Sexual DesireSTEP for SDDNCT07203417
Evaluating Sexual Psychoeducation in Couples With Sexual Desire Discrepancy
A study testing STEP-T, STEP-NT and Waitlist in people with Sexual Desire, run by University of British Columbia at 2 sites in Canada.
Trial summary
Sexual desire discrepancy (SDD) occurs when partners have different levels of sexual desire and are distressed by it. It is one of the most common reasons couples seek help, but no proven dyadic treatment currently exists. This study will test STEP, an online program designed to support couples with SDD. Read more about this study
- Who is it for?
- Ages 19 years and older
- Conditions the study is for
- Sexual Desire
- What is being tested?
- STEP-T, STEP-NT and Waitlist
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 216 participants
- Where
- 2 sitesCanada
- Study dates
- 1 Jan 2026to 31 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Be a couple;
- Be in a romantic relationship for at least one year;
- Be 19 years of age or older;
- Experience perceived and/or actual SDD with personal and/or relational distress reported by at least one partner;
- Be fluent in English;
- Be willing to participate in 8 weekly online treatment sessions;
Show all 11Show fewer
- For couples in long-distance relationships, be able to meet the partner in person and via video call to complete the couple's homework;
- Be willing to abstain from starting any new treatment for SDD for the duration of the study;
- Be willing to voluntarily complete questionnaires administered before, during, and after the treatment;
- Have access to an electronic device capable of running Zoom platform (if randomized to STEP-T);
- Have a stable internet connection.
Who cannot join
- Cases where the discrepancy is attributable to at least one partner identifying as asexual (asexuality is not considered a sexual dysfunction; APA, 2013);
- Presence of untreated psychiatric conditions at the time of recruitment (e.g., depression) that would interfere with participating in the treatment and homework;
- Receive dyadic psychosexual treatment for SDD elsewhere during the study period.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Canada2 sites, 2 recruiting
- Recruiting
UBC Sexual Health Lab, Vancouver Hospital
Vancouver, British Columbia, V5M 1M9
Lori A Brotto, PhD, 604 875 4111 ext. 68898, lori.brotto@vch.ca
- Recruiting
University of British Columbia
Vancouver, British Columbia, V5Z 1M9
Lori A Brotto, 604 875 4111, lori.brotto@ubc.ca
About this study
Official title: A Randomized Trial Comparing a Sex Education and Therapy Online Intervention Delivered With and Without Professional Guidance for the Treatment of Sexual Desire Discrepancy in Couples
Sexual desire discrepancy (SDD) occurs when partners have different levels of sexual desire and are distressed by it. It is one of the most common reasons couples seek help, but no proven dyadic treatment currently exists. This study will test STEP, an online program designed to support couples with SDD. The investigators will compare two formats of STEP: one with therapist support and one self-guided, against a waitlist control group. The investigators will also assess how satisfied couples are and how they engage with the two online formats. This study will generate new data on how effective STEP is with and without guidance, and inform treatment guidelines.
Read the detailed description
This study aims to evaluate the effectiveness of an 8-week online intervention (STEP) designed to reduce distress related to SDD in couples. Two formats of the intervention will be tested: a therapist-guided version (STEP-T) and a self-guided version (STEP-NT). Couples will be randomly assigned to one of these formats or to a waitlist control group.
The study will assess whether both versions of STEP reduce SDD and associated distress, and whether improvements are maintained over a 6-month follow-up. The investigators will also examine participants' satisfaction with the program, engagement, and retention rates.
In addition, the investigators will explore the psychological factors (e.g., quality of sexual communication, emotional intimacy, interoceptive awareness, and self-compassion) that may explain how the intervention works, as well as whether its effectiveness varies based on relationship duration and participants' perceptions of the treatment's credibility.
Finally, the study will gather exploratory information about potential contributing factors to SDD and how couples experience desire-related challenges, using structured worksheets.
