Depression - Major Depressive DisorderNCT07282366
Video Intervention to Reduce Depression-related Stigma Among Adolescents
A study testing Video-Based Psychoeducation on Personal Stigma, Video-Based Psychoeducation on Social Stigma (Non-Depressed Adolescents) and Neutral Health Education Video in people with Depression - Major Depressive Disorder, run by Jian-Jun Ou at 1 site in China.
Trial summary
Depression-related stigma is a major barrier to help-seeking among adolescents with depression. In China, few interventions specifically target stigma reduction in this population. Read more about this study
- Who is it for?
- Ages 8 to 18 yearsHealthy volunteers can take part
- Conditions the study is for
- Depression - Major Depressive Disorder
- What is being tested?
- Video-Based Psychoeducation on Personal Stigma, Video-Based Psychoeducation on Social Stigma (Non-Depressed Adolescents) and Neutral Health Education Video
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 500 participants
- Where
- 1 siteChina
- Study dates
- 20 Dec 2025to 20 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 8 to 18 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Adolescents aged 8-18 years.
- Able to understand and complete questionnaires in Chinese.
- Normal or corrected-to-normal vision and hearing.
- Have at least a primary school education level.
- Provide written informed consent from both the participant and their parent or guardian.
- For the depressed group: score > 9 on the Patient Health Questionnaire for Adolescents (PHQ-A).
- For the non-depressed group: score ≤ 9 on the PHQ-A.
Who cannot join
- Presence of severe physical illness or neurological disease (e.g., traumatic brain injury).
- Cognitive impairment, intellectual disability, or significant visual/hearing impairment that prevents participation.
- Current psychotic symptoms or severe psychiatric comorbidities.
- Active suicidal or self-harming behaviors during the study period.
- Failure to comply with study procedures or withdrawal of consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site
Department of Psychiatry, Xiangya Second Hospital, Central South University
Changsha, Hunan
Jianjun Ou, doctor, 17775861486, oujianjun@csu.edu.cn
About this study
Official title: Effect of a Video-Based Intervention on Depression-Related Stigma Among Adolescents
Depression-related stigma is a major barrier to help-seeking among adolescents with depression. In China, few interventions specifically target stigma reduction in this population. This study aims to evaluate the effectiveness of a video-based psychoeducational intervention in reducing depression-related stigma and improving help-seeking attitudes among adolescents.
Adolescents aged 8-18 years are recruited from outpatient clinics and schools and screened using the Patient Health Questionnaire-9. Participants are categorized as depressed or non-depressed and randomly assigned into intervention or control groups: depressed adolescents receive a video on personal stigma, non-depressed adolescents receive a video on social stigma, while control groups watch a neutral myopia education video. The study hypothesizes that video-based education can effectively reduce stigma and promote positive help-seeking behaviors among adolescents.
- Conditions
- Depression - Major Depressive Disorder
- Being tested
- Video-Based Psychoeducation on Personal Stigma, Video-Based Psychoeducation on Social Stigma (Non-Depressed Adolescents), Neutral Health Education Video
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Video-Based Psychoeducation on Personal StigmaBehavioural
Participants in this arm are depressed adolescents (PHQ-A >9) who receive a video-based psychoeducational intervention designed to reduce personal stigma toward depression. The intervention consists of short online videos (approximately 3-5 minutes each) developed by the research team and delivered through a WeChat mini-program. The videos include animated and narrative content explaining the nature of depression, correcting common misconceptions, and promoting empathy, self-acceptance, and help-seeking attitudes. The aim is to reduce internalized stigma, improve depression literacy, and encourage professional help-seeking among adolescents with depression.
Video-Based Psychoeducation on Social Stigma (Non-Depressed Adolescents)Behavioural
Participants in this arm are non-depressed (PHQ-A ≤ 9) adolescents who receive a video-based psychoeducational intervention aimed at reducing social stigma toward individuals with depression. The intervention consists of short online videos (approximately 3-5 minutes each) created by the research team and delivered via a WeChat mini-program. The videos use engaging animation and real-life narratives to explain the symptoms and causes of depression, challenge negative stereotypes, and promote understanding and acceptance of people experiencing depression. The goal is to decrease prejudicial attitudes and social distance toward people with depression and to enhance mental health literacy among adolescents.
