Alveolar Bone GraftingATBGNCT07267637
Autogenous Tooth Bone Graft for Alveolar Socket Preservation
A study testing "Autogenous Tooth Bone Graft" in people with Alveolar Bone Grafting and Bone Regeneration Following Wisdom Teeth Extraction, run by Haifaa Mohammed Al-hussini at 1 site in Yemen.
Trial summary
The purpose of this clinical experiment is to assess how well autogenous tooth bone grafting preserves the alveolar socket after surgical tooth extraction. Before being inserted into the socket, the graft is made from the patient's own extracted tooth and ground into a particle. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Alveolar Bone Grafting, Bone Regeneration Following Wisdom Teeth Extraction, Tooth Extraction Site Healing
- What is being tested?
- "Autogenous Tooth Bone Graft"
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteYemen
- Study dates
- 14 Jul 2024to 31 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- - Absence of systemic diseases.
- Very good to accepted oral hygiene.
- Patients with impacted teeth requiring extraction.
- Patients between the ages of 16 and 50.
- No history of smoking.
- No history of any other drug use.
- Patients who were cooperative, motivated, to attend the follow-up and maintenance visits.
Who cannot join
- Systemic conditions or pharmacological therapies that could be an absolute contraindication for the intervention (such as un controlled diabetics, immunocompromised states, or treatment with oral or parenteral bisphosphonates).
- Poor oral hygiene.
- Acute exacerbation of chronic infection like pain or swelling.
- Pregnant women, children, elderly (>60 years), physically and mentally challenged, terminally and seriously ill.
- Hight Smoking tendency.
- Patients who refused to participate in the trial.
- Uncooperative Patients who won't be able to maintain the follow up visits
Trial locations and contacts
1 site in 1 country.
About this study
Official title: "Autogenous Tooth Bone Graft for Alveolar Socket Preservation: A CBCT-Based Clinical Trial With 6-Month Follow-Up"
The purpose of this clinical experiment is to assess how well autogenous tooth bone grafting preserves the alveolar socket after surgical tooth extraction. Before being inserted into the socket, the graft is made from the patient's own extracted tooth and ground into a particle. Twenty Yemeni patients who needed their teeth extracted are included in the trial, and they will be followed up with clinical and radiographic procedures using cone-beam computed tomography (CBCT) for six months. The primary objective is to ascertain whether the autogenous dental bone graft can preserve the height, width, and density of alveolar bone, offering a secure, affordable, and biocompatible substitute for traditional grafting materials.
Read the detailed description
This interventional clinical study investigates the role of autogenous tooth bone graft in alveolar socket preservation after surgical tooth extraction. The extracted tooth is cleaned, dried, processed into particulate graft material manually using bone crusher, and disinfect and treated using (NaOH) and (Na CL). The graft particles are immediately placed into the fresh extraction socket and sutured. Twenty Yemeni patients requiring impacted lower third molar and upper canine teeth surgical extractions will be included. The healing process will be evaluated both clinically and radiographically over a 6-month period. Cone-beam computed tomography (CBCT) scans will be used to assess bone density and alveolar ridge dimensions before extraction and at six months' post-intervention. The study aims to determine whether autogenous tooth bone grafts can effectively reduce post-extraction alveolar bone resorption and maintain ridge dimensions, supporting their potential use as an autologous, biocompatible, and economically feasible graft material for clinical socket preservation.
- Conditions
- Alveolar Bone Grafting, Bone Regeneration Following Wisdom Teeth Extraction, Tooth Extraction Site Healing
- Being tested
- "Autogenous Tooth Bone Graft"
- Keywords
- Autogenous Tooth Bone Graft, Socket Preservation, CBCT Imaging, Bone Density Measurement, Bone Regeneration in Dentistry
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
"Autogenous Tooth Bone Graft"Biological
"The intervention involves the use of the patient's own extracted tooth to create a bone graft for alveolar socket preservation following surgical tooth extraction. The patient's tooth is carefully processed to remove caries, periodontal ligaments, pulp, and any restorative materials, leaving behind a complete tooth structure (enamel, dentin, and cementum). This tooth is then crushed, disinfected, and treated before being placed into the empty socket. This graft helps maintain the structure of the alveolar bone by promoting natural bone regeneration and preventing resorption. The bone graft will be monitored for its efficacy in preserving alveolar bone height, width, and density, assessed using Cone Beam Computed Tomography (CBCT)."
