Stroke, IschemicINDEXNCT07199920
Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination.
A study testing Achieva 3.0T dStream Philips in people with Stroke, Ischemic, run by University Hospital, Grenoble at 1 site in France.
Trial summary
Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Stroke, Ischemic
- What is being tested?
- Achieva 3.0T dStream Philips
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteFrance
- Study dates
- 1 Oct 2025to 1 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age > 18 years
- Subacute ischemic stroke patients (< 15 days after onset)
- Middle cerebral artery or anterior cerebral artery territory stroke
- Modified Rankin Scale (mRS) = 0-4
Who cannot join
- MRI contraindications
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination, a Pilot Study and Proof of Concept
Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy).
The recent concept of MRI "Fingerprint" (Magnetic Resonance Fingerprinting, MRF) allows the production of a rapid single sequence and the extraction of numerous parameters.
Demonstrating the feasibility and interpretability of multimodal MRI images acquired in MRF would make it possible to consider implementing and, ultimately, replacing conventional sequences, with the aim of shortening acute stroke management times, increasing the number of sequences acquired within a short timeframe (by increasing informativeness), and thus improving patients\' short and long-term vital and functional prognosis.
- Conditions
- Stroke, Ischemic
- Being tested
- Achieva 3.0T dStream Philips
- Keywords
- MRF (Magnetic Resonance Fingerprinting), stroke, MRI
- Medical subject headings
- Ischemic Stroke, Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Achieva 3.0T dStream PhilipsDevice
Classic and MRF sequences will be carried out on the clinical machine (Achieva 3.0T dStream Philips) of the IRMaGe platform (CHUGA, Université Grenoble Alpes, Inserm, CNRS).
| Study group | Role | What they receive |
|---|---|---|
| Experimental | Experimental | Every patient will perform classic brain MRI with additional MRF sequences. Receives: Device: Achieva 3.0T dStream Philips |
What is being measured
The primary outcome is the main question the study is designed to answer.
Success rate and interpretability of images acquired in MRF
Assessment of the success rate and interpretability (subjective evaluation with Likert scales of very satisfactory, satisfactory, insufficient, or unacceptable)
Measured: From enrollment to the end of the MRI exam
Secondary outcomes (1)
Characterize and extract the physical parameters of the signal acquired with MRF.
Comparison of MRF imaging metrics: signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), using mean values per ROI (region of interest).
Segmentation and comparison of lesions, with calculation of the Dice similarity coefficient and/or SSIM (Structural SIMilarity).
Visualization and description of artifacts encountered during acquisition (e.g., motion).
Quantification of delays:
Acquisition time: retrieval of raw data directly from MRI consoles. Reconstruction time: measurement of computation times. Extraction of information on cerebral microvas
Measured: From enrollment to the end of the MRI exam
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Sep 2025
- Study start1 Oct 2025 (estimated)
- Primary completion1 Sep 2026 (estimated)
- Study completion1 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Stroke, IschemicStudies of the same condition, open and under way.
- More trials run by University Hospital, GrenobleThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Sequential
- Masking
- None (open label)
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Grenoble
- Sponsor type
- University, hospital or other
- Collaborators
- Grenoble Institut des Neurosciences
- Responsible party
- Sponsor
- Investigators
- Loïc LEGRIS, Dr, Principal investigator, llegris@chu-grenoble.fr
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07199920
- Sponsor's protocol ID
- 38RC23.0410
- Acronym
- INDEX
- Status last verified
- Aug 2025
- First submitted
- 14 Feb 2024
- Last updated
- 30 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination, a Pilot Study and Proof of Concept
- ClinicalTrials.gov ID
- NCT07199920
- Acronym / sponsor ID
- INDEX / 38RC23.0410
- Conditions
- Stroke, Ischemic
- Keywords
- MRF (Magnetic Resonance Fingerprinting), stroke, MRI
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- University Hospital, GrenobleUniversity, hospital or other
- Collaborators
- Grenoble Institut des Neurosciences
- Study start
- 1 Oct 2025 (estimated)
- Primary completion
- 1 Sep 2026 (estimated)
- Study completion
- 1 Jan 2027 (estimated)
- First posted
- 30 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy).
The recent concept of MRI "Fingerprint" (Magnetic Resonance Fingerprinting, MRF) allows the production of a rapid single sequence and the extraction of numerous parameters.
Demonstrating the feasibility and interpretability of multimodal MRI images acquired in MRF would make it possible to consider implementing and, ultimately, replacing conventional sequences, with the aim of shortening acute stroke management times, increasing the number of sequences acquired within a short timeframe (by increasing informativeness), and thus improving patients\' short and long-term vital and functional prognosis.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Sequential
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Experimental | Experimental | Device: Achieva 3.0T dStream PhilipsEvery patient will perform classic brain MRI with additional MRF sequences. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age > 18 years
- Subacute ischemic stroke patients (< 15 days after onset)
- Middle cerebral artery or anterior cerebral artery territory stroke
- Modified Rankin Scale (mRS) = 0-4
Key exclusion criteria (1 listed)
- MRI contraindications
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Achieva 3.0T dStream PhilipsClassic and MRF sequences will be carried out on the clinical machine (Achieva 3.0T dStream Philips) of the IRMaGe platform (CHUGA, Université Grenoble Alpes, Inserm, CNRS). | Device | Experimental |
Primary outcome
Success rate and interpretability of images acquired in MRF
Time frame: From enrollment to the end of the MRI exam
Assessment of the success rate and interpretability (subjective evaluation with Likert scales of very satisfactory, satisfactory, insufficient, or unacceptable)
1 secondary outcome
Characterize and extract the physical parameters of the signal acquired with MRF.
Time frame: From enrollment to the end of the MRI exam
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Sep 2025.
- Individual participant dataSharing planned: No
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ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window
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Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion
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Improving Visual Field Deficits With Noninvasive Brain Stimulation
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Loïc LEGRIS, Dr principal investigator
llegris@chu-grenoble.fr
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Achieva 3.0T dStream Philips in people with Stroke, Ischemic, run by University Hospital, Grenoble at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 30 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zaza Putkaradze, Dr (0476767842, zputkaradze@chu-grenoble.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Success rate and interpretability of images acquired in MRF (time frame: From enrollment to the end of the MRI exam). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2025.