Neutral Health Education VideoBehavioural
Participants in this arm watch a neutral health education video that serves as a control condition. The video, approximately 3-5 minutes in length, focuses on myopia prevention and eye health and contains no content related to mental health or depression. It is matched in duration and presentation style to the experimental videos to control for exposure time and viewing experience. The control video is delivered through the same WeChat mini-program platform and viewed once under the supervision of teachers, clinicians, or guardians. This condition allows for comparison of the specific effects of the depression-related stigma reduction videos with a neutral educational video of a similar format.
| Study group | Role | What they receive |
|---|---|---|
| Depressed adolescents - video intervention on personal stigma | Experimental | Not described Receives: Behavioral: Video-Based Psychoeducation on Personal Stigma |
| Depressed adolescents - control video | Placebo comparator | Not described Receives: Behavioral: Neutral Health Education Video |
| Non-depressed adolescents - video intervention on social stigma | Experimental | Not described Receives: Behavioral: Video-Based Psychoeducation on Social Stigma (Non-Depressed Adolescents) |
| Non-depressed adolescents - control video | Placebo comparator | Not described Receives: Behavioral: Neutral Health Education Video |
What is being measured
The primary outcome is the main question the study is designed to answer.
Depression Stigma Scale
The Depression Stigma Scale is used as the primary outcome measure for participants with a baseline PHQ-A score > 9. The Depression Stigma Scale is an 18-item self-report measure rated on a 5-point Likert scale. Total scores range from 0 to 72, with higher scores indicating greater stigma toward depression
Measured: At baseline, immediately post-intervention, and week 8
Depression social stigma scale
The Depression Social Stigma Scale is used as the primary outcome measure for participants with a baseline PHQ-A score ≤ 9. The Depression Social Stigma Scale is an 18-item self-report questionnaire rated on a 4-point Likert scale. Total scores range from 18 to 72, with higher scores indicating greater social stigma toward depression
Measured: At baseline, imediately post-intervention, and week 8
Secondary outcomes (3)
Attitudes Toward Seeking Professional Psychological Help Scale-Short Form
The ATSPPH-SF is a 10-item self-report questionnaire scored on a Likert 4-point scale. Total scores range from 0 to 30, with higher scores indicating more positive attitudes toward seeking professional psychological help.
Measured: At baseline, imediately post-intervention, and week 8
General Help-Seeking Questionnaire
The General Help-Seeking Questionnaire assesses intentions to seek help from different sources. Responses are rated on a 7-point Likert scale. Total scores range from 18-126, with higher scores indicating greater intention to seek help.
Measured: At baseline, imediately post-intervention, and week 8
Depression Literacy Questionnaire
The Depression Literacy Questionnaire is a 22-item self-report measure assessing knowledge about depression. Total scores range from 0 to 22, with higher scores indicating greater depression literacy.
Measured: At baseline, imediately post-intervention, and week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Dec 2025
- Study start20 Dec 2025 (estimated)
- Primary completion20 Nov 2026 (estimated)
- Study completion20 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Depression - Major Depressive DisorderStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Jian-Jun Ou
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Jian-Jun Ou, Central South University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07282366
- Sponsor's protocol ID
- LYG20220038
- Status last verified
- Nov 2025
- First submitted
- 17 Nov 2025
- Last updated
- 15 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of a Video-Based Intervention on Depression-Related Stigma Among Adolescents
- ClinicalTrials.gov ID
- NCT07282366
- Acronym / sponsor ID
- LYG20220038
- Conditions
- Depression - Major Depressive Disorder
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 500 participants (estimated)
- Lead sponsor
- Jian-Jun OuUniversity, hospital or other
- Study start
- 20 Dec 2025 (estimated)
- Primary completion
- 20 Nov 2026 (estimated)
- Study completion
- 20 Dec 2026 (estimated)
- First posted
- 15 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Depression-related stigma is a major barrier to help-seeking among adolescents with depression. In China, few interventions specifically target stigma reduction in this population. This study aims to evaluate the effectiveness of a video-based psychoeducational intervention in reducing depression-related stigma and improving help-seeking attitudes among adolescents.
Adolescents aged 8-18 years are recruited from outpatient clinics and schools and screened using the Patient Health Questionnaire-9. Participants are categorized as depressed or non-depressed and randomly assigned into intervention or control groups: depressed adolescents receive a video on personal stigma, non-depressed adolescents receive a video on social stigma, while control groups watch a neutral myopia education video. The study hypothesizes that video-based education can effectively reduce stigma and promote positive help-seeking behaviors among adolescents.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Depressed adolescents - video intervention on personal stigma | Experimental | Behavioral: Video-Based Psychoeducation on Personal Stigma |
| Depressed adolescents - control video | Placebo comparator | Behavioral: Neutral Health Education Video |
| Non-depressed adolescents - video intervention on social stigma | Experimental | Behavioral: Video-Based Psychoeducation on Social Stigma (Non-Depressed Adolescents) |
| Non-depressed adolescents - control video | Placebo comparator | Behavioral: Neutral Health Education Video |
Who may qualify
- Ages
- 8 to 18 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (7 listed)
- Adolescents aged 8-18 years.
