Clinical trials: Randomised Controlled Trial
Pulmnary Hypertension
Investigating a Well-being Review in Pulmonary Hypertension
Pulmonary Hypertension (PH) is a rare disease that makes patients easily become breathless. There is evidence that people with PH can benefit from exercise; we want to look at how they can access rehabilitation in their local…
- Trial name
- NCT04840251
- Testing
- Well-being review and rehabiliation, Qualitative Interviews
- Where
- United Kingdom
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Influenza A
Flufenamic Acid for Hospitalised Influenza Infection
It is well recognized that respiratory viruses cause substantial disease burden every year. Among all known respiratory viruses, influenza virus is the greatest cause of disability-adjusted life years lost, excess…
- Trial name
- NCT03238612
- Testing
- FFA, clarithromycin, oseltamivir, Oseltamivir alone
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Neurocognitive
Neurocognition in NSCLC Patients Treated With Osimertinib or Osimertinib + WBI
This is a prospective, randomised, positive-controlled, study to assess the neurocognitive function of upfront Osimertinib compared to whole-brain irradiation (WBI) plus Osimertinib in EGFR-mutant (Ex 19Del and L858R) NSCLC…
- Trial name
- NCT04829019
- Testing
- Osimertinib and whole-brain irradiation, Osimertinib
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Sun Yat-sen University
Venous Ulcer
Community RCT of the Effectiveness of Two Compression Bandaging Technologies
Leg ulcers are emotionally distressing and painful, and often require months or years to heal. Although rarely acknowledged as a pressing health care issue, leg ulcers comprise a common, complex, and costly condition, managed…
- Trial name
- NCT00202267
- Testing
- Four-layer Bandage (Elastomeric), Short-stretch Bandage (Non-elastomeric)
- Where
- 15 sites in Canada
- Volunteers
- 426 people
- Sponsor
- Queen's University
Osteoarthritis of the Knee
Cabbage Leaf Wraps in Osteoarthritis of the Knee
This randomised controlled trial aims to investigate the efficacy of cabbage leaf cataplasms in the treatment of primary symptomatic osteoarthritis of the knee.
- Trial name
- KoGon (NCT02027792)
- Testing
- Cabbage leave wraps, Diclofenac Gel
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Universität Duisburg-Essen
Telemedicine, Emergency Medical Service
Audiovisual Consultations in Prehospital Emergency Care: Randomised Controlled Trial
This study investigates safety and efficacy of the use of audiovisual consultations of emergency medical service (EMS) doctor by paramedics for low urgency events in areas covered with paramedic crews only from emergency medical…
- Trial name
- Telemedicine (NCT04312321)
- Testing
- Mandatory phone call consultation, Mandatory audiovisual consultation
- Where
- Czechia
- Volunteers
- 600 people
- Sponsor
- Zdravotnicka Zachranna Sluzba Karlovarskeho Kraje, P.O.
Acquired Bleeding Disorder, Trauma
Evaluation of Recombinant Factor VIIa in Patients With Severe Bleeding
This trial is conducted globally. The purpose of the trial is to evaluate that activated recombinant human factor VII (eptacog alfa (activated)) is safe and effective in severely injured trauma patients by assessing mortality and…
- Trial name
- CONTROL (NCT00184548)
- Testing
- eptacog alfa (activated)
- Where
- 14 sites in United States, Brazil and 12 more
- Volunteers
- 554 people
- Sponsor
- Novo Nordisk A/S
Fibromyalgia
Effectiveness of Video-based Multicomponent Treatment for Fibromyalgia Plus Face-to-face Sesions in Nature or at Sea
The aim of this study was to examine the effectiveness of a video-based multicomponent program: the Fibrowalk Virtual plus face-to-face sessions for patients with fibromyalgia (FM) in nature or at sea (FM) compared to Fibrowalk…
- Trial name
- NCT05395832
- Testing
- TAU + multicomponent treatment VIRTUAL FIBROWALK + 4 face-to-face sessions at sea, TAU + multicomponent treatment VIRTUAL FIBROWALK + 4 face-to-face sessions in nature, TAU + multicomponent treatment VIRTUAL FIBROWALK
- Where
- Spain
- Volunteers
- 109 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Depression
Promoting Wellbeing for Women With Depression: A Pragmatic Randomised Controlled Trial (RCT) of an Exercise Programme
The investigators want to find out if their specially designed exercise programme will be more successful at helping women with depression to feel better than a basic programme will, by measuring the effect the programme has on…
- Trial name
- NCT00546221
- Testing
- Psychosocial support exercise programme, Prescribed exercise
- Where
- 3 sites in United Kingdom
- Volunteers
- 43 people
- Sponsor
- University of Nottingham
Pain
The Effect of White Noise and Swaddling on Pain, Heart Rate, and Oxygen Saturation in Term İnfants Undergoing Eye Examinations
Eye examinations for vision screening in infants cause pain and stress. Aim: To evaluate the effect of white noise and swaddling on pain, heart rate, and oxygen saturation in term infants undergoing post-discharge eye…
- Trial name
- NCT06535984
- Testing
- White Noise, Swaddling, White Noise+Swaddling
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Postoperative Pain, Pulmonary Function Tests
The Effect of Superficial Parasternal Intercostal Plane Block on Pulmonary Function Tests After Cardiac Surgery
In adult patients undergoing cardiac surgery, does adding an sPIP block to standard care compared to standard care alone result in a smaller decrease in PFTs?
