AzTrials
AzTrials

Advanced Non-Small Cell Lung CancerPhase 3NCT07222566

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

A Phase 3 study testing PF-08634404, Pembrolizumab and Chemotherapy Regimen 1 in people with Advanced Non-Small Cell Lung Cancer and Non-Small Cell Lung Cancer, run by Pfizer at 484 sites in 20 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

This study is being done to find out if a new medicine called PF-08634404, when given with chemotherapy, works better than the present standard treatment (pembrolizumab with chemotherapy) for adults with a type of lung cancer called non-small cell lung cancer (NSCLC) that is either locally advanced (spread to nearby… Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
PF-08634404, Pembrolizumab and Chemotherapy Regimen 1
Type of treatment
Injection or infusion
Could I receive a placebo?
No, everyone receives an active treatment
How many people
1,410 participants
Where
484 sitesin 20 countries
Study dates
6 Jan 2026to 26 Aug 2032
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • 18 years of age or older at screening.
  • Have pathologically confirmed locally advanced (Stage IIIB/IIIC) or metastatic (Stage IV)squamous or non-squamous NSCLC and not be a candidate for complete surgical resection and curative concurrent/sequential chemoradiotherapy (according to the 9th edition of the Union for International Cancer Control and American Joint Committee on Cancer lung cancer Tumor, lymph nodes, metastasis (TNM) staging system).
  • Have tumor tissue available, either paraffin block or slides from a core, excisional or fine needle biopsy
  • PD-L1 status available based on local testing results
  • Measurable disease based on RECIST v1.1 per investigator.
  • Eastern Cooperative Oncology Group performance status (ECOG) score of 0 or 1
  • Expected survival ≥12 weeks

Who cannot join

  • Participants with known actionable genomic alteration (AGAs), including estimated glomerular filtration rate (EGFR), anaplastic lymphoma kinase (ALK), Repressor of Silencing 1 (ROS1), neurotrophic tyrosine receptor kinase (NTRK), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), rearranged during transfection (RET), and mesenchymal-epithelial transition (MET), for which there are available first-line therapies per local standard-of-care (SOC) are ineligible. Documented negative results for EGFR, ALK, and ROS1 AGAs are required for participants with non-squamous histology.
  • Known active CNS lesions are excluded. Participants with definitively treated brain metastases (surgery and/or radiotherapy) may be eligible. Clinically inactive brain metastases of longest diameter < 1 cm are permitted.
  • Participants with clinically significant risk of hemorrhage or fistula are excluded.
  • Participants with any history of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy.
  • Unresolved toxicities from prior anti-tumor therapy, that did not recover to NCI CTCAE v5.0 Grade 0 or 1.
  • Known to have a history of a severe allergy to any component of the study intervention, or a history of severe allergic reaction to chimeric or humanized antibody.
Show all 32Show fewer
  • History of allogeneic organ / hematopoietic stem cell transplantation.
  • Participants with any of the following respiratory conditions:
  • Evidence of noninfectious or drug-induced interstitial lung disease (ILD) or pneumonitis
  • Grade ≥3 pulmonary disease unrelated to underlying malignancy
  • History of uncontrolled comorbidities within 6 months prior to the first dose including uncontrolled cardiac and cerebrovascular conditions, hypertension, diabetes, significant vascular disease or arterial/severe venous thromboembolic events.
  • Major surgery < 4 weeks or minor surgery < 3 days prior to first dose of study intervention.
  • History of severe bleeding tendency or coagulation dysfunction
  • History of esophageal varices, severe ulcers, unhealed wounds, gastrointestinal perforation, abdominal fistula, gastrointestinal obstruction, intra-abdominal abscess, or acute gastrointestinal bleeding within 6 months prior to the first dose.
  • Participants with acute, chronic or symptomatic infections including participants positive for active HIV, hepatitis B virus (HBV), or Hepatitis C virus (HCV).
  • Participants with history of immunodeficiency
  • Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior (in the past 5 years) or laboratory abnormality that may increase the risk of study participation or make the participant inappropriate for the study.
  • Previous systemic anti-tumor therapy including:
  • Prior systemic therapy, including anti-PD-(L)1 therapy, for locally advanced, unresectable, or metastatic NSCLC.
  • Previous treatment with immunotherapy
  • Prior radiotherapy > 30 Gy to the lung < 6 months of first dose of study intervention
  • Palliative local therapy < 2 weeks before the first dose of study intervention;
  • Non-specific immunomodulatory therapy < 2 weeks before the first dose.
  • Prior systemic anti-angiogenic therapy
  • Prior immune-related AE that led to anti-PD-(L)1 treatment discontinuation, adverse events from prior immunotherapy not improved to Grade 1 before screening, or required treatment with systemic immunosuppressive therapy.
  • Prior and concomitant therapy:
  • therapeutic oral or parenteral anticoagulants or thrombolytic agents < 10 days to the first dose.
  • chronic antiplatelet therapy <7 days to randomization.
  • live or attenuated live vaccine < 4 weeks to the first dose.
  • current high-dose systemic corticosteroids.
  • prohibited concomitant medication(s) < 21 days to the first dose.
  • Breastfeeding participants, participants of childbearing potential, and male participants who are unwilling to follow contraceptive measures.

Trial locations and contacts

484 sites in 20 countries. Contact the study team or a site near you to ask about taking part.

Pfizer CT.gov Call Center contact

1-800-718-1021

ClinicalTrials.gov_Inquiries@pfizer.com

484 sites in 20 countries

United States226 sites, 226 recruiting

  • Texas Oncology - West Texas

    Abilene, Texas, 79606

    Recruiting

  • New York Oncology Hematology

    Albany, New York, 12206

    Recruiting

  • University of New Mexico Comprehensive Cancer Center

    Albuquerque, New Mexico, 87131

    Recruiting

  • Texas Oncology - Northeast Texas

    Allen, Texas, 75013

    Recruiting

  • Texas Oncology - West Texas

    Amarillo, Texas, 79124

    Recruiting

  • Oncura Health - Anaheim

    Anaheim, California, 92805

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Annapolis, Maryland, 21401

    Recruiting

  • Texas Oncology - DFW

    Arlington, Texas, 76012

    Recruiting

  • Texas Oncology - DFW

    Arlington, Texas, 76014

    Recruiting

  • Illinois Cancer Specialists

    Arlington Heights, Illinois, 60005

    Recruiting

  • Texas Oncology - Central/South Texas

    Austin, Texas, 78758

    Recruiting

  • Texas Oncology - Gulf Coast

    Beaumont, Texas, 77702

    Recruiting

  • Texas Oncology - DFW

    Bedford, Texas, 76022

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Bethesda, Maryland, 20817

    Recruiting

  • Illinois CancerCare - Bloomington

    Bloomington, Illinois, 61704

    Recruiting

  • Florida Cancer Specialists

    Bonita Springs, Florida, 34135

    Recruiting

  • Florida Cancer Specialists

    Bradenton, Florida, 34211

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Brandywine, Maryland, 20613

    Recruiting

  • Pioneer Research Center

    Bullhead City, Arizona, 86442

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Burnsville, Minnesota, 55337

    Recruiting

  • Aultman Hospital

    Canton, Ohio, 44710

    Recruiting

  • Aultman Medical Group Hematology and Oncology

    Canton, Ohio, 44710

    Recruiting

  • Florida Cancer Specialists

    Cape Coral, Florida, 33909

    Recruiting

  • Ironwood Cancer & Research Centers

    Chandler, Arizona, 85224

    Recruiting

  • UVA Comprehensive Cancer Center

    Charlottesville, Virginia, 22903

    Recruiting

  • UVA Health Fontaine Research Park

    Charlottesville, Virginia, 22903

    Recruiting

  • University of Virginia

    Charlottesville, Virginia, 22908

    Recruiting

  • UVA Health Cancer Care Pantops

    Charlottesville, Virginia, 22911

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Chaska, Minnesota, 55318

    Recruiting

  • Tennessee Oncology, PLLC - Chattanooga Downtown

    Chattanooga, Tennessee, 37403

    Recruiting

  • Tennessee Oncology, PLLC - Chattanooga - Medical Park II

    Chattanooga, Tennessee, 37404

    Recruiting

  • University of Illinois Hospital and Health Sciences System (Outpatient Cancer Center)

