Pain (Visceral, Somatic, or Neuropathic)Buccal TrunkNCT07330518
Comparison of Conventional Buccal Nerve Block Versus Buccal Nerve Trunk Block During Extraction of Posterior Mandibular Teeth
A study testing Conventional Buccal Nerve Block and Buccal Nerve Trunk Block in people with Pain (Visceral, Somatic, or Neuropathic), run by Watim Medical & Dental College at 1 site in Pakistan.
Trial summary
This randomised control trial will compare the efficacy of conventional buccal nerve block versus buccal trunk block using visual analogue scale to evaluate pain and additional anesthesia injection during extraction of mandibular molars. Read more about this study
- Who is it for?
- Ages 20 to 60 years
- Conditions the study is for
- Pain (Visceral, Somatic, or Neuropathic)
- What is being tested?
- Conventional Buccal Nerve Block and Buccal Nerve Trunk Block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 sitePakistan
- Study dates
- 20 Mar 2026to 1 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients aged 20 to 60 years
- Patients of both gender
- Patient requiring extraction of mandibular molars
Who cannot join
- Pregnant women
- Pathologies associated with teeth i.e. cysts, tumors
- Patients on radiotherapy or chemotherapy
- Patients with mandibular fracture
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Watim Medical College & Dental Hospital
Islamabad, Islamabad, Pakistan, 46500
Syed Saad Aftab Mohiuddin, BDS, 00923488572003, saadaftab94@gmail.com
About this study
Official title: Comparison of Conventional Buccal Nerve Block Versus Buccal Nerve Trunk Block for Anaesthesia of Buccal Mucosa During Extraction of Mandibular Posterior Teeth
This randomised control trial will compare the efficacy of conventional buccal nerve block versus buccal trunk block using visual analogue scale to evaluate pain and additional anesthesia injection during extraction of mandibular molars.
Read the detailed description
Dental extraction of mandibular posterior teeth require buccal mucosa anesthesia for pain free extraction. Conventional buccal nerve block is the commonly used technique for anesthesia of buccal mucosa but often is not effective and requires multiple injections. This study aims to compare coventional buccal nerve block with buccal nerve trunk block on the basis of Efficacy of local anesthesia which will be determined by need for supplemental infiltration: Use of more than 1 anesthesia cartridges during procedure will be labelled as need for supplemental infiltration.
Intraoperative pain perception: It was assessed while giving injection and during extraction of the tooth using the visual analog scale (VAS) scores. Score of more than 4 will be labelled as positive pain perception.
- Conditions
- Pain (Visceral, Somatic, or Neuropathic)
- Being tested
- Conventional Buccal Nerve Block, Buccal Nerve Trunk Block
- Keywords
- Buccal Trunk Block
- Medical subject headings
- Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional Buccal Nerve BlockProcedure or surgery
Arm Description: Administration of anesthesia at the level of occlusion lateral to last mandibular molar. Needle is inserted until bone contact is achieved. 1ml lidocaine with 1:100000 anesthesia is administered.
Buccal Nerve Trunk BlockProcedure or surgery
Arm Description: Administration of anesthesia 10 mm above occlusal plane lateral to last mandibular molar. 1ml lidocaine with 1:100000 anesthesia is administered.
| Study group | Role | What they receive |
|---|---|---|
| Conventional Buccal Nerve Block for anesthesia of buccal mucosa | Experimental | Administration of anesthesia using conventional buccal nerve block technique for anesthesia of buccal mucosa. Receives: Procedure: Conventional Buccal Nerve Block |
| Buccal Nerve Trunk Block | Experimental | Administration of anesthesia at the buccal trunk 10mm above the coventional buccal nerve block for anesthesia of buccal mucosa. Receives: Procedure: Buccal Nerve Trunk Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Intraoperative pain perception
It was assessed while giving injection and during extraction of the tooth using the visual analog scale (VAS) scores. Facial pain scale uses facial expression to evaluate the amount of pain. It has scores ranging from 0 to 10 with 0 as the least pain and 10 as the worst pain. Score of more than 4 will be labelled as positive pain perception.
