AgingFAXAGENCT07207044
FAXAGE: Fasting And Exercise To Slow Aging In Humans
A study testing Exercise - Strength + Cardio, Time-restricted feeding and Time-restricted feeding + Exercise in people with Aging and Healthy Aging, run by University of Copenhagen at 1 site in Denmark.
Trial summary
FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise and fasting group and a control group. Read more about this study
- Who is it for?
- Ages 20 years and olderHealthy volunteers can take part
- Conditions the study is for
- Aging, Healthy Aging, Aging Frailty
- What is being tested?
- Exercise - Strength + Cardio, Time-restricted feeding and Time-restricted feeding + Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 240 participants
- Where
- 1 siteDenmark
- Study dates
- 1 Oct 2025to 30 Aug 2042
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Provision of signed and dated informed consent
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Aged >20 years
- In good general health meaning maximally 1 well-managed chronic disease
- Non-smoker.
Who cannot join
- Inability or unwillingness to adhere to the TRF regiment
- Inability or unwillingness to perform the prescribed physical exercise
- Treatment with other investigational drug or intervention within 1 year
- >1 hour of systematic strenuous exercise or strength training a week
- Current time-restricted eating habits
- Severe or dysregulated medical disease (i.e. active cancer, uncontrolled diabetes, severe pulmonary or heart disease)
Show all 9Show fewer
- >1 well-managed chronic disease
- Smoker
- Use of systemic glucocorticoids, androgens or antiandrogens.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Denmark1 site, 1 recruiting
- Recruiting
University of Copenhagen
Copenhagen, Copenhagen N, 2200
Morten Scheibye-Knudsen, MD, +4542507060, mscheibye@sund.ku.dk
About this study
Official title: FAXAGE: A Randomized, Controlled Clinical Trial Of Fasting And Exercise To Slow Aging In Humans
FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise and fasting group and a control group. The intervention will last for one year, and tests of biomarkers of aging will be performed at baseline, after 3 months, 6 months and at the end of the intervention. A reference group of participants over the age of 20 equally distributed by age and sex will be used to train an algorithm for determination of biological age. The study will include both physical, molecular and digital biomarkers including DNA-methylation, VO2max, body composition and face- and voice-age. The main outcome of the project is DNA-methylation age at week 52. Secondary outcomes are the rest of the tested biomarkers at week 52. It is hypothesised that the intervention groups will have similar superior benefits after the 52 weeks of intervention.
- Conditions
- Aging, Healthy Aging, Aging Frailty
- Being tested
- Exercise - Strength + Cardio, Time-restricted feeding, Time-restricted feeding + Exercise
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise - Strength + CardioBehavioural
Supervised strength training 2x/week + self-administered cardio training 2x/week.
Time-restricted feedingBehavioural
Time-restricted feeding in a 16/8 regimen - 16 hours of fast and 8 hours of eating per day.
Time-restricted feeding + ExerciseBehavioural
Strength and cardio exercise 2x/week each combined with time-restricted feeding in a 16/8 regimen.
| Study group | Role | What they receive |
|---|---|---|
| TRF | Experimental | Not described Receives: Behavioral: Time-restricted feeding |
| EXE | Experimental | Not described Receives: Behavioral: Exercise - Strength + Cardio |
| FAX | Experimental | Not described Receives: Behavioral: Time-restricted feeding + Exercise |
| CON | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
DNA-methylation age
Changes in predicted biological age from baseline based on DNA-methylation from isolated peripheral blood mononucleated cells after 52 weeks of intervention
Measured: From enrollment until end of intervention at 52 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Oct 2025
- Study start1 Oct 2025
- Primary completion30 Aug 2027 (estimated)
- Study completion30 Aug 2042 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for AgingStudies of the same condition, open and under way.