    Chicago, Illinois, 60612

    Recruiting

  • University of Illinois Hospital and Health Sciences System

    Chicago, Illinois, 60612

    Recruiting

  • Illinois Cancer Specialists

    Chicago, Illinois, 60631

    Recruiting

  • Oncology Hematology Care Clinical Trials

    Cincinnati, Ohio, 45211

    Recruiting

  • Oncology Hematology Care Clinical Trials

    Cincinnati, Ohio, 45242

    Recruiting

  • Oncology Hematology Care Clinical Trials

    Cincinnati, Ohio, 45245

    Recruiting

  • Florida Cancer Specialists

    Clearwater, Florida, 33761

    Recruiting

  • Clermont Oncology Center

    Clermont, Florida, 34711

    Recruiting

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106

    Recruiting

  • New York Oncology Hematology

    Clifton Park, New York, 12065

    Recruiting

  • Maryland Oncology Hematology - Columbia

    Columbia, Maryland, 21044

    Recruiting

  • Allina Health Cancer Institute - Mercy Hospital

    Coon Rapids, Minnesota, 55433

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Coon Rapids, Minnesota, 55433

    Recruiting

  • BRCR Global- Coral Springs

    Coral Springs, Florida, 33065

    Recruiting

  • Pontchartrain Cancer Center

    Covington, Louisiana, 70433

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75203

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75230

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75231

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75237

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75246

    Recruiting

  • Florida Cancer Specialists

    Daytona Beach, Florida, 32117

    Recruiting

  • Texas Oncology - Northeast Texas

    Denison, Texas, 75020

    Recruiting

  • Texas Oncology - Northeast Texas

    Denton, Texas, 76201

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Edina, Minnesota, 55435

    Recruiting

  • Texas Oncology - West Texas

    El Paso, Texas, 79902

    Recruiting

  • Texas Oncology - West Texas

    El Paso, Texas, 79915

    Recruiting

  • Texas Oncology - West Texas

    El Paso, Texas, 79938

    Recruiting

  • Oncology Hematology Care Clinical Trials

    Fairfield, Ohio, 45014

    Recruiting

  • Highlands Oncology Group

    Fayetteville, Arkansas, 72703

    Recruiting

  • Cancer Specialists of North Florida

    Fleming Island, Florida, 32003

    Recruiting

  • Florida Cancer Specialists

    Fleming Island, Florida, 32003

    Recruiting

  • Texas Oncology - Northeast Texas

    Flower Mound, Texas, 75028

    Recruiting

  • Helios Clinical Research

    Fort Lauderdale, Florida, 33316

    Recruiting

  • Florida Cancer Specialists - South

    Fort Myers, Florida, 33901

    Recruiting

  • Florida Cancer Specialists

    Fort Myers, Florida, 33905

    Recruiting

  • Florida Cancer Specialists

    Fort Myers, Florida, 33908

    Recruiting

  • Texas Oncology - DFW

    Fort Worth, Texas, 76104

    Recruiting

  • Memorial Care Orange Coast Medical Center Attn

    Fountain Valley, California, 92708

    Recruiting

  • MemorialCare Orange Coast Medical Center

    Fountain Valley, California, 92708

    Recruiting

  • OC Blood and Cancer Care

    Fountain Valley, California, 92708

    Recruiting

  • Oncura Health - Fountain Valley

    Fountain Valley, California, 92708

    Recruiting

  • Tennessee Oncology, PLLC - Franklin

    Franklin, Tennessee, 37067

    Recruiting

  • Florida Cancer Specialists

    Gainesville, Florida, 32605

    Recruiting

  • Illinois CancerCare - Galesburg

    Galesburg, Illinois, 61401

    Recruiting

  • Tennessee Oncology, PLLC - Gallatin

    Gallatin, Tennessee, 37066

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Germantown, Maryland, 20876

    Recruiting

  • Ironwood Cancer & Research Centers

    Gilbert, Arizona, 85297

    Recruiting

  • Ironwood Cancer & Research Centers

    Glendale, Arizona, 85306

    Recruiting

  • Oncura Health - Corporate (Central IDS & Regulatory Only)

    Glendale, California, 91204

    Recruiting

  • Ironwood Cancer & Research Centers

    Goodyear, Arizona, 85395

    Recruiting

  • Texas Oncology - DFW

    Grapevine, Texas, 76051

    Recruiting

  • Pontchartrain Cancer Center

    Hammond, Louisiana, 70403

    Recruiting

  • Northwest Cancer Specialists, P.C

    Happy Valley, Oregon, 97015

    Recruiting

  • Texas Oncology - Central/South Texas

    Harlingen, Texas, 78550

    Recruiting

  • Hattiesburg Clinic Hematology/Oncology

    Hattiesburg, Mississippi, 39401

    Recruiting

  • Hope and Healing Cancer Services

    Hinsdale, Illinois, 60521

    Recruiting

  • Kelsey Research Foundation

    Houston, Texas, 77005

    Not yet recruiting

  • Kelsey-Seybold Clinic - North Houston Campus

    Houston, Texas, 77014

    Not yet recruiting

  • Texas Oncology - Gulf Coast

    Houston, Texas, 77024

    Recruiting

  • Kelsey-Seybold Clinic - Berthelsen Main Campus

    Houston, Texas, 77025

    Not yet recruiting

  • Texas Oncology - Gulf Coast

    Houston, Texas, 77054

    Recruiting

  • Kelsey-Seybold Clinic - Memorial Villages Campus

    Houston, Texas, 77055

    Not yet recruiting

  • Texas Oncology - Gulf Coast

    Houston, Texas, 77070

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Hudson, Wisconsin, 54016

    Recruiting

  • Texas Oncology - Gulf Coast

    Humble, Texas, 77338

    Recruiting

  • Community Health Network, Inc

    Indianapolis, Indiana, 46219

    Recruiting

  • Community Health Network, Inc.

    Indianapolis, Indiana, 46227

    Recruiting

  • Community Health Network, Inc.

    Indianapolis, Indiana, 46250

    Recruiting

  • US Oncology Investigational Products Center (IPC)

    Irving, Texas, 75063

    Recruiting

  • US Oncology Investigational Products Center

    Irving, Texas, 75063

    Recruiting

  • Cancer Specialists of North Florida

    Jacksonville, Florida, 32204

    Recruiting

  • Cancer Specialists of North Florida

    Jacksonville, Florida, 32218

    Recruiting

  • Cancer Specialists of North Florida

    Jacksonville, Florida, 32256

    Recruiting

  • Cancer Specialists of North Florida

    Jacksonville, Florida, 32258

    Recruiting

  • Tennessee Cancer Specialists Dowell Springs location

    Knoxville, Tennessee, 37909

    Recruiting

  • University of Tennessee Medical Center

    Knoxville, Tennessee, 37920

    Recruiting

  • Tennessee Cancer Specialists - Parkwest Location

    Knoxville, Tennessee, 37932

    Recruiting

  • Memorial Care Saddleback Medical Center Attn

    Laguna Hills, California, 92653

    Recruiting

  • MemorialCare Saddleback Medical Center

    Laguna Hills, California, 92653

    Recruiting

  • Florida Cancer Specialists

    Largo, Florida, 33770

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Largo, Maryland, 20774

    Recruiting

  • Tennessee Oncology, PLLC - Lebanon

    Lebanon, Tennessee, 37090

    Recruiting

  • Florida Cancer Specialists

    Lecanto, Florida, 34461

    Recruiting

  • Texas Oncology - Northeast Texas

    Lewisville, Texas, 75056

    Recruiting

  • NHO Revive Research Institute, LLC

    Lincoln, Nebraska, 68506

    Recruiting

  • NHO Support Center

    Lincoln, Nebraska, 68506

    Recruiting

  • Cancer Partners of Nebraska

    Lincoln, Nebraska, 68516

    Recruiting

  • Stockton Hematology Oncology Medical Group

    Lodi, California, 95242

    Recruiting

  • Memorial Care Long Beach Medical Center

    Long Beach, California, 90806

    Recruiting

  • Texas Oncology - Northeast Texas

    Longview, Texas, 75601

    Recruiting

  • Cancer and Blood Research Center, LLC (Storage)