| Study group | Role | What they receive |
|---|---|---|
| Autogenous Tooth Bone Graft Intervention Group | Experimental | "In this arm of the study, participants will receive an autogenous tooth bone graft for alveolar socket preservation following surgical tooth extraction. The intervention involves the extraction of the patient's own tooth, which will be processed and used as a bone graft. This graft will be placed into the empty socket immediately after the extraction. The purpose of this intervention is to prevent bone resorption, promote natural healing, and support bone regeneration within the extraction site. CBCT scans will be performed before extraction to measure baseline bone dimensions and will be repeated 6 months post-intervention to assess the success of bone preservation in terms of height, width, and density." Receives: Biological: "Autogenous Tooth Bone Graft" |
What is being measured
The primary outcome is the main question the study is designed to answer.
"Alveolar Bone Height, Width, and Density Preservation with Autogenous Tooth Bone Graft"
This study aims to evaluate the effectiveness of autogenous tooth bone grafts in preserving alveolar bone following tooth extraction. The study will assess changes in alveolar bone height, width, and density using Cone Beam Computed Tomography (CBCT) at two time points: before extraction (baseline) and 6 months post-grafting.
The outcome measures are:
Alveolar Bone Height: Measured in millimeters using CBCT at baseline and 6 months.
Alveolar Bone Width: Measured in millimeters using CBCT at baseline and 6 months.
Alveolar Bone Density: Measured in Hounsfield units using CBCT at both time points.
The intervention involves using the patient's own extracted tooth to create a bone graft placed into the socket, promoting healing and bone regeneration. This study will determine the effectiveness of autogenous tooth bone grafts in preventing bone resorption and preserving alveolar socket structure.
Measured: "Before extraction and 6 months post-intervention"
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Dec 2025
- Study start14 Jul 2024
- Primary completion1 Nov 2025
- Study completion31 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Alveolar Bone GraftingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- This is a single-arm, open-label clinical trial designed to evaluate the efficacy of autogenous tooth bone grafts for alveolar socket preservation following sugrical tooth extraction. The intervention involves the use of the patient's own extracted tooth to prepare the bone graft, which will be placed into the extraction socket. The primary objective is to assess changes in alveolar bone height, width, and density before extraction and after six months of intervention using Cone Beam Computed Tomography (CBCT). All participants will undergo the same procedure, and no control group will be included. The study aims to explore the feasibility and outcomes of using autogenous grafts in dental socket preservation procedures
- Masking
- None (open label)
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Haifaa Mohammed Al-hussini
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Haifaa Mohammed Al-hussini, Sana'a University
- Investigators
- Haifaa Alhussini, BDS, MSc, Principal investigator, Sana'a University Faculty of Dentistry
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07267637
- Sponsor's protocol ID
- SU-DENT-ATBG-2025-HH
- Acronym
- ATBG
- Status last verified
- Dec 2025
- First submitted
- 23 Nov 2025
- Last updated
- 5 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: "We will share anonymized individual participant data (IPD), including baseline characteristics, clinical assessments, and key outcome measures (alveolar bone height, width, and density) collected before and after the autogenous tooth bone graft intervention. Access to the data will be granted to qualified researchers who meet the criteria for data sharing and comply with the applicable data use agreement."
Publications
Valdec S, Pasic P, Soltermann A, Thoma D, Stadlinger B, Rucker M. Alveolar ridge preservation with autologous particulated dentin-a case series. Int J Implant Dent. 2017 Dec;3(1):12. doi: 10.1186/s40729-017-0071-9. Epub 2017 Mar 30.
PubMed 28361377Mahardawi B, Damrongsirirat N, Dhanesuan K, Subbalekha K, Mattheos N, Pimkhaokham A. Radiographic changes after alveolar ridge preservation using autogenous raw tooth particles versus xenograft: A prospective controlled clinical trial. Clin Oral Implants Res. 2024 Dec;35(12):1597-1606. doi: 10.1111/clr.14348. Epub 2024 Aug 12.
