Cervicogenic HeadacheNCT07310823
Mangement of Cervicogenic Headache by Maual Therapy
A study testing suboccipital myofacial release, maitland mobilization and combined myofacsial release with maitland mobilization in people with Cervicogenic Headache and Neck Pain Musculoskeletal, run by Cairo University at 1 site in Egypt.
Trial summary
This study aims to investigate immediate and short-term effect of combining suboccipital myofascial release with Maitland mobilization techniques on headache intensity, duration, and frequency, CFRT, upper cervical ROM, general neck mobility, and PPT of upper trapezius and suboccipital muscles. Read more about this study
- Who is it for?
- Ages 20 to 40 years
- Conditions the study is for
- Cervicogenic Headache, Neck Pain Musculoskeletal
- What is being tested?
- suboccipital myofacial release, maitland mobilization and combined myofacsial release with maitland mobilization
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 57 participants
- Where
- 1 siteEgypt
- Study dates
- 20 Dec 2025to 1 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Each patient will be included in our study if only he/she meets all of the following criteria:
- Age between 20- 40 year.
- No physiotherapy intervention at least for the last three months (Mohamed et al., 2019).
- Neck pain elicited and disturbed by neck movement or maintained position pain produced by pressure over upper cervical (Dunning et al.,2021).
- Limited neck motion with flexion and rotation test less than or equal 32 degree on both right and left side (Dunning et al.,2021).
- Patients suffered from intermittent headaches of varying duration and pain level at least once every week through the last 3 months (Hall et al., 2010; Khalil., et al 2019).
Show all 13Show fewer
- The patient will be excluded if he /she meets one of the following criteria:
- Physical therapy intervention during last three months (Mohamed et al., 2019).
- Primary headaches such as migraine or tension type headache (Mohammadi et al.,2021).
- Cervical radiculopathy, history of neck trauma and previous surgery at neck or shoulder, spondylosis (Mohammadi et al.,2021).
- Vertebrobasilar insufficiency or vestibular dysfunctions (Mohamed et al., 2019).
- Any degenerative vertebral lesion (Shabbir et al., 2021).
- Concomitant medical diagnosis of any primary headache (tension type or migraine) (Shabbir et al., 2021).
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: IMMEDIATE AND SHORT-TERM EFFECT OF COMBINING SUBOCCIPITAL MYOFASCIAL RELEASE WITH MAITLAND MOBILIZATION ON CERVICOGENIC HEADACHE
This study aims to investigate immediate and short-term effect of combining suboccipital myofascial release with Maitland mobilization techniques on headache intensity, duration, and frequency, CFRT, upper cervical ROM, general neck mobility, and PPT of upper trapezius and suboccipital muscles.
Read the detailed description
Cervicogenic headache (CGH) was firstly defined by Ottar Sjaastad a Norwegian neurologist in 1980 as subtype of headache that is irritated by cervical spine movement . CHG is not a primary cause of headache, yet it is a specific type of headache that is caused by different structural abnormalities of the upper neck region leading to neck pain . Headache generally was documented as a high prevalent condition among people. It was classified into three main different types including migraine, tension type and CGH . CGH is common among patients that is responsible for 15-20% of all headache types .
The underlying pathophysiological mechanism of CGH includes any structural abnormality or irritation of the three upper cervical segments (c1, c2 and c3) and muscles supplied by their nerves which consequently led to unilateral referred pain around anatomical bone structures of head, occipital, frontal and temporal regions . Upper cervical pain is the main characteristic of CGH that is presented in 80 percent of the cases . CGH originate from musculoskeletal component disorders such as spine or muscles or disc and another component that aggravates neck pain and mainly arises from upper cervical and atlantooccipital joint that refers symptoms to head or temporal area .
Management of CGH includes pharmacological and non-pharmacological treatment. Regarding the pharmacological treatment, it may relieve pain efficiently, yet, it has many side effects on both short and long term. On the other side, non-pharmacological therapy has positive effects on both pain and function with minimal side effects. It includes manual therapy such as massage, spinal manipulation, and myofascial release, ROM exercises, stretching exercises, strengthening exercise and mobilization techniques aiming at pain relief and curing headache.
The effect of manual therapy had been suggested to be due to modifying sensitivity of the trigeminocervical nucleus . Additionally, myofascial release as a type of manual therapy is observed to relieve pain that is caused by restriction of soft tissue and reduce tissue load that improves eventually ROM (Tavakkoli et al., 2024). Specifically, the myofascial release for the suboccipital region aims at reliving stress and increasing elasticity of suboccipital muscles that were shortened or spasmed due to long and bad body habits such as forward head posture.
