Pain (Visceral, Somatic, or Neuropathic)NCT07296926
Distolingual Infiltration Verses Conventional Nerve Block in Mandibular Third Molar Extraction
A study testing Conventional Inferior Alveolar and Buccal Nerve Block and Distolingual Infiltration plus Conventional Nerve Block in people with Pain (Visceral, Somatic, or Neuropathic), run by Watim Medical & Dental College at 1 site in Pakistan.
Trial summary
This randomized controlled trial will compare the effectiveness of adding distolingual infiltration to conventional inferior alveolar and buccal nerve blocks for mandibular third molar extraction. A total of 120 patients will be allocated into two groups. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Pain (Visceral, Somatic, or Neuropathic)
- What is being tested?
- Conventional Inferior Alveolar and Buccal Nerve Block and Distolingual Infiltration plus Conventional Nerve Block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Aug 2024to 15 Apr 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy individuals
- Male and female
- Age 18-45 years
- Mandibular third molar impaction - all positions
- Mandibular third molar impaction - all classes
Who cannot join
- ASA status III and above
- Patients requiring multiple extractions in the same appointment
- Allergy to lignocaine
- Patients in whom adrenaline is contraindicated
- Medically compromised individuals e.g. poorly controlled diabetes, hypertension
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Dr Aimen Zafar
Islamabad
aimen zafar zafar masood, bds, 00923361056720, aimenali216@gmail.com
About this study
Official title: Comparison of Efficacy of Distolingual Infiltration in Conjugation With Conventional Inferior Alveolar Nerve Block to Conventional Inferior Alveolar Nerve Block Alone for Extraction of Mandibular Third Molar
This randomized controlled trial will compare the effectiveness of adding distolingual infiltration to conventional inferior alveolar and buccal nerve blocks for mandibular third molar extraction. A total of 120 patients will be allocated into two groups. Pain during flap elevation and bone guttering will be assessed using the Visual Analogue Scale.
Read the detailed description
Mandibular third molar extraction is a common oral and maxillofacial surgery procedure that requires profound local anesthesia. Despite conventional inferior alveolar, lingual and buccal nerve blocks, the distolingual gingiva may remain non-anesthetized due to accessory innervation via the mylohyoid and other nerves. Distolingual infiltration may improve anesthesia in this area.
This randomized controlled trial will enroll 120 patients requiring mandibular third molar extraction. Participants will be randomized into two groups: conventional inferior alveolar and buccal nerve block (Group A) and the same technique with additional distolingual infiltration (Group B). Pain during mucoperiosteal flap elevation and bone guttering will be recorded on a 0-10 Visual Analogue Scale. The primary objective is to determine whether distolingual infiltration improves pain control compared to the conventional technique.
- Conditions
- Pain (Visceral, Somatic, or Neuropathic)
- Being tested
- Conventional Inferior Alveolar and Buccal Nerve Block, Distolingual Infiltration plus Conventional Nerve Block
- Medical subject headings
- Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional Inferior Alveolar and Buccal Nerve BlockProcedure or surgery
Standard inferior alveolar and long buccal nerve block for mandibular third molar extraction.
Distolingual Infiltration plus Conventional Nerve BlockProcedure or surgery
Distolingual infiltration (0.2 ml) administered in addition to conventional inferior alveolar during mandibular third molar extraction.
| Study group | Role | What they receive |
|---|---|---|
| conventional nerve block injection | Active comparator | Inferior alveolar and buccal nerve block using 2% lignocaine with adrenaline (1:80,000) without distolingual infiltration. Receives: Procedure: Conventional Inferior Alveolar and Buccal Nerve Block |
| conventional inferior alveolar with distolingual infilterate injection | Experimental | Inferior alveolar supplemented with distolingual infiltration using 2% lignocaine with adrenaline (1:80,000). Receives: Procedure: Distolingual Infiltration plus Conventional Nerve Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain during mucoperiosteal flap elevation
Pain intensity experienced during flap elevation will be assessed using the Visual Analogue Scale (VAS). This is a 0-10 point numerical scale where participants indicate the pain level experienced at the time of flap elevation.
Measurement Tool:
Visual Analogue Scale (VAS)
Scale:
- Minimum score: 0 (no pain)
- Maximum score: 10 (worst possible pain)
- Directionality: Higher scores indicate worse pain
Measured: During mucoperiosteal flap elevation on the day of surgery
Pain During Bone Guttering
Pain intensity during bone guttering will be recorded using the Visual Analogue Scale (VAS).
