Oral Malodor (Halitosis)NCT07329062
Effect of Toothpastes on Oral Malodor
A study testing Propolis Containing Toothpaste, Probiotic containing toothpaste and Phosphate-based formulation toothpaste in people with Oral Malodor (Halitosis), run by Çankırı Karatekin University at 1 site in Turkey (Türkiye).
Trial summary
This study aimed to evaluate the effects of different toothpaste formulations on oral malodor in young adults, addressing the lack of clinical evidence regarding propolis- and probiotic-containing toothpastes, which have predominantly been investigated in mouthrinse, tablet, or chewing gum formulations. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Oral Malodor (Halitosis)
- What is being tested?
- Propolis Containing Toothpaste, Probiotic containing toothpaste and Phosphate-based formulation toothpaste
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 30 Jan 2025to 25 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- • No systemic diseases or medications known to cause halitosis
- No active periodontal disease requiring treatment
- No antibiotic use within the previous month
- No orthodontic or removable space-maintaining appliances
- Non-smokers
- Organoleptic score >0 and Breath-Checker® (BC) score >0 at baseline
Who cannot join
- Participants reporting systemic conditions, active periodontal therapy, smoking, or antibiotic usage were excluded.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Investigation of the Effect of Toothpastes With Different Ingredients on Oral Malodor in Young Adults
This study aimed to evaluate the effects of different toothpaste formulations on oral malodor in young adults, addressing the lack of clinical evidence regarding propolis- and probiotic-containing toothpastes, which have predominantly been investigated in mouthrinse, tablet, or chewing gum formulations.
Volunteers aged 18-30 years with baseline organoleptic assessment (OA) and Breath Checker® (BC) scores >0 were randomized into four toothpaste groups: propolis-containing (Glimo Beta), probiotic-containing (Glimo Pi), phosphate-based (Glimo Gamma), and a standard fluoride toothpaste (Sensodyne). Allocation concealment was ensured using identical coded containers, and outcome assessors were blinded. After exclusions, 52 participants completed the study. Oral malodor was evaluated at baseline (T0) and Day 14 (T1) using OA, BC measurements, and self-perceived oral malodor scores.
- Conditions
- Oral Malodor (Halitosis)
- Being tested
- Propolis Containing Toothpaste, Probiotic containing toothpaste, Phosphate-based formulation toothpaste, Standard fluoride toothpaste
- Keywords
- Oral Malodor, Propolis, Probiotic toothpaste
- Medical subject headings
- Halitosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Propolis Containing ToothpasteOther
Participants were instructed to brush their teeth using propolis toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.
Probiotic containing toothpasteOther
Participants were instructed to brush their teeth using probiotic toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.
Phosphate-based formulation toothpasteOther
Participants were instructed to brush their teeth using Phosphate-based formulation toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.
Standard fluoride toothpasteOther
Participants were instructed to brush their teeth using standard fluoride toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.
| Study group | Role | What they receive |
|---|---|---|
| Propolis containing toothpaste | Experimental | Participants in this arm used propolis containing toothpaste twice daily for routine oral hygiene during the study period. Receives: Other: Propolis Containing Toothpaste |
| probiotic containing toothpaste | Experimental | Participants in this arm used probiotic containing toothpaste twice daily for routine oral hygiene during the study period. Receives: Other: Probiotic containing toothpaste |
| Phosphate-based formulation toothpaste | Experimental | Participants in this arm used phosphate-based formulation toothpaste twice daily for routine oral hygiene during the study period. Receives: Other: Phosphate-based formulation toothpaste |
| Standard fluoride | Experimental | Participants in this arm used standard fluoride containing toothpaste twice daily for routine oral hygiene during the study period. Receives: Other: Standard fluoride toothpaste |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in oral malodor severity
Oral malodor was assessed using an organoleptic scoring method and a portable breath checker device. The change in scores from baseline to the end of the intervention period was evaluated.