The effect of suboccipital release has been documented in different studies according to a systematic review . It improves pain and ROM in patients with CGH. It is used as an immediate pain killer in suboccipital region and improve ROM along cervical and disability of neck during functional activities through correct forward head abnormality.
Another manual therapy technique is Maitland mobilization that includes using oscillation movement at specific joint for enhancing and restoring normal accessory movement of that joint by gliding, rolling, and spinning movement within the joint and is graded according to the aim of treatment . It helps in maintaining normal mobility by normalizing friction between bundle of muscle and nearing structure to reduce pressure on sensitive areas and eventually improving pain and function.
However, there are many authors studied the effect of suboccipital release and the effect of Maitland mobilization on CGH patients, yet, to authors knowledge, there is no study investigated the immediate and short-term combined effect of both suboccipital release with Maitland mobilization. Therefore, this study aims to investigate the immediate and short-term effect of combining suboccipital release with Maitland mobilization on headache intensity, duration, and frequency, cervical flexion rotation test (CFRT), upper cervical ROM, general neck mobility, and pressure pain threshold (PPT) of upper trapezius and suboccipital muscles.
Statement of The Problem This study will be conducted to answer the following question: What is the immediate and short-term effect of combining suboccipital myofascial release with Maitland mobilization techniques on headache intensity, duration, and frequency, CFRT, upper cervical ROM, general neck mobility, and PPT of upper trapezius and suboccipital muscles.
Purpose of The Study This study aims to investigate immediate and short-term effect of combining suboccipital myofascial release with Maitland mobilization techniques on headache intensity, duration, and frequency, CFRT, upper cervical ROM, general neck mobility, and PPT of upper trapezius and suboccipital muscles.
Significance of The Study Headache affects about 66% of population leading to pain, function deterioration, work productivity reduction and increase cost on society. It negatively impacts quality of life .
Suboccipital myofascial release had been documented as an effective method for manging CGH through improve neck disability pain and cervical ROM even than mulligan technique. It is also more effective than conventional physical therapy in reducing pain and intensity of CGH .
On the other hand, Maitland mobilization has been used for a variety of pain and ROM management in mechanical neck pain and CGH. When it had been used combined with postural correction for CGH, it improved pain and function disability more than conventional physical therapy.
As previously mentioned, there are many authors studied the effect of suboccipital release and the effect of Maitland mobilization solely on CGH patients, yet, to authors knowledge, there is no published studies on the immediate nor the short-term effect of combining suboccipital release with Maitland mobilization. Therefore, this study aims to investigate the immediate and short-term effect of combining suboccipital myofascial release with Maitland mobilization on headache intensity, duration, and frequency, CFRT, upper cervical ROM, general neck mobility, and PPT of upper trapezius and suboccipital muscles.
This study will improve the understanding of effective treatments for managing CGH. By examining the combination of soft tissue release with Maitland Mobilization, it highlights how these methods, when used together, can achieve better results in alleviating pain and reducing disability compared to applying each technique individually. This approach targets both joint dysfunction and muscle tension, promoting faster recovery, enhancing quality of life, and lowering healthcare costs. Additionally, this research provides physiotherapists and manual therapists with a practical guide for implementing non-invasive and cost-effective treatment protocols, reducing dependence on pharmacological or surgical interventions. Moreover, this study will broaden the scope for future investigations into combined manual therapy interventions for other musculoskeletal conditions. Ultimately, this study benefits practitioners, patients, and healthcare systems by offering a targeted, interdisciplinary approach to managing CGH effectively.
Delimitation
The study will be delimited to:
- Patients age will range from 20-40 years.
- Fifity- seven patients (both genders) .
- The International Classification of Headache Disorders-III criteria 2018 and CFRT as a base for selecting CGH.
- The VAS for assessing headache intensity.
- The CFRT for diagnosing CGH and evaluating patient progression.
- The CROM device for assessing the upper cervical ROM and the neck general mobility in all directions.
- The pressure algometer for measuring the PPT.
Basic Assumptions
It will be assumed that:
- All patients will follow all the given instructions strictly during the study duration, regarding the assessment and the treatment procedure.
- All participants will be evaluated under the same environmental conditions.