    Los Alamitos, California, 90720

    Recruiting

  • Cancer and Blood Specialty Clinic

    Los Alamitos, California, 90720

    Recruiting

  • Oncura Health - Good Samaritan

    Los Angeles, California, 90017

    Recruiting

  • California Research Institute

    Los Angeles, California, 90027

    Recruiting

  • Stockton Hematology Oncology Medical Group

    Manteca, California, 95336

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Maple Grove, Minnesota, 55369

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Maplewood, Minnesota, 55109

    Recruiting

  • Aultman Massillon

    Massillon, Ohio, 44646

    Recruiting

  • Texas Oncology - Central/South Texas

    McAllen, Texas, 78503

    Recruiting

  • Texas Oncology - Northeast Texas

    McKinney, Texas, 75071

    Recruiting

  • Ironwood Cancer & Research Centers

    Mesa, Arizona, 85202

    Recruiting

  • Ironwood Cancer & Research Centers

    Mesa, Arizona, 85206

    Recruiting

  • Texas Oncology - West Texas

    Midland, Texas, 79701

    Recruiting

  • Froedtert Hospital/Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226

    Recruiting

  • Allina Health Cancer Institute - Abbott Northwestern Hospital

    Minneapolis, Minnesota, 55407

    Recruiting

  • Stockton Hematology Oncology Medical Group

    Modesto, California, 95350

    Recruiting

  • Tennesseee Oncology, PLLC - Mount Juliet

    Mount Juliet, Tennessee, 37122

    Recruiting

  • Tennessee Oncology, PLLC - Murfreesboro

    Murfreesboro, Tennessee, 37129

    Recruiting

  • Florida Cancer Specialists

    N. Venice, Florida, 34275

    Recruiting

  • Florida Cancer Specialists

    Naples, Florida, 34102

    Recruiting

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203

    Recruiting

  • Tennessee Oncology, PLLC-Elliston Place Plaza Medical Oncology &Hematology

    Nashville, Tennessee, 37203

    Recruiting

  • Tennessee Oncology, PLLC - Saint Thomas West

    Nashville, Tennessee, 37205

    Recruiting

  • Cancer Specialists of North Florida

    Neptune Beach, Florida, 32266

    Recruiting

  • Hope and Healing Cancer Services

    New Lenox, Illinois, 60451

    Recruiting

  • Illinois Cancer Specialists

    Niles, Illinois, 60714

    Recruiting

  • Aultman North

    North Canton, Ohio, 44720

    Recruiting

  • Hematology Oncology Associates of Rockland

    Nyack, New York, 10960

    Recruiting

  • Florida Cancer Specialists

    Ocala, Florida, 34474

    Recruiting

  • Texas Oncology - West Texas

    Odessa, Texas, 79761

    Recruiting

  • Alpha Clinical Research Centers LLC

    Orange City, Florida, 32763

    Recruiting

  • Florida Cancer Specialists

    Orange City, Florida, 32763

    Recruiting

  • Mid Florida Hematology and Oncology Center

    Orange City, Florida, 32763

    Recruiting

  • Florida Cancer Specialists

    Orlando, Florida, 32806

    Recruiting

  • Orlando Health Ambulatory Care Center

    Orlando, Florida, 32806

    Recruiting

  • Orlando Health Cancer Institute

    Orlando, Florida, 32806

    Recruiting

  • Orlando Health Orlando Regional Medical Center

    Orlando, Florida, 32806

    Recruiting

  • Aultman Orrville Hospital

    Orrville, Ohio, 44667

    Recruiting

  • Illinois CancerCare-Ottawa-Fox River Cancer Center

    Ottawa, Illinois, 61350

    Recruiting

  • Texas Oncology - Northeast Texas

    Palestine, Texas, 75801

    Recruiting

  • Cancer Care Centers of Brevard, Inc.

    Palm Bay, Florida, 32901

    Recruiting

  • Florida Cancer Specialists

    Palm Beach Gardens, Florida, 33410

    Recruiting

  • Texas Oncology - Northeast Texas

    Paris, Texas, 75460

    Recruiting

  • Texas Oncology - Gulf Coast

    Pearland, Texas, 77584

    Recruiting

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554

    Recruiting

  • Illinois CancerCare, P.C.

    Peoria, Illinois, 61615

    Recruiting

  • Illinois CancerCare-Peru - Valley Regional Cancer Center

    Peru, Illinois, 61354

    Recruiting

  • Ironwood Cancer & Research Centers

    Phoenix, Arizona, 85028

    Recruiting

  • FirstHealth Cancer Center

    Pinehurst, North Carolina, 28374

    Recruiting

  • FirstHealth Moore Regional Hospital

    Pinehurst, North Carolina, 28374

    Recruiting

  • Texas Oncology - DFW

    Plano, Texas, 75075

    Recruiting

  • Texas Oncology - DFW

    Plano, Texas, 75093

    Recruiting

  • Florida Cancer Specialists

    Port Charlotte, Florida, 33980

    Recruiting

  • Hematology Oncology Associates of the Treasure Coast

    Port Saint Lucie, Florida, 34952

    Recruiting

  • Northwest Cancer Specialists, P.C.

    Portland, Oregon, 97227

    Recruiting

  • Oncura Health - Riverside

    Riverside, California, 92501

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Rockville, Maryland, 20850

    Recruiting

  • Highlands Oncology Group

    Rogers, Arkansas, 72758

    Recruiting

  • Roseville Medical Plaza Care Center

    Roseville, California, 95661

    Not yet recruiting

  • Sutter Medical Center, Sacramento Infusion Center at Roseville

    Roseville, California, 95661

    Not yet recruiting

  • Sutter Roseville Medical Center

    Roseville, California, 95661

    Not yet recruiting

  • Cancer Specialists of North Florida

    Saint Augustine, Florida, 32086

    Recruiting

  • Allina Health Cancer Institute - United Hospital

    Saint Paul, Minnesota, 55102

    Recruiting

  • Huntsman Cancer Institute, University of Utah

    Salt Lake City, Utah, 84112

    Recruiting

  • Sansum Clinic

    Santa Barbara, California, 93105

    Recruiting

  • CHRISTUS St. Vincent Regional Cancer Center

    Santa Fe, New Mexico, 87505

    Recruiting

  • Florida Cancer Specialists

    Sarasota, Florida, 34236

    Recruiting

  • Ironwood Cancer & Research Centers

    Scottsdale, Arizona, 85260

    Recruiting

  • Florida Cancer Specialists

    Sebring, Florida, 33870

    Recruiting

  • Tennessee Oncology, PLLC -Shelbyville

    Shelbyville, Tennessee, 37160

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Silver Spring, Maryland, 20904

    Recruiting

  • Sansum Clinic

    Solvang, California, 93463

    Recruiting

  • Kelsey-Seybold Clinic - Springwoods Village Campus

    Spring, Texas, 77389

    Not yet recruiting

  • Highlands Oncology Group

    Springdale, Arkansas, 72762

    Recruiting

  • Florida Cancer Specialists

    St. Petersburg, Florida, 33701

    Recruiting

  • Florida Cancer Specialists

    St. Petersburg, Florida, 33705

    Recruiting

  • Stockton Hematology Oncology Group

    Stockton, California, 95204

    Recruiting

  • Kelsey-Seybold Clinic - Fort Bend Campus

    Sugar Land, Texas, 77478

    Not yet recruiting

  • Texas Oncology - Gulf Coast

    Sugar Land, Texas, 77479

    Recruiting

  • Florida Cancer Specialists

    Tallahassee, Florida, 32308

    Recruiting

  • BRCR Medical Center Inc.