The investigators hypothesize that: a) Both STEP-T (therapist-guided) and STEP-NT (self-guided) will significantly reduce sexual desire discrepancy (SDD) and related distress, compared to a waitlist control group; b) Participants in both intervention groups will show improvements in sexual satisfaction, relationship satisfaction, and sexual pleasure; c) These improvements will be maintained at 6-month follow-up; d) STEP-T will produce greater improvements than STEP-NT; e) Participants will report moderate to high satisfaction, consistent homework engagement, and retention rates above 70%, with higher engagement expected in the STEP-T group; f) Increases in interoceptive awareness, emotional intimacy, and sexual communication will predict improvements in SDD and distress. Improvements in self-compassion will predict reduced distress; g) Longer relationship duration and higher perceived treatment credibility will be associated with better outcomes.
Once both members of the couple have consented to participate in the study, they will be emailed a Qualtrics link to individually complete a baseline battery of questionnaires (Time 1) and their alphanumerical code to both keep their answers confidential and make researchers able to associate their answers for statistical purposes. In the baseline battery of questionnaires, participants will complete demographic questions (e.g., age, marital status), measures assessing primary and secondary outcomes, measures of mediators, and of relationship duration (moderator). Once completed, participants will be randomized to STEP-T, STEP-NT, or a waitlist control condition. Participants will be informed about which treatment type they were randomized to via e-mail. Couples initially randomized to the waitlist will complete a second baseline battery of questionnaires (including the same measures of the first baseline battery) after a 10-week waiting period. No treatment will be given to waitlist participants during this waiting period. After this period, they will be randomized to either STEP-T or STEP-NT and will be informed about which treatment type they were randomized to via e-mail.
After scheduling the start date of the treatment, couples in the STEP-T group will meet online with the therapist via videoconferencing software (secure university Zoom account) for 120 minutes/week for 8 weeks. Couples in the STEP-NT group will also have their treatment start date scheduled and will receive one self-guided module per week via email over the course of 8 weeks. Treatment for both groups will begin within one week following the completion of the baseline assessment battery. Participants in both STEP-T and STEP-NT will individually complete, immediately before the start of the next module (for STEP-NT)/session(for STEP-T), an online measure and a homework checklist assessing their engagement with the previously completed module.
In the event that a session (STEP-T) or a module (STEP-NT) is rescheduled, it will preferably be made up within the same week it was originally planned. If that is not possible, the session/module will be made up the following week, in order to minimize the impact on the overall program schedule. Couples in STEP-T will complete treatment credibility measure immediately after session 1 while those in STEP-NT will complete it immediately before receiving module 2. Before Session 3, both members of the couple will be asked to email their completed 3P and Basson's sexual response model worksheets. Before Session 4, both members of the couple will be asked to email their sexual beliefs worksheets. Before Session 5, participants will be asked to email their CBT diamond worksheets and their biases worksheets. Time 1 and an additional questionnaire (measure of treatment satisfaction) will be readministered 2-4 weeks after treatment (Time 2), and again at 6-month follow-up (Time 3; except measure of treatment satisfaction).
The study will be administered entirely online. The research team will follow up with participants who do not respond to emails, fail to complete questionnaires, or miss a session without prior notice, sending up to three reminder emails. If participants do not respond after three follow-up attempts, they will be excluded from the treatment.
- Conditions
- Sexual Desire
- Being tested
- STEP-T, STEP-NT, Waitlist
- Keywords
- Psychoeducation, Sex Therapy, Online Intervention, Dyadic Treatment
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
STEP-TBehavioural
Couples in the STEP-T group will meet online with a therapist for 120 minutes once a week over 8 weeks. Each meeting consists of a therapist-led session focused on the psychoeducational content from the STEP module. Sessions begin with a review of the homework completed during the previous week and end with the assignment of new sex therapy homework related to that day's session. After each session, the therapist will email the couple the module that includes the session's psychoeducational handouts and the sex therapy homework to be completed prior to the next session.
