Vitamin CNCT07302828
Effect of Double Nutri® Liposomal Encapsulation Technology on Human Absorption of Vitamin C and Glutathione Liquid Sachet
A study testing Vitamin C and Glutathione without liposome and Liposomal Vitamin C and Glutathione in people with Vitamin C and Glutathione, run by TCI Co., Ltd. at 1 site in Taiwan.
Trial summary
The objective of this study is to evaluate whether Double Nutri® liposomal encapsulation technology can enhance the oral absorption of liquid vitamin C and glutathione supplements in humans. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Vitamin C, Glutathione
- What is being tested?
- Vitamin C and Glutathione without liposome and Liposomal Vitamin C and Glutathione
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteTaiwan
- Study dates
- 15 Dec 2025to 2 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older, of any sex, who are willing to sign the informed consent form and are able to fully comply with all study procedures.
Who cannot join
- Pregnant or breastfeeding women, or individuals unwilling to use physical contraceptive methods during the study period, such as condoms or intrauterine devices (IUDs).
- Employees of TCI Co., Ltd and their family members.
- Individuals who, within 30 days prior to study initiation, have been taking vitamin C supplements at doses greater than 200 mg per day, glutathione supplements at doses greater than 100 mg per day, or medications that may affect endogenous vitamin C or glutathione levels, such as oral contraceptives and estrogen preparations (including ethinylestradiol, desogestrel, gestodene, drospirenone, cyproterone acetate), or acetaminophen.
- Individuals with chronic gastrointestinal diseases (including irritable bowel syndrome [IBS], inflammatory bowel disease [IBD], chronic diarrhea, Crohn's disease, celiac disease, bowel control disorders/fecal incontinence, pancreatitis, peptic ulcer disease, colorectal cancer, short bowel syndrome, and ulcerative colitis), a history of epilepsy or seizures, liver or kidney disease, malignancy, endocrine disorders, psychiatric disorders, alcohol or drug abuse, or other significant organic diseases based on medical history.
- Individuals who have undergone gastrointestinal surgery, organ transplantation, or other major surgical procedures.
- Individuals who experienced acute gastroenteritis within two weeks prior to study initiation.
- Individuals with a known allergy to any components of the testing samples.
Trial locations and contacts
1 site in 1 country.
About this study
The objective of this study is to evaluate whether Double Nutri® liposomal encapsulation technology can enhance the oral absorption of liquid vitamin C and glutathione supplements in humans.
Read the detailed description
This study is a single-center, self-controlled crossover human trial designed to evaluate the differences in blood concentration changes and bioavailability following a single oral dose of liquid vitamin C and glutathione supplements.
Healthy adult participants aged 18 years and older will be enrolled. Each participant will complete two study sessions, with a minimum washout period of 7 days between sessions. On each study day, venous blood samples will be collected prior to test product administration (0 minutes) to assess vitamin C levels, glutathione levels, complete blood count, blood lipids, blood glucose, and liver and kidney function indicators.
After baseline blood collection, a standardized breakfast will be provided and consumed within 10 minutes, followed by administration of the test product. Venous blood samples will then be collected at 0.5, 1, 2, 4, 6, and 8 hours post-intake to measure vitamin C and glutathione concentrations. Lunch will be provided after the 4-hour blood draw, and dinner will be provided after the 8-hour blood draw. Identical meals will be provided during both study sessions.
- Conditions
- Vitamin C, Glutathione
- Being tested
- Vitamin C and Glutathione without liposome, Liposomal Vitamin C and Glutathione
- Keywords
- vitamin c, glutathione, liposomal, human bioavailability, Double Nutri
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vitamin C and Glutathione without liposomeDietary supplement
Each administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione.
Liposomal Vitamin C and GlutathioneDietary supplement
Also called GLUTA BRIGHT, Double Nutri Vitamin C and Glutathione
Each administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione, and the product is processed using the Double Nutri liposomal technology.
| Study group | Role | What they receive |
|---|---|---|
| Vitamin C and Glutathione without liposome | Active comparator | Each administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione Receives: Dietary Supplement: Vitamin C and Glutathione without liposome |
| Liposomal Vitamin C and Glutathione | Experimental | Each administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione, and the test sample is processed using the Double Nutri liposomal technology Receives: Dietary Supplement: Liposomal Vitamin C and Glutathione |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood vitamin C level (ug/mL)
Blood vitamin C levels will be measured at fasting and at 0.5, 1, 2, 4, 6, and 8 hours post-intake.
Measured: at 8 hours after taking test sample
Blood glutathione level (μmol/L)
Whole blood glutathione levels will be measured at fasting and at 0.5, 1, 2, 4, 6, and 8 hours post-intake.
Measured: at 8 hours after taking test sample
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Dec 2025
- Study start15 Dec 2025
- Primary completion16 Jan 2026
- Study completion2 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Vitamin CStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- TCI Co., Ltd.
