Music TherapyNCT07255339
The Effect of Music Therapy on Pain and Anxiety in Patients After Coronary Artery Bypass Grafting
A study testing Music therapy group in people with Music Therapy and Pain, run by University of Gaziantep at 1 site in Turkey (Türkiye).
Trial summary
Coronary artery disease is a frequently occurring, life-threatening disease that has caused high morbidity and mortality, and has resulted in a high rate of death, both in our country and worldwide over the past five years. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Music Therapy, Pain, Anxiety
- What is being tested?
- Music therapy group
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 29 Jul 2022to 16 Jun 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients over 18 years of age with no hearing impairment
- Planned for coronary artery bypass graft surgery
- Not diagnosed with a psychiatric disorder and therefore not taking medication
- Volunteer to participate in the study
Who cannot join
- Patients who refuse to participate in the study
- Patients who volunteer to participate and then withdraw from the study at any stage.
Trial locations and contacts
1 site in 1 country.
About this study
Coronary artery disease is a frequently occurring, life-threatening disease that has caused high morbidity and mortality, and has resulted in a high rate of death, both in our country and worldwide over the past five years. The most commonly used method for the treatment of coronary artery disease is coronary artery bypass grafting (CABG). This surgery aims to restore blood flow to the myocardium, which has become inadequate due to blockage or stenosis in the coronary arteries that feed the heart, by using an artery graft and to prolong life to a better standard. Surgical procedures such as coronary artery bypass grafting are psychologically, economically, socially, and physically detrimental to patients. Coronary artery bypass grafting, a major surgical procedure, can lead to serious postoperative complications. Some of these include postoperative pain and anxiety. Pain is one of the first complications observed, especially in the early postoperative period. The heart is one of the most important vital organs, and interventions in this regard trigger a fear of death in individuals and, consequently, cause them to experience significant anxiety after the operation. In addition to pharmacological methods, non-pharmacological methods are also used in pain and anxiety management. Music therapy is one of these methods used in the treatment of pain and anxiety. Music has always been a cultural and universal heritage of societies, present from past to present. Music therapy is a specialized field that incorporates the patient's body, mind, and spirit integrity, facilitates treatment using evidence-based practices, and utilizes all aspects of music within a therapeutic relationship to alleviate patient distress. Music therapy has consistently been a part of treatment methods from past to present and has been shown to have positive effects. Depression can affect stress hormones, leading to an increase in heart rate and an imbalance in oxygen demand. Disruption of sleep patterns before surgery can lead to anxiety and pain. Previous studies have shown that music therapy balances the body, mind, and spirit integrity of individuals within the endocrine and nervous systems.
Read the detailed description
Coronary artery disease (CAD) has remained one of the leading causes of high morbidity and mortality both in our country and worldwide over the past five years. According to global epidemiological data, cardiovascular diseases account for nearly one-third of all deaths, making them a major public health concern. CAD is characterized by atherosclerotic plaque formation and the narrowing of coronary vessels, which results in reduced myocardial oxygenation. As the disease progresses, coronary artery bypass grafting (CABG) becomes one of the most commonly used and effective treatment methods. The primary goal of CABG is to restore myocardial blood flow distal to the stenotic or occluded coronary artery by using arterial or venous grafts, thereby improving cardiac perfusion and enhancing both quality of life and overall survival.
CABG is a major surgical intervention that imposes significant psychological, physiological, social, and economic burdens on patients. In the postoperative period, patients frequently experience severe pain, anxiety, sleep disturbances, stress, depressive symptoms, hemodynamic instability, and reduced quality of life. The intensity of postoperative pain is affected by the invasiveness of the procedure, such as sternotomy, placement of chest tubes, surgical drains, and limited mobility. Moreover, undergoing a surgical procedure involving the heart-a vital organ-often triggers fear of death, a sense of loss of control, uncertainty about recovery, and concerns about postoperative complications, all of which contribute to heightened anxiety levels.
While pharmacological treatments are essential in managing postoperative pain and anxiety, they are often insufficient on their own. For this reason, non-pharmacological interventions are increasingly recommended as complementary approaches during the recovery process. Among these interventions-such as breathing exercises, relaxation techniques, massage therapy, and aromatherapy-music therapy has gained particular attention due to its demonstrated benefits.
