Third Molars ExtractionNCT07190950
Effects of Low-level Laser Therapy on Soft and Hard Tissue Healing After Impacted Mandibular Third Molar Extraction
A study testing Low Level Laser Therapy in people with Third Molars Extraction and Low Level Laser Therapy, run by University of Medicine and Pharmacy at Ho Chi Minh City at 1 site in Vietnam.
Trial summary
Impacted lower third molar extraction is one of the most commonly performed dental procedures in daily practice. However, this is considered a relatively invasive procedure. During the surgery, dental surgeon must reflect a full-thickness flap, remove bone to expose the tooth, section and deliver the tooth. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Third Molars Extraction, Low Level Laser Therapy, Bone Healing
- What is being tested?
- Low Level Laser Therapy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 1 siteVietnam
- Study dates
- 1 Sep 2024to 30 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy patients (at least 18 years of age) have both jaws lower impacted third molars indicated to be extracted. Both teeth are the same of
Who cannot join
- -
Trial locations and contacts
1 site in 1 country.
Vietnam1 site
University of medicine and pharmacy at Ho Chi Minh city
Ho Chi Minh City, 7000000
About this study
Impacted lower third molar extraction is one of the most commonly performed dental procedures in daily practice. However, this is considered a relatively invasive procedure. During the surgery, dental surgeon must reflect a full-thickness flap, remove bone to expose the tooth, section and deliver the tooth. As a result, after surgery, patients often experience many complications, from swelling, pain, jaw tightness, etc. to alveolar bone loss, periodontal problems distal to the second molar, etc.
Therefore, clinicians are always looking for additional therapies to minimize complications, helping patients have a more comfortable experience after wisdom tooth surgery.
Read more
To date, placing grafting materials such as bone or other biological materials (growth factors, platelet-rich plasma, platelet-rich fibrin) into the tooth socket has been shown to be able to preserve the alveolar crest after extraction. However, these materials require preparation time, are costly, and have the risk of infection related to bone grafts.
Meanwhile, low-level laser therapy (LLLT) is known as a safe, non-invasive therapy that can affect cell metabolism without causing tissue damage. This therapy has been widely applied in many fields of medicine in general and in dentistry in particular. Low-level lasers have been studied to help reduce swelling, pain, and jaw tightness after impacted lower wisdom teeth surgery. In vitro or in vivo studies evaluating the healing effect of low-level lasers have given very positive results. However, there is still a lack of scientific evidence to prove the healing effect of low-level lasers on human tooth extraction sockets.
The study we conducted is a scientific study, in the field of Dentistry. This study aimed to evaluate the effectiveness of low-level laser on soft tissue and bone healing after surgical extraction of impacted lower third molars in a group of Vietnamese population.
- Being tested
- Low Level Laser Therapy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Low Level Laser TherapyProcedure or surgery
Also called LLLT
Patients will receive LLLT at one side after third molar extraction surgery. There will be 7 sessions at the day of surgery, then first, third, seventh, fourteenth, twenty first, twenty eighth day after surgery.
| Study group | Role | What they receive |
|---|---|---|
| Control arm | No intervention | After had third molar extraction at one side, patients do not receive low level laser therapy at this site (by not activating the tip) |
| Experiment arm | Experimental | After had third molar extraction at the other side, patients receive 7 sessions of low level laser therapy at this side (the day of surgery, then first day, third day, seventh day, fourteenth day, twenty first day, twenty eighth day after surgery) Receives: Procedure: Low Level Laser Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
wound healing score
Base on IPR scale (Inflammatory Proliferative Remodeling Scale) by Hamzani et al. (2018)
Measured: at third, seventh and thirtieth day after third molar extraction surgery
New bone density
Based on periapical X-rays taken on the day of surgery right after extraction, first and third month, we calculate new bone density by calculate the pixel density at extracted socket.
Measured: The day of surgery, first and third month after surgery
Changing of alveolar crest level distal to second lower molar
After taking periapical X-rays on the day of surgery right after extraction, first and third month, we measure alveolar crest level distal to second lower molar from the base of extracted socket to cemento-enamel junction (CEJ) of second molar (the reference is a 5 mm stainless steel straight wire buried in rubber impression)
Measured: the day of surgery, first and third month after third molar extraction surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Sep 2025
- Study start1 Sep 2024
- Primary completion30 Aug 2025
- Study completion30 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Third Molars ExtractionStudies of the same condition, open and under way.
