Laparotomy Closure After Abdominal SurgeryNCT07241507
Effect of Continuous Versus Interrupted Suturing on Wound Dehiscence and Infection After Abdominal Surgery
A study testing Continuous suturing and Interrupted suturing in people with Laparotomy Closure After Abdominal Surgery and Wound Infection, Surgical, run by Allama Iqbal Teaching Hospital at 1 site in Pakistan.
Trial summary
The goal of this clinical trial is to learn whether the type of suturing technique used to close the abdomen after exploratory laparotomy affects the rate of wound complications. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Laparotomy Closure After Abdominal Surgery, Wound Infection, Surgical, Dehiscence of Laparotomy Wound
- What is being tested?
- Continuous suturing and Interrupted suturing
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 sitePakistan
- Study dates
- 11 Sep 2024to 10 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Undergoing exploratory laparotomy
- Both emergency and elective
Who cannot join
- Patients undergoing second laparotomy or re- laparotomy
- Patients on steroid therapy (assessed on medical record review)
- Patients who die within 28-days of surgery
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Allama Iqbal Teaching Hospital, Dera Ghazi Khan
Dera Ghazi Khan, Punjab Province, 32200
About this study
Official title: Frequency of Wound Dehiscence and Wound Infection in Continuous Versus Interrupted Suturing for Abdominal Closure in Exploratory Laparotomy
The goal of this clinical trial is to learn whether the type of suturing technique used to close the abdomen after exploratory laparotomy affects the rate of wound complications. Specifically, the study aims to find out if using interrupted sutures results in fewer cases of wound dehiscence (wound reopening) compared to continuous sutures.
The main question the study seeks to answer is:
Read more
Does interrupted suturing reduce the frequency of wound dehiscence compared to continuous suturing in patients undergoing exploratory laparotomy?
Researchers will also observe and compare wound infection rates between the two suturing methods.
About 80 adult patients (18-60 years old) undergoing exploratory laparotomy at the Department of General Surgery, DHQ Teaching Hospital, Dera Ghazi Khan, will take part in this study. Participants will be randomly assigned to one of two groups:
Group A: Continuous abdominal closure using No. 1 Vicryl suture
Group B: Interrupted abdominal closure using No. 1 Vicryl suture
All participants will have their baseline characteristics recorded, including age, gender, obesity, diabetes, and smoking status. The surgical technique and postoperative care will follow the hospital's standard protocols. After surgery, patients will be followed for four weeks with weekly clinical assessments to check for wound infection or wound dehiscence.
The hypothesis is that patients whose abdominal wounds are closed with interrupted sutures will have a lower frequency of wound dehiscence compared to those with continuous sutures.
The findings will help guide surgeons on which abdominal closure method provides better wound healing and fewer postoperative complications.
- Conditions
- Laparotomy Closure After Abdominal Surgery, Wound Infection, Surgical, Dehiscence of Laparotomy Wound, Suture, Interrupted, Continuous Suture
- Being tested
- Continuous suturing, Interrupted suturing
- Keywords
- exploratory laparotomy, Surgical wound infection, Wound dehiscence
- Medical subject headings
- Surgical Wound Infection
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Continuous suturingProcedure or surgery
After an exploratory laparotomy continuous suturing using a single thread of Vicryl No. 1 will be used to stitch the incision's fascial layer together, 1 cm distance from wound edges and between each stitch, creating a line of even tension across the wound.
Interrupted suturingProcedure or surgery
After an exploratory laparotomy, interrupted suturing using a single thread of Vicryl No. 1 will be used to stitch the incision's fascial layer together, 1 cm distance from wound edges and between each stitch. A knot will be tied after each suture is passed through the tissue, and each stitch will be secured with its own knot.
| Study group | Role | What they receive |
|---|---|---|
| Group A - Continuous | Active comparator | Continuous Suture Receives: Procedure: Continuous suturing |
| Group B - Interrupted | Experimental | Interrupted Suture Receives: Procedure: Interrupted suturing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Wound Dehiscence
A partial or total separation of previously approximated wound edges, on clinical examination of surgical wound.
