Pachychoroid DiseaseCVANCT07236671
Progression Patterns of Choroidal Venous Alterations
An observational study of Pachychoroid Disease, run by Singapore National Eye Centre at 4 sites in 3 countries.
Trial summary
This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Read more about this study
- Who is it for?
- Ages 45 years and older
- Conditions the study is for
- Pachychoroid Disease
- How many people
- 250 participants
- Where
- 4 sitesin 3 countries
- Study dates
- 4 Mar 2025to Aug 2029
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: This study will aim to recruit 170 participants in Singapore National Eye Centre (SNEC) and 50 participants in National University Hospital, 30 participants from the University of Malaya
Who may be able to join
- Adults aged 45 years or older.
- Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant.
- Willing to undergo pupil dilation, and protocol-required procedures for both eyes
- Willing to provide written informed consent
Who cannot join
- Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period
- Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery)
- Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders
- Pregnant or nursing women
- Persons who are unable to give informed consent
Trial locations and contacts
4 sites in 3 countries. Contact the study team or a site near you to ask about taking part.
4 sites in 3 countries
Singapore2 sites, 2 recruiting
- Recruiting
National University Hospital, Singapore
Singapore
Wendy Wong, +65, wendy_wong@nuhs.edu.sg
- Recruiting
Singapore National Eye Centre/ Singapore Eye Research Institute
Singapore
Gemmy Cheung, +65 63227460, gemmy.cheung.c.m@singhealth.com.sg
Hong Kong1 site, 1 recruiting
- Recruiting
Hong Kong University
Hong Kong
Angie Fong, 852 2518 1430, fongahc@hku.hk
Malaysia1 site, 1 recruiting
- Recruiting
University of Malaya Medical Centre
Kuala Lumpur
Lott Pooi Wah Dr, 03-79677022, lottpw@um.edu.my
About this study
Official title: International Multi-centre, Prospective, Longitudinal Cohort to Evaluate the Progression Pattern of Choroidal Venous Alterations
This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.
Read the detailed description
This study aims to document the longitudinal progression pattern and the incidence rate of progression of choroidal venous alteration (defined as either an increase in number of quadrants with pachyvessels or formation of new anastomoses which violates the physiological watershed It will provide valuable natural history data to study the pattern of evolution of choroidal vessels over time and validate the proposed multi-hit theory over a period of three years.
- Conditions
- Pachychoroid Disease
What is being measured
The primary outcome is the main question the study is designed to answer.
Progression of choroidal venous alterations
Proportion of eyes demonstrating progression of choroidal venous alterations, defined as either an increase in number of quadrants with pachyvessels or formation of new choroidal anastomoses.
Measured: 3 years
Secondary outcomes (2)
Incidence of progression of pachychoroid disease manifestation
New onset of Central Serous Chorioretinopathy (CSCR), focal Retinal Pigment Epithelium (RPE) changes, or other pachychorois related findings.
Measured: 3 years
Risk factors associated with progression of choroidal venous alteration
Assessment of demographic, cilinical, and imaging parameters associated with progression.
Measured: 3 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Nov 2025
- Study start4 Mar 2025
- Primary completionJun 2029 (estimated)
- Study completionAug 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pachychoroid DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 250 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Singapore National Eye Centre
- Sponsor type
- Other government
- Collaborators
- National University Hospital, Singapore, University of Malaya, Hong Kong University
- Responsible party
- Principal investigator, Gemmy Cheung Chui Ming, Singapore National Eye Centre
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07236671
- Sponsor's protocol ID
- 2024-4359
- Acronym
- CVA
- Status last verified
- Nov 2025
- First submitted
- 14 Nov 2025
- Last updated
- 12 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- International Multi-centre, Prospective, Longitudinal Cohort to Evaluate the Progression Pattern of Choroidal Venous Alterations
- ClinicalTrials.gov ID
- NCT07236671
- Acronym / sponsor ID
- CVA / 2024-4359
- Conditions
- Pachychoroid Disease
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 250 participants (estimated)
- Lead sponsor
- Singapore National Eye CentreOther government
- Collaborators
- National University Hospital, Singapore, University of Malaya, Hong Kong University
- Study start
- 4 Mar 2025 (actual)
- Primary completion
- Jun 2029 (estimated)
- Study completion
- Aug 2029 (estimated)
- First posted
- 19 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.
Detailed description
This study aims to document the longitudinal progression pattern and the incidence rate of progression of choroidal venous alteration (defined as either an increase in number of quadrants with pachyvessels or formation of new anastomoses which violates the physiological watershed It will provide valuable natural history data to study the pattern of evolution of choroidal vessels over time and validate the proposed multi-hit theory over a period of three years.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 45 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- This study will aim to recruit 170 participants in Singapore National Eye Centre (SNEC) and 50 participants in National University Hospital, 30 participants from the University of Malaya
Key inclusion criteria (4 listed)
- Adults aged 45 years or older.
- Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant.
- Willing to undergo pupil dilation, and protocol-required procedures for both eyes
- Willing to provide written informed consent
Key exclusion criteria (5 listed)
- Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period
- Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery)
- Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders
- Pregnant or nursing women
- Persons who are unable to give informed consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Progression of choroidal venous alterations
Time frame: 3 years
Proportion of eyes demonstrating progression of choroidal venous alterations, defined as either an increase in number of quadrants with pachyvessels or formation of new choroidal anastomoses.
2 secondary outcomes
Incidence of progression of pachychoroid disease manifestation
Time frame: 3 years
Risk factors associated with progression of choroidal venous alteration
Time frame: 3 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
4 sites in 3 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Pachychoroid Disease, run by Singapore National Eye Centre at 4 sites in 3 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 12 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 4 sites in Singapore, Hong Kong, Malaysia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Gemmy Cheung (+65 63227460, gemmy.cheung.c.m@singhealth.com.sg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Progression of choroidal venous alterations (time frame: 3 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Jun 2026.