Knee InjuriesNCT07300098
Epidemiological Evaluation of Knee Injuries in Children Admitted to Assiut University Hospitals From 2022 to 2025.
An observational study of Knee Injuries, run by Assiut University at 1 site in Egypt.
Trial summary
To categorize and analyze the incidence of the knee injuries in children admitted in Assiut University from 2022 to 2025 and to establish a data base about children less than 18 years who have knee injuries for further studies. Read more about this study
- Who is it for?
- Ages 1 year to 18 years
- Conditions the study is for
- Knee Injuries
- How many people
- 300 participants
- Where
- 1 siteEgypt
- Study dates
- 10 Dec 2025to 1 Jan 2026
- How long will I take part?
- 10 Weeks
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 1 year to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: Children admitted with knee injuries (open or closed) in Assiut University.
Who may be able to join
- Children admitted with knee injuries (open or closed) in Assiut University.
Who cannot join
- No
Trial locations and contacts
1 site in 1 country.
About this study
To categorize and analyze the incidence of the knee injuries in children admitted in Assiut University from 2022 to 2025 and to establish a data base about children less than 18 years who have knee injuries for further studies.
Read the detailed description
Knee injuries are common in children and constitute about 5 %of the injuries presenting to emergency department in 1 to 18 y age group . The presence of physis or growth plate, which is weaker compared to the adjacent ligaments make injury patterns in children different from those in adults, as the same amount of force would produce a physeal fracture or avulsion injury in children but a ligament injury in an adult.
Kraus et al. divided patients according to age to infants (younger than 1 year); pre-school aged children (1-6 years); prepubertal school-aged children (7-10 years); early adolescent patients (11-14 years); late adolescent patients (15-18 years) and a five diagnosis-related groups : extraarticular soft tissue injuries, intraarticular soft tissue injuries, patella disorders, fractures, and overload injuries. They found extraarticular soft tissue injuries were most common and fractures were rare.
Skak et al found that children with ligament injuries and physeal fractures had a median age of 12 years. No lesions of the cruciate ligaments without bony avulsion were diagnosed. the most frequent cause of injuries was falls.
The most frequent traumatic injuries reported involve the cruciate and collateral ligaments (medial collateral ligament [MCL], posterior cruciate ligament [PCL], anterior cruciate ligament [ACL], and lateral collateral ligament [LCL]), menisci, and patella. Overall, females are reported to have a higher risk of sustaining a knee injury than males. Ligament injuries ,specifically ACL injuries, are among the most devastating knee injuries for young patients. Female patients have two to eight times greater risk of sustaining an ACL injury as compared with male patients. After ACL injury, there is a significant risk of developing osteoarthritis regardless of the treatment intervention, such as ACL on surgery.
The rationale of the research is to establish a data base about children less than 18 years who have knee injuries for further studies.
research and injury pattern analysis. All imaging studies stored in PACS and the operative notes and clinical data documented will be verified to enhance data validity and completeness.
The data collection process will not be limited to basic demographic and diagnostic variables. A comprehensive data abstraction form will be developed to ensure standardized retrieval of relevant clinical presentation, radiological, and final management of the patients. The extracted data will include mechanism and date of trauma, anatomical injury characteristics, associated injuries, type of management (conservative or operative), intra-operative details when applicable, radiological findings.
2.4.5 -Research outcome measures:
- Primary (main): The epidemiology (incidence and patterns) of knee injuries among children (<18 years) admitted to Assiut University Hospitals between 2022 and 2025 to establish a data base about children less than 18 years who have knee injuries for further studies .and all extracted data and radiological images will be securely entered into a password-protected, anonymized electronic database (such as Red cap) to ensure confidentiality, facilitate statistical analysis, and allow future reference by the research team in compliance with institutional ethical standards.
- Secondary (subsidiary): none
- Conditions
- Knee Injuries
- Keywords
- knee injuries
- Medical subject headings
- Knee Injuries
What is being measured
The primary outcome is the main question the study is designed to answer.
establish a data base about children less than 18 years who have knee injuries for further studies
The epidemiology (incidence and patterns) of knee injuries among children (<18 years) admitted to Assiut University Hospitals between 2022 and 2025 to establish a data base about children less than 18 years who have knee injuries for further studies .and all extracted data and radiological images will be securely entered into a password-protected, anonymized electronic database (such as Red cap) to ensure confidentiality, facilitate statistical analysis, and allow future reference by the research team in compliance with institutional ethical standards.