STEP-NTBehavioural
Couples in the STEP-NT group will receive STEP (i.e., one module per week for 8 weeks, including psychoeducational handouts and sex therapy homework), without the therapist-led online sessions. However, like couples in STEP-T, they will be allowed to contact the research team for clarifications related to the structure, instructions, or technical aspects of the exercises. This support will be limited to non-clinical guidance and will not involve any individualized feedback regarding participants' personal experiences or relationship dynamics.
WaitlistOther
While couples randomized to STEP-T and STEP-NT will complete one online baseline assessment battery before randomization, those assigned to the waitlist control condition will complete two baseline assessments online, spaced 10 weeks apart, before being randomized to one of the active treatment groups (i.e., STEP-T or STEP-NT). The 10-week waiting period was selected to match the time it takes couples to complete the 8 modules of STEP. This design allows us to determine that improvements in clinical outcomes are due to the STEP intervention rather than the mere passage of time. Following the post-waiting period assessment (i.e., the second baseline battery), waitlist participants will be randomized to STEP-T or STEP-NT.
| Study group | Role | What they receive |
|---|---|---|
| STEP-T | Active comparator | Participants assigned to this arm will receive STEP guided by a therapist. Receives: Behavioral: STEP-T |
| STEP-NT | Active comparator | Participants assigned to this arm will receive STEP without therapist guidance. Receives: Behavioral: STEP-NT |
| Waitlist | Other | Participants in this arm will not receive any treatment during the first 10 weeks. After 10 weeks, the participants in this arm are re-randomized to either STEP-T or STEP-NT. Receives: Other: Waitlist |
What is being measured
The primary outcome is the main question the study is designed to answer.
A change in relational sexual distress
Relational sexual distress will be measured using the 6-item Relational Concern subscale of the 30-item Sexual Satisfaction Scale (SSS; Meston \& Trapnell, 2005).
Measured: At baseline (T1), post-treatment (2-4 weeks after STEP completion; T2), and 6-month follow-up (T3).
A change in personal sexual distress
Personal sexual distress will be measured using the 13-item Female Sexual Distress Scale-Revised (female version: FSDS-R; Derogatis et al., 2008; male version: Santos-Iglesias et al., 2018).
Measured: At baseline (T1), post-treatment (2-4 weeks after STEP completion; T2), and 6-month follow-up (T3).
A change in perceived sexual desire discrepancy
Perceived sexual desire discrepancy will be measured by asking participants questions on their personal desire and their personal perception of partner's desire. Personal desire will be assessed by the 7-item Partner-related sexual desire subscale of the 13-item SDI-2 (Castro-Calvo et al., 2024). The personal perception of partner's desire will be measured by adapting the original version of SDI-2. SDD will be calculated by doing the absolute difference between one's personal desire and the personal perception of partner's desire scores.
Measured: At baseline (T1), post-treatment (2-4 weeks after STEP completion; T2), and 6-month follow-up (T3).
A change in actual sexual desire discrepancy
The actual sexual desire discrepancy will be measured by calculating the absolute difference between both partners' personal desire scores. Personal desire will be assessed by the 7-item Partner-related sexual desire subscale of the 13-item SDI-2 (Castro-Calvo et al., 2024).
Measured: At baseline (T1), post-treatment (2-4 weeks after STEP completion; T2), and 6-month follow-up (T3).
Secondary outcomes (4)
A change in sexual satisfaction
Sexual satisfaction will be measured by the 20-item The New Sexual Satisfaction Scale (NSSS; Stulhofer et al., 2010).
Measured: At baseline (T1), post-treatment (2-4 weeks after STEP completion, T2), and 6-month follow-up (T3).
A change in relational satisfaction
Relational satisfaction will be measured using the 7-item Relationship Satisfaction Scale (RAS; Hendrick et al., 1998).
Measured: At baseline (T1), post-treatment (2-4 weeks after STEP completion, T2), and 6-month follow-up (T3).
A change in sexual pleasure
Sexual pleasure will be measured using the Experiences of Sexual Pleasure Scale (ESPS; Jabs \& Brotto, manuscript in preparation).
