AzTrials
AzTrials

HyperaldosteronismCHAMPIONNCT07252284

CHina Adrenal Venous saMPling InvestigatiON

An observational study of Hyperaldosteronism and Adrenal Venous Sampling, run by Chinese Academy of Medical Sciences, Fuwai Hospital at 76 sites in China.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

Primary aldosteronism (PA) is a major cause of secondary hypertension, yet its optimal diagnosis and management remain challenging. This study comprehensively evaluates adrenal venous sampling (AVS), addressing key clinical, technical, and methodological issues, and aims to clarify the relationship between AVS-guided… Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
adrenal venous sampling
Type of treatment
Surgery or procedure
How many people
5,000 participants
Where
76 sitesChina
Study dates
1 May 2025to 31 Aug 2029
How long will I take part?
5 Years
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: All patients with confirmed primary aldosteronism underwent adrenal venous sampling.

Who may be able to join

  • Patients with confirmed primary aldosteronism;
  • Patients undergoing adrenal venous sampling for subtype classification of primary aldosteronism.

Who cannot join

  • Severe comorbidity, including stroke, myocardial infarction, heart failure, severe valvular heart disease, liver cirrhosis, and metastatic tumor within the previous 3 months；
  • An estimated glomerular filtration rate <45 ml/min/1.73 m2, or serum creatinine >176 μmol/L；
  • Patients who refuse adrenalectomy;
  • Suspected of having an adrenocortical carcinoma;
  • Allergy to contrast agent;
  • Pregnant, nursing, or planning to become pregnant

Trial locations and contacts

76 sites in 1 country. Contact the study team or a site near you to ask about taking part.

