Clinical trials: Bone Healing
Periodontitis
Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects
Over the last 30 years, the prevalence of periodontitis (PE) has increased substantially, including among younger populations, highlighting the need to improve the management of this condition as a chronic disease and to develop…
- Trial name
- NCT07522684
- Testing
- Polynucleotide and hyaluronic acid-based gel, Control, Xenogeneic bone graft
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- University of Sao Paulo
Forearm Fracture, Clavicle Fracture
Bone Ultrasound to Access Fracture Healing
The purpose of this study is to evaluate sequential fracture healing with radius/ulna fractures or clavicle fractures and compare ultrasound to radiographs.
- Trial name
- NCT02769117
- Testing
- Ultrasound on fractured bone, Ultrasound on contralateral intact bone
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Periodontal Pocket, Impacted Third Molar Tooth
Evaluation of Two Different Grafting Techniques After Mandibular Impacted Third Molar Surgery
This study evaluates the effectiveness of using Mineralized Plasmatic Matrix and β-tricalcium phosphate that placed to extraction socket as a graft material in terms of periodontal damage occurred in the distal aspect of the…
- Conditions
- Periodontal Pocket, Impacted Third Molar Tooth, Impacted Teeth With Abnormal Position
- Trial name
- NCT04366635
- Testing
- Impacted third molar surgery, Application of mineralised plasmatic matrix, Application of β-tricalcium phosphate
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Dental Implant, Transmucosal Healing
Comparing the Secondary Stability of Dental Implants: Immediate Gradual Loading Versus Early Loading Protocol in Posterior Maxilla
The aim of this split mouth study is to compare which method is better in reducing bone loss and healing times following implants.
- Conditions
- Dental Implant, Transmucosal Healing, Bone Loss
- Trial name
- NCT02309125
- Testing
- immediate progressive loading using gingival formers, submerged healing
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Proximal Humerus Fracture
Hanover Humerus Registry
This register study collects data of patients with proximal humerus and humerus shaft fractures to monitor the healing process by assessing shoulder function and quality of life according to the treatment method (operative or…
- Trial name
- HHR (NCT03060876)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Hannover Medical School
Tibial Fractures
Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT03826784
- Testing
- BHA
- Where
- United States
- Sponsor
- Carmell Therapeutics Corporation
Humeral Fracture
Does Teriparatide (rhPTH 1-34) Promote Fracture Healing in Proximal Humeral Fractures?
40 postmenopausal women, with a non-operated proximal humeral fracture, will be randomized to standard treatment (physiotherapy) or standard treatment + Forsteo (rhPTH 1-34) during 4 weeks.
- Trial name
- NCT01105832
- Testing
- Teriparatide
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- University Hospital, Linkoeping
Closed Fracture, Open Fracture
Efficacy of DBM on Fractures of the Shinbone (Tibia)
The Tibia bone (shinbone) is located in the leg, itis the most frequently fractured bone in the body and has very poor blood supply because it is surrounded by skin and fat instead of muscle like the thighbone causing healing…
- Trial name
- NCT00299052
- Testing
- Grafton DBM, Reamings
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Emory University
Radius Fractures
Association Between Hand-Eye Coordination and Handgrip Strength in Children Post-Healing of DRGF
The study investigates whether hand-eye coordination is related to handgrip strength in children (aged 5-12 years) after they have healed from distal radius greenstick fractures.
- Trial name
- NCT07037355
- Testing
- Handgrip Strength and Hand-Eye Coordination Assessment
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Superior University
Ulna Fractures
Prospective Case Series to Assess Complications of Using Distal Ulna Locking Plate of I.T.S.
Background of the study: Various studies show that the outcome of unstable distal ulna fractures after open reduction and internal fixation is better than closed reduction.
- Trial name
- DUL-ITS (NCT05329012)
- Testing
- DUL- Distal Ulna Locking PLate (I.T.S)
- Volunteers
- 22 people
- Sponsor
- Medical University Innsbruck
Proximal Humeral Fracture
A Clinical Trial Investigating Iloprost as Medication to Improve Bone Healing in Patients With Proximal Humeral Fracture
The main objective of this study is to establish the safety as well as the efficacy of local insertion of Iloprost at the fracture site for bone healing of the proximal humeral fracture.