Measured: At baseline (T1), post-treatment (2-4 weeks after STEP completion, T2), and 6-month follow-up (T3).
Treatment satisfaction
Treatment satisfaction will be measured by the 11-item Erectile Dysfunction Inventory of Treatment Satisfaction - Patient Version (Patient EDITS; Althof et al., 1999; adapted for use with a dyadic sample with SDD).
Measured: At post-treatment (2-4 weeks after STEP completion, T2).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2025
- Study start1 Jan 2026
- Primary completion30 Apr 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Sexual DesireStudies of the same condition, open and under way.
- More trials run by University of British ColumbiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This is a parallel-assignment interventional study with three arms: STEP-T, STEP-NT, and Waitlist. Participants are initially randomized to one of these three arms. After 10 weeks, participants in the Waitlist arm are re-randomized to either STEP-T or STEP-NT. STEP-T and STEP-NT participants continue their assigned interventions without crossover. This design allows us to determine that improvements in clinical outcomes are due to the STEP intervention rather than the mere passage of time.
- Masking
- None (open label)
- Enrolment
- 216 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of British Columbia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Lori Brotto, University of British Columbia
- Investigators
- Lori A Brotto, Principal investigator, University of British Columbia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07203417
- Sponsor's protocol ID
- MFE-193938
- Acronym
- STEP for SDD
- Status last verified
- Sep 2025
- First submitted
- 20 Sep 2025
- Last updated
- 5 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is no plan to share individual participant data (IPD) for this study, due to the sensitive nature of couple-level data and the associated risk of re-identification.
Publications
Marieke D, Joana C, Giovanni C, Erika L, Patricia P, Yacov R, Aleksandar S. Sexual Desire Discrepancy: A Position Statement of the European Society for Sexual Medicine. Sex Med. 2020 Jun;8(2):121-131. doi: 10.1016/j.esxm.2020.02.008. Epub 2020 Mar 16.
PubMed 32192965Brotto LA, Zdaniuk B, Chivers ML, Jabs F, Grabovac AD, Lalumiere ML. Mindfulness and Sex Education for Sexual Interest/Arousal Disorder: Mediators and Moderators of Treatment Outcome. J Sex Res. 2023 May;60(4):508-521. doi: 10.1080/00224499.2022.2126815. Epub 2022 Sep 30.
PubMed 36178481Brotto LA, Zdaniuk B, Chivers ML, Jabs F, Grabovac A, Lalumiere ML, Weinberg J, Schonert-Reichl KA, Basson R. A randomized trial comparing group mindfulness-based cognitive therapy with group supportive sex education and therapy for the treatment of female sexual interest/arousal disorder. J Consult Clin Psychol. 2021 Jul;89(7):626-639. doi: 10.1037/ccp0000661.
PubMed 34383535
Study at a glance
From the registry record, last updated by the sponsor on 5 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized Trial Comparing a Sex Education and Therapy Online Intervention Delivered With and Without Professional Guidance for the Treatment of Sexual Desire Discrepancy in Couples
- ClinicalTrials.gov ID
- NCT07203417
- Acronym / sponsor ID
- STEP for SDD / MFE-193938
- Conditions
- Sexual Desire
- Keywords
- Psychoeducation, Sex Therapy, Online Intervention, Dyadic Treatment
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 216 participants (estimated)
- Lead sponsor
- University of British ColumbiaUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 30 Apr 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 2 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Sexual desire discrepancy (SDD) occurs when partners have different levels of sexual desire and are distressed by it. It is one of the most common reasons couples seek help, but no proven dyadic treatment currently exists. This study will test STEP, an online program designed to support couples with SDD. The investigators will compare two formats of STEP: one with therapist support and one self-guided, against a waitlist control group. The investigators will also assess how satisfied couples are and how they engage with the two online formats. This study will generate new data on how effective STEP is with and without guidance, and inform treatment guidelines.