- More trials run by University of Medicine and Pharmacy at Ho Chi Minh CityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nguyen Hoang Ngoc Hiep, University of Medicine and Pharmacy at Ho Chi Minh City
- Investigators
- Ly Thi Bich Nguyen, Doctor of Philosophy, Study director
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07190950
- Sponsor's protocol ID
- 24368-ĐHYD
- Status last verified
- Sep 2025
- First submitted
- 17 Sep 2025
- Last updated
- 25 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Low-level Laser Therapy on Soft and Hard Tissue Healing After Impacted Mandibular Third Molar Extraction
- ClinicalTrials.gov ID
- NCT07190950
- Acronym / sponsor ID
- 24368-ĐHYD
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- University of Medicine and Pharmacy at Ho Chi Minh CityUniversity, hospital or other
- Study start
- 1 Sep 2024 (actual)
- Primary completion
- 30 Aug 2025 (actual)
- Study completion
- 30 Sep 2025 (actual)
- First posted
- 24 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Impacted lower third molar extraction is one of the most commonly performed dental procedures in daily practice. However, this is considered a relatively invasive procedure. During the surgery, dental surgeon must reflect a full-thickness flap, remove bone to expose the tooth, section and deliver the tooth. As a result, after surgery, patients often experience many complications, from swelling, pain, jaw tightness, etc. to alveolar bone loss, periodontal problems distal to the second molar, etc.
Therefore, clinicians are always looking for additional therapies to minimize complications, helping patients have a more comfortable experience after wisdom tooth surgery.
To date, placing grafting materials such as bone or other biological materials (growth factors, platelet-rich plasma, platelet-rich fibrin) into the tooth socket has been shown to be able to preserve the alveolar crest after extraction. However, these materials require preparation time, are costly, and have the risk of infection related to bone grafts.
Meanwhile, low-level laser therapy (LLLT) is known as a safe, non-invasive therapy that can affect cell metabolism without causing tissue damage. This therapy has been widely applied in many fields of medicine in general and in dentistry in particular. Low-level lasers have been studied to help reduce swelling, pain, and jaw tightness after impacted lower wisdom teeth surgery. In vitro or in vivo studies evaluating the healing effect of low-level lasers have given very positive results. However, there is still a lack of scientific evidence to prove the healing effect of low-level lasers on human tooth extraction sockets.
The study we conducted is a scientific study, in the field of Dentistry. This study aimed to evaluate the effectiveness of low-level laser on soft tissue and bone healing after surgical extraction of impacted lower third molars in a group of Vietnamese population.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control arm | No intervention | –After had third molar extraction at one side, patients do not receive low level laser therapy at this site (by not activating the tip) |
| Experiment arm | Experimental | Procedure: Low Level Laser TherapyAfter had third molar extraction at the other side, patients receive 7 sessions of low level laser therapy at this side (the day of surgery, then first day, third day, seventh day, fourteenth day, twenty first day, twenty eighth day after surgery) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Healthy patients (at least 18 years of age) have both jaws lower impacted third molars indicated to be extracted. Both teeth are the same of
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Low Level Laser TherapyAlso: LLLTPatients will receive LLLT at one side after third molar extraction surgery. There will be 7 sessions at the day of surgery, then first, third, seventh, fourteenth, twenty first, twenty eighth day after surgery. | Procedure or surgery | Experiment arm |
Primary outcome
wound healing score
Time frame: at third, seventh and thirtieth day after third molar extraction surgery
Base on IPR scale (Inflammatory Proliferative Remodeling Scale) by Hamzani et al. (2018)
New bone density
Time frame: The day of surgery, first and third month after surgery
Based on periapical X-rays taken on the day of surgery right after extraction, first and third month, we calculate new bone density by calculate the pixel density at extracted socket.
Changing of alveolar crest level distal to second lower molar
Time frame: the day of surgery, first and third month after third molar extraction surgery
After taking periapical X-rays on the day of surgery right after extraction, first and third month, we measure alveolar crest level distal to second lower molar from the base of extracted socket to cemento-enamel junction (CEJ) of second molar (the reference is a 5 mm stainless steel straight wire buried in rubber impression)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ly Thi Bich Nguyen, Doctor of Philosophy study director
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Low Level Laser Therapy in people with Third Molars Extraction and Low Level Laser Therapy, run by University of Medicine and Pharmacy at Ho Chi Minh City at 1 site in Vietnam.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Vietnam. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
wound healing score (time frame: at third, seventh and thirtieth day after third molar extraction surgery). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2026.