- Trial name
- Ilobone (NCT04543682)
- Testing
- 0.125 ng/kg/min Iloprost, 0.25 ng/kg/min Iloprost, open reduction and internal fixation with an angular stable plate (PHILOS)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Autologous Platelet Rich Plasma Effect on Bone Healing
The Effect of Using Autologous Platelet Rich Plasma on Posterior Lumbar Interbody Fusion
the study aims to determine the effect of using Autologous platelet rich plasma on both the quality \& rate of posterior lumbar interbody fusion \& its outcome on the Patient regarding postoperative lumbar pain \& functional…
- Trial name
- NCT03261843
- Testing
- autologous platelet rich plasma, posterior lumbar interbody fusion without autologous platelet rich plasma
- Volunteers
- 60 people
- Sponsor
- Assiut University
Bone Fracture
Enhancement of Bone Regeneration and Healing in the Extremities by the Use of Autologous BonoFill-II
The purpose of this clinical study is to evaluate the safety and the efficacy of BonoFill-II as an autologous bone-regenerating graft in the reconstruction of deficient bone in two clinical indications: 1.
- Trial name
- NCT03024008
- Testing
- BonoFill-II
- Where
- 6 sites in Israel
- Volunteers
- 40 people
- Sponsor
- BonusBio Group Ltd
Impacted Third Molar Tooth
The Effect of Melatonin Application Following Removal of Impacted Third Molar
In the present study, the main hypothesis hypothesizes that the local application of melatonin in the post-extraction socket produces favorable differences in the immediate postoperative period, as anti-inflammatory, analgesic…
- Trial name
- NCT04424875
- Testing
- 3 mg melatonin
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Fayoum University
Dental Implant, Immediate Dental Implant Placement
Melatonin Effect on Immediate Dental Implants in the Posterior Mandible
This pilot randomized controlled clinical trial aims to evaluate the feasibility, clinical safety, and preliminary radiographic osteogenic effects of applying topical 1% w/w melatonin gel during immediate implant placement in the…
- Conditions
- Dental Implant, Immediate Dental Implant Placement, Alveolar Bone Loss, Bone Density
- Trial name
- NCT07869030
- Testing
- 1% w/w Melatonin Gel, Standard Immediate Dental Implant Placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Future University in Egypt
Rotator Cuff Tears, Micro Fracture
Microfracture at Proximal Humerus Lateral to Footprint Could Enhance the Rotator Cuff Healing
The goal of this clinical trial is to test whether there is any effect on rotator cuff healing by making microfracture at the lateral side of the footprint.
- Trial name
- NCT05624164
- Testing
- Lateralised microfracture
- Where
- 2 sites in China
- Volunteers
- 88 people
- Sponsor
- Affiliated Hospital of Nantong University
Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss
Early Dental Implant Installation in Regeneration Sites: a Prof of Concept Prospective Case Study
This study will evaluate bone healing after tooth extraction and alveolar ridge preservation, a common procedure used to maintain the bone volume needed for future dental implant placement.
- Trial name
- NCT07766057
- Testing
- Alveolar Ridge preservation and early implant placement
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Franco Cavalla
Osteoporosis
Osteoporosis and Dental Implant
The purpose of this study is to evaluate the influence of alendronate therapy on the wound healing after dental implants in patients with osteoporosis.
- Trial name
- OPOZAHN (NCT00727493)
- Testing
- alendronate once weekly 70mg
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Alveolar Process Defect
Ridge Augmentation Comparing a Block Allograft to a Demineralized Bone Matrix Allograft.
This study with compare the ridge dimension changes for a block allograft vs. a demineralized bone matrix moldable allograft.
- Trial name
- NCT02127112
- Testing
- Block Allograft plus Matrix Allograft, Moldable Matrix Allograft
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Vitamin D, Long Bone Fracture
Longitudinal Study of Patients Following Long Bone Fracture
Studies in chickens show that blood levels of a particular form of vitamin D (called 24,25-dihydroxvitamin D) increase after bone fracture.
- Trial name
- NCT01170572
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Barts & The London NHS Trust