Measured: From enrollment to 28-days of operation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Nov 2025
- Study start11 Sep 2024
- Primary completion10 Mar 2025
- Study completion10 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Laparotomy Closure After Abdominal SurgeryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Allama Iqbal Teaching Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Muhammad Shehroz Sarwar, Allama Iqbal Teaching Hospital
- Investigators
- Malik N Fareed, FCPS, Study chair, Allama Iqbal Teaching Hospital Dera Ghazi Khan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07241507
- Sponsor's protocol ID
- U1111-1329-8430
- Status last verified
- Nov 2025
- First submitted
- 17 Nov 2025
- Last updated
- 21 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Frequency of Wound Dehiscence and Wound Infection in Continuous Versus Interrupted Suturing for Abdominal Closure in Exploratory Laparotomy
- ClinicalTrials.gov ID
- NCT07241507
- Acronym / sponsor ID
- U1111-1329-8430
- Conditions
- Laparotomy Closure After Abdominal Surgery, Wound Infection, Surgical, Dehiscence of Laparotomy Wound, Suture, Interrupted, Continuous Suture
- Keywords
- exploratory laparotomy, Surgical wound infection, Wound dehiscence
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Allama Iqbal Teaching HospitalOther government
- Study start
- 11 Sep 2024 (actual)
- Primary completion
- 10 Mar 2025 (actual)
- Study completion
- 10 Mar 2025 (actual)
- First posted
- 21 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn whether the type of suturing technique used to close the abdomen after exploratory laparotomy affects the rate of wound complications. Specifically, the study aims to find out if using interrupted sutures results in fewer cases of wound dehiscence (wound reopening) compared to continuous sutures.
The main question the study seeks to answer is:
Does interrupted suturing reduce the frequency of wound dehiscence compared to continuous suturing in patients undergoing exploratory laparotomy?
Researchers will also observe and compare wound infection rates between the two suturing methods.
About 80 adult patients (18-60 years old) undergoing exploratory laparotomy at the Department of General Surgery, DHQ Teaching Hospital, Dera Ghazi Khan, will take part in this study. Participants will be randomly assigned to one of two groups:
Group A: Continuous abdominal closure using No. 1 Vicryl suture
Group B: Interrupted abdominal closure using No. 1 Vicryl suture
All participants will have their baseline characteristics recorded, including age, gender, obesity, diabetes, and smoking status. The surgical technique and postoperative care will follow the hospital's standard protocols. After surgery, patients will be followed for four weeks with weekly clinical assessments to check for wound infection or wound dehiscence.
The hypothesis is that patients whose abdominal wounds are closed with interrupted sutures will have a lower frequency of wound dehiscence compared to those with continuous sutures.
The findings will help guide surgeons on which abdominal closure method provides better wound healing and fewer postoperative complications.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A - Continuous | Active comparator | Procedure: Continuous suturingContinuous Suture |
| Group B - Interrupted | Experimental | Procedure: Interrupted suturingInterrupted Suture |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Undergoing exploratory laparotomy
- Both emergency and elective
Key exclusion criteria (3 listed)
- Patients undergoing second laparotomy or re- laparotomy
- Patients on steroid therapy (assessed on medical record review)
- Patients who die within 28-days of surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Continuous suturingAfter an exploratory laparotomy continuous suturing using a single thread of Vicryl No. 1 will be used to stitch the incision's fascial layer together, 1 cm distance from wound edges and between each stitch, creating a line of even tension across the wound. | Procedure or surgery | Group A - Continuous |
| Interrupted suturingAfter an exploratory laparotomy, interrupted suturing using a single thread of Vicryl No. 1 will be used to stitch the incision's fascial layer together, 1 cm distance from wound edges and between each stitch. A knot will be tied after each suture is passed through the tissue, and each stitch will be secured with its own knot. | Procedure or surgery | Group B - Interrupted |
Primary outcome
Wound Dehiscence
Time frame: From enrollment to 28-days of operation
A partial or total separation of previously approximated wound edges, on clinical examination of surgical wound.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Nov 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Malik N Fareed, FCPS study chair
Allama Iqbal Teaching Hospital Dera Ghazi Khan
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Continuous suturing and Interrupted suturing in people with Laparotomy Closure After Abdominal Surgery and Wound Infection, Surgical, run by Allama Iqbal Teaching Hospital at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Wound Dehiscence (time frame: From enrollment to 28-days of operation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Nov 2025.