PubMed 39132806
Study at a glance
From the registry record, last updated by the sponsor on 5 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- "Autogenous Tooth Bone Graft for Alveolar Socket Preservation: A CBCT-Based Clinical Trial With 6-Month Follow-Up"
- ClinicalTrials.gov ID
- NCT07267637
- Acronym / sponsor ID
- ATBG / SU-DENT-ATBG-2025-HH
- Conditions
- Alveolar Bone Grafting, Bone Regeneration Following Wisdom Teeth Extraction, Tooth Extraction Site Healing
- Keywords
- Autogenous Tooth Bone Graft, Socket Preservation, CBCT Imaging, Bone Density Measurement, Bone Regeneration in Dentistry
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Haifaa Mohammed Al-hussiniUniversity, hospital or other
- Study start
- 14 Jul 2024 (actual)
- Primary completion
- 1 Nov 2025 (actual)
- Study completion
- 31 Aug 2026 (estimated)
- First posted
- 5 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this clinical experiment is to assess how well autogenous tooth bone grafting preserves the alveolar socket after surgical tooth extraction. Before being inserted into the socket, the graft is made from the patient's own extracted tooth and ground into a particle. Twenty Yemeni patients who needed their teeth extracted are included in the trial, and they will be followed up with clinical and radiographic procedures using cone-beam computed tomography (CBCT) for six months. The primary objective is to ascertain whether the autogenous dental bone graft can preserve the height, width, and density of alveolar bone, offering a secure, affordable, and biocompatible substitute for traditional grafting materials.
Detailed description
This interventional clinical study investigates the role of autogenous tooth bone graft in alveolar socket preservation after surgical tooth extraction. The extracted tooth is cleaned, dried, processed into particulate graft material manually using bone crusher, and disinfect and treated using (NaOH) and (Na CL). The graft particles are immediately placed into the fresh extraction socket and sutured. Twenty Yemeni patients requiring impacted lower third molar and upper canine teeth surgical extractions will be included. The healing process will be evaluated both clinically and radiographically over a 6-month period. Cone-beam computed tomography (CBCT) scans will be used to assess bone density and alveolar ridge dimensions before extraction and at six months' post-intervention. The study aims to determine whether autogenous tooth bone grafts can effectively reduce post-extraction alveolar bone resorption and maintain ridge dimensions, supporting their potential use as an autologous, biocompatible, and economically feasible graft material for clinical socket preservation.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- This is a single-arm, open-label clinical trial designed to evaluate the efficacy of autogenous tooth bone grafts for alveolar socket preservation following sugrical tooth extraction. The intervention involves the use of the patient's own extracted tooth to prepare the bone graft, which will be placed into the extraction socket. The primary objective is to assess changes in alveolar bone height, width, and density before extraction and after six months of intervention using Cone Beam Computed Tomography (CBCT). All participants will undergo the same procedure, and no control group will be included. The study aims to explore the feasibility and outcomes of using autogenous grafts in dental socket preservation procedures
| Arm | Type | Receives |
|---|---|---|
| Autogenous Tooth Bone Graft Intervention Group | Experimental | Biological: "Autogenous Tooth Bone Graft""In this arm of the study, participants will receive an autogenous tooth bone graft for alveolar socket preservation following surgical tooth extraction. The intervention involves the extraction of the patient's own tooth, which will be processed and used as a bone graft. This graft will be placed into the empty socket immediately after the extraction. The purpose of this intervention is to prevent bone resorption, promote natural healing, and support bone regeneration within the extraction site. CBCT scans will be performed before extraction to measure baseline bone dimensions and will be repeated 6 months post-intervention to assess the success of bone preservation in terms of height, width, and density." |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- - Absence of systemic diseases.
- Very good to accepted oral hygiene.
- Patients with impacted teeth requiring extraction.
- Patients between the ages of 16 and 50.
- No history of smoking.
Key exclusion criteria (7 listed)
- Systemic conditions or pharmacological therapies that could be an absolute contraindication for the intervention (such as un controlled diabetics, immunocompromised states, or treatment with oral or parenteral bisphosphonates).
- Poor oral hygiene.
- Acute exacerbation of chronic infection like pain or swelling.
- Pregnant women, children, elderly (>60 years), physically and mentally challenged, terminally and seriously ill.