    Tamarac, Florida, 33321

    Recruiting

  • Florida Cancer Specialists

    Tampa, Florida, 33607

    Recruiting

  • Florida Cancer Specialists

    Tavares, Florida, 32778

    Recruiting

  • Florida Cancer Specialists

    The Villages, Florida, 32159

    Recruiting

  • Texas Oncology - Gulf Coast

    The Woodlands, Texas, 77380

    Recruiting

  • Northwest Cancer Specialists, P.C

    Tigard, Oregon, 97223

    Recruiting

  • Cancer and Blood Specialty Clinic

    Torrance, California, 90505

    Recruiting

  • Stockton Hematology Oncology Medical Group

    Tracy, California, 95377

    Recruiting

  • Florida Cancer Specialists

    Trinity, Florida, 34655

    Recruiting

  • Texas Oncology - Northeast Texas

    Tyler, Texas, 75702

    Recruiting

  • Oncura Health - Valley Presbyterian

    Van Nuys, California, 91405

    Recruiting

  • Northwest Cancer Specialists, P.C.

    Vancouver, Washington, 98684

    Recruiting

  • Texas Oncology - Central/South Texas

    Waco, Texas, 76712

    Recruiting

  • Illinois CancerCare-Washington

    Washington, Illinois, 61571

    Recruiting

  • Kelsey-Seybold Clinic - Bay Area Campus Building A

    Webster, Texas, 77598

    Not yet recruiting

  • Kelsey-Seybold Clinic - Bay Area Campus Building B

    Webster, Texas, 77598

    Not yet recruiting

  • Kelsey-Seybold Clinic - Bay Area Campus Building C

    Webster, Texas, 77598

    Not yet recruiting

  • Texas Oncology - Gulf Coast

    Webster, Texas, 77598

    Recruiting

  • Florida Cancer Specialists

    Wellington, Florida, 33414

    Recruiting

  • Texas Oncology - Central/South Texas

    Weslaco, Texas, 78596

    Recruiting

  • Florida Cancer Specialists - East

    West Palm Beach, Florida, 33401

    Recruiting

  • Texas Oncology - West Texas

    Wichita Falls, Texas, 76310

    Recruiting

  • Carolina Cancer Research Center

    Wilson, North Carolina, 27893

    Recruiting

  • Florida Cancer Specialists

    Winter Park, Florida, 32789

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Woodbury, Minnesota, 55125

    Recruiting

Other trials in United States

China38 sites, 38 recruiting

  • Beijing Cancer hospital

    Beijing, Beijing Municipality, 100142

    Recruiting

  • Beijing Peking Union Medical College Hospital

    Beijing, Beijing Municipality, 100730

    Recruiting

  • Beijing Chest Hospital, Capital Medical University

    Beijing, 101149

    Recruiting

  • The First Hospital of Jilin University

    Changchun, Jilin, 130021

    Not yet recruiting

  • Xiangya Hospital Central South University

    Changsha, Hunan, 410008

    Not yet recruiting

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan, 410011

    Recruiting

  • Sichuan Cancer hospital

    Chengdu, Sichuan, 610041

    Recruiting

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, Chongqing Municipality, 400016