- Trial name
- PIPACS (NCT05999721)
- Testing
- superficial parasternal intercostal plane block, Standard care
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Shai Fein
Estrogen Profile
The Effects of EstroSense®/MD vs Placebo in Improving the Estrogen Profile in Females
According to the Canadian Cancer Society, 1 in 9 Canadian women will develop breast cancer in her lifetime and 1 in 30 will die. The single greatest risk factor of breast cancer is poor estrogen metabolism.
- Trial name
- NCT02385916
- Testing
- EstroSense®/MD
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Steroid-refractory Acute Graft-versus-host Disease
Trial of Efficacy and Safety of MC0518 Versus Best Available Therapy in Participants With Steroid-Refractory Acute Graft Versus Host Disease
The purpose of this trial is the comparative evaluation of overall response rate (ORR) in paediatric participants with steroid-refractory acute graft-versus-host disease (SR-aGvHD) at Visit Day 28 after treatment with MC0518 or…
- Trial name
- BALDER (NCT06075706)
- Testing
- MC0518, BAT
- Where
- 36 sites in France, Germany and 3 more
- Volunteers
- 49 people
- Sponsor
- medac GmbH
Total Hip Replacement
Unrestricted Rehabilitation Pathway Following Total Hip Replacement
The purpose of ReHip2 is to explore the impact on function and quality of life in patients following Total Hip Replacement (THR).
- Trial name
- ReHip2 (NCT03833258)
- Testing
- Rehabilitation with no precautions
- Where
- 2 sites in United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Manchester
Transcranial Direct Current Stimulation (tDCS), Ageing
Investigating the Effectiveness of a 2-week Novel Non-invasive Brain Stimulation Technique on Cognitive Outcomes in Healthy Adults
The goal of this randomised controlled trial is to investigate the effects of a 2-week high-frequency transcranial pulsed current stimulation (tPCS) on cognitive outcomes in older and healthy adults.
- Conditions
- Transcranial Direct Current Stimulation (tDCS), Ageing, Executive Functioning, Transcranial Electric Stimulation
- Trial name
- NCT06991764
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Cannabis Use Disorder
Cannabidiol: a Novel Intervention for Cannabis Use Problems?
The purpose of this trial is to investigate a novel treatment for cannabis dependence: cannabidiol. Between 96 and 168 young people who want to quit cannabis and meet criteria for moderate cannabis use disorder (DSM-5) will be…
- Trial name
- NCT02044809
- Testing
- Cannabidiol
- Where
- United Kingdom
- Volunteers
- 82 people
- Sponsor
- University College, London
Gingival Hyperplasia, Dental Plaque
Clinical Efficacy of Chlorhexidine Varnish in Reducing Gingival Hyperplasia, Plaque Accumulation, and White Spot Lesions in Orthodontic Patients
This study investigates whether applying a chlorohexidine varnish (a dental coating) reduces gum overgrowth, plaque buildup, and early tooth decay (white spots) in patients with braces.
- Conditions
- Gingival Hyperplasia, Dental Plaque, Tooth Demineralization
- Trial name
- NCT07115784
- Testing
- Chlorhexidine Varnish
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Major Depression Disorder
Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets Versus Venlafaxine Hydrochloride Sustained-release Tablets in Patients With Major Depression Disorder
The purpose of this study is to evaluate efficacy and safety of toludesvenlafaxine hydrochloride sustained-release tablets in the treatment of major depression disorder compared to venlafaxine hydrochloride sustained-release…
- Trial name
- NCT06278038
- Testing
- Toludesvenlafaxine hydrochloride sustained-release tablets, Venlafaxine hydrochloride sustained-release tablets
- Where
- China
- Volunteers
- 84 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Rare Disorders, Rare Diseases
AI-assisted Rare Disease Diagnosis
A multicentre randomised controlled trial evaluating whether a rare-disease diagnostic large language model can improve diagnostic quality, efficiency, and health-economic outcomes for physicians managing patients with suspected…
- Trial name
- NCT07650799
- Testing
- AI system
- Where
- 12 sites in China
- Volunteers
- 1,056 people
- Sponsor
- Peking Union Medical College Hospital
Pleural Effusion, Malignant
Out Patient Talc Slurry Via Indwelling Pleural Catheter for Malignant Pleural Effusion Vs Usual Inpatient Management
This is a multicentre randomised controlled trial evaluating global health related quality of life outcomes in patients with malignant pleural effusions.
- Trial name
- OPTIMUM (NCT02517749)
- Testing
- Chest Drain Insertion and Talc Pleurodesis, Indwelling Pleural Catheter Insertion and Talc Pleurodesis
- Where
- United Kingdom
- Volunteers
- 142 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
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