Multiple Sclerosis (MS)NCT07195110
Prevalence of Periodontitis in Egyptian Multiple Sclerosis Patients.
An observational study of Multiple Sclerosis (MS) and Periodontal Diseases, run by Cairo University at 1 site in Egypt.
Trial summary
The goal of this observational study is to explore the association between multiple sclerosis and periodontal disease in a sample of Egyptian population The main question it aims to answer is: Is there an association between MS and periodontal disease Participants already diagnosed with multiple sclerosis. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Multiple Sclerosis (MS), Periodontal Diseases
- How many people
- 293 participants
- Where
- 1 siteEgypt
- Study dates
- 18 Sep 2025to 16 Mar 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: MS patients to be recruited and selected from sheikh Zayed Al-Nahayan Hospital
Who may be able to join
- Patients diagnosed with MS
- Adult patients ≥ 18 years old.
- Patients providing an informed consent
Who cannot join
- Periodontal therapy within the last 3 months.
- Having surgical therapy or undergoing orthodontic treatment
- Smokers
- Pregnant females
- Patients with systemic condition know to impact the periodontal condition other than MS (eg. Diabetes Mellitus)
- Patients having more than 5 lost teeth
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Prevalence of Periodontal Disease Among Egyptian Patients With Multiple Sclerosis S: A Cross Sectional Study
The goal of this observational study is to explore the association between multiple sclerosis and periodontal disease in a sample of Egyptian population
The main question it aims to answer is:
- Is there an association between MS and periodontal disease Participants already diagnosed with multiple sclerosis. A conventional oral examination will be held on a dental unit, filling charts and patients' acceptance to participate in the survey.
Read the detailed description
Periodontal disease is a chronic inflammatory condition leading to progressive destruction of the supporting structures of the teeth. Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that may share common inflammatory pathways with periodontal disease. Recent evidence suggests that systemic inflammation may influence the severity and progression of both conditions.
This study will recruit participants already diagnosed with MS and assess their periodontal status using standard clinical parameters, including clinical attachment loss (CAL), probing pocket depth, and bleeding on probing measured at six sites per tooth using a periodontal probe. Data will be collected through a conventional oral examination in a dental unit, and results will be compared to evaluate the prevalence and potential association between MS and periodontal disease within this population.
- Conditions
- Multiple Sclerosis (MS), Periodontal Diseases
- Medical subject headings
- Multiple Sclerosis, Periodontal Diseases
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of periodontal disease as assessed by clinical periodontal parameters ( clinical attachment loss )within the study population.
CAL will be measured as the distance from the cementoenamel junction (CEJ) to the base of the periodontal pocket using a periodontal probe at six sites per tooth. Mean CAL will be calculated for each participant to assess periodontal tissue destruction.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Sep 2025
- Study start18 Sep 2025
- Primary completion1 Feb 2026
- Study completion16 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Multiple Sclerosis (MS)Studies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 293 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hend Mohamed wageh Eltonsy, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07195110
- Sponsor's protocol ID
- PER4-1-2
- Status last verified
- Sep 2025
- First submitted
- 17 Sep 2025
- Last updated
- 18 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared due to privacy considerations and limitations in data-sharing infrastructure. Only aggregate study results will be published and made publicly available.
Study at a glance
From the registry record, last updated by the sponsor on 18 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prevalence of Periodontal Disease Among Egyptian Patients With Multiple Sclerosis S: A Cross Sectional Study
- ClinicalTrials.gov ID
- NCT07195110
- Acronym / sponsor ID
- PER4-1-2
- Conditions
- Multiple Sclerosis (MS), Periodontal Diseases
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 293 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 18 Sep 2025 (actual)
- Primary completion
- 1 Feb 2026 (actual)
- Study completion
- 16 Mar 2026 (actual)
- First posted
- 26 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to explore the association between multiple sclerosis and periodontal disease in a sample of Egyptian population
The main question it aims to answer is:
- Is there an association between MS and periodontal disease Participants already diagnosed with multiple sclerosis. A conventional oral examination will be held on a dental unit, filling charts and patients' acceptance to participate in the survey.
Detailed description
Periodontal disease is a chronic inflammatory condition leading to progressive destruction of the supporting structures of the teeth. Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that may share common inflammatory pathways with periodontal disease. Recent evidence suggests that systemic inflammation may influence the severity and progression of both conditions.
This study will recruit participants already diagnosed with MS and assess their periodontal status using standard clinical parameters, including clinical attachment loss (CAL), probing pocket depth, and bleeding on probing measured at six sites per tooth using a periodontal probe. Data will be collected through a conventional oral examination in a dental unit, and results will be compared to evaluate the prevalence and potential association between MS and periodontal disease within this population.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- MS patients to be recruited and selected from sheikh Zayed Al-Nahayan Hospital
Key inclusion criteria (3 listed)
- Patients diagnosed with MS
- Adult patients ≥ 18 years old.
- Patients providing an informed consent
Key exclusion criteria (6 listed)
- Periodontal therapy within the last 3 months.
- Having surgical therapy or undergoing orthodontic treatment
- Smokers
- Pregnant females
- Patients with systemic condition know to impact the periodontal condition other than MS (eg. Diabetes Mellitus)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Prevalence of periodontal disease as assessed by clinical periodontal parameters ( clinical attachment loss )within the study population.
Time frame: Baseline
CAL will be measured as the distance from the cementoenamel junction (CEJ) to the base of the periodontal pocket using a periodontal probe at six sites per tooth. Mean CAL will be calculated for each participant to assess periodontal tissue destruction.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Mar 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared due to privacy considerations and limitations in data-sharing infrastructure. Only aggregate study results will be published and made publicly available.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Multiple Sclerosis (MS) and Periodontal Diseases, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Prevalence of periodontal disease as assessed by clinical periodontal parameters ( clinical attachment loss )within the study population. (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Mar 2026.