Measured: Within 2hours of anesthesia administration
Need for supplemental infiltration
Use of more than 1 anesthesia cartridges during procedure will be labelled as need for supplemental infiltration.
Measured: Within 2 hour of initial anesthesia administration
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jan 2026
- Study start20 Mar 2026 (estimated)
- Primary completion1 Jan 2027 (estimated)
- Study completion1 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Pain (Visceral, Somatic, or Neuropathic)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Watim Medical & Dental College
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, SYED SAAD AFTAB, Watim Medical & Dental College
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07330518
- Sponsor's protocol ID
- WM&DCR/R&D(ERB)/2023/68
- Acronym
- Buccal Trunk
- Status last verified
- Dec 2025
- First submitted
- 8 Dec 2025
- Last updated
- 4 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
1.Risbaf-Fakoor S, Hashemzehi H, Jahantigh H, Arab K, Gholami L. Adjunctive low-level laser therapy using 980-nm diode laser after impacted mandibular third molar surgery: a randomized clinical trial. Avicenna J Clin Med. 2020; 26 (4):199-205. 2.Mahat A, Yadav R, Yadav A, Acharya P, Dongol A, Sagtani A et al. A comparative study of the effect of sutureless versus multiple sutures technique on complications following third molar surgery in Nepalese subpopulation. Int J Dent. 2020; 2020(1):1-6. 3.Sruthi MA, Ramakrishnan M. Transpapillary injection technique as a substitute for palatal infiltration: a split-mouth randomized clinical trial. Int J Clin Pediatr Dent. 2021; 14(5):640-3. 4.Decloux D, Ouanounou A. Local anaesthesia in dentistry: a review. Int Dent J. 2020; 71(2):87-95. 5.Wang YH, Wang DR, Liu JY, Pan J. Local anesthesia in oral and maxillofacial surgery: A review of current opinion. J Dent Sci. 2021; 16(4):1055-65. 6.Koyata T, Yanai C, Shionoya Y, Takasugi Y, Sunada K. Buccal nerve trunk block anesthetizes the buccal mucosa beyond the papilla of the parotid duct. J Oral Maxillofac Surg. 2023;81(3):272-9. 7.Figueiredo R, Sofos S, Soriano-Pons E, Camps-Font O, Sanmarti-Garcia G, Gay-Escoda C, Valmaseda-Castellón E. Is it possible to extract lower third molars with infiltration anaesthesia techniques using articaine? A double-blind randomized clinical trial. Acta Odontol. Scand. 2021 Jan 2;79(1):1-8.
Study at a glance
From the registry record, last updated by the sponsor on 4 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Conventional Buccal Nerve Block Versus Buccal Nerve Trunk Block for Anaesthesia of Buccal Mucosa During Extraction of Mandibular Posterior Teeth
- ClinicalTrials.gov ID
- NCT07330518
- Acronym / sponsor ID
- Buccal Trunk / WM&DCR/R&D(ERB)/2023/68
- Conditions
- Pain (Visceral, Somatic, or Neuropathic)
- Keywords
- Buccal Trunk Block
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Watim Medical & Dental CollegeUniversity, hospital or other
- Study start
- 20 Mar 2026 (estimated)
- Primary completion
- 1 Jan 2027 (estimated)
- Study completion
- 1 Jan 2027 (estimated)
- First posted
- 9 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomised control trial will compare the efficacy of conventional buccal nerve block versus buccal trunk block using visual analogue scale to evaluate pain and additional anesthesia injection during extraction of mandibular molars.
Detailed description
Dental extraction of mandibular posterior teeth require buccal mucosa anesthesia for pain free extraction. Conventional buccal nerve block is the commonly used technique for anesthesia of buccal mucosa but often is not effective and requires multiple injections. This study aims to compare coventional buccal nerve block with buccal nerve trunk block on the basis of Efficacy of local anesthesia which will be determined by need for supplemental infiltration: Use of more than 1 anesthesia cartridges during procedure will be labelled as need for supplemental infiltration.