Measured: between 2022 and 2025
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Dec 2025
- Study start10 Dec 2025
- Primary completion1 Jan 2026 (estimated)
- Study completion1 Jan 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for Knee InjuriesStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 300 participants (estimated)
- Target duration
- 10 Weeks
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohamed Mahmoud Ebrahim Abd Allah, Assiut University
- Investigators
- Nariman Abol Oyoun, associated prof, Study chair, Assiut UniversityHatem Galal El-Din Zaki, prof, Study chair, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07300098
- Sponsor's protocol ID
- evaluation of knee injuries
- Status last verified
- Dec 2025
- First submitted
- 10 Dec 2025
- Last updated
- 23 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
O'Kane JW, Neradilek M, Polissar N, Sabado L, Tencer A, Schiff MA. Risk Factors for Lower Extremity Overuse Injuries in Female Youth Soccer Players. Orthop J Sports Med. 2017 Oct 23;5(10):2325967117733963. doi: 10.1177/2325967117733963. eCollection 2017 Oct.
PubMed 29114563Arnold A, Thigpen CA, Beattie PF, Kissenberth MJ, Shanley E. Overuse Physeal Injuries in Youth Athletes. Sports Health. 2017 Mar/Apr;9(2):139-147. doi: 10.1177/1941738117690847. Epub 2017 Feb 6.
PubMed 28165873Swenson DM, Collins CL, Best TM, Flanigan DC, Fields SK, Comstock RD. Epidemiology of knee injuries among U.S. high school athletes, 2005/2006-2010/2011. Med Sci Sports Exerc. 2013 Mar;45(3):462-9. doi: 10.1249/MSS.0b013e318277acca.
PubMed 23059869Butler LS, Janosky JJ, Sugimoto D. Pediatric and Adolescent Knee Injuries: Risk Factors and Preventive Strategies. Clin Sports Med. 2022 Oct;41(4):799-820. doi: 10.1016/j.csm.2022.05.011.
PubMed 36210172Skak SV, Jensen TT, Poulsen TD, Sturup J. Epidemiology of knee injuries in children. Acta Orthop Scand. 1987 Feb;58(1):78-81. doi: 10.3109/17453678709146348.
PubMed 3577744Kraus T, Svehlik M, Singer G, Schalamon J, Zwick E, Linhart W. The epidemiology of knee injuries in children and adolescents. Arch Orthop Trauma Surg. 2012 Jun;132(6):773-9. doi: 10.1007/s00402-012-1480-0. Epub 2012 Feb 23.
PubMed 22358221Parikh SN, Shrivastava RK. Evaluation of Children with Injuries Around the Knee. Indian J Pediatr. 2016 Aug;83(8):844-51. doi: 10.1007/s12098-015-1993-y. Epub 2016 Feb 29.
PubMed 26924653
Study at a glance
From the registry record, last updated by the sponsor on 23 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Epidemiological Evaluation of Knee Injuries in Children Admitted to Assiut University Hospitals From 2022 to 2025.
- ClinicalTrials.gov ID
- NCT07300098
- Acronym / sponsor ID
- evaluation of knee injuries
- Conditions
- Knee Injuries
- Keywords
- knee injuries
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 300 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 10 Dec 2025 (actual)
- Primary completion
- 1 Jan 2026 (estimated)
- Study completion
- 1 Jan 2026 (estimated)
- First posted
- 23 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To categorize and analyze the incidence of the knee injuries in children admitted in Assiut University from 2022 to 2025 and to establish a data base about children less than 18 years who have knee injuries for further studies.
Detailed description
Knee injuries are common in children and constitute about 5 %of the injuries presenting to emergency department in 1 to 18 y age group . The presence of physis or growth plate, which is weaker compared to the adjacent ligaments make injury patterns in children different from those in adults, as the same amount of force would produce a physeal fracture or avulsion injury in children but a ligament injury in an adult.
Kraus et al. divided patients according to age to infants (younger than 1 year); pre-school aged children (1-6 years); prepubertal school-aged children (7-10 years); early adolescent patients (11-14 years); late adolescent patients (15-18 years) and a five diagnosis-related groups : extraarticular soft tissue injuries, intraarticular soft tissue injuries, patella disorders, fractures, and overload injuries. They found extraarticular soft tissue injuries were most common and fractures were rare.
Skak et al found that children with ligament injuries and physeal fractures had a median age of 12 years. No lesions of the cruciate ligaments without bony avulsion were diagnosed. the most frequent cause of injuries was falls.
The most frequent traumatic injuries reported involve the cruciate and collateral ligaments (medial collateral ligament [MCL], posterior cruciate ligament [PCL], anterior cruciate ligament [ACL], and lateral collateral ligament [LCL]), menisci, and patella. Overall, females are reported to have a higher risk of sustaining a knee injury than males. Ligament injuries ,specifically ACL injuries, are among the most devastating knee injuries for young patients. Female patients have two to eight times greater risk of sustaining an ACL injury as compared with male patients. After ACL injury, there is a significant risk of developing osteoarthritis regardless of the treatment intervention, such as ACL on surgery.