Music therapy is a specialized, evidence-based discipline that utilizes the therapeutic elements of music within a structured patient-therapist relationship to support the individual's physical, psychological, and spiritual well-being. By employing components such as rhythm, melody, and harmony, music therapy aims to regulate emotional responses and promote healing. Studies have shown that music has significant effects on the autonomic nervous system; it activates the parasympathetic system, helping to stabilize heart rate, reduce blood pressure, regulate breathing, and decrease levels of stress-related hormones, including cortisol. Consequently, music therapy alleviates both the perception of pain and anxiety.
Furthermore, disruptions in sleep patterns prior to surgery can exacerbate anxiety and pain, while chronic stress and elevated stress hormones may negatively affect heart rate, oxygen demand, and overall cardiopulmonary stability. Previous research has demonstrated that music therapy can help regulate the mind-body-spirit connection within the endocrine and nervous systems, thereby promoting physiological balance and emotional comfort in individuals undergoing major surgical procedures such as CABG.
- Conditions
- Music Therapy, Pain, Anxiety, Randomised Controlled Trial, Coronary Artery Bypass Grafting
- Being tested
- Music therapy group
- Keywords
- Coronary artery bypass grafting, Music therapy, Pain, Anxiety, Randomized controlled trial
- Medical subject headings
- Pain, Anxiety Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Music therapy groupOther
In the study, patients undergoing coronary artery bypass graft surgery will be exposed to music before and during surgery. The Beck Anxiety Inventory and Visual Analog Scale will be administered postoperatively.
| Study group | Role | What they receive |
|---|---|---|
| Music therapy group | Active comparator | Music therapy group Receives: Other: Music therapy group |
| Control group | No intervention | Control group |
What is being measured
The primary outcome is the main question the study is designed to answer.
The effect of music played on anxiety in patients undergoing coronary artery bypass graft surgery
"Not at all" indicates no anxiety at all, while "I had a very hard time tolerating it at a serious level" indicates the highest possible anxiety.
Measured: From enrollment to the end of treatment at one years
The effect of music played on pain in patients undergoing coronary artery bypass graft surgery
Zero is equivalent to no pain, and 10 indicates the worst possible pain
Measured: From enrollment to the end of treatment at one years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Dec 2025
- Study start29 Jul 2022
- Primary completion8 Nov 2022
- Study completion16 Jun 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Music TherapyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Gaziantep
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tuğba Albayram, University of Gaziantep
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07255339
- Sponsor's protocol ID
- 2022/17-03
- Status last verified
- Nov 2025
- First submitted
- 15 Nov 2025
- Last updated
- 5 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: I do not plan to share your IPD with other researchers.
Study at a glance
From the registry record, last updated by the sponsor on 5 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Music Therapy on Pain and Anxiety in Patients After Coronary Artery Bypass Grafting
- ClinicalTrials.gov ID
- NCT07255339
- Acronym / sponsor ID
- 2022/17-03
- Conditions
- Music Therapy, Pain, Anxiety, Randomised Controlled Trial, Coronary Artery Bypass Grafting
- Keywords
- Coronary artery bypass grafting, Music therapy, Pain, Anxiety, Randomized controlled trial
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- University of GaziantepUniversity, hospital or other
- Study start
- 29 Jul 2022 (actual)
- Primary completion
- 8 Nov 2022 (actual)
- Study completion
- 16 Jun 2023 (actual)
- First posted
- 1 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Coronary artery disease is a frequently occurring, life-threatening disease that has caused high morbidity and mortality, and has resulted in a high rate of death, both in our country and worldwide over the past five years. The most commonly used method for the treatment of coronary artery disease is coronary artery bypass grafting (CABG). This surgery aims to restore blood flow to the myocardium, which has become inadequate due to blockage or stenosis in the coronary arteries that feed the heart, by using an artery graft and to prolong life to a better standard. Surgical procedures such as coronary artery bypass grafting are psychologically, economically, socially, and physically detrimental to patients. Coronary artery bypass grafting, a major surgical procedure, can lead to serious postoperative complications. Some of these include postoperative pain and anxiety. Pain is one of the first complications observed, especially in the early postoperative period. The heart is one of the most important vital organs, and interventions in this regard trigger a fear of death in individuals and, consequently, cause them to experience significant anxiety after the operation. In addition to pharmacological methods, non-pharmacological methods are also used in pain and anxiety management. Music therapy is one of these methods used in the treatment of pain and anxiety. Music has always been a cultural and universal heritage of societies, present from past to present. Music therapy is a specialized field that incorporates the patient's body, mind, and spirit integrity, facilitates treatment using evidence-based practices, and utilizes all aspects of music within a therapeutic relationship to alleviate patient distress. Music therapy has consistently been a part of treatment methods from past to present and has been shown to have positive effects. Depression can affect stress hormones, leading to an increase in heart rate and an imbalance in oxygen demand. Disruption of sleep patterns before surgery can lead to anxiety and pain. Previous studies have shown that music therapy balances the body, mind, and spirit integrity of individuals within the endocrine and nervous systems.