Detailed description
This study aims to evaluate the effectiveness of an 8-week online intervention (STEP) designed to reduce distress related to SDD in couples. Two formats of the intervention will be tested: a therapist-guided version (STEP-T) and a self-guided version (STEP-NT). Couples will be randomly assigned to one of these formats or to a waitlist control group.
The study will assess whether both versions of STEP reduce SDD and associated distress, and whether improvements are maintained over a 6-month follow-up. The investigators will also examine participants' satisfaction with the program, engagement, and retention rates.
In addition, the investigators will explore the psychological factors (e.g., quality of sexual communication, emotional intimacy, interoceptive awareness, and self-compassion) that may explain how the intervention works, as well as whether its effectiveness varies based on relationship duration and participants' perceptions of the treatment's credibility.
Finally, the study will gather exploratory information about potential contributing factors to SDD and how couples experience desire-related challenges, using structured worksheets.
The investigators hypothesize that: a) Both STEP-T (therapist-guided) and STEP-NT (self-guided) will significantly reduce sexual desire discrepancy (SDD) and related distress, compared to a waitlist control group; b) Participants in both intervention groups will show improvements in sexual satisfaction, relationship satisfaction, and sexual pleasure; c) These improvements will be maintained at 6-month follow-up; d) STEP-T will produce greater improvements than STEP-NT; e) Participants will report moderate to high satisfaction, consistent homework engagement, and retention rates above 70%, with higher engagement expected in the STEP-T group; f) Increases in interoceptive awareness, emotional intimacy, and sexual communication will predict improvements in SDD and distress. Improvements in self-compassion will predict reduced distress; g) Longer relationship duration and higher perceived treatment credibility will be associated with better outcomes.
Once both members of the couple have consented to participate in the study, they will be emailed a Qualtrics link to individually complete a baseline battery of questionnaires (Time 1) and their alphanumerical code to both keep their answers confidential and make researchers able to associate their answers for statistical purposes. In the baseline battery of questionnaires, participants will complete demographic questions (e.g., age, marital status), measures assessing primary and secondary outcomes, measures of mediators, and of relationship duration (moderator). Once completed, participants will be randomized to STEP-T, STEP-NT, or a waitlist control condition. Participants will be informed about which treatment type they were randomized to via e-mail. Couples initially randomized to the waitlist will complete a second baseline battery of questionnaires (including the same measures of the first baseline battery) after a 10-week waiting period. No treatment will be given to waitlist participants during this waiting period. After this period, they will be randomized to either STEP-T or STEP-NT and will be informed about which treatment type they were randomized to via e-mail.
After scheduling the start date of the treatment, couples in the STEP-T group will meet online with the therapist via videoconferencing software (secure university Zoom account) for 120 minutes/week for 8 weeks. Couples in the STEP-NT group will also have their treatment start date scheduled and will receive one self-guided module per week via email over the course of 8 weeks. Treatment for both groups will begin within one week following the completion of the baseline assessment battery. Participants in both STEP-T and STEP-NT will individually complete, immediately before the start of the next module (for STEP-NT)/session(for STEP-T), an online measure and a homework checklist assessing their engagement with the previously completed module.
In the event that a session (STEP-T) or a module (STEP-NT) is rescheduled, it will preferably be made up within the same week it was originally planned. If that is not possible, the session/module will be made up the following week, in order to minimize the impact on the overall program schedule. Couples in STEP-T will complete treatment credibility measure immediately after session 1 while those in STEP-NT will complete it immediately before receiving module 2. Before Session 3, both members of the couple will be asked to email their completed 3P and Basson's sexual response model worksheets. Before Session 4, both members of the couple will be asked to email their sexual beliefs worksheets. Before Session 5, participants will be asked to email their CBT diamond worksheets and their biases worksheets. Time 1 and an additional questionnaire (measure of treatment satisfaction) will be readministered 2-4 weeks after treatment (Time 2), and again at 6-month follow-up (Time 3; except measure of treatment satisfaction).