    Recruiting

  • Chongqing University Cancer Hospital

    Chongqing, Chongqing Municipality, 400030

    Recruiting

  • Fujian Cancer Hospital

    Fuzhou, Fujian, 350014

    Recruiting

  • Southern Medical University Nanfang Hospital

    Guangzhou, Guangdong, 510515

    Recruiting

  • The first Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310003

    Not yet recruiting

  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310016

    Recruiting

  • Anhui Provincial Cancer Hospital

    Hefei, Anhui, 230031

    Recruiting

  • Second Affiliated hospital of Anhui Medical University

    Hefei, Anhui, 230601

    Recruiting

  • Huizhou Central People's Hospital

    Huizhou, Guangdong, 516001

    Recruiting

  • Jiangmen Central Hospital

    Jiangmen, Guangdong, 529000

    Recruiting

  • Jinan Central Hospital

    Jinan, Shandong, 250013

    Recruiting

  • LinYi Cancer Hospital

    Linyi, Shandong, 276000

    Recruiting

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang, Henan, 471000

    Recruiting

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang, Henan, 471003

    Recruiting

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006

    Recruiting

  • The First Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330209

    Recruiting

  • Jiangsu Province Hospital

    Nanjing, Jiangsu, 210000

    Recruiting

  • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

    Nanjing, Jiangsu, 210031

    Recruiting

  • Guangxi Medical University Affiliated Tumor Hospital

    Nanning, Guangxi, 530200

    Recruiting

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai Municipality, 200032

    Recruiting

  • Shanghai Chest Hospital

    Shanghai, 200030

    Recruiting

  • Shanghai East Hospital

    Shanghai, 200123

    Recruiting

  • Shanxi Cancer Hospital

    Taiyuan, Shanxi, 030013

    Recruiting

  • Taizhou Hospital of Zhejiang Province

    Taizhou, Zhejiang, 317000

    Recruiting

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, 325000

    Recruiting

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei, 430048

    Recruiting

  • Hubei Cancer Hospital

    Wuhan, 430079

    Recruiting

  • Xiangyang Central Hospital

    Xiangyang, Hubei, 441106

    Recruiting

  • The First Affiliated Hospital of Henan Medical University

    Xinxiang, Jiangxi, 453100

    Not yet recruiting

  • Northern Jiangsu People's Hospital

    Yangzhou, Jiangsu, 225001

    Recruiting

  • Henan Cancer Hospital

    Zhengzhou, Henan, 450008

    Recruiting

Other trials in China

Japan31 sites, 31 recruiting

  • National Hospital Organization Asahikawa Medical Center

    Asahikawa, Hokkaido, 0708644

    Recruiting

  • National Hospital Organization Beppu Medical Center

    Beppu, Oita Prefecture, 874-0011

    Recruiting

  • Nippon Medical School Hospital

    Bunkyo-ku, Tokyo, 113-8603

    Recruiting

  • Tokyo Metropolitan Komagome Hospital

    Bunkyo-ku, Tokyo, 113-8677

    Recruiting

  • National Hospital Organization Chiba Medical Center

    Chiba, Chiba, 260-8606

    Recruiting

  • National Cancer Center Hospital

    Chuo-ku, Tokyo, 104-0045

    Recruiting

  • National Hospital Organization Kyushu Medical Center

    Fukuoka, 810-8563

    Recruiting

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395

    Recruiting

  • NHO Mito Medical Center

    Higashiibaraki-gun, Ibaraki, 311-3193

    Recruiting

  • Kansai Medical University Hospital

    Hirakata-shi, Osaka, 573-1191

    Recruiting

  • National Hospital Organization Kanazawa Medical Center

    Kanazawa, Ishikawa-ken, 920-8650

    Recruiting

  • National Hospital Organization Tokyo National Hospital

    Kiyose, Tokyo, 204-8585

    Recruiting

  • Kobe Minimally Invasive Cancer Center

    Kobe, Hyōgo, 650-0046

    Recruiting

  • Kobe City Medical Center General Hospital

    Kobe, Hyōgo, 650-0047

    Recruiting

  • National Hospital Organization Kochi National Hospital

    Kochi, 780-8077

    Recruiting

  • Kurume University Hospital

    Kurume, Fukuoka, 830-0011

    Recruiting

  • National Hospital Organization Kyoto Medical Center

    Kyoto, 612-8555

    Recruiting

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Ehime, 791-0280

    Recruiting

  • Nagoya University Hospital

    Nagoya, Aichi-ken, 466-8560

    Recruiting

  • Kochi Medical School Hospital

    Nankoku, Kochi, 783-8505

    Recruiting

  • Niigata Prefectural Cancer Center Niigata Hospital

    Niigata, Niigata, 951-8566

    Recruiting

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1192

    Recruiting

  • National Hospital Organization Nagasaki Medical Center

    Ōmura, Nagasaki, 856-8562

    Recruiting

  • National Hospital Organization Osaka Medical Center

    Osaka, 540-0006

    Recruiting

  • Gunma Prefectural Cancer Center

    Otashi, Gunma, 373-8550

    Recruiting

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 060-8648

    Recruiting

  • Sendai Kousei Hospital

    Sendai, Miyagi, 9810914

    Recruiting

  • National Center for Global Health and Medicine

    Shinjyuku-ku, Tokyo, 162-8655

    Recruiting

  • The University of Osaka Hospital

    Suita, Osaka, 565-0871

    Recruiting

  • Mie Chuo Medical Center

    Tsu, Mie-ken, 514-1101

    Recruiting

  • National Hospital Organization Yamaguchi Ube Medical Center

    Ube, Yamaguchi, 755-0241

    Recruiting

Other trials in Japan

Brazil20 sites, 20 recruiting

  • Hospital de Cancer de Barretos/Fundacao Pio XII

    Barretos, São Paulo, 14.784-400

    Recruiting

  • Hospital Erasto Gaertner

    Curitiba, Paraná, 81520-060

    Recruiting

  • Centro de Pesquisas Oncológicas CEPON

    Florianópolis, Santa Catarina, 88034-000

    Recruiting

  • Centro Regional Integrado de Oncologia - CRIO

    Fortaleza, Ceará, 60336-232

    Recruiting

  • Liga Norte Riograndense Contra o Câncer

    Natal, Rio Grande do Norte, 59062-000

    Recruiting

  • Hospital de Clínicas de Passo Fundo

    Passo Fundo, Rio Grande do Sul, 99010-260

    Recruiting

  • Irmandade da Santa Casa de Misericórdia de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90050-170

    Recruiting

  • Hospital Moinhos de Vento

    Porto Alegre, Rio Grande do Sul, 90560-032

    Recruiting

  • Hospital de Câncer de Recife

    Recife, Pernambuco, 50040-000

    Recruiting

  • Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)

    Ribeirão Preto, São Paulo, 14051-140

    Recruiting

  • Instituto Nacional de Câncer - INCA

    Rio de Janeiro, 20230-130

    Recruiting

  • Ensino e Terapia de Inovação Clínica AMO - ETICA

    Salvador, Estado de Bahia, 41950-640

    Recruiting

  • Faculdade de Medicina do ABC

    Santo André, São Paulo, 09060-870

    Recruiting

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

    Sao Jose Rio Preto, São Paulo, 15090-000

    Recruiting

  • Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein

    São Paulo, São Paulo, 05652-900

    Recruiting

  • Icesp - Instituto Do Câncer Do Estado de São Paulo

    São Paulo, 01246-000

    Recruiting

  • Hospital Alemao Oswaldo Cruz

    São Paulo, 01329-020

    Recruiting

  • Centro Paulista de Oncologia Clínica

    São Paulo, 04.538-132

    Recruiting

  • IBCC - Núcleo de Pesquisa e Ensino

    São Paulo, 04014-002

    Recruiting

  • Afecc Hospital Santa Rita de Cássia

    Vitória, Espírito Santo, 29.043-260

    Recruiting

Other trials in Brazil

Spain20 sites, 20 recruiting

  • Parc de Salut Mar - Hospital del Mar

    Barcelona, Barcelona [barcelona], 08003

    Recruiting

  • Hospital Universitari Vall d'Hebron

    Barcelona, Barcelona [barcelona], 08035

    Recruiting

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041

    Recruiting

  • Hospital General Universitario de Elche

    Elche, Alicante, 03203

    Recruiting

  • Institut Català d'Oncologia (ICO) - Girona

    Girona, Girona [gerona], 17007

    Recruiting

  • Hospital Universitario San Cecilio

    Granada, Andalusia, 18016

    Recruiting

  • Hospital Universitario Juan Ramon Jimenez

    Huelva, 21005

    Recruiting

  • Hospital Jerez de la Frontera

    Jerez de la Frontera, Cádiz, 11407

    Recruiting

  • Institut Català d'Oncologia - L'Hospitalet

    L'Hospitalet de Llobregat, Catalunya [cataluña], 08908

    Recruiting

  • Hospital Insular de Gran Canaria

    Las Palmas de Gran Canaria, LAS Palmas, 35016

    Recruiting

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, Comunidad de, 28041

    Recruiting

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007

    Recruiting

  • Hospital Clinico San Carlos

    Madrid, 28040

    Recruiting

  • Hospital Universitari Son Espases

    Palma, 07120

    Recruiting

  • CHUS - Hospital Clinico Universitario

    Santiago de Compostela, A Coruña [LA Coruña], 15706

    Recruiting

  • Hospital Universitario Virgen de Valme

    Seville, Andalusia, 41014

    Recruiting

  • Hospital Universitario de Toledo

    Toledo, 45007

    Recruiting

  • Hospital Universitario de Torrejón

    Torrejón de Ardoz, Madrid, Comunidad de, 28850

    Recruiting

  • Fundación Instituto Valenciano de Oncología

    Valencia, Valenciana, Comunitat, 46009

    Not yet recruiting

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009

    Recruiting

Other trials in Spain

India15 sites, 15 recruiting

  • Radhakrishna Multispecialty Hospital & IVF Centre

    Bangalore, Karnataka, 560085

    Recruiting

  • KLES Dr. Prabhakar Kore Hospital & M.R.C

    Belagavi, Karnataka, 590010

    Recruiting

  • Sparsh Hospitals & Critical Care (P) Ltd

    Bhubaneswar, Odisha, 751007

    Recruiting

  • Artemis hospital

    Gurugram, Haryana, 122001

    Recruiting

  • Basavatarakam Indo American Cancer Hospital & Research Institute

    Hyderabad, Telangana, 500034

    Recruiting

  • Chittaranjan National Cancer Institute

    Kolkata, West Bengal, 700026

    Recruiting

  • Caritas Hospital

    Kottayam, Kerala, 686630

    Recruiting

  • National Cancer Institute

    Nagpur, Maharashtra, 441108

    Recruiting

  • Apex Wellness Hospital

    Nashik, Maharashtra, 422009

    Recruiting

  • Fortis Hospital

    New Delhi, National Capital Territory of Delhi, 110088

    Recruiting

  • Rajiv Gandhi Cancer Institute And Research Centre

    North West Delhi, National Capital Territory of Delhi, 110085

    Recruiting

  • Sahyadri Super Speciality Hospital

    Pune, Maharashtra, 411004

    Recruiting

  • Nirmal Hospital Pvt Ltd.

