No ConditionNCT07221643
Carotenoids in the Skin and Immune Aging
An observational study of No Condition and Skin Carotenoids and Immune-aging, run by Stanford University at 1 site in United States.
Trial summary
This study aims to examine the connection between the level of carotenoids in the skin and a number of immune related health parameters. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- No Condition, Skin Carotenoids and Immune-aging
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 9 Oct 2025to 1 Apr 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Healthy individuals who are either between 18 to 30 years old or over 65 years old.
Who may be able to join
- Willing and able to provide written informed consent
- Age 18-30 years OR 65 years and older
- Healthy individuals without uncontrolled medical conditions (over the counter inhaled and topical steroids allowed)
- Fiitzpatrick I-VI (all skin types)
Who cannot join
- Pregnant or breastfeeding
- uncontrolled medical conditions
- Skin conditions on the upper extremity that would interfere with skin measurements of carotenoid levels such as active atopic dermatitis or psoriasis
- Concurrent use of medications that affect the immune system, within 4 weeks of enrollment (eg. prednisone, biologics, methotrexate, rapamycin, prescription topical steroids, prescription inhaled steroids, others)
- Unable to follow study protocol
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Po-Han Ho, MD contact
United States1 site, 1 recruiting
- Recruiting
Stanford Health - General Dermatology Clinic
Redwood City, California, 94063
Anne Lynn S. Chang, MD
About this study
Official title: Carotenoids in the Skin and Immune Aging: a Pilot Observational Study
This study aims to examine the connection between the level of carotenoids in the skin and a number of immune related health parameters.
- Conditions
- No Condition, Skin Carotenoids and Immune-aging
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Young adult | Participants are 18 to 30 years old. | |
| Older adult | Participants are over 65 years old. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Skin carotenoid levels and skin aging features
We will assess the skin carotenoid levels' correlation with skin aging features, such as wrinkles, fine lines, and age spots.
Measured: one day
Secondary outcomes (2)
Skin carotenoid levels and biomarkers of aging
We will assess the skin carotenoid levels' correlation with biomarkers associated with aging, such as C-reactive protein, telomere length, telomerase activity etc.
Measured: one day
Skin carotenoid levels and self-reported perception of health
We will assess the skin carotenoid levels' correlation with self reported scores on general health and health beliefs, incidence of respiratory, gut and skin allergy symptoms, and sleep quality.
Measured: 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Oct 2025
- Study start9 Oct 2025
- Primary completion1 Mar 2026 (estimated)
- Study completion1 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for No ConditionStudies of the same condition, open and under way.
- More trials run by Stanford UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Stanford University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Anne Chang, Stanford University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07221643
- Sponsor's protocol ID
- 80982
- Status last verified
- Oct 2025
- First submitted
- 30 Sep 2025
- Last updated
- 15 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Carotenoids in the Skin and Immune Aging: a Pilot Observational Study
- ClinicalTrials.gov ID
- NCT07221643
- Acronym / sponsor ID
- 80982
- Conditions
- No Condition, Skin Carotenoids and Immune-aging
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Stanford UniversityUniversity, hospital or other
- Study start
- 9 Oct 2025 (actual)
- Primary completion
- 1 Mar 2026 (estimated)
- Study completion
- 1 Apr 2026 (estimated)
- First posted
- 28 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to examine the connection between the level of carotenoids in the skin and a number of immune related health parameters.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Young adult | – | –Participants are 18 to 30 years old. |
| Older adult | – | –Participants are over 65 years old. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Healthy individuals who are either between 18 to 30 years old or over 65 years old.
Key inclusion criteria (4 listed)
- Willing and able to provide written informed consent
- Age 18-30 years OR 65 years and older
- Healthy individuals without uncontrolled medical conditions (over the counter inhaled and topical steroids allowed)
- Fiitzpatrick I-VI (all skin types)
Key exclusion criteria (5 listed)
- Pregnant or breastfeeding
- uncontrolled medical conditions
- Skin conditions on the upper extremity that would interfere with skin measurements of carotenoid levels such as active atopic dermatitis or psoriasis
- Concurrent use of medications that affect the immune system, within 4 weeks of enrollment (eg. prednisone, biologics, methotrexate, rapamycin, prescription topical steroids, prescription inhaled steroids, others)
- Unable to follow study protocol
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Skin carotenoid levels and skin aging features
Time frame: one day
We will assess the skin carotenoid levels' correlation with skin aging features, such as wrinkles, fine lines, and age spots.
2 secondary outcomes
Skin carotenoid levels and biomarkers of aging
Time frame: one day
Skin carotenoid levels and self-reported perception of health
Time frame: 2 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Dec 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Po-Han Ho, MD contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of No Condition and Skin Carotenoids and Immune-aging, run by Stanford University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Xiaochen Zhong, BA (408-816-0111, xczhong@stanford.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Skin carotenoid levels and skin aging features (time frame: one day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Dec 2025.