Persistent Physical Symptoms (PPS)TOCliFFDNCT07272148
The Pilot of the Turku Outpatient Clinic for Functional and Fatigue Disorders
An observational study of Persistent Physical Symptoms (PPS) and Functional Disorder, run by Turku University Hospital at 1 site in Finland.
Trial summary
This study examined 125 working-age patients from the Turku Outpatient Clinic for Functional and Fatigue Disorders. "Patients participate in the clinic's biopsychosocial, multidisciplinary, and individually tailored rehabilitation. Read more about this study
- Who is it for?
- Ages 18 to 66 years
- Conditions the study is for
- Persistent Physical Symptoms (PPS), Functional Disorder, Fatigue Syndrome, Chronic
- What is being tested?
- Biopsychosocial, multidisciplinary, and individually tailored rehabilitation for patients with persisten symptoms
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 125 participants
- Where
- 1 siteFinland
- Study dates
- 1 Aug 2023to May 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 66 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of working-age patients with persistent symptoms in the wellbeing services county of Southwest Finland. Referrals to the clinic were made from primary health care, occupational health care, private health services, and specialized health care.
Who may be able to join
- patients suffering persistent symptoms
- referred to the clinic between August 1, 2023 to April 30, 2025
Who cannot join
- ineligible for the study because of the need for extensive additional examinations in a specialized field, acute substance abuse problems, and/or lack of motivation.
Trial locations and contacts
1 site in 1 country.
Finland1 site
Academic Health and Social Services Centre
Turku, Southwest Finland, 20520
About this study
Official title: The Pilot of the Turku Outpatient Clinic for Functional and Fatigue Disorders in the Welbeing Services County of Southwest Finland
This study examined 125 working-age patients from the Turku Outpatient Clinic for Functional and Fatigue Disorders. "Patients participate in the clinic's biopsychosocial, multidisciplinary, and individually tailored rehabilitation. The aim of the rehabilitation is to improve patients' functional capacity and provide them with tools to manage and cope with their symptoms. In addition, the goal is to break the cycle of unnecessary examinations that cause harm to the patient. Socioeconomic data, as well as information related to functional capacity, symptoms, and quality of life, are collected from patients at the start of rehabilitation and again at six and twelve months after the beginning of rehabilitation. In addition, data on patients' use of social and health care services are requested from registers for the year preceding the start of rehabilitation and for the year following rehabilitation.
- Being tested
- Biopsychosocial, multidisciplinary, and individually tailored rehabilitation for patients with persisten symptoms
- Medical subject headings
- Fatigue Syndrome, Chronic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Biopsychosocial, multidisciplinary, and individually tailored rehabilitation for patients with persisten symptomsBehavioural
The clinic's staff included a pilot project coordinator, a physician, an occupational therapist, a physiotherapist, a psychologist, a rehabilitation counselor, and a ward secretary. At the physician's initial visit, stress system sensitization, burden factors, and need for symptomatic medication were assessed. In a joint rehabilitation team meeting, the patient met a psychologist, occupational therapist, physiotherapist, and rehabilitation counselor, who conducted a multidisciplinary evaluation and created an individualized rehabilitation plan. Patients then attended a course for persistent bodily symptoms, with some joining a psychophysical breathing group. Individual rehabilitation or counseling was provided according to each patient's needs.
| Study group | Role | What they receive |
|---|---|---|
| Patients suffering persistent symptoms | The clinic's staff included a pilot project coordinator, a physician, an occupational therapist, a physiotherapist, a psychologist, a rehabilitation counselor, and a ward secretary. At the physician's initial visit, stress system sensitization, burden factors, and need for symptomatic medication were assessed. In a joint rehabilitation team meeting, the patient met a psychologist, occupational therapist, physiotherapist, and rehabilitation counselor, who conducted a multidisciplinary evaluation and created an individualized rehabilitation plan. Patients then attended a course for persistent bodily symptoms, with some joining a psychophysical breathing group. Individual rehabilitation or counseling was provided according to each patient's needs. Receives: Behavioral: Biopsychosocial, multidisciplinary, and individually tailored rehabilitation for patients with persisten symptoms |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quality of life of the patients
WHOQOL-BREF
Measured: At baseline and at 6 and 12 months follow-ups
Secondary outcomes (1)
Functional limitations of the patients
WHODAS 2.0
Measured: At baseline and at 6 and 12 months follow-up
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Dec 2025
- Study start1 Aug 2023
- Primary completionMay 2026 (estimated)
- Study completionMay 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Persistent Physical Symptoms (PPS)Studies of the same condition, open and under way.