Hui Dong, MD contact

86-010-88322385

donghui666@sina.com

Xiongjing Jiang, MD contact

86-010-88322387

jiangxiongjing@163.com

76 sites in 1 country

China76 sites, 76 recruiting

  • Chuiyangliu Hospital affiliated to Tsinghua University

    Beijing, Beijing Municipality, 100022

    Lin Pi, MD, 010-87766377, pilindoctor@126.com

    Lin Pi, MD

    Recruiting

  • China-Japan Friendship Hospital

    Beijing, Beijing Municipality, 100029

    Wuqiang Che, MD, 010-84205136, chemokel@163.com

    Wuqiang Che, MD

    Recruiting

  • Peking University First Hospital

    Beijing, Beijing Municipality, 100034

    Wei Ma, MD, 13681050902, kmmawei@sina.com

    Wei Ma, MD

    Recruiting

  • Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College

    Beijing, Beijing Municipality, 100037

    Hui Dong, MD, 86-010-88322385, donghui666@sina.com

    Xiongjing Jiang, MD, 86-010-88322387, jiangxiongjing@163.com

    Recruiting

  • Peking University People's Hospital

    Beijing, Beijing Municipality, 100044

    Jing Liu, MD, 010-66583710, heartcenter@163.com

    Jing Liu, MD

    Recruiting

  • Beijing Luhe Hospital, Capital Medical University

    Beijing, Beijing Municipality, 101100

    Dong Zhao, MD, PhD, 010-69543901, zhaodong@ccmu.edu.cn

    Dong Zhao, MD, PhD

    Recruiting

  • Changdu People's Hospital of Tibet

    Chamdo, Tibet, 854000

    Rui Xiang, MD, 0895-4821745

    Rui Xiang, MD

    Recruiting

  • The First Hospital of Jilin University

    Changchun, Jilin, 130021

    Wei Zhao, MD, 0431-88782342, w_zhao@jlu.edu.cn

    Wei Zhao, MD

    Recruiting

  • Jilin Province FAW General Hospital

    Changchun, Jilin, 130051

    Wenhai Wang, MM, 043185904542, 767732002@qq.com

    Wenhai Wang, MM

    Recruiting

  • The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, China

    Chengdu, Sichuan, 610031

    Zhen Zhang, MD, 13708042927, 31350377@qq.com

    Zhen Zhang, MD

    Recruiting

  • The First Affiliated Hospital of Chengdu Medical College

    Chengdu, Sichuan, 610500

    Peijian Wang, MD, 18980718263, wpjmed@aliyun.com

    Peijian Wang, MD

    Recruiting

  • Chengdu Fifth People's Hospital

    Chengdu, Sichuan, 611130

    Mingjian Lang, (028) 8271 0681, zcl628@163.com

    Mingjian Lang, MD

    Recruiting

  • Chongqing University Central Hospital

    Chongqing, Chongqing Municipality, 400000

    Dongying Zhang, MD, 13608398395, zhangdongying@cqmu.edu.cn

    Dongying Zhang, MD

    Recruiting

  • Chongqing General Hospital

    Chongqing, Chongqing Municipality, 401147

    Rui He, MM, 023-63390560, 253942231@qq.com

    Rui He, MM

    Recruiting

  • People's Hospital Affiliated to ChongqingThree Gorges Medical college

    Chongqing, Chongqing Municipality, 404100

    Xianhu Luo, MD, 15923433929, 826863635@qq.com

    Xianhu Luo, MD

    Recruiting

  • Affilated Zhongshan Hospital of Dalian University

    Dalian, Liaoning, 116001

    Minglian Gong, MD, 0411-62896223, gongml777@126.com

    Minglian Gong, MD

    Recruiting

  • Frist Aiffiliated Hospital of Dalian Medical University

    Dalian, Liaoning, 116011

    Yinong Jiang, MD, 0411-83635963, yinongjiang@163.com

    Yinong Jiang, MD

    Recruiting

  • The second hospital of Dalian Medical University

    Dalian, Liaoning, 116027

    Nan Niu, MD, 17709875885, nn_6581@aliyun.com

    Nan Niu, MD

    Recruiting

  • The Forth People's Hosptal of Nanhai District of Foshan City

    Foshan, Guangdong, 528211

    Yayan Han, MD, 0757-86866918, hyy321521@sohu.com

    Yayan Han, MD

    Recruiting

  • First Affiliated Hospital, Fujian Medical University, Fuzhou, China,

    Fuzhou, Fujian, 0591-87982222

    Feng Peng, MD, 0591-87982222, pengfeng@fjmu.edu.cn

    Feng Peng, MD

    Recruiting

  • The First Affiliated Hospital of Gannan Medical University

    Ganzhou, Jiangxi, 341000

    Jiayuan Ling, MD, 18807972012, 15803152@qq.com

    Jiayuan Yuan, MD

    Recruiting

  • Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)

    Guangzhou, Guangdong, 510080

    Yingqing Feng, MD, 13602863389, fyq1819@163.com

    Yingqing Feng, MD

    Recruiting

  • Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, China.