Hypotheses
- There will be no significant difference between using the three techniques (suboccipital myofascial release alone, Maitland mobilization alone, nor the combined protocol) on headache intensity in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on headache duration in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on headache frequency in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on CFRT in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on upper cervical ROM in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on general neck mobility in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on PPT of upper trapezius muscle in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on PPT of suboccipital muscle in patients with CGH neither immediately nor after one week follow up.
Definitions of Terms Cervicogenic headache (CGH): It is defined as secondary headache that is associated with cervical disorders and pain originate from upper cervical problem and refer to head and radiate into one or more area and exact mechanism is unknown .
Maitland mobilization: It is one of the popular physical therapy approaches in form of oscillation passive movement of the joint to reduce pain or decrease soft tissue stiffness to increase ROM.
Neck pain: It is a popular musculoskeletal disorder that causes pain in about 67% of people and occurs in upper thoracic spine that physiologically involves movement of neck and shoulder and exacerbate by bad posture.
Pressure pain threshold (PPT): is defined as the minimal amount of pressure where a sense of pressure first changes to pain.
It is defined as nuchal line inhibition technique at muscles surrounding base of the skull and C1 and C2 its technique to release facia by using gentle pressure and stretch for long duration
- Conditions
- Cervicogenic Headache, Neck Pain Musculoskeletal
- Being tested
- suboccipital myofacial release, maitland mobilization, combined myofacsial release with maitland mobilization
- Keywords
- cervicogenic headache, suboccipital myofacial release, maitland mobilization, neck pain, CROM
- Medical subject headings
- Post-Traumatic Headache, Neck Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
suboccipital myofacial releaseOther
one session of myofacial release for suboccipital muscle
maitland mobilizationOther
one session of upper cervical vertebral grade one and two mobilization
combined myofacsial release with maitland mobilizationOther
one session of myofacsial release and maitland mobilization for upper cervical and suboccipital muscle
| Study group | Role | What they receive |
|---|---|---|
| Group A (Suboccipital Myofascial Release) | Active comparator | Patients in this group will receive suboccipital myofascial release therapy for one session. Receives: Other: suboccipital myofacial release |
| Group B (Maitland Mobilization) | Active comparator | Patients in this group will receive Maitland mobilization therapy for one session. Receives: Other: maitland mobilization |
| Group C (Combined Group) | Active comparator | Patients in this group will receive both techniques; suboccipital myofascial release therapy then Maitland mobilization for one session. Receives: Other: combined myofacsial release with maitland mobilization |
What is being measured
The primary outcome is the main question the study is designed to answer.
headache intensity
headache intensity Description: headache intensity which represent the primary outcome by using numerical analogue scale for measure intensity before treatment and one week post treatment
Measured: Time Frame: before treatment and one week after treatment
Secondary outcomes (1)
Headache Frequency Headache Duration Cervical Flexion Rotation Test Neck Mobility Assessment Pressure Pain Threshold
Headache Frequency number of headache episode per day or week . headache duration time of headache during single episode .Cervical Flexion Rotation Test used for determine. upper cervical lesion Mobility Assessment using CROM device for measure ROM of all neck movement .Pressure Pain Threshold using algometer for measure pain threshold level at suboccipital and upper trapezius muscle
Measured: Headache Frequency and headache duration before and one week after treatment. Cervical Flexion Rotation Test and Mobility Assessment and Pressure Pain Threshold measurement before and after and one week post treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Dec 2025
- Study start20 Dec 2025 (estimated)
- Primary completion30 Jan 2026 (estimated)
- Study completion1 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Cervicogenic HeadacheStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- A randomized controlled trial in which patients will be randomly assigned into three equal groups (19 patients per group) via the RANDOM.ORG method. Each group will receive a specific physical therapy management according the following: * Group A (Suboccipital Myofascial Release): Patients in this group will receive suboccipital myofascial release therapy for one session. * Group B (Maitland Mobilization): Patients in this group will receive Maitland mobilization therapy for one session. * Group C (Combined Group): Patients in this group will receive both techniques; suboccipital myofascial release therapy then Maitland mobilization for one session.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 57 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohamed Alaa Mahmoud Ahmed, Cairo University
- Investigators
- . MAHA MOSTAFA MOHAMMED ALIBEINY, ASS.PROF, Study director, cairo uneversity faculty of physical therapy
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07310823
- Sponsor's protocol ID
- CGH mangment
- Status last verified
- Dec 2025
- First submitted
- 16 Dec 2025
- Last updated
- 30 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Verma S, Tripathi M, Chandra PS. Cervicogenic Headache: Current Perspectives. Neurol India. 2021 Mar-Apr;69(Supplement):S194-S198. doi: 10.4103/0028-3886.315992.