Detailed description
Coronary artery disease (CAD) has remained one of the leading causes of high morbidity and mortality both in our country and worldwide over the past five years. According to global epidemiological data, cardiovascular diseases account for nearly one-third of all deaths, making them a major public health concern. CAD is characterized by atherosclerotic plaque formation and the narrowing of coronary vessels, which results in reduced myocardial oxygenation. As the disease progresses, coronary artery bypass grafting (CABG) becomes one of the most commonly used and effective treatment methods. The primary goal of CABG is to restore myocardial blood flow distal to the stenotic or occluded coronary artery by using arterial or venous grafts, thereby improving cardiac perfusion and enhancing both quality of life and overall survival.
CABG is a major surgical intervention that imposes significant psychological, physiological, social, and economic burdens on patients. In the postoperative period, patients frequently experience severe pain, anxiety, sleep disturbances, stress, depressive symptoms, hemodynamic instability, and reduced quality of life. The intensity of postoperative pain is affected by the invasiveness of the procedure, such as sternotomy, placement of chest tubes, surgical drains, and limited mobility. Moreover, undergoing a surgical procedure involving the heart-a vital organ-often triggers fear of death, a sense of loss of control, uncertainty about recovery, and concerns about postoperative complications, all of which contribute to heightened anxiety levels.
While pharmacological treatments are essential in managing postoperative pain and anxiety, they are often insufficient on their own. For this reason, non-pharmacological interventions are increasingly recommended as complementary approaches during the recovery process. Among these interventions-such as breathing exercises, relaxation techniques, massage therapy, and aromatherapy-music therapy has gained particular attention due to its demonstrated benefits.
Music therapy is a specialized, evidence-based discipline that utilizes the therapeutic elements of music within a structured patient-therapist relationship to support the individual's physical, psychological, and spiritual well-being. By employing components such as rhythm, melody, and harmony, music therapy aims to regulate emotional responses and promote healing. Studies have shown that music has significant effects on the autonomic nervous system; it activates the parasympathetic system, helping to stabilize heart rate, reduce blood pressure, regulate breathing, and decrease levels of stress-related hormones, including cortisol. Consequently, music therapy alleviates both the perception of pain and anxiety.
Furthermore, disruptions in sleep patterns prior to surgery can exacerbate anxiety and pain, while chronic stress and elevated stress hormones may negatively affect heart rate, oxygen demand, and overall cardiopulmonary stability. Previous research has demonstrated that music therapy can help regulate the mind-body-spirit connection within the endocrine and nervous systems, thereby promoting physiological balance and emotional comfort in individuals undergoing major surgical procedures such as CABG.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Music therapy group | Active comparator | Other: Music therapy groupMusic therapy group |
| Control group | No intervention | –Control group |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients over 18 years of age with no hearing impairment
- Planned for coronary artery bypass graft surgery
- Not diagnosed with a psychiatric disorder and therefore not taking medication
- Volunteer to participate in the study
Key exclusion criteria (2 listed)
- Patients who refuse to participate in the study
- Patients who volunteer to participate and then withdraw from the study at any stage.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Music therapy groupIn the study, patients undergoing coronary artery bypass graft surgery will be exposed to music before and during surgery. The Beck Anxiety Inventory and Visual Analog Scale will be administered postoperatively. | Other | Music therapy group |
Primary outcome
The effect of music played on anxiety in patients undergoing coronary artery bypass graft surgery
Time frame: From enrollment to the end of treatment at one years
"Not at all" indicates no anxiety at all, while "I had a very hard time tolerating it at a serious level" indicates the highest possible anxiety.
The effect of music played on pain in patients undergoing coronary artery bypass graft surgery
Time frame: From enrollment to the end of treatment at one years
Zero is equivalent to no pain, and 10 indicates the worst possible pain
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Dec 2025.
- Individual participant dataSharing planned: No. I do not plan to share your IPD with other researchers.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Music therapy group in people with Music Therapy and Pain, run by University of Gaziantep at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The effect of music played on anxiety in patients undergoing coronary artery bypass graft surgery (time frame: From enrollment to the end of treatment at one years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Dec 2025.