Measurement Tool:
Visual Analogue Scale (VAS)
Scale:
- Minimum: 0 (no pain)
- Maximum: 10 (worst pain)
- Higher scores = worse pain
Measured: During bone guttering on the day of surgery.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Dec 2025
- Study start15 Aug 2024
- Primary completion15 Feb 2026 (estimated)
- Study completion15 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pain (Visceral, Somatic, or Neuropathic)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Watim Medical & Dental College
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, aimen zafar, Watim Medical & Dental College
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07296926
- Sponsor's protocol ID
- DSG-2023-335-4631-A
- Status last verified
- Dec 2025
- First submitted
- 26 Nov 2025
- Last updated
- 6 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Efficacy of Distolingual Infiltration in Conjugation With Conventional Inferior Alveolar Nerve Block to Conventional Inferior Alveolar Nerve Block Alone for Extraction of Mandibular Third Molar
- ClinicalTrials.gov ID
- NCT07296926
- Acronym / sponsor ID
- DSG-2023-335-4631-A
- Conditions
- Pain (Visceral, Somatic, or Neuropathic)
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- Watim Medical & Dental CollegeUniversity, hospital or other
- Study start
- 15 Aug 2024 (actual)
- Primary completion
- 15 Feb 2026 (estimated)
- Study completion
- 15 Apr 2026 (estimated)
- First posted
- 22 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial will compare the effectiveness of adding distolingual infiltration to conventional inferior alveolar and buccal nerve blocks for mandibular third molar extraction. A total of 120 patients will be allocated into two groups. Pain during flap elevation and bone guttering will be assessed using the Visual Analogue Scale.
Detailed description
Mandibular third molar extraction is a common oral and maxillofacial surgery procedure that requires profound local anesthesia. Despite conventional inferior alveolar, lingual and buccal nerve blocks, the distolingual gingiva may remain non-anesthetized due to accessory innervation via the mylohyoid and other nerves. Distolingual infiltration may improve anesthesia in this area.
This randomized controlled trial will enroll 120 patients requiring mandibular third molar extraction. Participants will be randomized into two groups: conventional inferior alveolar and buccal nerve block (Group A) and the same technique with additional distolingual infiltration (Group B). Pain during mucoperiosteal flap elevation and bone guttering will be recorded on a 0-10 Visual Analogue Scale. The primary objective is to determine whether distolingual infiltration improves pain control compared to the conventional technique.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| conventional nerve block injection | Active comparator | Procedure: Conventional Inferior Alveolar and Buccal Nerve BlockInferior alveolar and buccal nerve block using 2% lignocaine with adrenaline (1:80,000) without distolingual infiltration. |
| conventional inferior alveolar with distolingual infilterate injection | Experimental | Procedure: Distolingual Infiltration plus Conventional Nerve BlockInferior alveolar supplemented with distolingual infiltration using 2% lignocaine with adrenaline (1:80,000). |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Healthy individuals
Key exclusion criteria (5 listed)
- ASA status III and above
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional Inferior Alveolar and Buccal Nerve BlockStandard inferior alveolar and long buccal nerve block for mandibular third molar extraction. | Procedure or surgery | conventional nerve block injection |
| Distolingual Infiltration plus Conventional Nerve BlockDistolingual infiltration (0.2 ml) administered in addition to conventional inferior alveolar during mandibular third molar extraction. | Procedure or surgery | conventional inferior alveolar with distolingual infilterate injection |
Primary outcome
Pain during mucoperiosteal flap elevation
Time frame: During mucoperiosteal flap elevation on the day of surgery
Pain intensity experienced during flap elevation will be assessed using the Visual Analogue Scale (VAS). This is a 0-10 point numerical scale where participants indicate the pain level experienced at the time of flap elevation. Measurement Tool: Visual Analogue Scale (VAS) Scale: * Minimum score: 0 (no pain) * Maximum score: 10 (worst possible pain) * Directionality: Higher scores indicate worse pain
Pain During Bone Guttering
Time frame: During bone guttering on the day of surgery.
Pain intensity during bone guttering will be recorded using the Visual Analogue Scale (VAS). Measurement Tool: Visual Analogue Scale (VAS) Scale: * Minimum: 0 (no pain) * Maximum: 10 (worst pain) * Higher scores = worse pain
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jan 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional Inferior Alveolar and Buccal Nerve Block and Distolingual Infiltration plus Conventional Nerve Block in people with Pain (Visceral, Somatic, or Neuropathic), run by Watim Medical & Dental College at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact dr aimen zafar Aimen zafar, bds (+923361056720, aimenali216@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain during mucoperiosteal flap elevation (time frame: During mucoperiosteal flap elevation on the day of surgery). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jan 2026.