Neglect, SensoryNeglex01NCT07227844
Mixed-Reality Visual Attention Task for Neglect Diagnosis and Rehabilitation
A study testing VR Neglect Training in people with Neglect, Sensory and Neglect, Hemispatial, run by Markey Olson at 1 site in United States.
Trial summary
Neglect, a common and disabling neurological deficit post-CNS injury, profoundly hinders recovery and escalates healthcare costs. Current diagnostic tools are often insensitive or impractical, and while therapies exist, a significant research gap remains. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Neglect, Sensory, Neglect, Hemispatial, Neglect, Hemisensory
- What is being tested?
- VR Neglect Training
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 5 participants
- Where
- 1 siteUnited States
- Study dates
- 31 Dec 2025to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- The study will involve patients over the age of 18 who have been diagnosed with a neurological injury that includes: ischemic stroke, hemorrhagic stroke, tumor, or trauma.
- Neurological injury that localizes to only one side of the brain
- At least one hand that retains dexterity enough to use a controller to extinguish the visual stimulus.
- Cognitive ability to understand simple instructions on how to use the device
- Visual fields intact
Who cannot join
- Bilateral symptomatic injury
- Inability to consent or to comply with study
- Blindness or severe visual deficits other than neglect
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
Barrow Neurological Institute
Phoenix, Arizona, 85013
Markey Olson, PhD, 602-406-5944, neuromodulationresearch@commonspirit.org
About this study
Official title: Pilot Study of a Mixed-Reality Visual Attention Task for Neglect Diagnosis and Rehabilitation
Neglect, a common and disabling neurological deficit post-CNS injury, profoundly hinders recovery and escalates healthcare costs. Current diagnostic tools are often insensitive or impractical, and while therapies exist, a significant research gap remains. Traditional methods, including standardized scales and paper-pencil tests, lack precision; even advanced video oculography is limited by cost and accessibility. Rehabilitative approaches like visual scanning and prism adaptation offer some benefit, but more effective solutions are needed. This project utilizes a non-invasive neuromodulatory training approach via a mixed-reality visual attention task delivered through a virtual reality headset. This system aims to improve both neglect diagnosis and personalized therapeutic intervention. The study will assess the headset's safety and practicality, its capacity to detect and lateralize neglect, and its long-term effect on improving attention to the neglected field. By measuring reaction times to visual stimuli within the VR environment, the research seeks to develop a more accessible and impactful tool for both assessing and treating neglect, potentially enabling self-directed therapy and enhancing patient outcomes.
- Conditions
- Neglect, Sensory, Neglect, Hemispatial, Neglect, Hemisensory
- Being tested
- VR Neglect Training
- Keywords
- neglect
- Medical subject headings
- Perceptual Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
VR Neglect TrainingDevice
VR Neglect Training
| Study group | Role | What they receive |
|---|---|---|
| Treatment | Experimental | Not described Receives: Device: VR Neglect Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Improvement in Neglect
Measured as improvement in percentage of lines detected at each location in the VR app
Measured: 6 months
Secondary outcomes (2)
Feasibility/Usage, sessions
Number of sessions completed by each participant
Measured: 6 months
Feasibility/Usage, time
Total time spent using the device
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Nov 2025
- Study start31 Dec 2025 (estimated)
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Neglect, SensoryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 5 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Markey Olson
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Markey Olson, St. Joseph's Hospital and Medical Center, Phoenix
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07227844
- Sponsor's protocol ID
- 26-500-131-30-06
- Acronym
- Neglex01
- Status last verified
- Nov 2025
- First submitted
- 7 Nov 2025
- Last updated
- 13 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 13 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pilot Study of a Mixed-Reality Visual Attention Task for Neglect Diagnosis and Rehabilitation
- ClinicalTrials.gov ID
- NCT07227844
- Acronym / sponsor ID
- Neglex01 / 26-500-131-30-06
- Conditions
- Neglect, Sensory, Neglect, Hemispatial, Neglect, Hemisensory
- Keywords
- neglect
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 5 participants (estimated)
- Lead sponsor
- Markey OlsonUniversity, hospital or other
- Study start
- 31 Dec 2025 (estimated)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 13 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Neglect, a common and disabling neurological deficit post-CNS injury, profoundly hinders recovery and escalates healthcare costs. Current diagnostic tools are often insensitive or impractical, and while therapies exist, a significant research gap remains. Traditional methods, including standardized scales and paper-pencil tests, lack precision; even advanced video oculography is limited by cost and accessibility. Rehabilitative approaches like visual scanning and prism adaptation offer some benefit, but more effective solutions are needed. This project utilizes a non-invasive neuromodulatory training approach via a mixed-reality visual attention task delivered through a virtual reality headset. This system aims to improve both neglect diagnosis and personalized therapeutic intervention. The study will assess the headset's safety and practicality, its capacity to detect and lateralize neglect, and its long-term effect on improving attention to the neglected field. By measuring reaction times to visual stimuli within the VR environment, the research seeks to develop a more accessible and impactful tool for both assessing and treating neglect, potentially enabling self-directed therapy and enhancing patient outcomes.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Treatment | Experimental | Device: VR Neglect Training |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- The study will involve patients over the age of 18 who have been diagnosed with a neurological injury that includes: ischemic stroke, hemorrhagic stroke, tumor, or trauma.
- Neurological injury that localizes to only one side of the brain
- At least one hand that retains dexterity enough to use a controller to extinguish the visual stimulus.
- Cognitive ability to understand simple instructions on how to use the device
- Visual fields intact
Key exclusion criteria (3 listed)
- Bilateral symptomatic injury
- Inability to consent or to comply with study
- Blindness or severe visual deficits other than neglect
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| VR Neglect TrainingVR Neglect Training | Device | Treatment |
Primary outcome
Improvement in Neglect
Time frame: 6 months
Measured as improvement in percentage of lines detected at each location in the VR app
2 secondary outcomes
Feasibility/Usage, sessions
Time frame: 6 months
Feasibility/Usage, time
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Nov 2025.
- Individual participant dataSharing planned: Undecided
Related trials for Neglect, Sensory
RecruitingObservational study
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Rare Disorders, Undiagnosed Disorders
Recruiting
Somatosensory Stimulation for Unilateral Neglect Post Stroke (SSUN)
Stroke, Unilateral Neglect Syndrome
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing VR Neglect Training in people with Neglect, Sensory and Neglect, Hemispatial, run by Markey Olson at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 13 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Markey Olson, PhD (602-406-5944, neuromodulationresearch@commonspirit.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Improvement in Neglect (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Nov 2025.