- Hight Smoking tendency.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| "Autogenous Tooth Bone Graft""The intervention involves the use of the patient's own extracted tooth to create a bone graft for alveolar socket preservation following surgical tooth extraction. The patient's tooth is carefully processed to remove caries, periodontal ligaments, pulp, and any restorative materials, leaving behind a complete tooth structure (enamel, dentin, and cementum). This tooth is then crushed, disinfected, and treated before being placed into the empty socket. This graft helps maintain the structure of the alveolar bone by promoting natural bone regeneration and preventing resorption. The bone graft will be monitored for its efficacy in preserving alveolar bone height, width, and density, assessed using Cone Beam Computed Tomography (CBCT)." | Biological | Autogenous Tooth Bone Graft Intervention Group |
Primary outcome
"Alveolar Bone Height, Width, and Density Preservation with Autogenous Tooth Bone Graft"
Time frame: "Before extraction and 6 months post-intervention"
This study aims to evaluate the effectiveness of autogenous tooth bone grafts in preserving alveolar bone following tooth extraction. The study will assess changes in alveolar bone height, width, and density using Cone Beam Computed Tomography (CBCT) at two time points: before extraction (baseline) and 6 months post-grafting. The outcome measures are: Alveolar Bone Height: Measured in millimeters using CBCT at baseline and 6 months. Alveolar Bone Width: Measured in millimeters using CBCT at baseline and 6 months. Alveolar Bone Density: Measured in Hounsfield units using CBCT at both time points. The intervention involves using the patient's own extracted tooth to create a bone graft placed into the socket, promoting healing and bone regeneration. This study will determine the effectiveness of autogenous tooth bone grafts in preventing bone resorption and preserving alveolar socket structure.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Dec 2025.
- Results publication: PubMed 28361377Valdec S, Pasic P, Soltermann A, Thoma D, Stadlinger B, Rucker M. Alveolar ridge preservation with autologous particulated dentin-a case series. Int J Implant Dent. 2017 Dec;3(1):12. doi: 10.1186/s40729-017-0071-9. Epub 2017 Mar 30.
- Results publication: PubMed 39132806Mahardawi B, Damrongsirirat N, Dhanesuan K, Subbalekha K, Mattheos N, Pimkhaokham A. Radiographic changes after alveolar ridge preservation using autogenous raw tooth particles versus xenograft: A prospective controlled clinical trial. Clin Oral Implants Res. 2024 Dec;35(12):1597-1606. doi: 10.1111/clr.14348. Epub 2024 Aug 12.
- This study compares the effectiveness of autogenous raw tooth particles versus xenografts in preserving alveolar bone after tooth extraction. It uses radiographic assessments to evaluate bone resorption and preservation over time. The research provides iLink provided by the sponsor.
- "This study discusses the use of autologous particulated dentin as a bone substitute for alveolar ridge preservation. The method demonstrates the potential of autologous dentin for bone augmentation in implant therapy, providing a viable alternative to xLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. "We will share anonymized individual participant data (IPD), including baseline characteristics, clinical assessments, and key outcome measures (alveolar bone height, width, and density) collected before and after the autogenous tooth bone graft intervention. Access to the data will be granted to qualified researchers who meet the criteria for data sharing and comply with the applicable data use agreement."
Related trials for Alveolar Bone Grafting
Recruiting
Effect of Collagen Membrane on Ridge Preservation
Dehiscence, Tooth Extraction
Not yet recruiting
Autogenous and Xenograft Bone Mix in Alveolar Ridge Reconstruction
Horizontal Alveolar Ridge Deficiency
Not yet recruiting
Bone and Soft Tissue Healing After Socket Preservation With NOVAMag or Permamem Membranes
Alveolar Bone Loss, Tooth Loss / Rehabilitation
Not yet recruiting
Shell Technique for Implant Site Development
Ridge Augmentation, Ridge Deficiency
Not yet recruiting
Hyaluronic Acid Combined With Xenograft Versus Xenograft Alone in Immediate Implant Placement
Immediate Implant Placement in the Esthetic Zone, NON-RESTORABLE TOOTH IN ESTHETIC ZONE
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Haifaa Alhussini, BDS, MSc principal investigator
Sana'a University Faculty of Dentistry
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing "Autogenous Tooth Bone Graft" in people with Alveolar Bone Grafting and Bone Regeneration Following Wisdom Teeth Extraction, run by Haifaa Mohammed Al-hussini at 1 site in Yemen.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 5 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Yemen. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
"Alveolar Bone Height, Width, and Density Preservation with Autogenous Tooth Bone Graft" (time frame: "Before extraction and 6 months post-intervention"). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07267637, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Dec 2025.