The rationale of the research is to establish a data base about children less than 18 years who have knee injuries for further studies.
research and injury pattern analysis. All imaging studies stored in PACS and the operative notes and clinical data documented will be verified to enhance data validity and completeness.
The data collection process will not be limited to basic demographic and diagnostic variables. A comprehensive data abstraction form will be developed to ensure standardized retrieval of relevant clinical presentation, radiological, and final management of the patients. The extracted data will include mechanism and date of trauma, anatomical injury characteristics, associated injuries, type of management (conservative or operative), intra-operative details when applicable, radiological findings.
2.4.5 -Research outcome measures:
- Primary (main): The epidemiology (incidence and patterns) of knee injuries among children (<18 years) admitted to Assiut University Hospitals between 2022 and 2025 to establish a data base about children less than 18 years who have knee injuries for further studies .and all extracted data and radiological images will be securely entered into a password-protected, anonymized electronic database (such as Red cap) to ensure confidentiality, facilitate statistical analysis, and allow future reference by the research team in compliance with institutional ethical standards.
- Secondary (subsidiary): none
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 10 Weeks
Who may qualify
- Ages
- 1 year to 18 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- Children admitted with knee injuries (open or closed) in Assiut University.
Key inclusion criteria (1 listed)
- Children admitted with knee injuries (open or closed) in Assiut University.
Key exclusion criteria (1 listed)
- No
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
establish a data base about children less than 18 years who have knee injuries for further studies
Time frame: between 2022 and 2025
The epidemiology (incidence and patterns) of knee injuries among children (<18 years) admitted to Assiut University Hospitals between 2022 and 2025 to establish a data base about children less than 18 years who have knee injuries for further studies .and all extracted data and radiological images will be securely entered into a password-protected, anonymized electronic database (such as Red cap) to ensure confidentiality, facilitate statistical analysis, and allow future reference by the research team in compliance with institutional ethical standards.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Dec 2025.
- Results publication: PubMed 29114563O'Kane JW, Neradilek M, Polissar N, Sabado L, Tencer A, Schiff MA. Risk Factors for Lower Extremity Overuse Injuries in Female Youth Soccer Players. Orthop J Sports Med. 2017 Oct 23;5(10):2325967117733963. doi: 10.1177/2325967117733963. eCollection 2017 Oct.
- Results publication: PubMed 28165873Arnold A, Thigpen CA, Beattie PF, Kissenberth MJ, Shanley E. Overuse Physeal Injuries in Youth Athletes. Sports Health. 2017 Mar/Apr;9(2):139-147. doi: 10.1177/1941738117690847. Epub 2017 Feb 6.
- Results publication: PubMed 23059869Swenson DM, Collins CL, Best TM, Flanigan DC, Fields SK, Comstock RD. Epidemiology of knee injuries among U.S. high school athletes, 2005/2006-2010/2011. Med Sci Sports Exerc. 2013 Mar;45(3):462-9. doi: 10.1249/MSS.0b013e318277acca.
- Results publication: PubMed 36210172Butler LS, Janosky JJ, Sugimoto D. Pediatric and Adolescent Knee Injuries: Risk Factors and Preventive Strategies. Clin Sports Med. 2022 Oct;41(4):799-820. doi: 10.1016/j.csm.2022.05.011.
- Results publication: PubMed 3577744Skak SV, Jensen TT, Poulsen TD, Sturup J. Epidemiology of knee injuries in children. Acta Orthop Scand. 1987 Feb;58(1):78-81. doi: 10.3109/17453678709146348.
- Results publication: PubMed 22358221Kraus T, Svehlik M, Singer G, Schalamon J, Zwick E, Linhart W. The epidemiology of knee injuries in children and adolescents. Arch Orthop Trauma Surg. 2012 Jun;132(6):773-9. doi: 10.1007/s00402-012-1480-0. Epub 2012 Feb 23.
- Results publication: PubMed 26924653Parikh SN, Shrivastava RK. Evaluation of Children with Injuries Around the Knee. Indian J Pediatr. 2016 Aug;83(8):844-51. doi: 10.1007/s12098-015-1993-y. Epub 2016 Feb 29.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nariman Abol Oyoun, associated prof study chair
Assiut University
Hatem Galal El-Din Zaki, prof study chair
Assiut University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Knee Injuries, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 23 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
establish a data base about children less than 18 years who have knee injuries for further studies (time frame: between 2022 and 2025). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07300098, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Dec 2025.