- More trials run by Turku University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 125 participants (actual)
Sponsor and investigators
- Lead sponsor
- Turku University Hospital
- Sponsor type
- Other government
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07272148
- Sponsor's protocol ID
- T1398-2023-2
- Acronym
- TOCliFFD
- Status last verified
- Nov 2025
- First submitted
- 17 Nov 2025
- Last updated
- 9 Dec 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Only upon reasonable request.
Study at a glance
From the registry record, last updated by the sponsor on 9 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Pilot of the Turku Outpatient Clinic for Functional and Fatigue Disorders in the Welbeing Services County of Southwest Finland
- ClinicalTrials.gov ID
- NCT07272148
- Acronym / sponsor ID
- TOCliFFD / T1398-2023-2
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 125 participants (actual)
- Lead sponsor
- Turku University HospitalOther government
- Study start
- 1 Aug 2023 (actual)
- Primary completion
- May 2026 (estimated)
- Study completion
- May 2027 (estimated)
- First posted
- 9 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examined 125 working-age patients from the Turku Outpatient Clinic for Functional and Fatigue Disorders. "Patients participate in the clinic's biopsychosocial, multidisciplinary, and individually tailored rehabilitation. The aim of the rehabilitation is to improve patients' functional capacity and provide them with tools to manage and cope with their symptoms. In addition, the goal is to break the cycle of unnecessary examinations that cause harm to the patient. Socioeconomic data, as well as information related to functional capacity, symptoms, and quality of life, are collected from patients at the start of rehabilitation and again at six and twelve months after the beginning of rehabilitation. In addition, data on patients' use of social and health care services are requested from registers for the year preceding the start of rehabilitation and for the year following rehabilitation.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients suffering persistent symptoms | – | Behavioral: Biopsychosocial, multidisciplinary, and individually tailored rehabilitation for patients with persisten symptomsThe clinic's staff included a pilot project coordinator, a physician, an occupational therapist, a physiotherapist, a psychologist, a rehabilitation counselor, and a ward secretary. At the physician's initial visit, stress system sensitization, burden factors, and need for symptomatic medication were assessed. In a joint rehabilitation team meeting, the patient met a psychologist, occupational therapist, physiotherapist, and rehabilitation counselor, who conducted a multidisciplinary evaluation and created an individualized rehabilitation plan. Patients then attended a course for persistent bodily symptoms, with some joining a psychophysical breathing group. Individual rehabilitation or counseling was provided according to each patient's needs. |
Who may qualify
- Ages
- 18 to 66 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of working-age patients with persistent symptoms in the wellbeing services county of Southwest Finland. Referrals to the clinic were made from primary health care, occupational health care, private health services, and specialized health care.
Key inclusion criteria (2 listed)
- patients suffering persistent symptoms
- referred to the clinic between August 1, 2023 to April 30, 2025
Key exclusion criteria (1 listed)
- ineligible for the study because of the need for extensive additional examinations in a specialized field, acute substance abuse problems, and/or lack of motivation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Biopsychosocial, multidisciplinary, and individually tailored rehabilitation for patients with persisten symptomsThe clinic's staff included a pilot project coordinator, a physician, an occupational therapist, a physiotherapist, a psychologist, a rehabilitation counselor, and a ward secretary. At the physician's initial visit, stress system sensitization, burden factors, and need for symptomatic medication were assessed. In a joint rehabilitation team meeting, the patient met a psychologist, occupational therapist, physiotherapist, and rehabilitation counselor, who conducted a multidisciplinary evaluation and created an individualized rehabilitation plan. Patients then attended a course for persistent bodily symptoms, with some joining a psychophysical breathing group. Individual rehabilitation or counseling was provided according to each patient's needs. | Behavioural | Patients suffering persistent symptoms |
Primary outcome
Quality of life of the patients
Time frame: At baseline and at 6 and 12 months follow-ups
WHOQOL-BREF
1 secondary outcome
Functional limitations of the patients
Time frame: At baseline and at 6 and 12 months follow-up
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Dec 2025.
- Individual participant dataSharing planned: Undecided. Only upon reasonable request.
Related trials for Persistent Physical Symptoms (PPS)
Recruiting
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Persistent Physical Symptoms (PPS), Bodily Distress Syndrome
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Persistent Physical Symptoms (PPS) and Functional Disorder, run by Turku University Hospital at 1 site in Finland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 9 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Finland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quality of life of the patients (time frame: At baseline and at 6 and 12 months follow-ups). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Dec 2025.