    Surat, Gujarat, 395002

    Recruiting

  • Bhakti Vedanta Hospital and Research Institute

    Thane, Maharashtra, 401107

    Recruiting

  • Kailash Cancer Hospital & Research Centre

    Vadodara, Gujarat, 391760

    Recruiting

Other trials in India

Turkey (Türkiye)15 sites, 15 recruiting

  • Adana Medical Park Seyhan Hastanesi

    Adana, 01140

    Recruiting

  • Adana Sehir Egitim ve Arastirma Hastanesi

    Adana, 01370

    Recruiting

  • Gulhane Egitim Arastirma Hastanesi

    Ankara, 06010

    Recruiting

  • Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi

    Ankara, 06200

    Recruiting

  • Memorial Ankara Hastanesi

    Ankara, 06520

    Recruiting

  • Gazi University Health Research and Application Center Gazi Hospital

    Ankara, 06560

    Recruiting

  • Ankara Bilkent Şehir Hastanesi

    Ankara, 06800

    Recruiting

  • Dicle Üniversitesi

    Diyarbakır, 21200

    Recruiting

  • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi

    Gaziantep, 27310

    Recruiting

  • Istinye University - Liv Hospital - Topkapi

    Istanbul, İstanbul, 34010

    Recruiting

  • Istanbul Universitesi Istanbul Tıp Fakultesi Hastanesi

    Istanbul, İstanbul, 34093

    Recruiting

  • Medipol Mega Universite Hastanesi

    Istanbul, İstanbul, 34214

    Recruiting

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

    Istanbul, İstanbul, 34722

    Recruiting

  • Samsun Medical Park Hastanesi

    Samsun, 55200

    Recruiting

  • Acibadem Altunizade Hospital

    Üsküdar / İstanbul, İ̇stanbul, 34662

    Recruiting

Other trials in Turkey (Türkiye)

Germany14 sites, 14 recruiting

  • Helios Klinikum Emil von Behring Berlin-Zehlendorf

    Berlin, 14165

    Recruiting

  • Klinikum Chemnitz gGmbH

    Chemnitz, Saxony, 09116

    Recruiting

  • Marien Hospital Düsseldorf

    Düsseldorf, 40479

    Recruiting

  • Krankenhaus Nordwest GmbH

    Frankfurt am Main, Hesse, 60488

    Recruiting

  • Franziskus-Hospital Harderberg

    Georgsmarienhütte, Lower Saxony, 49124

    Recruiting

  • SRH Wald-Klinikum Gera GmbH

    Gera, 07548

    Recruiting

  • LungenClinic Grosshansdorf

    Großhansdorf, 22927

    Recruiting

  • Krankenhaus Martha-Maria Halle-Dölau

    Halle, Saxony-Anhalt, 06120

    Recruiting

  • MVZ am Klinikum Aschaffenburg

    Hösbach, 63768

    Recruiting

  • Klinikum Kassel GmbH

    Kassel, Hesse, 34125

    Recruiting

  • Universitätsklinikum Schleswig-Holstein

    Lübeck, Schleswig-Holstein, 23538

    Recruiting

  • Kliniken Maria Hilf GmbH

    Mönchengladbach, 41063

    Recruiting

  • Klinikum der Ludwig-Maximilians-Universitaet Muenchen

    München, Bavaria, 81377

    Recruiting

  • Universitätsklinikum Ulm

    Ulm, 89081

    Recruiting

Other trials in Germany

Argentina13 sites, 13 recruiting

  • Investigaciones Clinicas Moleculares (ICM)

    Buenos Aires, Buenos Aires F.D., C1425

    Recruiting

  • Hospital Italiano de Buenos Aires

    Buenos Aires, 1199

    Recruiting

  • Centro Medico Austral

    Buenos Aires, C1019

    Recruiting

  • Centro de Investigaciones Metabólicas (CINME)

    Buenos Aires, C1056ABI

    Recruiting

  • Clinica Adventista Belgrano

    CABA, Buenos Aires F.D., C1430EGF

    Recruiting

  • Instituto Argentino de Diagnóstico y Tratamiento (IADT)

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1122AAL

    Recruiting

  • Hospital Italiano de Córdoba

    Córdoba, Córdoba Province, X5004BAL

    Recruiting

  • Centro Medico de Enfermedades Respiratorias

    Florida, Buenos Aires, 1602

    Recruiting

  • Fundación CORI para la Investigación y Prevención del Cáncer

    La Rioja, F5300COE

    Recruiting

  • Investigaciones Oncologicas C. Colon S.A.

    Mar del Plata, Buenos Aires, 7600

    Recruiting

  • Fundacion Centro Oncologico de Integracion Regional

    Mendoza, M5500AYB

    Recruiting

  • Centro de Investigación Pergamino

    Pergamino, Buenos Aires, B2700

    Recruiting

  • Hospital Universitario Austral

    Pilar, Buenos Aires, 1629

    Recruiting

Other trials in Argentina

Italy13 sites, 13 recruiting

  • Centro di Riferimento Oncologico (CRO) IRCCS

    Aviano, Pordenone, 33081

    Recruiting

  • ASST Spedali Civili di Brescia

    Brescia, 25123

    Recruiting

  • Azienda Sanitaria Territoriale Pesaro Urbino (AST PU)

    Fano, Pesaro AND Urbino, 61032

    Recruiting

  • Azienda Ospedaliera Universitaria Careggi

    Florence, 50134

    Recruiting

  • IRCCS Azienda Ospedaliera Metropolitana (AOM)

    Genova, 16132

    Recruiting

  • IRCCS Istituto Romagnolo per lo Studio Tumori (IRST) "Dino Amadori"

    Meldola, FC, 47014

    Recruiting

  • Istituto Europeo di Oncologia IRCCS

    Milan, Lombardy, 20141

    Recruiting

  • IRCCS Ospedale San Raffaele

    Milan, 20132

    Recruiting

  • Humanitas Istituto Clinico Catanese

    Misterbianco, Catania, 95045

    Recruiting

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale

    Naples, Campania, 80131

    Recruiting

  • Ausl Della Romagna- Ospedale Santa Maria Delle Croci Ravenna

    Ravenna, 48121

    Recruiting

  • IRCCS Istituto Nazionale dei Tumori Regina Elena

    Roma, ROME, 00144

    Recruiting

  • Ospedale Isola Tiberina - Gemelli Isola

    Roma, ROME, 00186

    Recruiting

Other trials in Italy

Taiwan11 sites, 11 recruiting

  • Changhua Christian Hospital

    Changhua County, Changhua, 50006

    Recruiting

  • National Taiwan University Hospital - Hsinchu branch

    Hsinchu, 300195

    Recruiting

  • Chang Gung Memorial Hospital at Kaohsiung

    Kaohsiung City, 83301

    Recruiting

  • Chung Shan Medical University Hospital

    Taichung, 402306

    Recruiting

  • China Medical University Hospital

    Taichung, 404332

    Recruiting

  • National Cheng Kung University Hospital

    Tainan, 704

    Recruiting

  • National Taiwan University Hospital

    Taipei, 10002

    Recruiting

  • National Taiwan University Cancer Center (NTUCC)

    Taipei, 106

    Recruiting

  • Taipei Medical University Hospital

    Taipei, 110

    Recruiting

  • Taipei Veterans General Hospital

    Taipei, 11217

    Recruiting

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, 333

    Recruiting

Other trials in Taiwan

Australia10 sites, 10 recruiting

  • Sunshine Coast University Hospital

    Birtinya, Queensland, 4575

    Recruiting

  • Calvary Connery Centre

    Elizabeth Vale, South Australia, 5112

    Recruiting

  • St Vincent's Hospital (Melbourne)