- Able to understand and complete questionnaires in Chinese.
- Normal or corrected-to-normal vision and hearing.
- Have at least a primary school education level.
- Provide written informed consent from both the participant and their parent or guardian.
Key exclusion criteria (5 listed)
- Presence of severe physical illness or neurological disease (e.g., traumatic brain injury).
- Cognitive impairment, intellectual disability, or significant visual/hearing impairment that prevents participation.
- Current psychotic symptoms or severe psychiatric comorbidities.
- Active suicidal or self-harming behaviors during the study period.
- Failure to comply with study procedures or withdrawal of consent.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Video-Based Psychoeducation on Personal StigmaParticipants in this arm are depressed adolescents (PHQ-A >9) who receive a video-based psychoeducational intervention designed to reduce personal stigma toward depression. The intervention consists of short online videos (approximately 3-5 minutes each) developed by the research team and delivered through a WeChat mini-program. The videos include animated and narrative content explaining the nature of depression, correcting common misconceptions, and promoting empathy, self-acceptance, and help-seeking attitudes. The aim is to reduce internalized stigma, improve depression literacy, and encourage professional help-seeking among adolescents with depression. | Behavioural | Depressed adolescents - video intervention on personal stigma |
| Video-Based Psychoeducation on Social Stigma (Non-Depressed Adolescents)Participants in this arm are non-depressed (PHQ-A ≤ 9) adolescents who receive a video-based psychoeducational intervention aimed at reducing social stigma toward individuals with depression. The intervention consists of short online videos (approximately 3-5 minutes each) created by the research team and delivered via a WeChat mini-program. The videos use engaging animation and real-life narratives to explain the symptoms and causes of depression, challenge negative stereotypes, and promote understanding and acceptance of people experiencing depression. The goal is to decrease prejudicial attitudes and social distance toward people with depression and to enhance mental health literacy among adolescents. | Behavioural | Non-depressed adolescents - video intervention on social stigma |
| Neutral Health Education VideoParticipants in this arm watch a neutral health education video that serves as a control condition. The video, approximately 3-5 minutes in length, focuses on myopia prevention and eye health and contains no content related to mental health or depression. It is matched in duration and presentation style to the experimental videos to control for exposure time and viewing experience. The control video is delivered through the same WeChat mini-program platform and viewed once under the supervision of teachers, clinicians, or guardians. This condition allows for comparison of the specific effects of the depression-related stigma reduction videos with a neutral educational video of a similar format. | Behavioural | Depressed adolescents - control video, Non-depressed adolescents - control video |
Primary outcome
Depression Stigma Scale
Time frame: At baseline, immediately post-intervention, and week 8
The Depression Stigma Scale is used as the primary outcome measure for participants with a baseline PHQ-A score > 9. The Depression Stigma Scale is an 18-item self-report measure rated on a 5-point Likert scale. Total scores range from 0 to 72, with higher scores indicating greater stigma toward depression
Depression social stigma scale
Time frame: At baseline, imediately post-intervention, and week 8
The Depression Social Stigma Scale is used as the primary outcome measure for participants with a baseline PHQ-A score ≤ 9. The Depression Social Stigma Scale is an 18-item self-report questionnaire rated on a 4-point Likert scale. Total scores range from 18 to 72, with higher scores indicating greater social stigma toward depression
3 secondary outcomes
Attitudes Toward Seeking Professional Psychological Help Scale-Short Form
Time frame: At baseline, imediately post-intervention, and week 8
General Help-Seeking Questionnaire
Time frame: At baseline, imediately post-intervention, and week 8
Depression Literacy Questionnaire
Time frame: At baseline, imediately post-intervention, and week 8
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Dec 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Video-Based Psychoeducation on Personal Stigma, Video-Based Psychoeducation on Social Stigma (Non-Depressed Adolescents) and Neutral Health Education Video in people with Depression - Major Depressive Disorder, run by Jian-Jun Ou at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 15 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jianjun Ou, doctor (17775861486, oujianjun@csu.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Depression Stigma Scale (time frame: At baseline, immediately post-intervention, and week 8). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Dec 2025.