PubMed 34003165Priyanka, D. A. T. (2023). A Literature Review to Find the Effectiveness of Suboccipital Myofascial Release Technique in Reducing Cervicogenic Headache. Int J Sci Res, 12(4).
Lerner-Lentz A, O'Halloran B, Donaldson M, Cleland JA. Pragmatic application of manipulation versus mobilization to the upper segments of the cervical spine plus exercise for treatment of cervicogenic headache: a randomized clinical trial. J Man Manip Ther. 2021 Oct;29(5):267-275. doi: 10.1080/10669817.2020.1834322. Epub 2020 Nov 5.
PubMed 33148134
Study at a glance
From the registry record, last updated by the sponsor on 30 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- IMMEDIATE AND SHORT-TERM EFFECT OF COMBINING SUBOCCIPITAL MYOFASCIAL RELEASE WITH MAITLAND MOBILIZATION ON CERVICOGENIC HEADACHE
- ClinicalTrials.gov ID
- NCT07310823
- Acronym / sponsor ID
- CGH mangment
- Conditions
- Cervicogenic Headache, Neck Pain Musculoskeletal
- Keywords
- cervicogenic headache, suboccipital myofacial release, maitland mobilization, neck pain, CROM
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 57 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 20 Dec 2025 (estimated)
- Primary completion
- 30 Jan 2026 (estimated)
- Study completion
- 1 Feb 2026 (estimated)
- First posted
- 30 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate immediate and short-term effect of combining suboccipital myofascial release with Maitland mobilization techniques on headache intensity, duration, and frequency, CFRT, upper cervical ROM, general neck mobility, and PPT of upper trapezius and suboccipital muscles.
Detailed description
Cervicogenic headache (CGH) was firstly defined by Ottar Sjaastad a Norwegian neurologist in 1980 as subtype of headache that is irritated by cervical spine movement . CHG is not a primary cause of headache, yet it is a specific type of headache that is caused by different structural abnormalities of the upper neck region leading to neck pain . Headache generally was documented as a high prevalent condition among people. It was classified into three main different types including migraine, tension type and CGH . CGH is common among patients that is responsible for 15-20% of all headache types .
The underlying pathophysiological mechanism of CGH includes any structural abnormality or irritation of the three upper cervical segments (c1, c2 and c3) and muscles supplied by their nerves which consequently led to unilateral referred pain around anatomical bone structures of head, occipital, frontal and temporal regions . Upper cervical pain is the main characteristic of CGH that is presented in 80 percent of the cases . CGH originate from musculoskeletal component disorders such as spine or muscles or disc and another component that aggravates neck pain and mainly arises from upper cervical and atlantooccipital joint that refers symptoms to head or temporal area .
Management of CGH includes pharmacological and non-pharmacological treatment. Regarding the pharmacological treatment, it may relieve pain efficiently, yet, it has many side effects on both short and long term. On the other side, non-pharmacological therapy has positive effects on both pain and function with minimal side effects. It includes manual therapy such as massage, spinal manipulation, and myofascial release, ROM exercises, stretching exercises, strengthening exercise and mobilization techniques aiming at pain relief and curing headache.
The effect of manual therapy had been suggested to be due to modifying sensitivity of the trigeminocervical nucleus . Additionally, myofascial release as a type of manual therapy is observed to relieve pain that is caused by restriction of soft tissue and reduce tissue load that improves eventually ROM (Tavakkoli et al., 2024). Specifically, the myofascial release for the suboccipital region aims at reliving stress and increasing elasticity of suboccipital muscles that were shortened or spasmed due to long and bad body habits such as forward head posture.
The effect of suboccipital release has been documented in different studies according to a systematic review . It improves pain and ROM in patients with CGH. It is used as an immediate pain killer in suboccipital region and improve ROM along cervical and disability of neck during functional activities through correct forward head abnormality.
Another manual therapy technique is Maitland mobilization that includes using oscillation movement at specific joint for enhancing and restoring normal accessory movement of that joint by gliding, rolling, and spinning movement within the joint and is graded according to the aim of treatment . It helps in maintaining normal mobility by normalizing friction between bundle of muscle and nearing structure to reduce pressure on sensitive areas and eventually improving pain and function.