The study will be administered entirely online. The research team will follow up with participants who do not respond to emails, fail to complete questionnaires, or miss a session without prior notice, sending up to three reminder emails. If participants do not respond after three follow-up attempts, they will be excluded from the treatment.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- This is a parallel-assignment interventional study with three arms: STEP-T, STEP-NT, and Waitlist. Participants are initially randomized to one of these three arms. After 10 weeks, participants in the Waitlist arm are re-randomized to either STEP-T or STEP-NT. STEP-T and STEP-NT participants continue their assigned interventions without crossover. This design allows us to determine that improvements in clinical outcomes are due to the STEP intervention rather than the mere passage of time.
| Arm | Type | Receives |
|---|---|---|
| STEP-T | Active comparator | Behavioral: STEP-TParticipants assigned to this arm will receive STEP guided by a therapist. |
| STEP-NT | Active comparator | Behavioral: STEP-NTParticipants assigned to this arm will receive STEP without therapist guidance. |
| Waitlist | Other | Other: WaitlistParticipants in this arm will not receive any treatment during the first 10 weeks. After 10 weeks, the participants in this arm are re-randomized to either STEP-T or STEP-NT. |
Who may qualify
- Ages
- 19 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (11 listed)
- Be a couple;
- Be in a romantic relationship for at least one year;
- Be 19 years of age or older;
- Experience perceived and/or actual SDD with personal and/or relational distress reported by at least one partner;
- Be fluent in English;
Key exclusion criteria (3 listed)
- Cases where the discrepancy is attributable to at least one partner identifying as asexual (asexuality is not considered a sexual dysfunction; APA, 2013);
- Presence of untreated psychiatric conditions at the time of recruitment (e.g., depression) that would interfere with participating in the treatment and homework;
- Receive dyadic psychosexual treatment for SDD elsewhere during the study period.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| STEP-TCouples in the STEP-T group will meet online with a therapist for 120 minutes once a week over 8 weeks. Each meeting consists of a therapist-led session focused on the psychoeducational content from the STEP module. Sessions begin with a review of the homework completed during the previous week and end with the assignment of new sex therapy homework related to that day's session. After each session, the therapist will email the couple the module that includes the session's psychoeducational handouts and the sex therapy homework to be completed prior to the next session. | Behavioural | STEP-T |
| STEP-NTCouples in the STEP-NT group will receive STEP (i.e., one module per week for 8 weeks, including psychoeducational handouts and sex therapy homework), without the therapist-led online sessions. However, like couples in STEP-T, they will be allowed to contact the research team for clarifications related to the structure, instructions, or technical aspects of the exercises. This support will be limited to non-clinical guidance and will not involve any individualized feedback regarding participants' personal experiences or relationship dynamics. | Behavioural | STEP-NT |
| WaitlistWhile couples randomized to STEP-T and STEP-NT will complete one online baseline assessment battery before randomization, those assigned to the waitlist control condition will complete two baseline assessments online, spaced 10 weeks apart, before being randomized to one of the active treatment groups (i.e., STEP-T or STEP-NT). The 10-week waiting period was selected to match the time it takes couples to complete the 8 modules of STEP. This design allows us to determine that improvements in clinical outcomes are due to the STEP intervention rather than the mere passage of time. Following the post-waiting period assessment (i.e., the second baseline battery), waitlist participants will be randomized to STEP-T or STEP-NT. | Other | Waitlist |
Primary outcome
A change in relational sexual distress
Time frame: At baseline (T1), post-treatment (2-4 weeks after STEP completion; T2), and 6-month follow-up (T3).
Relational sexual distress will be measured using the 6-item Relational Concern subscale of the 30-item Sexual Satisfaction Scale (SSS; Meston \& Trapnell, 2005).
A change in personal sexual distress
Time frame: At baseline (T1), post-treatment (2-4 weeks after STEP completion; T2), and 6-month follow-up (T3).