    Fitzroy, Victoria, 3065

    Recruiting

  • Gympie Hospital

    Gympie, Queensland, 4570

    Recruiting

  • Icon Cancer Centre Hobart

    Hobart, Tasmania, 7000

    Recruiting

  • Nepean Hospital

    Kingswood, New South Wales, 2747

    Recruiting

  • Nambour General Hospital

    Nambour, Queensland, 4560

    Recruiting

  • Sir Charles Gairdner Hospital

    Perth, Western Australia, 6009

    Recruiting

  • Mater Misericordiae Limited

    South Brisbane, Queensland, 4101

    Recruiting

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065

    Recruiting

Other trials in Australia

Canada10 sites, 10 recruiting

  • Arthur J.E. Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2

    Recruiting

  • Centre Integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint -Jean

    Chicoutimi, Quebec, G7H 5H6

    Recruiting

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2

    Recruiting

  • Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre

    Greenfield Park, Quebec, J4V2H1

    Recruiting

  • London Health Sciences Centre - Verspeeten Family Cancer Centre

    London, Ontario, N6A 5W9

    Recruiting

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1

    Recruiting

  • Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎ

    Montreal, Quebec, H4J 1C5

    Recruiting

  • Centre integre universitaire de sante et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke

    Sherbrooke, Quebec, J1H 5N4

    Recruiting

  • Princess Margaret Cancer Centre - University Health Network

    Toronto, Ontario, M5G 2M9

    Recruiting

  • Windsor Regional Hospital Cancer Program

    Windsor, Ontario, N8W 1L9

    Recruiting

Other trials in Canada

Poland9 sites, 9 recruiting

  • Pratia Onkologia Katowice

    Katowice, Silesian Voivodeship, 40-519

    Recruiting

  • Uniwersyteckie Centrum Kliniczne im. prof. K.Gibinskiego SUM w Katowicach

    Katowice, 40-514

    Recruiting

  • Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej

    Kielce, 25-734

    Recruiting

  • Instytut MSF Sp zoo

    Lodz, 90-302

    Recruiting

  • Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie

    Lublin, 20-090

    Recruiting

  • SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu

    Opole, 45-061

    Recruiting

  • Radomskie Centrum Onkologii

    Radom, Masovian Voivodeship, 26-600

    Recruiting

  • NZOZ Provita Prolife Centrum Medyczne

    Tomaszów Mazowiecki, Łódź Voivodeship, 97-200

    Recruiting

  • Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii

    Wroclaw, 53-413

    Recruiting

Other trials in Poland

Hungary8 sites, 8 recruiting

  • Farkasgyepui Tudogyogyintezet

    Farkasgyepű, 8582

    Recruiting

  • Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház

    Gyula, 5700

    Recruiting

  • Somogy Vármegyei Kaposi Mór Oktató Kórház

    Kaposvár, Somogy County, 7400

    Recruiting

  • Bacs-Kiskun Varmegyei Oktatokorhaz

    Kecskemét, Bács-Kiskun county, 6000

    Recruiting

  • Pécsi Tudományegyetem Klinikai Központ

    Pécs, 7624

    Recruiting

  • Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz

    Szolnok, 5004

    Recruiting

  • Komarom-Esztergom Varmegyei Szent Borbala Korhaz

    Tatabánya, 2800

    Recruiting

  • Reformatus Pulmonologiai Centrum

    Törökbálint, 2045

    Recruiting

Other trials in Hungary

France7 sites, 7 recruiting

  • Institut de Cancérologie de l'Ouest

    Angers, Maine ET Loire, 49055

    Not yet recruiting

  • Hôpital Ambroise Paré

    Boulogne-Billancourt, Île-de-France Region, 92100

    Recruiting

  • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren

    Limoges, Haute Vienne, 87042

    Recruiting

  • Groupe hospitalier Paris saint Joseph

    Paris, 75014

    Recruiting

  • Hopitaux Universitaires Paris Centre-Hopital Cochin

    Paris, 75014

    Recruiting

  • Chru de Nancy-Brabois

    Vandœuvre-lès-Nancy, 54500

    Recruiting

  • Gustave Roussy

    Villejuif, 94805

    Not yet recruiting

Other trials in France

Greece7 sites, 7 recruiting

  • Thoracic General Hospital of Athens "I Sotiria"

    Athens, Attikí, 115 27

    Recruiting

  • Metropolitan General Hospital

    Athens, Attikí, 155 62

    Recruiting

  • Metropolitan Hospital

    Athens, Attikí, 185 47

    Recruiting

  • Errikos Dunant Hospital Center

    Athens, 115 26

    Recruiting

  • University General Hospital of Heraklion

    Heraklion, 71500

    Recruiting

  • University General Hospital of Larissa

    Larissa, Thessalía, 41110

    Recruiting

  • European Interbalkan Medical Center

    Thessaloniki, Kentrikí Makedonía, 570 01

    Recruiting

Other trials in Greece

Czechia6 sites, 6 recruiting

  • Fakultni nemocnice Brno

    Brno, 625 00

    Recruiting

  • Fakultni nemocnice Olomouc

    Olomouc, 779 00

    Recruiting

  • Nemocnice AGEL Ostrava - Vitkovice a.s.

    Ostrava, 703 84

    Recruiting

  • Multiscan s.r.o.

    Pardubice, 532 03

    Recruiting

  • Fakultni Thomayerova nemocnice

    Prague, 140 59

    Recruiting

  • Fakultni nemocnice v Motole

    Prague, 150 06

    Recruiting

Other trials in Czechia

Israel6 sites, 6 recruiting

  • Shaare Zedek Medical Center

    Jerusalem, Jerusalem, 9103102

    Recruiting

  • Hadassah Medical Center

    Jerusalem, Jerusalem, 9112001

    Recruiting

  • Rabin Medical Center

    Petah Tikva, Central District, 4941492

    Recruiting

  • Sheba Medical Center

    Ramat Gan, HA Merkaz, 5265601

    Not yet recruiting

  • Sourasky Medical Center

    Tel Aviv, TELL ABĪB, 6423906

    Recruiting

  • Yitzhak Shamir Medical Center

    Tsrifin, HA Merkaz, 7033001

    Recruiting

Other trials in Israel

Puerto Rico5 sites, 5 recruiting

  • Pan American Center for Oncology Trials, LLC - Bayamón Office

    Bayamón, 00959

    Recruiting

  • Pan American Center for Oncology Trials, LLC- Dorado Office

    Dorado, 00646

    Recruiting

  • Pan American Center for Oncology Trials, LLC - Manati Office

    Manati, 00674

    Recruiting

  • Pan American Center for Oncology Trials, LLC - Mayaguez Office

    Mayagüez, 00680

    Recruiting

  • BRCR Global Puerto Rico - Hato Rey

    San Juan, 00917

    Recruiting

Other trials in Puerto Rico

About this study

Official title: AN INTERVENTIONAL PHASE 3, DOUBLE-BLIND, RANDOMIZED STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08634404 IN COMBINATION WITH CHEMOTHERAPY VERSUS PEMBROLIZUMAB IN COMBINATION WITH CHEMOTHERAPY IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER

This study is being done to find out if a new medicine called PF-08634404, when given with chemotherapy, works better than the present standard treatment (pembrolizumab with chemotherapy) for adults with a type of lung cancer called non-small cell lung cancer (NSCLC) that is either locally advanced (spread to nearby tissues) or has spread to other parts of the body.

To join the study, participants must meet the following conditions:

Read more
  • Be 18 years or older.
  • Have locally advanced (Stage IIIB/IIIC) or metastatic (Stage IV) squamous or non-squamous NSCLC.
  • Is not a candidate for complete surgical resection or curative chemoradiotherapy.
  • Do not have known actionable genomic alterations
  • Be treatment naïve for advanced or metastatic disease

Participants in this study will be assigned to two different parts of the study depending on their type of tumor: participants with squamous NSCLC will be assigned to Part 1, while participants with non-squamous NSCLC will be assigned to Part 2.

