platform (TechnoBody™ Pro-Kin). Both static and dynamic balance parameters will be recorded. Outcome measures include sway area (cm²), sway velocity (cm/s), and postural stability index.
Measured: Baseline and after 6 weeks of intervention
Secondary outcomes (3)
Change in Oxygen Saturation
Peripheral oxygen saturation (SpO₂, %) will be measured using a pulse oximeter placed on the finger. Measurements will be taken before and after exercise sessions, and changes from baseline to week 6 will be recorded.
Measured: Baseline and immediately after exercise sessions (pre- and post-intervention at 6 weeks)
Change in Blood Pressure
Systolic and diastolic blood pressure will be measured using a validated digital sphygmomanometer. Measurements will be taken at rest before and after exercise sessions. The change from baseline to week 6 will be compared between groups.
Measured: Baseline and immediately after exercise sessions (pre- and post-intervention at 6 weeks)
Change in Body Mass Index (BMI)
Body mass index (kg/m²) will be calculated from height and weight measured with a digital body composition analyzer (Tanita device). Changes from baseline to week 6 will be analyzed.
Measured: Baseline and after 6 weeks of intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2025
- Study start29 Sep 2025 (estimated)
- Primary completion30 Nov 2025 (estimated)
- Study completion30 Nov 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for Healthy VolunteersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This randomized controlled trial uses a parallel assignment design. Healthy young adults will be randomly allocated into two groups: (1) an experimental group performing sit-to-stand exercises with blood flow restriction (BFR), and (2) a control group performing the same exercises without BFR. Both groups will follow the intervention for six weeks, with two sessions per week. Pre- and post-intervention assessments will be conducted to compare outcomes between groups.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mehmet Akif Guler
- Sponsor type
- University, hospital or other
- Collaborators
- The Scientific and Technological Research Council of Turkey
- Responsible party
- Sponsor-investigator, Mehmet Akif Guler, Selcuk University
- Investigators
- Mehmet Akif Güler, PhD, PT, Principal investigator, Selçuk University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07182812
- Sponsor's protocol ID
- 1919B012413960
- Other IDs
- 1919B012413960
- Acronym
- BFR-LUMBEX
- Status last verified
- Sep 2025
- First submitted
- 14 Sep 2025
- Last updated
- 19 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data (IPD) related to primary and secondary outcomes will be available upon reasonable request from qualified researchers after publication of study results. Data will be shared through secure institutional repositories in compliance with Selçuk University ethical guidelines.
Publications
Qadah RM, Al-Sharman A, Shalash RJ, Arumugam A. Are accelerometer-measured sitting and physical activity times associated with muscle mass and strength in healthy young adults in the UAE? Heliyon. 2024 May 8;10(10):e30899. doi: 10.1016/j.heliyon.2024.e30899. eCollection 2024 May 30.
PubMed 38770340Meiners KM, Loudon JK. Dynamic and Static Assessment of Single-Leg Postural Control in Female Soccer Players. J Sport Rehabil. 2020 Feb 1;29(2):174-178. doi: 10.1123/jsr.2018-0072.
PubMed 30526247Madarame H, Neya M, Ochi E, Nakazato K, Sato Y, Ishii N. Cross-transfer effects of resistance training with blood flow restriction. Med Sci Sports Exerc. 2008 Feb;40(2):258-63. doi: 10.1249/mss.0b013e31815c6d7e.
PubMed 18202577Lee KH, Chon SC. Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow Restriction Exercise during Sit to Stand Movements. Med Sci Monit. 2024 Jan 25;30:e942508. doi: 10.12659/MSM.942508.
PubMed 38268184Loenneke JP, Wilson JM, Marin PJ, Zourdos MC, Bemben MG. Low intensity blood flow restriction training: a meta-analysis. Eur J Appl Physiol. 2012 May;112(5):1849-59. doi: 10.1007/s00421-011-2167-x. Epub 2011 Sep 16.
PubMed 21922259Demoulin C, Vanderthommen M, Duysens C, Crielaard JM. Spinal muscle evaluation using the Sorensen test: a critical appraisal of the literature. Joint Bone Spine. 2006 Jan;73(1):43-50. doi: 10.1016/j.jbspin.2004.08.002.
PubMed 16461206Amano S, Ludin AF, Clift R, Nakazawa M, Law TD, Rush LJ, Manini TM, Thomas JS, Russ DW, Clark BC. Effectiveness of blood flow restricted exercise compared with standard exercise in patients with recurrent low back pain: study protocol for a randomized controlled trial. Trials. 2016 Feb 12;17:81. doi: 10.1186/s13063-016-1214-7.
