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Neuromuscular ControlNCT07221305

RIIP REPS Neuromuscular Training

A study of Neuromuscular Control and Healthy, run by Hospital for Special Surgery, New York at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The purpose of this study is to assess both the feasibility and efficacy of a 6-week mobile-application-based neuromuscular training program in high school athletes by measuring adherence rates and examining changes in agility and neuromuscular control. Read more about this study

Who is it for?
Ages 14 to 18 yearsHealthy volunteers can take part
Could I receive a placebo?
No, everyone receives an active treatment
How many people
19 participants
Where
1 siteUnited States
Study dates
2 Jul 2023to 29 Oct 2023
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 14 to 18 years
  • All sexes
  • Healthy volunteers accepted
  • Child, Adult

Who may be able to join

  • Age 14-18
  • Actively participating in an organized sport OR have participated in an organized sport in the last 12 months
  • Pre-intervention testing completed AND post-intervention testing completed within 2 weeks of completing the 6 week program

Who cannot join

  • Individuals whose physical activity and/or sports participation is currently limited by an illness or injury
  • Individuals with previous lower extremity injury and/or surgery
  • Individuals who are not fluent in English
  • Individuals without access to an iOS or Android mobile phone

Trial locations and contacts

1 site in 1 country.

United States1 site

  • Hospital for Special Surgery

    New York, New York, 10021

Other trials in United States

About this study

Official title: Feasibility and Efficacy of Delivering a Mobile Application-Based Neuromuscular Training Program to High School Athletes: Adherence, Agility, and Single Leg Squat Kinematics

The purpose of this study is to assess both the feasibility and efficacy of a 6-week mobile-application-based neuromuscular training program in high school athletes by measuring adherence rates and examining changes in agility and neuromuscular control. Outcomes were measured both during the intervention (adherence) as well as at pre- and post-intervention data collection sessions.

Read the detailed description

This study recruited high school athletes (ages 14-18) from Westchester County, NY to participate in a six week mobile application-based neuromuscular control training program that was downloaded onto each participant's personal smartphone and consisted of 24 unique 7-minute sessions. Pre/post intervention assessments included (1) an agility T test and (2) a video-recorded single leg squat test from sagittal and coronal planes. Sagittal plane analysis captured peak knee and hip flexion angles; coronal plane analysis assessed alignment of the knee, hips, and trunk. These subcomponent scores were combined into an 8-point composite movement quality score previously described by Di Paolo et al. Paired t-tests and effect sizes (Cohen's d) were computed to evaluate pre-post changes in agility T test performance and Di Paolo single leg squat composite and subcomponent scores. Participants were arranged by adherence into high (≥12 sessions) and low (<12 sessions) groups to determine if any relationship existed between adherence and outcome measures.

Being tested
Neuromuscular Control Training
Keywords
Neuromuscular Control Training, Injury Prevention, High School Athletes

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Neuromuscular Control TrainingOther

    Also called Neuromuscular Training, NMT

    The mobile app-based neuromuscular control training program was administered via the RIIP REPS application. The program consisted of 24 unique 7-minute sessions. Each session emphasized bodyweight training targeting landing mechanics, trunk and hip control, balance, and posterior chain engagement. The sessions progressed in difficulty throughout the intervention.

Study groups in NCT07221305
Study groupRoleWhat they receive
Neuromuscular Control Training ProgramExperimentalThe intervention was a self-paced neuromuscular control training program that athletes completed on their mobile phones via the RIIP REPS app. Athletes were instructed to complete 4 sessions per week throughout the 6 week intervention.
Receives: Other: Neuromuscular Control Training

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Compliance

    Compliance with the RIIP REPS mobile program was defined by how many sessions were completed by each participant. Full compliance consisted of the recommended four sessions per week for a total of 24 sessions over the 6 week period. Adherence tiers were determined based on the number of sessions completed and were as follows: low adherence (<12 sessions), and high adherence (>12 sessions).

    Measured: Throughout the 6 week intervention

Secondary outcomes (2)

  1. Movement Quality

    Athletes completed a total of 12 single-leg squats (SLS), guided by trained sports medicine educators. The test protocol consisted of three SLS per leg in the frontal plane and three in the sagittal plane. In the frontal plane, the athlete faced the camera; for the sagittal plane, the athlete turned 90 degrees, maintaining the same squatting leg toward the camera. If a participant lost balance during a repetition, they were instructed to repeat the squat to ensure three successful trials per view. Videos were then analyzed based on the criteria set forth by Di Paolo et al. and the measurements were then used to compute a composite score (0 through 8) with a higher score indicating better performance.

    Measured: Testing was performed before and within 2 weeks after the 6 week intervention.

  2. Agility T Test

    The T test is a widely used measure of change-of-direction speed and agility, consisting of a T-shaped running course that challenges lateral, forward, and backward movement. Athletes began at the base of the "T," sprinted forward 10 yards to touch a central cone, shuffled 5 yards to one side to touch another cone, shuffled 10 yards laterally to the opposite side to touch a second cone, returned to the center cone via shuffle, and then backpedaled to the starting point. Proper technique and cone touches were required for a valid trial. To ensure timing accuracy, each trial was independently timed by two study personnel using handheld stopwatches. The average of the two recorded times was used for analysis.

    Measured: Testing was performed before and within 2 weeks after the 6 week intervention.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Oct 2025
  2. Study start2 Jul 2023
  3. Primary completion22 Oct 2023
  4. Study completion29 Oct 2023

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
19 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07221305
Sponsor's protocol ID
IRB #2023-0499
Status last verified
Oct 2025
First submitted
23 Oct 2025
Last updated
30 Oct 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Petushek EJ, Sugimoto D, Stoolmiller M, Smith G, Myer GD. Evidence-Based Best-Practice Guidelines for Preventing Anterior Cruciate Ligament Injuries in Young Female Athletes: A Systematic Review and Meta-analysis. Am J Sports Med. 2019 Jun;47(7):1744-1753. doi: 10.1177/0363546518782460. Epub 2018 Jul 12.

    PubMed 30001501

  • Steib S, Rahlf AL, Pfeifer K, Zech A. Dose-Response Relationship of Neuromuscular Training for Injury Prevention in Youth Athletes: A Meta-Analysis. Front Physiol. 2017 Nov 14;8:920. doi: 10.3389/fphys.2017.00920. eCollection 2017.

    PubMed 29184511

  • Di Paolo S, Musa F, d'Orsi GM, Grassi A, Vulpiani MC, Zaffagnini S, Della Villa F. A comprehensive two-dimensional scoring system to assess the single-leg squat task in football players. Knee. 2024 Jun;48:52-62. doi: 10.1016/j.knee.2024.02.016. Epub 2024 Mar 20.

    PubMed 38513322

Questions about this trial

What is this clinical trial studying?

A study of Neuromuscular Control and Healthy, run by Hospital for Special Surgery, New York at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 30 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Compliance (time frame: Throughout the 6 week intervention). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07221305, which also lists 3 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Oct 2025.

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