No Condition, Healthy IndividualsNCT07245199
Protein Intake Distribution to Support Muscle Anabolism in Healthy Young Adults
A study testing protein intake in people with No Condition, Healthy Individuals, run by Maastricht University Medical Center at 1 site in Netherlands.
Trial summary
The purpose of the study is to evaluate whether the distribution pattern of daily protein intake affects how much muscle protein can be built in the muscle after resistance exercise and at rest. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- No Condition, Healthy Individuals
- What is being tested?
- protein intake
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteNetherlands
- Study dates
- Jan 2026to 1 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged between 18-40 years
- Healthy
- 18.5 ≤ BMI 30 ≤ kg・m-2
Who cannot join
- Smoking
- Sports/exercise >4 sessions/week or a structured resistance or endurance training schedule
- Lactose intolerant or allergies to milk protein
- A history of neuromuscular problems
- Use of anticoagulation medication
- Individuals on any medications known to affect protein metabolism (i.e. , non-steroidal anti-inflammatories, or prescription acne medications).
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- Strict vegetarian
- Injury or condition that would limit the participant from performing the resistance exercise.
- Pregnancy
- Hormone replacement therapy
- Blood donation within the past 2 months
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
The purpose of the study is to evaluate whether the distribution pattern of daily protein intake affects how much muscle protein can be built in the muscle after resistance exercise and at rest.
- Conditions
- No Condition, Healthy Individuals
- Being tested
- protein intake
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
protein intakeDietary supplement
1x 100g
protein intakeDietary supplement
4x 25 g
Protein intakeDietary supplement
15x 7 g
| Study group | Role | What they receive |
|---|---|---|
| BALANCED | Experimental | Not described Receives: Dietary Supplement: protein intake |
| SIP | Experimental | Not described Receives: Dietary Supplement: Protein intake |
| BOLUS | Experimental | Not described Receives: Dietary Supplement: protein intake |
What is being measured
The primary outcome is the main question the study is designed to answer.
fractional synthetic rate
Measured: 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Nov 2025
- Study startJan 2026 (estimated)
- Primary completion1 Jan 2027 (estimated)
- Study completion1 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for No Condition, Healthy IndividualsStudies of the same condition, open and under way.
- More trials run by Maastricht University Medical CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 36 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Maastricht University Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07245199
- Sponsor's protocol ID
- NL-010056 / METC25-038
- Other IDs
- NL-010056 / METC25-038
- Status last verified
- Sep 2025
- First submitted
- 2 Oct 2025
- Last updated
- 24 Nov 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Mamerow MM, Mettler JA, English KL, Casperson SL, Arentson-Lantz E, Sheffield-Moore M, Layman DK, Paddon-Jones D. Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J Nutr. 2014 Jun;144(6):876-80. doi: 10.3945/jn.113.185280. Epub 2014 Jan 29.
PubMed 24477298Areta JL, Burke LM, Ross ML, Camera DM, West DW, Broad EM, Jeacocke NA, Moore DR, Stellingwerff T, Phillips SM, Hawley JA, Coffey VG. Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis. J Physiol. 2013 May 1;591(9):2319-31. doi: 10.1113/jphysiol.2012.244897. Epub 2013 Mar 4.
PubMed 23459753
Study at a glance
From the registry record, last updated by the sponsor on 24 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Protein Intake Distribution to Support Muscle Anabolism in Healthy Young Adults
- ClinicalTrials.gov ID
- NCT07245199
- Acronym / sponsor ID
- NL-010056 / METC25-038
- Conditions
- No Condition, Healthy Individuals
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 36 participants (estimated)
- Lead sponsor
- Maastricht University Medical CenterUniversity, hospital or other
- Study start
- Jan 2026 (estimated)
- Primary completion
- 1 Jan 2027 (estimated)
- Study completion
- 1 Jan 2027 (estimated)
- First posted
- 24 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of the study is to evaluate whether the distribution pattern of daily protein intake affects how much muscle protein can be built in the muscle after resistance exercise and at rest.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| BALANCED | Experimental | Dietary Supplement: protein intake |
| SIP | Experimental | Dietary Supplement: Protein intake |
| BOLUS | Experimental | Dietary Supplement: protein intake |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Aged between 18-40 years
- Healthy
- 18.5 ≤ BMI 30 ≤ kg・m-2
Key exclusion criteria (11 listed)
- Smoking
- Sports/exercise >4 sessions/week or a structured resistance or endurance training schedule
- Lactose intolerant or allergies to milk protein
- A history of neuromuscular problems
- Use of anticoagulation medication
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| protein intake1x 100g | Dietary supplement | BOLUS |
| protein intake4x 25 g | Dietary supplement | BALANCED |
| Protein intake15x 7 g | Dietary supplement | SIP |
Primary outcome
fractional synthetic rate
Time frame: 24 hours
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Nov 2025.
- Results publication: PubMed 24477298Mamerow MM, Mettler JA, English KL, Casperson SL, Arentson-Lantz E, Sheffield-Moore M, Layman DK, Paddon-Jones D. Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J Nutr. 2014 Jun;144(6):876-80. doi: 10.3945/jn.113.185280. Epub 2014 Jan 29.
- Results publication: PubMed 23459753Areta JL, Burke LM, Ross ML, Camera DM, West DW, Broad EM, Jeacocke NA, Moore DR, Stellingwerff T, Phillips SM, Hawley JA, Coffey VG. Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis. J Physiol. 2013 May 1;591(9):2319-31. doi: 10.1113/jphysiol.2012.244897. Epub 2013 Mar 4.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing protein intake in people with No Condition, Healthy Individuals, run by Maastricht University Medical Center at 1 site in Netherlands.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 24 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Netherlands. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
fractional synthetic rate (time frame: 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07245199, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Nov 2025.