However, there are many authors studied the effect of suboccipital release and the effect of Maitland mobilization on CGH patients, yet, to authors knowledge, there is no study investigated the immediate and short-term combined effect of both suboccipital release with Maitland mobilization. Therefore, this study aims to investigate the immediate and short-term effect of combining suboccipital release with Maitland mobilization on headache intensity, duration, and frequency, cervical flexion rotation test (CFRT), upper cervical ROM, general neck mobility, and pressure pain threshold (PPT) of upper trapezius and suboccipital muscles.
Statement of The Problem This study will be conducted to answer the following question: What is the immediate and short-term effect of combining suboccipital myofascial release with Maitland mobilization techniques on headache intensity, duration, and frequency, CFRT, upper cervical ROM, general neck mobility, and PPT of upper trapezius and suboccipital muscles.
Purpose of The Study This study aims to investigate immediate and short-term effect of combining suboccipital myofascial release with Maitland mobilization techniques on headache intensity, duration, and frequency, CFRT, upper cervical ROM, general neck mobility, and PPT of upper trapezius and suboccipital muscles.
Significance of The Study Headache affects about 66% of population leading to pain, function deterioration, work productivity reduction and increase cost on society. It negatively impacts quality of life .
Suboccipital myofascial release had been documented as an effective method for manging CGH through improve neck disability pain and cervical ROM even than mulligan technique. It is also more effective than conventional physical therapy in reducing pain and intensity of CGH .
On the other hand, Maitland mobilization has been used for a variety of pain and ROM management in mechanical neck pain and CGH. When it had been used combined with postural correction for CGH, it improved pain and function disability more than conventional physical therapy.
As previously mentioned, there are many authors studied the effect of suboccipital release and the effect of Maitland mobilization solely on CGH patients, yet, to authors knowledge, there is no published studies on the immediate nor the short-term effect of combining suboccipital release with Maitland mobilization. Therefore, this study aims to investigate the immediate and short-term effect of combining suboccipital myofascial release with Maitland mobilization on headache intensity, duration, and frequency, CFRT, upper cervical ROM, general neck mobility, and PPT of upper trapezius and suboccipital muscles.
This study will improve the understanding of effective treatments for managing CGH. By examining the combination of soft tissue release with Maitland Mobilization, it highlights how these methods, when used together, can achieve better results in alleviating pain and reducing disability compared to applying each technique individually. This approach targets both joint dysfunction and muscle tension, promoting faster recovery, enhancing quality of life, and lowering healthcare costs. Additionally, this research provides physiotherapists and manual therapists with a practical guide for implementing non-invasive and cost-effective treatment protocols, reducing dependence on pharmacological or surgical interventions. Moreover, this study will broaden the scope for future investigations into combined manual therapy interventions for other musculoskeletal conditions. Ultimately, this study benefits practitioners, patients, and healthcare systems by offering a targeted, interdisciplinary approach to managing CGH effectively.
Delimitation
The study will be delimited to:
- Patients age will range from 20-40 years.
- Fifity- seven patients (both genders) .
- The International Classification of Headache Disorders-III criteria 2018 and CFRT as a base for selecting CGH.
- The VAS for assessing headache intensity.
- The CFRT for diagnosing CGH and evaluating patient progression.
- The CROM device for assessing the upper cervical ROM and the neck general mobility in all directions.
- The pressure algometer for measuring the PPT.
Basic Assumptions
It will be assumed that:
- All patients will follow all the given instructions strictly during the study duration, regarding the assessment and the treatment procedure.
- All participants will be evaluated under the same environmental conditions.
Hypotheses
- There will be no significant difference between using the three techniques (suboccipital myofascial release alone, Maitland mobilization alone, nor the combined protocol) on headache intensity in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on headache duration in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on headache frequency in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on CFRT in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on upper cervical ROM in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on general neck mobility in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on PPT of upper trapezius muscle in patients with CGH neither immediately nor after one week follow up.
- There will be no significant difference between using the three techniques on PPT of suboccipital muscle in patients with CGH neither immediately nor after one week follow up.
Definitions of Terms Cervicogenic headache (CGH): It is defined as secondary headache that is associated with cervical disorders and pain originate from upper cervical problem and refer to head and radiate into one or more area and exact mechanism is unknown .
Maitland mobilization: It is one of the popular physical therapy approaches in form of oscillation passive movement of the joint to reduce pain or decrease soft tissue stiffness to increase ROM.