Personal sexual distress will be measured using the 13-item Female Sexual Distress Scale-Revised (female version: FSDS-R; Derogatis et al., 2008; male version: Santos-Iglesias et al., 2018).
A change in perceived sexual desire discrepancy
Time frame: At baseline (T1), post-treatment (2-4 weeks after STEP completion; T2), and 6-month follow-up (T3).
Perceived sexual desire discrepancy will be measured by asking participants questions on their personal desire and their personal perception of partner's desire. Personal desire will be assessed by the 7-item Partner-related sexual desire subscale of the 13-item SDI-2 (Castro-Calvo et al., 2024). The personal perception of partner's desire will be measured by adapting the original version of SDI-2. SDD will be calculated by doing the absolute difference between one's personal desire and the personal perception of partner's desire scores.
A change in actual sexual desire discrepancy
Time frame: At baseline (T1), post-treatment (2-4 weeks after STEP completion; T2), and 6-month follow-up (T3).
The actual sexual desire discrepancy will be measured by calculating the absolute difference between both partners' personal desire scores. Personal desire will be assessed by the 7-item Partner-related sexual desire subscale of the 13-item SDI-2 (Castro-Calvo et al., 2024).
4 secondary outcomes
A change in sexual satisfaction
Time frame: At baseline (T1), post-treatment (2-4 weeks after STEP completion, T2), and 6-month follow-up (T3).
A change in relational satisfaction
Time frame: At baseline (T1), post-treatment (2-4 weeks after STEP completion, T2), and 6-month follow-up (T3).
A change in sexual pleasure
Time frame: At baseline (T1), post-treatment (2-4 weeks after STEP completion, T2), and 6-month follow-up (T3).
Treatment satisfaction
Time frame: At post-treatment (2-4 weeks after STEP completion, T2).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Jan 2026.
- Background: PubMed 32192965Marieke D, Joana C, Giovanni C, Erika L, Patricia P, Yacov R, Aleksandar S. Sexual Desire Discrepancy: A Position Statement of the European Society for Sexual Medicine. Sex Med. 2020 Jun;8(2):121-131. doi: 10.1016/j.esxm.2020.02.008. Epub 2020 Mar 16.
- Background: PubMed 36178481Brotto LA, Zdaniuk B, Chivers ML, Jabs F, Grabovac AD, Lalumiere ML. Mindfulness and Sex Education for Sexual Interest/Arousal Disorder: Mediators and Moderators of Treatment Outcome. J Sex Res. 2023 May;60(4):508-521. doi: 10.1080/00224499.2022.2126815. Epub 2022 Sep 30.
- Background: PubMed 34383535Brotto LA, Zdaniuk B, Chivers ML, Jabs F, Grabovac A, Lalumiere ML, Weinberg J, Schonert-Reichl KA, Basson R. A randomized trial comparing group mindfulness-based cognitive therapy with group supportive sex education and therapy for the treatment of female sexual interest/arousal disorder. J Consult Clin Psychol. 2021 Jul;89(7):626-639. doi: 10.1037/ccp0000661.
- Individual participant dataSharing planned: No. There is no plan to share individual participant data (IPD) for this study, due to the sensitive nature of couple-level data and the associated risk of re-identification.
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BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder
Early-stage Breast Cancer, Hypoactive Sexual Desire Disorder
Not yet recruitingPhase 2
An Open-Label Study of 50 Mg Oral Testosterone Undecanoate (Kyztrex) in Menopausal Women with Low Testosterone and HSDD
Hypoactive Sexual Desire Disorder
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Lori A Brotto principal investigator
University of British Columbia
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing STEP-T, STEP-NT and Waitlist in people with Sexual Desire, run by University of British Columbia at 2 sites in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 11 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Roberta Galizia (604 875 4111, roberta.galizia@ubc.ca), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
A change in relational sexual distress (time frame: At baseline (T1), post-treatment (2-4 weeks after STEP completion; T2), and 6-month follow-up (T3).). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07203417, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Jan 2026; AzTrials last refreshed its copy on 6 Nov 2026.