PubMed 26867541
Study at a glance
From the registry record, last updated by the sponsor on 19 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Blood Flow Restriction Sit-to-Stand Exercises on Lumbar Extensor Muscle Endurance, Balance, and Physiological Parameters in Healthy Young Adults: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07182812
- Acronym / sponsor ID
- BFR-LUMBEX / 1919B012413960
- Conditions
- Healthy Volunteers, Low Back Pain, Postural Balance, Muscle Fatigue, Endurance
- Keywords
- Blood Flow Restriction Exercise, Sit-to-Stand Exercise, Lumbar Extensor Muscles, Muscle Endurance, Postural Balance, Physiological Parameters (Oxygen Saturation, Heart Rate, Blood Pressure), Young Adults, Randomized Controlled Trial
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- Mehmet Akif GulerUniversity, hospital or other
- Collaborators
- The Scientific and Technological Research Council of Turkey
- Study start
- 29 Sep 2025 (estimated)
- Primary completion
- 30 Nov 2025 (estimated)
- Study completion
- 30 Nov 2025 (estimated)
- First posted
- 19 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to examine the effects of blood flow restriction (BFR) exercises on back muscle endurance and balance in healthy young adults. BFR is a training method that involves applying controlled pressure to the limbs with a cuff while performing simple exercises. It has been shown to improve muscle strength and endurance even at low exercise loads, reducing stress on the joints.
In this study, participants aged 20 to 25 years will be randomly assigned to two groups. One group will perform sit-to-stand (STS) exercises combined with BFR, while the other group will perform the same exercises without BFR. The exercise program will last 6 weeks, with 2 sessions per week.
Before and after the program, participants will be assessed for:
Lumbar extensor muscle endurance (using the Biering-Sørensen test)
Balance performance (using a computerized balance platform)
Physiological responses such as oxygen saturation, heart rate, and blood pressure
The purpose of this research is to determine whether BFR exercises improve spinal muscle endurance and balance more effectively than standard sit-to-stand exercises. The results may provide new insights into the use of BFR training as a safe and practical strategy for improving posture, preventing back problems, and enhancing physical performance in young adults.
Detailed description
Detailed Description:
Low back muscle endurance and postural balance are essential components of physical health, functional capacity, and injury prevention. Weakness or fatigue in lumbar extensor muscles is associated with spinal instability, poor posture, and an increased risk of low back pain. Similarly, reduced balance control may impair daily activities and athletic performance. Sedentary lifestyles and prolonged sitting are known to negatively affect these functions in young adults.
Blood flow restriction (BFR) training is an innovative exercise method in which a cuff is applied to partially restrict blood flow in the exercising limb during low-load resistance or functional exercises. This technique has been shown to enhance muscle strength, hypertrophy, and endurance with relatively low mechanical stress, thereby reducing the potential risks associated with high-intensity training. While BFR has been studied extensively in the context of lower-limb strength training, its effects on spinal musculature and balance performance are not well understood.
The present randomized controlled trial is designed to investigate the effects of BFR applied during sit-to-stand (STS) exercises on lumbar extensor muscle endurance and balance performance in healthy young adults. Participants will be randomly assigned to one of two groups:
BFR Exercise Group: STS exercises performed with BFR applied to the thigh.
Control Group: STS exercises performed without BFR.
The intervention will last six weeks, with two supervised exercise sessions per week. The BFR cuff pressure will be set at 60-80% of the individual's systolic blood pressure and monitored to ensure participant safety.
Assessments will be conducted at baseline and after the six-week training program. The primary outcomes are lumbar extensor endurance, measured with the Biering-Sørensen test, and postural balance, assessed using a computerized balance platform. Secondary outcomes include oxygen saturation, heart rate, and blood pressure responses before and after exercise sessions.
The study hypothesizes that participants in the BFR exercise group will show greater improvements in lumbar muscle endurance and balance compared to the control group. Findings from this trial will help clarify whether BFR-based functional training can be considered a safe and effective method not only for enhancing muscle performance but also for improving postural stability in healthy individuals. This may have future applications in sports performance, preventive strategies for low back disorders, and rehabilitation programs for populations with musculoskeletal impairments.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- This randomized controlled trial uses a parallel assignment design. Healthy young adults will be randomly allocated into two groups: (1) an experimental group performing sit-to-stand exercises with blood flow restriction (BFR), and (2) a control group performing the same exercises without BFR. Both groups will follow the intervention for six weeks, with two sessions per week. Pre- and post-intervention assessments will be conducted to compare outcomes between groups.