    Guiyang, Guizhou, 550002

    Fang Song, MD, 18685191199, songfangheart@126.com

    Fang Song, MD

    Recruiting

  • The Affiliated Hospital of Guizhou Medical University

    Guiyang, Guizhou, 550004

    Zhangrong Chen, MD, 0856-88689263, chenzhangrong71@163.com

    Zhangrong Chen, MD

    Recruiting

  • Hainan General Hospital, Department of Endocrinology

    Haikou, Hainan, 570311

    Haiyu Zhang, MM, 0898-68622221, yuhai_2013@163.com

    Haiyu Zhang, MM

    Recruiting

  • Hainan General Hospital, Department of Cardiology

    Hainan, Hainan, 570311

    Wang Liao, MD, 13518827831, crain_lw@163.com

    Wang Liao, MD

    Recruiting

  • Zhejiang Hospital

    Hangzhou, Zhejiang, 310000

    Yimin Tang, MD, 13758176000, tang5995@aliyun.com

    Yimin Tang, MD

    Recruiting

  • The First Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150001

    Dechao Zhao, MD, 0451-85555723, drzhaodechao@163.com

    Dechao Zhao, MD

    Recruiting

  • The Second Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150086

    Shuo Zhang, MD, 18645056661, zhangshuoemail@163.com

    Shuo Zhang, MD

    Recruiting

  • The first affiliated hospital of USTC

    Hefei, Anhui, 230036

    Xiangyong Kong, PhD, 0551-62284055, kxyong1234@163.com

    Xiangyong Kong, PhD

    Recruiting

  • the Second Hospital, Cheeloo College of Medicine, Shandong University

    Jinan, Shandong, 250000

    Qinghai Wang, MD, 0543-85875088, sdwqh1005@126.com

    Qinghai Wang, MD

    Recruiting

  • Qilu Hospital of Shandong University

    Jinan, Shandong, 250012

    Peili Bu, MD, 18560086596, bupeili@medmail.com.cn

    Peili Bu, MD

    Recruiting

  • Central Hospital Affiliated to Shandong First Medical University

    Jinan, Shandong, 250013

    Rui Xu, MD, PhD, 0531-88653212, xuruicn@hotmail.com

    Rui Xu, MD, PhD

    Recruiting

  • Kai Feng the Peoples Hospital

    Kaifeng, Henan, 475002

    Qingli Pan, MD, 0371-22730719, 742642136@qq.com

    Qingli Pan, MD

    Recruiting

  • The Second Affiliated Hospital Of Guizhou Medical University

    Kaili, Guizhou, 556000

    Yumei Xiang, MD, 0855-3833103, 1016313267@qq.com

    Yumei Xiang, MD

    Recruiting

  • The First Affiliated Hospital of Kunming Medical University

    Kunming, Yunnan, 650031

    Lihua Zhang, PhD, 0871-65324888-6133, lihuazhang772002@163.com

    Lihua Zhang, PhD

    Recruiting

  • Yan'an Affiliated Hospital of Kunming Medical University

    Kunming, Yunnan, 650051

    Yan He, MD, 0871-63211375, 1349561462@qq.com

    Yan He, MD

    Recruiting

  • Fuwai Yunnan Cardiovascular Hospital

    Kunming, Yunnan, 650102

    Zihong Guo, MD, 0871-68515973, guozihong1962@163.com

    Zihong Guo, MD

    Recruiting

  • Lanzhou University Second Hospital

    Lanzhou, Gansu, 730000

    Wei Liang, MD, 0931-5190690, 758099072@qq.com

    Wei Liang, MD

    Recruiting

  • People's Hospital of Donga County, Shandong Province

    Liaocheng, Shandong, 252200

    Xiaoli Wang, MD, 15865751121, w15865751121@126.com

    Xiaoli Wang, MD

    Recruiting

  • Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006

    Yifei Dong, MD, PhD, 0791-8735-7354, yf_dong66@126.com

    Yifei Dong, MD, PhD

    Recruiting

  • Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College)

    Nanchang, Jiangxi, 330038

    Haohang Ruan, MBBS, 0791-87721036

    Haohang Ruan, MBBS

    Recruiting

  • The First Affiliated Hospital of Guangxi Medical University

    Nanning, Guangxi, 530000

    Jiangnan Huang, MD, 07715359553, huangjn1998@163.com

    Jiangnan Huang, MD

    Recruiting

  • The Second Affliated Hospital Of GuangXi Medical Univesity

    Nanning, Guangxi, 530007

    Houfa Ning, MM, 0771-3277215, houfa.ning@foxmail.com

    Houfa Ning, MM

    Recruiting

  • Nanning Third People's Hospital

    Nanning, Guangxi, 547000

    Yongqi Xiao, MBBS, 07713394390

    Yongqi Xiao, MBBS

    Recruiting

  • Qingdao Hospital University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)

    Qingdao, Shandong, 266000

    Nan Jia, MD, 17669783012, jiananchina@qq.com

    Nan Jia, MD

    Recruiting

  • Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine

    Shanghai, Shanghai Municipality, 200025

    Jiangzhong Xu, MD, PhD, 13761452329, jianzhongxv@outlook.com

    Jianzhong Xu, MD, PhD

    Recruiting

  • Shanghai Putuo District Central Hospital

    Shanghai, Shanghai Municipality, 200062

    Zongjun Liu, MD, 021-22233222, liuzongjun1548@shutcm.edu.cn

    Zongjun Liu, MD

    Recruiting

  • Shanghai General Hospital ( originally named Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine

    Shanghai, Shanghai Municipality, 200080

    Zhi Zhang, MD, 13621759762, 16683890@qq.com

    Zhi Zhang, MD

    Recruiting

  • Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen

    Shenzhen, Guangdong, 518000

    Jianqiong Kong, MD, 13510568376, 2653290915@qq.com

    Jianqiong Kong, MD

    Recruiting

  • Shenzhen Third People's Hospital，Shenzhen, Guangdong Province 518112, China

    Shenzhen, Guangdong, 518112

    Zhenzhong Zheng, MD, PhD, 0755-61222333, greateful@163.com

    Zhenzhong Zheng, MD, PhD

    Recruiting

  • Shenzhen Dapeng New District Kuiyong People's Hospital

    Shenzhen, Guangdong, 518116

    Tongqing Lu, MD, 0755-84204067, lutongqing@hotmail.com

    Tongqing Lu, MD

    Recruiting

  • the second hospital of ShanXi medical unversity

    Taiyuan, Shanxi, 030001

    Bin Yang, MD, 13546355355, yangbxys@163.com

    Bin Yang, MD

    Recruiting

  • Tangshan hongci Hospital

    Tangshan, Hebei, 063000

    Guijuan Zhang, MD, 0315-6272993, zhangguijun1212@63.com

    Guijuan Zhang, MD

    Recruiting

  • Tianjin Medical University General Hospital

    Tianjin, Tianjin Municipality, 300052

    Dianxun Fu, MD, 022-60814078, cmufudx1@126.com

    Dianxun Fu, MD

    Recruiting

  • The Second Hospital of Tianjin Medical University

    Tianjin, Tianjin Municipality, 300211

    Changle Liu, MD, 15522133881, lcl1979_2001@163.com

    Changle Liu, MD

    Recruiting

  • TEDA International Cardiovascular Hospital

    Tianjin, Tianjin Municipality, 300457

    Weiqiang Chen, MM, 022-65209995, 13821205212@163.com

    Weiqiang Wang, MM

    Recruiting

  • Inner Mongolia Xing'an League People's Hospital

    Ulanhot, Neimenggu, 137400

    Tao Guo, MM, 0482-8282080, guot18@lzu.edu.cn

    Tao Guo, MM

    Recruiting

  • Xinjiang Uygur Autonomous Region People's Hospital

    Ürümqi, Xinjiang, 830001

    Guoliang Wang, PhD, 0991-8563065, 908022751@qq.com

    Guoliang Wang, PhD

    Recruiting

  • Renmin Hospital of Wuhan University

    Wuhan, Hubei, 430060

    Hongxin Xu, MD, 18908640597, 303876340@qq.com

    Hongxin Xu, MD

    Recruiting

  • Xi'an People's Hospital

    Xi’an, Shanxi, 710018

    Kang Cheng, MD, PhD, 029-61199240, chengkang75@126.com

    Kang Cheng, MD, PhD

    Recruiting

  • Cardiovascular Hospital Xiamen University

    Xiamen, Fujian, 361016

    Tao Ye, MD, 029-2292337, yetao@xmu.edu.cn

    Tao Ye, MD

    Recruiting

  • Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science

    Xiangyang, Hubei, 441021

    Qingan Li, MD, 0710-2811051, 2145439882@qq.com

    Qingan Li, MD

    Recruiting

  • Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital

    Xining, Qinghai, 810000

    Xiaozhou Wang, MD, 0971-6288407, wxz_1978@163.com

    Xiaozhou Wang, MD

    Recruiting

  • Qinghai University Affiliated Hospital

    Xining, Qinghai, 810001

    Ming Ren, MM, 13709788862, qhrm-0971@163.com

    Ming Ren, MM

    Recruiting

  • Xuzhou Central Hospital, Jiangsu

    Xuzhou, Jiangsu, 221009

    Hongyun Ruan, MD, 0516-83985031, hongyunruan@163.com

    Hongyun Ruan, MD

    Recruiting

  • Yichang Central People's Hospital

    Yichang, Hubei, 43000

    Yunbo Lv, MD, 0717-6229791, 362435582@qq.com

    Yunbo Lv, MD

    Recruiting

  • The First People's Hospital of Yinchuan

    Yinchuan, Ningxia, 750000

    Fang Chen, PhD, 13895008699, cf720302@126.com

    Fang Chen, PhD

    Recruiting

  • Yili Kazak Autonomous Prefecture Friendship Hospital

    Yining, Xinjiang, 835000

    Wei Li, MBBS, 18935778517, 18935778517@163.com

    Wei Li, MBBS

    Recruiting

  • Fuwai Central China Cardiovascular Hospital

    Zhengzhou, Henan, 450000

    Qiuping Zhao, PhD, 0371-58681170, qiupingzhao@zzu.edu.cn

    Qiuping Zhao, PhD

    Recruiting

  • Henan Provincial People's Hospital

    Zhengzhou, Henan, 450003

    Min Liu, MD, 0371-65586642, liumin136@126.com

    Min Liu, MD

    Recruiting

  • Zhengzhou Central Hospital Affiliated to Zhengzhou University

    Zhengzhou, Henan, 450007

    Shuhua Yu, MM, 0371-67690941, 13613716677@139.com

    Shuhua Yu, MM

    Recruiting

  • Zhengzhou Yihe Hospital

    Zhengzhou, Henan, 450018

    Liang An, MD, 0371-56570913, 184530063@qq.com

    Liang An, MD

    Recruiting

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450052

    Youyou Du, MD, 0371-67966613, duyouyou_008@163.com

    Youyou Du, MD

    Recruiting

  • Zhoukou Central Hospital

    Zhoukou, Henan, 466000

