Severe BurnsCRRT-BURNNCT07195565
Association of Continuous Renal Replacement Therapy With Mortality and Length of Stay in Critically Burned Patients
An observational study of Severe Burns and Acute Kidney Injury, run by Pinar Timur Tasci at 1 site in Turkey (Türkiye).
Trial summary
This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Severe Burns, Acute Kidney Injury, Critical Illness
- How many people
- 238 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2021to 1 Jan 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients (≥18 years) admitted to and treated in the Burn Intensive Care Unit.
Who may be able to join
- Patients aged 18 years and older
- Admitted to and treated in the Burn Intensive Care Unit
Who cannot join
- Patients with an ICU stay of less than 24 hours
- Patients younger than 18 years
- Patients with known chronic kidney disease or history of kidney transplantation
- Patients admitted with toxic epidermal necrolysis (TEN)
- Patients with estimated glomerular filtration rate (eGFR) ≤ 15 mL/min/1.73m² at admission
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Dr. Lutfi Kirdar City Hospital, Department of Anesthesiology and Reanimation
Istanbul, 34865
About this study
Official title: The Relationship Between Continuous Renal Replacement Therapy, Mortality, and Hospital Length of Stay in Critically Ill Burn Patients
This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Secondary endpoints consist of comorbidity status, requirement for mechanical ventilation, inotropic support, and hospital length of stay among non-survivors.
Read the detailed description
Severe burn injury is frequently complicated by acute kidney injury (AKI), which is associated with high morbidity and mortality in intensive care settings. Continuous renal replacement therapy (CRRT) is often required in this patient population; however, the prognostic factors influencing survival remain incompletely defined.
In this retrospective study, we analyzed critically ill burn patients who required CRRT. The primary outcomes were the RIFLE classification at the time of CRRT initiation, the timing of therapy initiation, and patient survival. The secondary outcomes included the presence of comorbidities, the need for mechanical ventilation, inotropic support, and length of hospital stay in non-survivors.
By systematically evaluating these clinical parameters, the study aims to clarify the prognostic impact of CRRT in burn patients and to contribute evidence for optimizing the management of acute kidney injury in this critically ill population.
- Conditions
- Severe Burns, Acute Kidney Injury, Critical Illness
- Keywords
- Continuous Renal Replacement Therapy, RIFLE Criteria, Mortality, Hospital Length of Stay, Mechanical Ventilation, İnotropic Support
- Medical subject headings
- Burns, Acute Kidney Injury, Critical Illness
What is being measured
The primary outcome is the main question the study is designed to answer.
RIFLE criteria classification at CRRT initiation
Patients receiving CRRT will be classified according to the RIFLE criteria (Risk, Injury, Failure, Loss, End-stage kidney disease) at the time of CRRT initiation. The distribution across categories will be analyzed.
Measured: Baseline( Day0, at CRRT initiation)
Timing of CRRT initiation
Date and time of initiation of continuous renal replacement therapy (CRRT), obtained from patient medical records.
Measured: Baseline( Day0, at CRRT initiation, recorded from patient medical records)
Survival status of patients
Survival versus non-survival status at the end of hospitalization.
Measured: At hospital discharge ( end of hospitalization)
Secondary outcomes (4)
Presence of comorbidities in non-survivors
Documentation of chronic comorbidities (e.g., diabetes, hypertension, cardiovascular disease) in patients who died after CRRT.
Measured: Baseline( Day0, at hospital admission)
Requirement for mechanical ventilation in non-survivors
Need for invasive mechanical ventilation among non-survivors receiving CRRT.
Measured: Through ICU stay, up to hospital discharge (or death)
Requirement for inotropic support in non-survivors
Requirement for vasopressor or inotropic agents among non-survivors receiving CRRT.
Measured: Through ICU stay, up to hospital discharge or death
Hospital length of stay in non-survivors
Total length of hospitalization measured in days for patients who did not survive after CRRT.
Measured: From hospital admission through study completion( up to discharge or death)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Sep 2025
- Study start1 Jan 2021
- Primary completion1 Jan 2024
- Study completion1 Jan 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Severe BurnsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 238 participants (actual)
Sponsor and investigators
- Lead sponsor
- Pinar Timur Tasci
- Sponsor type
- Other government
- Responsible party
- Sponsor-investigator, Pinar Timur Tasci, Dr. Lutfi Kirdar Kartal Training and Research Hospital
- Investigators
- Elif Bombaci, MD, Principal investigator, Dr.Lutfi Kirdar City Hospital, Department of Anesthesiology and Reanimation, İstanbul, Turkey
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07195565
- Sponsor's protocol ID
- DrLutfiKirdarTRH-ANES-PTT-01
- Acronym
- CRRT-BURN
- Status last verified
- Sep 2025
- First submitted
- 14 Sep 2025
- Last updated
- 26 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will not be shared due to patient confidentiality and ethical considerations.