Each participant will be randomly assigned (like a flip of the coin) to one of two treatment groups in a blinded fashion:

  • Part 1 - Arm A or Part 2 - Arm C (Experimental Group): Will receive a new study medicine called PF-08634404 along with a kind of chemotherapy specific to the type of tumor.
  • Part 1 - Arm B or Part 2 - Arm D (Control Group): Will receive an approved medicine called pembrolizumab along with a kind of chemotherapy specific to the type of tumor.

Participants will receive their assigned treatment through intravenous (IV) infusions, which means the medicine is given directly into a vein. The treatment will be given in cycles, participants will receive PF-08634404 or Pembrolizumab in combination with chemotherapy followed by maintenance with either PF-08634404 or Pembrolizumab monotherapy (Part 1) or PF-08634404 or Pembrolizumab in combination with a chemotherapeutic drug (Part 2). Participants will continue receiving treatment if it is helping and not experiencing serious side effects.

The study will include regular visits for:

  • Treatment and health checks: while participant continues receiving treatment.
  • Tests to monitor how cancer responds: every 6 weeks during the first 48 weeks, then every 12 weeks thereafter.
Being tested
PF-08634404, Pembrolizumab, Chemotherapy Regimen 1, Chemotherapy Regimen 2
Keywords
non-squamous NSCLC, squamous NSCLC, metastatic (Stage IV) squamous or non-squamous NSCLC, Advanced or Metastatic Non-Small Cell Lung Cancer
Medical subject headings
Carcinoma, Non-Small-Cell Lung, Carcinoma, Lung Neoplasms, Neoplasm Metastasis

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • PF-08634404Biological

    Solution for infusion

  • PembrolizumabBiological

    Injection for IV use

  • Chemotherapy Regimen 1Drug

    Injection for IV use

  • Chemotherapy Regimen 2Drug

    Injection for IV use

Study groups in NCT07222566
Study groupRoleWhat they receive
Arm AExperimentalParticipants will receive PF-08634404 combined with chemotherapy regimen 1, followed by maintenance therapy with PF-08634404.
Receives: Biological: PF-08634404; Drug: Chemotherapy Regimen 1
Arm BActive comparatorParticipants will receive pembrolizumab combined with chemotherapy regimen 1, followed by maintenance therapy with pembrolizumab.
Receives: Biological: Pembrolizumab; Drug: Chemotherapy Regimen 1
Arm CExperimentalParticipants will receive PF-08634404 combined with chemotherapy regimen 2, followed by maintenance therapy with PF-08634404 and chemotherapy.
Receives: Biological: PF-08634404; Drug: Chemotherapy Regimen 2
Arm DActive comparatorParticipants will receive pembrolizumab combined with chemotherapy regimen 2, followed by maintenance therapy with pembrolizumab and chemotherapy.
Receives: Biological: Pembrolizumab; Drug: Chemotherapy Regimen 2

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Overall Survival

    Overall survival defined as the time from the date of randomization to the date of death due to any cause.

    Measured: Approximately 39 months

  2. Progression Free Survival (PFS) assessed by blinded independent central review (BICR)

    Progression-free survival is defined as the time from the date of randomization to the date of the first documentation of objective progressive disease (PD) assessed by BICR per RECIST v1.1, or death due to any cause, whichever occurs first.

    Measured: Approximately 32 months

Secondary outcomes (13)

  1. Confirmed objective response rate (ORR) using RECIST v1.1 as assessed by BICR

    ORR is defined as the proportion of participants in the analysis population having a best overall response (BOR) of confirmed CR or confirmed PR according to RECIST v1.1 as assessed by BICR.

    Measured: Approximately 32 months

  2. Progression Free Survival as assessed by Investigator

    Progression Free Survival (PFS) is defined as the time from the date of randomization to the date of the first documentation of objective PD assessed by investigator per RECIST v1.1, or death due to any cause, whichever occurs first.

    Measured: Approximately 32 months

  3. Confirmed ORR using RECIST v1.1 as assessed by investigator

    ORR is defined as the proportion of participants in the analysis population having a BOR of confirmed CR or confirmed PR according to RECIST v1.1 as assessed by BICR.

    Measured: Approximately 32 months

  4. Duration of Response (DoR) as assessed by BICR

    The time from the first documentation of objective response (CR or PR that is subsequently confirmed) to the date of the first documentation of PD as determined by BICR assessment per RECIST v1.1, or death due to any cause, whichever occurs first.

    Measured: Approximately 32 months

  5. Duration of Response (DoR) as assessed by Investigator

    The time from the first documentation of objective response (CR or PR that is subsequently confirmed) to the date of the first documentation of PD as determined by investigator assessment per RECIST v1.1, or death due to any cause, whichever occurs first.

    Measured: Approximately 32 months

  6. Number of Participants With Adverse Events (AEs)

    AEs as characterized by type, frequency, intensity as graded by NCI CTCAE version 5.0, timing, seriousness, and relationship to study intervention(s).

    Measured: Through end of study and up to approximately 39 months

  7. Number of Participants With Clinical Laboratory Abnormalities

    Laboratory test abnormalities as characterized by type, frequency, severity (as graded by NCI CTCAE version 5.0) and timing.

    Measured: through end of study and up to approximately 39 months

  8. Pharmacokinetics (PK): Serum concentrations of PF-08634404

    Predose and postdose concentrations of PF-08634404

    Measured: Through end of study and up to approximately 39 months

  9. Incidence of Anti-Drug Antibody (ADA) against PF-08634404.

    Measured: Through end of study and up to approximately 39 months

  10. Mean scores and Change from baseline in the global health status/quality of life (QoL) and physical function scores on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)

    The EORTC QLQ-C30 is a questionnaire for quantitative measure of health-related quality of life pertinent to participants with a broad range of cancers who are participating in international clinical trials.

    Measured: Approximately 39 months

  11. Time to definitive deterioration (TTdD) in in the global health status/QoL and physical function scores on the EORTC QLQ-C30

    TTdD is defined as the time from date of randomization to first onset of Patient Reported Outcome (PRO) deterioration without subsequent recovery.

    Measured: Approximately 39 months

  12. Mean scores and Change from Baseline in dyspnea, cough, and chest pain scores on the EORTC Quality of Life Cancer Questionnaire - Lung Cancer 13 QLQ-LC13

    EORTC QLQ-LC13 is a lung cancer specific module that serves as an additional 13 item questionnaire to the general EORTC cancer questionnaire, the EORTC QLQ-C30.

    Measured: Approximately 39 months

  13. TTdD in the dyspnea, cough, and chest pain scores on the EORTC QLQ-LC13

    TTdD is defined as the time from date of randomization to first onset of Patient Reported Outcome (PRO) deterioration without subsequent recovery.

    Measured: Approximately 39 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted30 Oct 2025
  2. Study start6 Jan 2026
  3. Primary completion27 Feb 2029 (estimated)
  4. Study completion26 Aug 2032 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
1,410 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07222566
Sponsor's protocol ID
C6461001
Other IDs
2025-523461-17-01, Symbiotic-Lung-01, 2025
Status last verified
Oct 2026
First submitted
28 Oct 2025
Last updated
8 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing PF-08634404, Pembrolizumab and Chemotherapy Regimen 1 in people with Advanced Non-Small Cell Lung Cancer and Non-Small Cell Lung Cancer, run by Pfizer at 484 sites in 20 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 32 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 484 sites in United States, China, Japan, Brazil, Spain and 15 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Pfizer CT.gov Call Center (1-800-718-1021, ClinicalTrials.gov_Inquiries@pfizer.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Overall Survival (time frame: Approximately 39 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07222566.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026.

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