Video-assisted Thoracoscopic Surgery (VATS)TCI-INHALENCT07288099
Target-Controlled Infusion (TCI) vs Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery (VATS)
An observational study of Video-assisted Thoracoscopic Surgery (VATS) and Thoracic Surgery, Video Assisted, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).
Trial summary
This study is designed as a prospective observational cohort to evaluate recovery after video-assisted thoracoscopic surgery (VATS). In our clinic, anesthesia for VATS is commonly provided either with target-controlled infusion (TCI) or with inhalational agents, depending on the routine practice of the… Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Video-assisted Thoracoscopic Surgery (VATS), Thoracic Surgery, Video Assisted, Postoperative Recovery
- Type of treatment
- Injection or infusion
- How many people
- 80 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 12 Jan 2026to 30 Jul 2026
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of adult patients undergoing elective video-assisted thoracoscopic surgery (VATS) at our institution. In routine practice, anesthesia for these procedures is provided either with target-controlled infusion (TCI) or with inhalational agents, according to the preference of the attending anesthesiologist. Patients between 18 and 65 years of age who meet the clinical criteria for VATS and are able to give informed consent will be included. Individuals with significant cardiorespiratory instability, ASA IV or higher, or conditions that may interfere with postoperative assessment will not be enrolled.
Who may be able to join
- Adults aged 18 to 65 years
- Patients scheduled for elective video-assisted thoracoscopic surgery (VATS)
- ASA physical status I-III
- Able to provide informed consent
- Planned postoperative recovery in PACU and surgical ward
Who cannot join
- ASA IV or higher
- Hemodynamic or respiratory instability before surgery
- Known allergy or contraindication to commonly used anesthetic agents
- Neurological or psychiatric conditions that may interfere with recovery assessment
- Emergency surgeries
- Patients who decline participation
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Istanbul University Cerrahpasa Medical Faculty
Istanbul, Istanbul
About this study
Official title: Prospective Observational Cohort Study Comparing Recovery Profiles After Target-Controlled Infusion Versus Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery
This study is designed as a prospective observational cohort to evaluate recovery after video-assisted thoracoscopic surgery (VATS). In our clinic, anesthesia for VATS is commonly provided either with target-controlled infusion (TCI) or with inhalational agents, depending on the routine practice of the anesthesiologist. No randomization or additional intervention will be performed.
During the study period, patients who receive either method as part of standard care will be followed, and perioperative and postoperative data will be recorded. Awakening time, extubation time, Aldrete score progression, pain levels, and early postoperative complications will be compared between the two groups. The aim is to better understand how these widely used anesthesia techniques may influence recovery in VATS patients and to support future clinical decision-making.
Read the detailed description
This study is planned as a prospective observational cohort carried out in patients undergoing video-assisted thoracoscopic surgery (VATS). In routine practice at our institution, anesthesia for these operations is provided either with target-controlled infusion (TCI)-based total intravenous anesthesia or with inhalational agents. The study will not change the type of anesthesia given to any patient. The method used will depend entirely on the attending anesthesiologist's usual clinical choice.
Patients receiving either technique during the study period will be followed, and perioperative variables will be documented. These include basic demographic data, intraoperative hemodynamic changes, duration of anesthesia, administered drug doses, and oxygenation parameters. Postoperative recovery will be assessed mainly through awakening and extubation times, Aldrete scores, sedation assessments, pain scores, and early complications such as nausea and vomiting.
The purpose of this observational design is to compare the two commonly used anesthesia approaches as they are applied in real clinical practice. By examining postoperative recovery patterns and any differences between groups, the study aims to provide practical information that may help guide anesthesia selection in VATS procedures. No additional risk or intervention will be introduced, and all patient data will be collected in accordance with routine clinical monitoring.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Thoracic Surgery, Video Assisted, Postoperative Recovery, General Anesthesia, Anesthesia Techniques
- Keywords
- Video-Assisted Thoracoscopic Surgery, VATS, Thoracic Surgery, Target-Controlled Infusion, Inhalational Anesthesia, Postoperative Recovery, Extubation Time
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| TCI Group | Patients receiving target-controlled infusion (TCI) anesthesia as part of routine clinical care during VATS procedures. No intervention is assigned by the study team. | |
| Inhalational Anesthesia Group | Patients receiving inhalational anesthesia (e.g., sevoflurane) as part of routine clinical care during VATS procedures. No intervention is assigned by the study team. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Extubation Time
Time from discontinuation of anesthesia to removal of the endotracheal tube. Extubation time will be recorded routinely in the operating room as part of standard postoperative monitoring.
Measured: Up to 30 minutes after the end of surgery
Secondary outcomes (3)
Awakening Time
Time from the end of anesthesia to the patient's first response to verbal command (eye opening or hand squeeze), recorded routinely in the operating room.
Measured: Up to 20 minutes after surgery
Aldrete Score Progression
Aldrete scores will be recorded at standard intervals in the post-anesthesia care unit (PACU) to evaluate early recovery. The time needed to reach an Aldrete score of 9 will be compared between groups.
Measured: PACU stay, up to 1 hour
Postoperative Pain Score (NRS)
Numeric Rating Scale (0-10) will be used to assess postoperative pain at PACU admission and during the early postoperative period.
Measured: First hour after PACU admission
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Dec 2025
- Study start12 Jan 2026
- Primary completion30 Jun 2026
- Study completion30 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Video-assisted Thoracoscopic Surgery (VATS)Studies of the same condition, open and under way.