Intraoperative pain perception: It was assessed while giving injection and during extraction of the tooth using the visual analog scale (VAS) scores. Score of more than 4 will be labelled as positive pain perception.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Conventional Buccal Nerve Block for anesthesia of buccal mucosa | Experimental | Procedure: Conventional Buccal Nerve BlockAdministration of anesthesia using conventional buccal nerve block technique for anesthesia of buccal mucosa. |
| Buccal Nerve Trunk Block | Experimental | Procedure: Buccal Nerve Trunk BlockAdministration of anesthesia at the buccal trunk 10mm above the coventional buccal nerve block for anesthesia of buccal mucosa. |
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Patients aged 20 to 60 years
- Patients of both gender
- Patient requiring extraction of mandibular molars
Key exclusion criteria (4 listed)
- Pregnant women
- Pathologies associated with teeth i.e. cysts, tumors
- Patients on radiotherapy or chemotherapy
- Patients with mandibular fracture
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional Buccal Nerve BlockArm Description: Administration of anesthesia at the level of occlusion lateral to last mandibular molar. Needle is inserted until bone contact is achieved. 1ml lidocaine with 1:100000 anesthesia is administered. | Procedure or surgery | Conventional Buccal Nerve Block for anesthesia of buccal mucosa |
| Buccal Nerve Trunk BlockArm Description: Administration of anesthesia 10 mm above occlusal plane lateral to last mandibular molar. 1ml lidocaine with 1:100000 anesthesia is administered. | Procedure or surgery | Buccal Nerve Trunk Block |
Primary outcome
Intraoperative pain perception
Time frame: Within 2hours of anesthesia administration
It was assessed while giving injection and during extraction of the tooth using the visual analog scale (VAS) scores. Facial pain scale uses facial expression to evaluate the amount of pain. It has scores ranging from 0 to 10 with 0 as the least pain and 10 as the worst pain. Score of more than 4 will be labelled as positive pain perception.
Need for supplemental infiltration
Time frame: Within 2 hour of initial anesthesia administration
Use of more than 1 anesthesia cartridges during procedure will be labelled as need for supplemental infiltration.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Feb 2026.
- Background1.Risbaf-Fakoor S, Hashemzehi H, Jahantigh H, Arab K, Gholami L. Adjunctive low-level laser therapy using 980-nm diode laser after impacted mandibular third molar surgery: a randomized clinical trial. Avicenna J Clin Med. 2020; 26 (4):199-205. 2.Mahat A, Yadav R, Yadav A, Acharya P, Dongol A, Sagtani A et al. A comparative study of the effect of sutureless versus multiple sutures technique on complications following third molar surgery in Nepalese subpopulation. Int J Dent. 2020; 2020(1):1-6. 3.Sruthi MA, Ramakrishnan M. Transpapillary injection technique as a substitute for palatal infiltration: a split-mouth randomized clinical trial. Int J Clin Pediatr Dent. 2021; 14(5):640-3. 4.Decloux D, Ouanounou A. Local anaesthesia in dentistry: a review. Int Dent J. 2020; 71(2):87-95. 5.Wang YH, Wang DR, Liu JY, Pan J. Local anesthesia in oral and maxillofacial surgery: A review of current opinion. J Dent Sci. 2021; 16(4):1055-65. 6.Koyata T, Yanai C, Shionoya Y, Takasugi Y, Sunada K. Buccal nerve trunk block anesthetizes the buccal mucosa beyond the papilla of the parotid duct. J Oral Maxillofac Surg. 2023;81(3):272-9. 7.Figueiredo R, Sofos S, Soriano-Pons E, Camps-Font O, Sanmarti-Garcia G, Gay-Escoda C, Valmaseda-Castellón E. Is it possible to extract lower third molars with infiltration anaesthesia techniques using articaine? A double-blind randomized clinical trial. Acta Odontol. Scand. 2021 Jan 2;79(1):1-8.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional Buccal Nerve Block and Buccal Nerve Trunk Block in people with Pain (Visceral, Somatic, or Neuropathic), run by Watim Medical & Dental College at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Syed Saad Aftab Mohiuddin (00923488572003, saadaftab94@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Intraoperative pain perception (time frame: Within 2hours of anesthesia administration). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07330518, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Feb 2026.