| Arm | Type | Receives |
|---|---|---|
| Blood Flow Restriction Exercise Group | Experimental | Behavioral: Blood Flow Restriction Sit-to-Stand ExerciseParticipants in this arm will perform sit-to-stand exercises combined with blood flow restriction (BFR) using a pneumatic cuff applied to the thigh. The cuff pressure will be set to 60-80% of the participant's systolic blood pressure. The program will be conducted for 6 weeks, with 2 sessions per week, supervised by a physiotherapist. |
| Control Exercise Group | Active comparator | Behavioral: Sit-to-Stand Exercise without Blood Flow RestrictionParticipants in this arm will perform the same sit-to-stand exercise protocol as the experimental group, but without blood flow restriction. Sessions will also be supervised twice weekly for 6 weeks, and assessments will be performed before and after the intervention. |
Who may qualify
- Ages
- 20 to 25 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age between 20 and 25 years
- Healthy, without musculoskeletal disorders
- No chronic neurological or systemic disease
- No regular exercise program in the last 3 months
- Voluntary participation with signed informed consent
Key exclusion criteria (6 listed)
- History of musculoskeletal disease, injury, or chronic low back pain
- Neurological conditions or regular use of medications affecting balance or cardiovascular function
- Pregnancy
- Participation in regular lumbar or core exercise programs within the last 3 months
- Any symptoms during exercise (e.g., excessive fatigue, dizziness, abnormal blood pressure changes) that may pose health risks
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Blood Flow Restriction Sit-to-Stand ExerciseParticipants perform sit-to-stand (STS) exercises with blood flow restriction applied using a pneumatic cuff placed on the thigh. Cuff pressure is set at 60-80% of the participant's systolic blood pressure. Sessions are supervised by a physiotherapist twice per week for six weeks. | Behavioural | Blood Flow Restriction Exercise Group |
| Sit-to-Stand Exercise without Blood Flow RestrictionParticipants perform the same sit-to-stand (STS) exercise protocol as the experimental group, but without blood flow restriction. Sessions are supervised twice weekly for six weeks, and outcomes are assessed before and after the program. | Behavioural | Control Exercise Group |
Primary outcome
Lumbar Extensor Muscle Endurance
Time frame: Baseline and after 6 weeks of intervention
Endurance of the lumbar extensor muscles will be assessed using the Biering-Sørensen Test. Participants maintain the upper body in a horizontal position while lying prone with the pelvis stabilized. The test duration (in seconds) until trunk decline >5-10° will be recorded.
Postural Balance Performance
Time frame: Baseline and after 6 weeks of intervention
Balance performance will be evaluated using a computerized balance platform (TechnoBody™ Pro-Kin). Both static and dynamic balance parameters will be recorded. Outcome measures include sway area (cm²), sway velocity (cm/s), and postural stability index.
3 secondary outcomes
Change in Oxygen Saturation
Time frame: Baseline and immediately after exercise sessions (pre- and post-intervention at 6 weeks)
Change in Blood Pressure
Time frame: Baseline and immediately after exercise sessions (pre- and post-intervention at 6 weeks)
Change in Body Mass Index (BMI)
Time frame: Baseline and after 6 weeks of intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Sep 2025.
- Background: PubMed 38770340Qadah RM, Al-Sharman A, Shalash RJ, Arumugam A. Are accelerometer-measured sitting and physical activity times associated with muscle mass and strength in healthy young adults in the UAE? Heliyon. 2024 May 8;10(10):e30899. doi: 10.1016/j.heliyon.2024.e30899. eCollection 2024 May 30.
- Background: PubMed 30526247Meiners KM, Loudon JK. Dynamic and Static Assessment of Single-Leg Postural Control in Female Soccer Players. J Sport Rehabil. 2020 Feb 1;29(2):174-178. doi: 10.1123/jsr.2018-0072.
- Background: PubMed 18202577Madarame H, Neya M, Ochi E, Nakazato K, Sato Y, Ishii N. Cross-transfer effects of resistance training with blood flow restriction. Med Sci Sports Exerc. 2008 Feb;40(2):258-63. doi: 10.1249/mss.0b013e31815c6d7e.
- Background: PubMed 38268184Lee KH, Chon SC. Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow Restriction Exercise during Sit to Stand Movements. Med Sci Monit. 2024 Jan 25;30:e942508. doi: 10.12659/MSM.942508.
- Background: PubMed 21922259Loenneke JP, Wilson JM, Marin PJ, Zourdos MC, Bemben MG. Low intensity blood flow restriction training: a meta-analysis. Eur J Appl Physiol. 2012 May;112(5):1849-59. doi: 10.1007/s00421-011-2167-x. Epub 2011 Sep 16.
- Background: PubMed 16461206Demoulin C, Vanderthommen M, Duysens C, Crielaard JM. Spinal muscle evaluation using the Sorensen test: a critical appraisal of the literature. Joint Bone Spine. 2006 Jan;73(1):43-50. doi: 10.1016/j.jbspin.2004.08.002.
- Background: PubMed 26867541Amano S, Ludin AF, Clift R, Nakazawa M, Law TD, Rush LJ, Manini TM, Thomas JS, Russ DW, Clark BC. Effectiveness of blood flow restricted exercise compared with standard exercise in patients with recurrent low back pain: study protocol for a randomized controlled trial. Trials. 2016 Feb 12;17:81. doi: 10.1186/s13063-016-1214-7.
- Individual participant dataSharing planned: Yes. De-identified individual participant data (IPD) related to primary and secondary outcomes will be available upon reasonable request from qualified researchers after publication of study results. Data will be shared through secure institutional repositories in compliance with Selçuk University ethical guidelines.
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Screening Protocol
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mehmet Akif Güler, PhD, PT principal investigator
Selçuk University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Blood Flow Restriction Sit-to-Stand Exercise and Sit-to-Stand Exercise without Blood Flow Restriction in people with Healthy Volunteers and Low Back Pain, run by Mehmet Akif Guler at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mehmet Akif Güler, PhD, PT (+90 542 464 42 09, makif.guler@selcuk.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Lumbar Extensor Muscle Endurance (time frame: Baseline and after 6 weeks of intervention). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07182812, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Sep 2025.