Neck pain: It is a popular musculoskeletal disorder that causes pain in about 67% of people and occurs in upper thoracic spine that physiologically involves movement of neck and shoulder and exacerbate by bad posture.
Pressure pain threshold (PPT): is defined as the minimal amount of pressure where a sense of pressure first changes to pain.
It is defined as nuchal line inhibition technique at muscles surrounding base of the skull and C1 and C2 its technique to release facia by using gentle pressure and stretch for long duration
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
- Model description
- A randomized controlled trial in which patients will be randomly assigned into three equal groups (19 patients per group) via the RANDOM.ORG method. Each group will receive a specific physical therapy management according the following: * Group A (Suboccipital Myofascial Release): Patients in this group will receive suboccipital myofascial release therapy for one session. * Group B (Maitland Mobilization): Patients in this group will receive Maitland mobilization therapy for one session. * Group C (Combined Group): Patients in this group will receive both techniques; suboccipital myofascial release therapy then Maitland mobilization for one session.
| Arm | Type | Receives |
|---|---|---|
| Group A (Suboccipital Myofascial Release) | Active comparator | Other: suboccipital myofacial releasePatients in this group will receive suboccipital myofascial release therapy for one session. |
| Group B (Maitland Mobilization) | Active comparator | Other: maitland mobilizationPatients in this group will receive Maitland mobilization therapy for one session. |
| Group C (Combined Group) | Active comparator | Other: combined myofacsial release with maitland mobilizationPatients in this group will receive both techniques; suboccipital myofascial release therapy then Maitland mobilization for one session. |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (13 listed)
- Each patient will be included in our study if only he/she meets all of the following criteria:
- Age between 20- 40 year.
- No physiotherapy intervention at least for the last three months (Mohamed et al., 2019).
- Neck pain elicited and disturbed by neck movement or maintained position pain produced by pressure over upper cervical (Dunning et al.,2021).
- Limited neck motion with flexion and rotation test less than or equal 32 degree on both right and left side (Dunning et al.,2021).
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| suboccipital myofacial releaseone session of myofacial release for suboccipital muscle | Other | Group A (Suboccipital Myofascial Release) |
| maitland mobilizationone session of upper cervical vertebral grade one and two mobilization | Other | Group B (Maitland Mobilization) |
| combined myofacsial release with maitland mobilizationone session of myofacsial release and maitland mobilization for upper cervical and suboccipital muscle | Other | Group C (Combined Group) |
Primary outcome
headache intensity
Time frame: Time Frame: before treatment and one week after treatment
headache intensity Description: headache intensity which represent the primary outcome by using numerical analogue scale for measure intensity before treatment and one week post treatment
1 secondary outcome
Headache Frequency Headache Duration Cervical Flexion Rotation Test Neck Mobility Assessment Pressure Pain Threshold
Time frame: Headache Frequency and headache duration before and one week after treatment. Cervical Flexion Rotation Test and Mobility Assessment and Pressure Pain Threshold measurement before and after and one week post treatment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Dec 2025.
- Results publication: PubMed 34003165Verma S, Tripathi M, Chandra PS. Cervicogenic Headache: Current Perspectives. Neurol India. 2021 Mar-Apr;69(Supplement):S194-S198. doi: 10.4103/0028-3886.315992.
- Results publicationPriyanka, D. A. T. (2023). A Literature Review to Find the Effectiveness of Suboccipital Myofascial Release Technique in Reducing Cervicogenic Headache. Int J Sci Res, 12(4).
- Results publication: PubMed 33148134Lerner-Lentz A, O'Halloran B, Donaldson M, Cleland JA. Pragmatic application of manipulation versus mobilization to the upper segments of the cervical spine plus exercise for treatment of cervicogenic headache: a randomized clinical trial. J Man Manip Ther. 2021 Oct;29(5):267-275. doi: 10.1080/10669817.2020.1834322. Epub 2020 Nov 5.
- Individual participant dataSharing planned: No
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Recruiting
"Effectiveness of Kaltenborn Mobilization Techniques Versus Maitland Mobilization on Management of Cervicogenic Headache
Cervicogenic Headache
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
. MAHA MOSTAFA MOHAMMED ALIBEINY, ASS.PROF study director
cairo uneversity faculty of physical therapy
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing suboccipital myofacial release, maitland mobilization and combined myofacsial release with maitland mobilization in people with Cervicogenic Headache and Neck Pain Musculoskeletal, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 30 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
headache intensity (time frame: Time Frame: before treatment and one week after treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07310823, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Dec 2025.