- More trials run by Istanbul University - CerrahpasaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 80 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Istanbul University - Cerrahpasa
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, mert katılmış, Istanbul University - Cerrahpasa
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07288099
- Sponsor's protocol ID
- E-24687260-604.01-1455240
- Acronym
- TCI-INHALE
- Status last verified
- Aug 2026
- First submitted
- 4 Dec 2025
- Last updated
- 4 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared because the study involves routinely collected clinical information, and the dataset contains sensitive patient details that cannot be made publicly available. All data will be used only within the study team and stored according to institutional privacy policies.
Study at a glance
From the registry record, last updated by the sponsor on 4 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prospective Observational Cohort Study Comparing Recovery Profiles After Target-Controlled Infusion Versus Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery
- ClinicalTrials.gov ID
- NCT07288099
- Acronym / sponsor ID
- TCI-INHALE / E-24687260-604.01-1455240
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Thoracic Surgery, Video Assisted, Postoperative Recovery, General Anesthesia, Anesthesia Techniques
- Keywords
- Video-Assisted Thoracoscopic Surgery, VATS, Thoracic Surgery, Target-Controlled Infusion, Inhalational Anesthesia, Postoperative Recovery, Extubation Time
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Istanbul University - CerrahpasaUniversity, hospital or other
- Study start
- 12 Jan 2026 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Jul 2026 (actual)
- First posted
- 17 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is designed as a prospective observational cohort to evaluate recovery after video-assisted thoracoscopic surgery (VATS). In our clinic, anesthesia for VATS is commonly provided either with target-controlled infusion (TCI) or with inhalational agents, depending on the routine practice of the anesthesiologist. No randomization or additional intervention will be performed.
During the study period, patients who receive either method as part of standard care will be followed, and perioperative and postoperative data will be recorded. Awakening time, extubation time, Aldrete score progression, pain levels, and early postoperative complications will be compared between the two groups. The aim is to better understand how these widely used anesthesia techniques may influence recovery in VATS patients and to support future clinical decision-making.
Detailed description
This study is planned as a prospective observational cohort carried out in patients undergoing video-assisted thoracoscopic surgery (VATS). In routine practice at our institution, anesthesia for these operations is provided either with target-controlled infusion (TCI)-based total intravenous anesthesia or with inhalational agents. The study will not change the type of anesthesia given to any patient. The method used will depend entirely on the attending anesthesiologist's usual clinical choice.
Patients receiving either technique during the study period will be followed, and perioperative variables will be documented. These include basic demographic data, intraoperative hemodynamic changes, duration of anesthesia, administered drug doses, and oxygenation parameters. Postoperative recovery will be assessed mainly through awakening and extubation times, Aldrete scores, sedation assessments, pain scores, and early complications such as nausea and vomiting.
The purpose of this observational design is to compare the two commonly used anesthesia approaches as they are applied in real clinical practice. By examining postoperative recovery patterns and any differences between groups, the study aims to provide practical information that may help guide anesthesia selection in VATS procedures. No additional risk or intervention will be introduced, and all patient data will be collected in accordance with routine clinical monitoring.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 1 Day
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| TCI Group | – | –Patients receiving target-controlled infusion (TCI) anesthesia as part of routine clinical care during VATS procedures. No intervention is assigned by the study team. |
| Inhalational Anesthesia Group | – | –Patients receiving inhalational anesthesia (e.g., sevoflurane) as part of routine clinical care during VATS procedures. No intervention is assigned by the study team. |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of adult patients undergoing elective video-assisted thoracoscopic surgery (VATS) at our institution. In routine practice, anesthesia for these procedures is provided either with target-controlled infusion (TCI) or with inhalational agents, according to the preference of the attending anesthesiologist. Patients between 18 and 65 years of age who meet the clinical criteria for VATS and are able to give informed consent will be included. Individuals with significant cardiorespiratory instability, ASA IV or higher, or conditions that may interfere with postoperative assessment will not be enrolled.
Key inclusion criteria (5 listed)
- Adults aged 18 to 65 years
- Patients scheduled for elective video-assisted thoracoscopic surgery (VATS)
- ASA physical status I-III
- Able to provide informed consent
- Planned postoperative recovery in PACU and surgical ward
Key exclusion criteria (6 listed)
- ASA IV or higher
- Hemodynamic or respiratory instability before surgery
- Known allergy or contraindication to commonly used anesthetic agents
- Neurological or psychiatric conditions that may interfere with recovery assessment
- Emergency surgeries
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Extubation Time
Time frame: Up to 30 minutes after the end of surgery
Time from discontinuation of anesthesia to removal of the endotracheal tube. Extubation time will be recorded routinely in the operating room as part of standard postoperative monitoring.
3 secondary outcomes
Awakening Time
Time frame: Up to 20 minutes after surgery
Aldrete Score Progression
Time frame: PACU stay, up to 1 hour
Postoperative Pain Score (NRS)
Time frame: First hour after PACU admission
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Aug 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared because the study involves routinely collected clinical information, and the dataset contains sensitive patient details that cannot be made publicly available. All data will be used only within the study team and stored according to institutional privacy policies.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Video-assisted Thoracoscopic Surgery (VATS) and Thoracic Surgery, Video Assisted, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Extubation Time (time frame: Up to 30 minutes after the end of surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Aug 2026.