    Baogong Wang, MD, 0394-8521613, 598634874@qq.com

    Baogong Wang, MD

    Recruiting

  • Zhuzhou Hospital Affiliated to Xiangya School of Medicine,Central South University

    Zhuzhou, Hunan, 412000

    Liang Tang, MBBS, 0733-28561703

    Liang Tang, MBBS

    Recruiting

Other trials in China

About this study

Official title: China Adrenal Venous Sampling Investigation: A National Multicenter Study

Primary aldosteronism (PA) is a major cause of secondary hypertension, yet its optimal diagnosis and management remain challenging. This study comprehensively evaluates adrenal venous sampling (AVS), addressing key clinical, technical, and methodological issues, and aims to clarify the relationship between AVS-guided management and long-term clinical and biochemical outcomes to optimize patient care and prognosis.

Read the detailed description

Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, yet its optimal diagnostic and therapeutic strategies remain challenging. Adrenal venous sampling (AVS) is regarded as the gold standard for subtype differentiation; however, important clinical, technical, and methodological issues have not been systematically addressed. This study is designed to comprehensively evaluate AVS and its clinical implications, aiming to elucidate the relationship between AVS-guided diagnosis and management of PA and long-term clinical and biochemical outcomes, while refining AVS protocols, standardizing clinical practice, optimizing therapeutic decision-making, and ultimately improving patient management and prognosis.

Being tested
adrenal venous sampling
Keywords
Adrenal venous sampling, Hyperaldosteronism, Antecubital approach, Femoral approach, Main adverse cardiovascular events
Medical subject headings
Hyperaldosteronism

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • adrenal venous samplingProcedure or surgery

    Patients with Primary Aldosteronism (PA) undergoing Adrenal Venous Sampling via antecubital approach or femoral approach to discriminate PA forms with unilateral from bilateral excess aldosterone production.

Study groups in NCT07252284
Study groupRoleWhat they receive
Adrenal Venous SamplingPatients with Primary Aldosteronism (PA) undergoing Adrenal Venous Sampling via antecubital approach or femoral approach to discriminate PA forms with unilateral from bilateral excess aldosterone production.
Receives: Procedure: adrenal venous sampling

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Major adverse cardiovascular events (MACE) at 1-year follow-up

    Incidence of major adverse cardiovascular events (MACE) at 1-year follow-up, including stroke, heart failure, severe arrhythmias, renal failure, myocardial infarction, and death.

    Measured: 1 year after AVS procedure

Secondary outcomes (20)

  1. The success rate of left adrenal venous sampling

    Successful sampling will be defined by high selectivity index (cortisol in the adrenal vein/cortisol in inferior vena cava >2 without ACTH simulation)

    Measured: At AVS procedure

  2. The success rate of right adrenal venous sampling

    Successful sampling will be defined by high selectivity index (cortisol in the adrenal vein/cortisol in inferior vena cava >2 without ACTH simulation)

    Measured: At AVS procedure

  3. The success rate of bilateral adrenal venous sampling

    Successful sampling will be defined by high selectivity index (cortisol in the adrenal vein/cortisol in inferior vena cava >2 without ACTH simulation)

    Measured: At AVS procedure

  4. Selection of intraoperative catheter

    Types of catheter at the time of Adrenal Venous Sampling via antecubital approach or femoral approach

    Measured: At AVS procedure

  5. Time of the procedure

    Time of the procedure

    Measured: At AVS procedure

  6. Time of fluoroscopy

    Time of fluoroscopy

    Measured: At AVS procedure

  7. The contrast agent dosage

    The contrast agent dosage

    Measured: At AVS procedure

  8. the incidence of complications

    Complications related to adrenal vein cannulations (adrenal vein hematoma, inferior vena cava dissection, puncture site hematoma, etc)

    Measured: 1 week after AVS procedure

  9. the cost of the procedure

    the cost of the procedure

    Measured: At AVS procedure

  10. Change in 24-hour ambulatory systolic blood pressure

    The difference in average systolic blood pressure measured by 24-hour ambulatory blood pressure monitoring (ABPM) between baseline and each follow-up time point.