- More trials run by University of CopenhagenThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 240 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Copenhagen
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07207044
- Sponsor's protocol ID
- H-25020642
- Acronym
- FAXAGE
- Status last verified
- Sep 2025
- First submitted
- 23 Sep 2025
- Last updated
- 28 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Fals EB, Springborg EC, Berthelsen AB, Nyeman-Nielsen J, Larsen S, Scheibye-Knudsen M. Study protocol for FAXAge: a randomized, controlled clinical trial of fasting and exercise to slow aging in humans. Geroscience. 2026 Jun 29. doi: 10.1007/s11357-026-02362-0. Online ahead of print.
PubMed 42373885
Study at a glance
From the registry record, last updated by the sponsor on 28 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- FAXAGE: A Randomized, Controlled Clinical Trial Of Fasting And Exercise To Slow Aging In Humans
- ClinicalTrials.gov ID
- NCT07207044
- Acronym / sponsor ID
- FAXAGE / H-25020642
- Conditions
- Aging, Healthy Aging, Aging Frailty
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 240 participants (estimated)
- Lead sponsor
- University of CopenhagenUniversity, hospital or other
- Study start
- 1 Oct 2025 (actual)
- Primary completion
- 30 Aug 2027 (estimated)
- Study completion
- 30 Aug 2042 (estimated)
- First posted
- 3 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise and fasting group and a control group. The intervention will last for one year, and tests of biomarkers of aging will be performed at baseline, after 3 months, 6 months and at the end of the intervention. A reference group of participants over the age of 20 equally distributed by age and sex will be used to train an algorithm for determination of biological age. The study will include both physical, molecular and digital biomarkers including DNA-methylation, VO2max, body composition and face- and voice-age. The main outcome of the project is DNA-methylation age at week 52. Secondary outcomes are the rest of the tested biomarkers at week 52. It is hypothesised that the intervention groups will have similar superior benefits after the 52 weeks of intervention.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| TRF | Experimental | Behavioral: Time-restricted feeding |
| EXE | Experimental | Behavioral: Exercise - Strength + Cardio |
| FAX | Experimental | Behavioral: Time-restricted feeding + Exercise |
| CON | No intervention | – |
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Provision of signed and dated informed consent
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Aged >20 years
- In good general health meaning maximally 1 well-managed chronic disease
- Non-smoker.
Key exclusion criteria (9 listed)
- Inability or unwillingness to adhere to the TRF regiment
- Inability or unwillingness to perform the prescribed physical exercise
- Treatment with other investigational drug or intervention within 1 year
- >1 hour of systematic strenuous exercise or strength training a week
- Current time-restricted eating habits
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise - Strength + CardioSupervised strength training 2x/week + self-administered cardio training 2x/week. | Behavioural | EXE |
| Time-restricted feedingTime-restricted feeding in a 16/8 regimen - 16 hours of fast and 8 hours of eating per day. | Behavioural | TRF |
| Time-restricted feeding + ExerciseStrength and cardio exercise 2x/week each combined with time-restricted feeding in a 16/8 regimen. | Behavioural | FAX |
Primary outcome
DNA-methylation age
Time frame: From enrollment until end of intervention at 52 weeks
Changes in predicted biological age from baseline based on DNA-methylation from isolated peripheral blood mononucleated cells after 52 weeks of intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Jan 2026.
- Derived from this study: PubMed 42373885Fals EB, Springborg EC, Berthelsen AB, Nyeman-Nielsen J, Larsen S, Scheibye-Knudsen M. Study protocol for FAXAge: a randomized, controlled clinical trial of fasting and exercise to slow aging in humans. Geroscience. 2026 Jun 29. doi: 10.1007/s11357-026-02362-0. Online ahead of print.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise - Strength + Cardio, Time-restricted feeding and Time-restricted feeding + Exercise in people with Aging and Healthy Aging, run by University of Copenhagen at 1 site in Denmark.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 28 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Denmark. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
DNA-methylation age (time frame: From enrollment until end of intervention at 52 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07207044, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jan 2026.