Diabetes (DM)NCT07321223
Comparison of Different Doses of Vitamin D Supplementation on Glycated Haemoglobin and Blood Glucose Parameters With Type II Diabetes Mellitus Having Vitamin d Deficiency
A study testing Vitamin D in people with Diabetes (DM) and Vitamin D Deficiency, run by University of Lahore at 1 site in Pakistan.
Trial summary
COMPARISON OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON GLYCATED HEMOGLOBIN (HbA1c) and BLOOD GLUCOSE PARAMETRS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS HAVING VITAMIN D DEFICIENCY" Read more about this study
- Who is it for?
- Ages 40 to 70 years
- Conditions the study is for
- Diabetes (DM), Vitamin D Deficiency
- What is being tested?
- Vitamin D
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 108 participants
- Where
- 1 sitePakistan
- Study dates
- 22 Aug 2024to 22 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients diagnosed of T2DM with the age of 40-70 years from both genders taking only metformin with an Hb1Ac range of 7.5-9% and 25-hydroxy Vitamin D levels (25[OH]D) <20ng/ml. Exclusion Criteria: Individuals
- Exclusion Criteria: Individuals with the following conditions will not be included as participants;
- Inability or unwilling to participate or Clinical proximal myopathy
- Renal, hepatic, endocrinological disorders or malignancies on basis of history
- Serum calcium levels > 10.5mg/dl
- Use of insulin or any change in dosage of current hypoglycemic medications during last 3 months
- Intake of vitamin D, calcium or omega 3 supplements within the past 3 months
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
About this study
COMPARISON OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON GLYCATED HEMOGLOBIN (HbA1c) and BLOOD GLUCOSE PARAMETRS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS HAVING VITAMIN D DEFICIENCY"
- Conditions
- Diabetes (DM), Vitamin D Deficiency
- Being tested
- Vitamin D
- Keywords
- Diabetes Mellitus, Vitamin D Deficiency
- Medical subject headings
- Diabetes Mellitus, Vitamin D Deficiency
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vitamin DDietary supplement
Vitamin D supplement capsules (50,000 IU, 200000 IU)
| Study group | Role | What they receive |
|---|---|---|
| Treatment Group-1 | Experimental | Treatment vitamin D capsules with different dosage (50,000IU) once a week for 90days Receives: Dietary Supplement: Vitamin D |
| Placebo | No intervention | Only Metformin and Balance Diet |
| Treatment Group 2 | Experimental | Treatment vitamin D capsules with different dosage (200000IU) once a week for 90days Receives: Dietary Supplement: Vitamin D |
What is being measured
The primary outcome is the main question the study is designed to answer.
HbA1c
Measured: 90 days
Secondary outcomes (1)
Blood Safety Profile (LFTs, RFTs)
Measured: 90 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jan 2026
- Study start22 Aug 2024
- Primary completion22 Nov 2024
- Study completion22 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Diabetes (DM)Studies of the same condition, open and under way.
- More trials run by University of LahoreThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 108 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07321223
- Sponsor's protocol ID
- IRB-UOL-FAHS/880/2021
- Status last verified
- Jun 2025
- First submitted
- 21 Dec 2025
- Last updated
- 6 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 6 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Different Doses of Vitamin D Supplementation on Glycated Haemoglobin and Blood Glucose Parameters With Type II Diabetes Mellitus Having Vitamin d Deficiency
- ClinicalTrials.gov ID
- NCT07321223
- Acronym / sponsor ID
- IRB-UOL-FAHS/880/2021
- Conditions
- Diabetes (DM), Vitamin D Deficiency
- Keywords
- Diabetes Mellitus, Vitamin D Deficiency
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 108 participants (estimated)
- Lead sponsor
- University of LahoreUniversity, hospital or other
- Study start
- 22 Aug 2024 (actual)
- Primary completion
- 22 Nov 2024 (actual)
- Study completion
- 22 Feb 2026 (estimated)
- First posted
- 6 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
COMPARISON OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON GLYCATED HEMOGLOBIN (HbA1c) and BLOOD GLUCOSE PARAMETRS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS HAVING VITAMIN D DEFICIENCY"
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Treatment Group-1 | Experimental | Dietary Supplement: Vitamin DTreatment vitamin D capsules with different dosage (50,000IU) once a week for 90days |
| Placebo | No intervention | –Only Metformin and Balance Diet |
| Treatment Group 2 | Experimental | Dietary Supplement: Vitamin DTreatment vitamin D capsules with different dosage (200000IU) once a week for 90days |
Who may qualify
- Ages
- 40 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Patients diagnosed of T2DM with the age of 40-70 years from both genders taking only metformin with an Hb1Ac range of 7.5-9% and 25-hydroxy Vitamin D levels (25[OH]D) <20ng/ml. Exclusion Criteria: Individuals
- Exclusion Criteria: Individuals with the following conditions will not be included as participants;
- Inability or unwilling to participate or Clinical proximal myopathy
- Renal, hepatic, endocrinological disorders or malignancies on basis of history
- Serum calcium levels > 10.5mg/dl
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vitamin DVitamin D supplement capsules (50,000 IU, 200000 IU) | Dietary supplement | Treatment Group 2, Treatment Group-1 |
Primary outcome
HbA1c
Time frame: 90 days
1 secondary outcome
Blood Safety Profile (LFTs, RFTs)
Time frame: 90 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jan 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vitamin D in people with Diabetes (DM) and Vitamin D Deficiency, run by University of Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 6 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
HbA1c (time frame: 90 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jan 2026.