BondingDMSONCT07196618
Bond Strength Evaluation
A study testing dimethyl sulfoxide and Cholorhexidine in people with Bonding, run by Al-Azhar University at 1 site in Egypt.
Trial summary
This study was evaluated the effect of dimethyl sulfoxide pretreatment on tensile bond strength and nanoleakage of resin composite bonded to aged dentin. Read more about this study
- Who is it for?
- Ages 50 to 75 years
- Conditions the study is for
- Bonding
- What is being tested?
- dimethyl sulfoxide and Cholorhexidine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Nov 2025to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients included in the study will be required to present at least one of non caries cervical lesion with sclerotic dentin without pulpal involvement.
- Age of patient: 50 - 75 years
- Patients with non caries cervical lesion will be standardized by clinical performance (FDI world dental federation).
Who cannot join
- Teeth with deep dentinal lesions with pulpal involvement, abscess, pain or swelling
- Developmental disorders and adjacent soft tissue lesions
- Patients with systemic illness will be excluded.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Dimethyl Sulfoxide Pretreatment on Tensile Bond Strength and Nanoleakage of Resin Composite Bonded to Aged Dentin
This study was evaluated the effect of dimethyl sulfoxide pretreatment on tensile bond strength and nanoleakage of resin composite bonded to aged dentin.
- Conditions
- Bonding
- Being tested
- dimethyl sulfoxide, Cholorhexidine
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
dimethyl sulfoxideDrug
dentin pretreated using dimethyl sulfoxide and follow up of patients at 2 weeks, 3 months and 6 months
CholorhexidineDrug
dentin pretreated using chlorhexidine and follow up of patients at 2 weeks, 3months and 6 months
| Study group | Role | What they receive |
|---|---|---|
| DMSO | Active comparator | Not described Receives: Drug: dimethyl sulfoxide |
| CHX | Active comparator | Not described Receives: Drug: Cholorhexidine |
What is being measured
The primary outcome is the main question the study is designed to answer.
clinical assessment evaluation using the FDI world dental federation criteria
Measured: post operative 2 weeks
Secondary outcomes (1)
clinical assessment evaluation using the FDI world dental federation criteria
Measured: post operative 3 months and 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Sep 2025
- Study start1 Nov 2025
- Primary completion1 May 2026
- Study completion1 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for BondingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Aisha Nasr Ali Zahran, Al-Azhar University
- Investigators
- Aisha Zahran, Study director, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07196618
- Sponsor's protocol ID
- P-OP-23-03
- Acronym
- DMSO
- Status last verified
- Sep 2025
- First submitted
- 9 Aug 2025
- Last updated
- 12 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Dimethyl Sulfoxide Pretreatment on Tensile Bond Strength and Nanoleakage of Resin Composite Bonded to Aged Dentin
- ClinicalTrials.gov ID
- NCT07196618
- Acronym / sponsor ID
- DMSO / P-OP-23-03
- Conditions
- Bonding
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- 1 Nov 2025 (actual)
- Primary completion
- 1 May 2026 (actual)
- Study completion
- 1 Jun 2026 (actual)
- First posted
- 29 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study was evaluated the effect of dimethyl sulfoxide pretreatment on tensile bond strength and nanoleakage of resin composite bonded to aged dentin.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| DMSO | Active comparator | Drug: dimethyl sulfoxide |
| CHX | Active comparator | Drug: Cholorhexidine |
Who may qualify
- Ages
- 50 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Patients included in the study will be required to present at least one of non caries cervical lesion with sclerotic dentin without pulpal involvement.
- Age of patient: 50 - 75 years
- Patients with non caries cervical lesion will be standardized by clinical performance (FDI world dental federation).
Key exclusion criteria (3 listed)
- Teeth with deep dentinal lesions with pulpal involvement, abscess, pain or swelling
- Developmental disorders and adjacent soft tissue lesions
- Patients with systemic illness will be excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| dimethyl sulfoxidedentin pretreated using dimethyl sulfoxide and follow up of patients at 2 weeks, 3 months and 6 months | Drug | DMSO |
| Cholorhexidinedentin pretreated using chlorhexidine and follow up of patients at 2 weeks, 3months and 6 months | Drug | CHX |
Primary outcome
clinical assessment evaluation using the FDI world dental federation criteria
Time frame: post operative 2 weeks
1 secondary outcome
clinical assessment evaluation using the FDI world dental federation criteria
Time frame: post operative 3 months and 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Aisha Zahran study director
Al-Azhar University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing dimethyl sulfoxide and Cholorhexidine in people with Bonding, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
clinical assessment evaluation using the FDI world dental federation criteria (time frame: post operative 2 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Aug 2026.