    Measured: At 1, 3, 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after treatment

  11. Change in 24-hour ambulatory diastolic blood pressure

    The difference in average diastolic blood pressure measured by 24-hour ambulatory blood pressure monitoring (ABPM) bewteen baseline and each follow-up time point.

    Measured: At 1, 3, 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after treatment

  12. Change in office systolic blood pressure

    The difference in systolic blood pressure measured during clinic visits (office blood pressure) between baseline and each follow-up time point

    Measured: At 1, 3, 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after treatment

  13. Change in office diastolic blood pressure

    The difference in diastolic blood pressure measured during clinic visits (office blood pressure) between baseline and each follow-up time point

    Measured: At 1, 3, 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after treatment

  14. Change in antihypertensive medication burden

    The change in the number and/or dosage of antihypertensive medications taken by patients between baseline and each follow-up time point

    Measured: At 1, 3, 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after treatment

  15. Change in urinary albumin-to-creatinine ratio (UACR)

    The difference in urinary albumin-to-creatinine ratio measured at baseline and at each follow-up time point

    Measured: At 1, 3, 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after treatment

  16. Change in left ventricular mass index (LVMI)

    The change in left ventricular mass index, as assessed by echocardiography, from baseline to each follow-up time point.

    Measured: At 1, 3, 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after treatment

  17. Change in pulse wave velocity (PWV) from baseline

    The change in pulse wave velocity measured between baseline and each follow-up time point。

    Measured: At 1, 3, 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after treatment

  18. Clinical Outcome According to Primary Aldosteronism Surgical Outcome (PASO) Criteria

    Clinical outcomes will be assessed at each follow-up visit afteradrenal surgery according to the PASO consensus criteria. Outcomes will be categorized as:

    (1)Complete clinical success: normal blood pressure without the need for any antihypertensive medication. (2)Partial clinical success: improvement in blood pressure and/or a reduction in the number or dosage of antihypertensive medications. (3)Absent clinical success: no improvement in blood pressure or antihypertensive medication burden.

    Measured: At 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after surgery

  19. Biochemical Outcome According to Primary Aldosteronism Surgical Outcome (PASO) Criteria

    Biochemical outcomes will be assessed at each follow-up visit after adrenal surgery according to the PASO consensus classification. Outcomes will be categorized as:(1)Complete biochemical success: normal serum potassium levels and a normalized aldosterone-to-renin ratio (ARR) without the need for potassium supplementation.(2)Partial biochemical success: improvement in biochemical parameters without full normalization.(3)Absent biochemical success: no improvement in biochemical markers compared to baseline.

    Measured: At 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after surgery

  20. Major adverse cardiovascular events (MACE)

    Incidence of major adverse cardiovascular events (MACE), including stroke, heart failure, severe arrhythmias, renal failure, myocardial infarction, and death.

    Measured: At 6 and 18 months; and 2, 3, 4, 5, and 10 years after AVS procedure

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted26 Nov 2025
  2. Study start1 May 2025
  3. Primary completion31 Aug 2029 (estimated)
  4. Study completion31 Aug 2029 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Other
Enrolment
5,000 participants (estimated)
Target duration
5 Years
IDs, dates and publications
ClinicalTrials.gov ID
NCT07252284
Sponsor's protocol ID
2024-2484
Acronym
CHAMPION
Status last verified
Nov 2025
First submitted
19 Nov 2025
Last updated
26 Nov 2025
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

An observational study of Hyperaldosteronism and Adrenal Venous Sampling, run by Chinese Academy of Medical Sciences, Fuwai Hospital at 76 sites in China.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 26 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 76 sites in China. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Hui Dong, MD (86-010-88322385, donghui666@sina.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Major adverse cardiovascular events (MACE) at 1-year follow-up (time frame: 1 year after AVS procedure). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07252284.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Nov 2025.

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