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Tong-Lin Wu, Principal investigator, TCI Co., Ltd.
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07302828
- Sponsor's protocol ID
- 25-098-A
- Status last verified
- Feb 2026
- First submitted
- 11 Dec 2025
- Last updated
- 3 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Double Nutri® Liposomal Encapsulation Technology on Human Absorption of Vitamin C and Glutathione Liquid Sachet
- ClinicalTrials.gov ID
- NCT07302828
- Acronym / sponsor ID
- 25-098-A
- Conditions
- Vitamin C, Glutathione
- Keywords
- vitamin c, glutathione, liposomal, human bioavailability, Double Nutri
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- TCI Co., Ltd.Industry (pharma, biotech, devices)
- Study start
- 15 Dec 2025 (actual)
- Primary completion
- 16 Jan 2026 (actual)
- Study completion
- 2 Feb 2026 (actual)
- First posted
- 24 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this study is to evaluate whether Double Nutri® liposomal encapsulation technology can enhance the oral absorption of liquid vitamin C and glutathione supplements in humans.
Detailed description
This study is a single-center, self-controlled crossover human trial designed to evaluate the differences in blood concentration changes and bioavailability following a single oral dose of liquid vitamin C and glutathione supplements.
Healthy adult participants aged 18 years and older will be enrolled. Each participant will complete two study sessions, with a minimum washout period of 7 days between sessions. On each study day, venous blood samples will be collected prior to test product administration (0 minutes) to assess vitamin C levels, glutathione levels, complete blood count, blood lipids, blood glucose, and liver and kidney function indicators.
After baseline blood collection, a standardized breakfast will be provided and consumed within 10 minutes, followed by administration of the test product. Venous blood samples will then be collected at 0.5, 1, 2, 4, 6, and 8 hours post-intake to measure vitamin C and glutathione concentrations. Lunch will be provided after the 4-hour blood draw, and dinner will be provided after the 8-hour blood draw. Identical meals will be provided during both study sessions.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Vitamin C and Glutathione without liposome | Active comparator | Dietary Supplement: Vitamin C and Glutathione without liposomeEach administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione |
| Liposomal Vitamin C and Glutathione | Experimental | Dietary Supplement: Liposomal Vitamin C and GlutathioneEach administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione, and the test sample is processed using the Double Nutri liposomal technology |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Adults aged 18 years or older, of any sex, who are willing to sign the informed consent form and are able to fully comply with all study procedures.
Key exclusion criteria (7 listed)
- Pregnant or breastfeeding women, or individuals unwilling to use physical contraceptive methods during the study period, such as condoms or intrauterine devices (IUDs).
- Employees of TCI Co., Ltd and their family members.
- Individuals who, within 30 days prior to study initiation, have been taking vitamin C supplements at doses greater than 200 mg per day, glutathione supplements at doses greater than 100 mg per day, or medications that may affect endogenous vitamin C or glutathione levels, such as oral contraceptives and estrogen preparations (including ethinylestradiol, desogestrel, gestodene, drospirenone, cyproterone acetate), or acetaminophen.
- Individuals with chronic gastrointestinal diseases (including irritable bowel syndrome [IBS], inflammatory bowel disease [IBD], chronic diarrhea, Crohn's disease, celiac disease, bowel control disorders/fecal incontinence, pancreatitis, peptic ulcer disease, colorectal cancer, short bowel syndrome, and ulcerative colitis), a history of epilepsy or seizures, liver or kidney disease, malignancy, endocrine disorders, psychiatric disorders, alcohol or drug abuse, or other significant organic diseases based on medical history.
- Individuals who have undergone gastrointestinal surgery, organ transplantation, or other major surgical procedures.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vitamin C and Glutathione without liposomeEach administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione. | Dietary supplement | Vitamin C and Glutathione without liposome |
| Liposomal Vitamin C and GlutathioneAlso: GLUTA BRIGHT, Double Nutri Vitamin C and GlutathioneEach administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione, and the product is processed using the Double Nutri liposomal technology. | Dietary supplement | Liposomal Vitamin C and Glutathione |
Primary outcome
Blood vitamin C level (ug/mL)
Time frame: at 8 hours after taking test sample
Blood vitamin C levels will be measured at fasting and at 0.5, 1, 2, 4, 6, and 8 hours post-intake.
Blood glutathione level (μmol/L)
Time frame: at 8 hours after taking test sample
Whole blood glutathione levels will be measured at fasting and at 0.5, 1, 2, 4, 6, and 8 hours post-intake.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Tong-Lin Wu principal investigator
TCI Co., Ltd.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vitamin C and Glutathione without liposome and Liposomal Vitamin C and Glutathione in people with Vitamin C and Glutathione, run by TCI Co., Ltd. at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood vitamin C level (ug/mL) (time frame: at 8 hours after taking test sample). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Feb 2026; AzTrials last refreshed its copy on 1 Nov 2026.