Study at a glance
From the registry record, last updated by the sponsor on 26 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Relationship Between Continuous Renal Replacement Therapy, Mortality, and Hospital Length of Stay in Critically Ill Burn Patients
- ClinicalTrials.gov ID
- NCT07195565
- Acronym / sponsor ID
- CRRT-BURN / DrLutfiKirdarTRH-ANES-PTT-01
- Conditions
- Severe Burns, Acute Kidney Injury, Critical Illness
- Keywords
- Continuous Renal Replacement Therapy, RIFLE Criteria, Mortality, Hospital Length of Stay, Mechanical Ventilation, İnotropic Support
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 238 participants (actual)
- Lead sponsor
- Pinar Timur TasciOther government
- Study start
- 1 Jan 2021 (actual)
- Primary completion
- 1 Jan 2024 (actual)
- Study completion
- 1 Jan 2024 (actual)
- First posted
- 26 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Secondary endpoints consist of comorbidity status, requirement for mechanical ventilation, inotropic support, and hospital length of stay among non-survivors.
Detailed description
Severe burn injury is frequently complicated by acute kidney injury (AKI), which is associated with high morbidity and mortality in intensive care settings. Continuous renal replacement therapy (CRRT) is often required in this patient population; however, the prognostic factors influencing survival remain incompletely defined.
In this retrospective study, we analyzed critically ill burn patients who required CRRT. The primary outcomes were the RIFLE classification at the time of CRRT initiation, the timing of therapy initiation, and patient survival. The secondary outcomes included the presence of comorbidities, the need for mechanical ventilation, inotropic support, and length of hospital stay in non-survivors.
By systematically evaluating these clinical parameters, the study aims to clarify the prognostic impact of CRRT in burn patients and to contribute evidence for optimizing the management of acute kidney injury in this critically ill population.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients (≥18 years) admitted to and treated in the Burn Intensive Care Unit.
Key inclusion criteria (2 listed)
- Patients aged 18 years and older
- Admitted to and treated in the Burn Intensive Care Unit
Key exclusion criteria (5 listed)
- Patients with an ICU stay of less than 24 hours
- Patients younger than 18 years
- Patients with known chronic kidney disease or history of kidney transplantation
- Patients admitted with toxic epidermal necrolysis (TEN)
- Patients with estimated glomerular filtration rate (eGFR) ≤ 15 mL/min/1.73m² at admission
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
RIFLE criteria classification at CRRT initiation
Time frame: Baseline( Day0, at CRRT initiation)
Patients receiving CRRT will be classified according to the RIFLE criteria (Risk, Injury, Failure, Loss, End-stage kidney disease) at the time of CRRT initiation. The distribution across categories will be analyzed.
Timing of CRRT initiation
Time frame: Baseline( Day0, at CRRT initiation, recorded from patient medical records)
Date and time of initiation of continuous renal replacement therapy (CRRT), obtained from patient medical records.
Survival status of patients
Time frame: At hospital discharge ( end of hospitalization)
Survival versus non-survival status at the end of hospitalization.
4 secondary outcomes
Presence of comorbidities in non-survivors
Time frame: Baseline( Day0, at hospital admission)
Requirement for mechanical ventilation in non-survivors
Time frame: Through ICU stay, up to hospital discharge (or death)
Requirement for inotropic support in non-survivors
Time frame: Through ICU stay, up to hospital discharge or death
Hospital length of stay in non-survivors
Time frame: From hospital admission through study completion( up to discharge or death)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Sep 2025.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared due to patient confidentiality and ethical considerations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Elif Bombaci, MD principal investigator
Dr.Lutfi Kirdar City Hospital, Department of Anesthesiology and Reanimation, İstanbul, Turkey
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Severe Burns and Acute Kidney Injury, run by Pinar Timur Tasci at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
RIFLE criteria classification at CRRT initiation (time frame: Baseline( Day0, at CRRT initiation)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Sep 2025.