Measured: Baseline and Day 14
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jan 2026
- Study start30 Jan 2025
- Primary completion30 Jun 2025
- Study completion25 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Oral Malodor (Halitosis)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- Çankırı Karatekin University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Basak Karasu, Çankırı Karatekin University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07329062
- Sponsor's protocol ID
- Approval No: 18, Date: 29/01/2
- Status last verified
- Jan 2026
- First submitted
- 29 Dec 2025
- Last updated
- 9 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared publicly due to privacy and ethical considerations.
Study at a glance
From the registry record, last updated by the sponsor on 9 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Effect of Toothpastes With Different Ingredients on Oral Malodor in Young Adults
- ClinicalTrials.gov ID
- NCT07329062
- Acronym / sponsor ID
- Approval No: 18, Date: 29/01/2
- Conditions
- Oral Malodor (Halitosis)
- Keywords
- Oral Malodor, Propolis, Probiotic toothpaste
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- Çankırı Karatekin UniversityUniversity, hospital or other
- Study start
- 30 Jan 2025 (actual)
- Primary completion
- 30 Jun 2025 (actual)
- Study completion
- 25 Dec 2025 (actual)
- First posted
- 9 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aimed to evaluate the effects of different toothpaste formulations on oral malodor in young adults, addressing the lack of clinical evidence regarding propolis- and probiotic-containing toothpastes, which have predominantly been investigated in mouthrinse, tablet, or chewing gum formulations.
Volunteers aged 18-30 years with baseline organoleptic assessment (OA) and Breath Checker® (BC) scores >0 were randomized into four toothpaste groups: propolis-containing (Glimo Beta), probiotic-containing (Glimo Pi), phosphate-based (Glimo Gamma), and a standard fluoride toothpaste (Sensodyne). Allocation concealment was ensured using identical coded containers, and outcome assessors were blinded. After exclusions, 52 participants completed the study. Oral malodor was evaluated at baseline (T0) and Day 14 (T1) using OA, BC measurements, and self-perceived oral malodor scores.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Propolis containing toothpaste | Experimental | Other: Propolis Containing ToothpasteParticipants in this arm used propolis containing toothpaste twice daily for routine oral hygiene during the study period. |
| probiotic containing toothpaste | Experimental | Other: Probiotic containing toothpasteParticipants in this arm used probiotic containing toothpaste twice daily for routine oral hygiene during the study period. |
| Phosphate-based formulation toothpaste | Experimental | Other: Phosphate-based formulation toothpasteParticipants in this arm used phosphate-based formulation toothpaste twice daily for routine oral hygiene during the study period. |
| Standard fluoride | Experimental | Other: Standard fluoride toothpasteParticipants in this arm used standard fluoride containing toothpaste twice daily for routine oral hygiene during the study period. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- • No systemic diseases or medications known to cause halitosis
Key exclusion criteria (1 listed)
- Participants reporting systemic conditions, active periodontal therapy, smoking, or antibiotic usage were excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Propolis Containing ToothpasteParticipants were instructed to brush their teeth using propolis toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene. | Other | Propolis containing toothpaste |
| Probiotic containing toothpasteParticipants were instructed to brush their teeth using probiotic toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene. | Other | probiotic containing toothpaste |
| Phosphate-based formulation toothpasteParticipants were instructed to brush their teeth using Phosphate-based formulation toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene. | Other | Phosphate-based formulation toothpaste |
| Standard fluoride toothpasteParticipants were instructed to brush their teeth using standard fluoride toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene. | Other | Standard fluoride |
Primary outcome
Change in oral malodor severity
Time frame: Baseline and Day 14
Oral malodor was assessed using an organoleptic scoring method and a portable breath checker device. The change in scores from baseline to the end of the intervention period was evaluated.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jan 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared publicly due to privacy and ethical considerations.
Related trials for Oral Malodor (Halitosis)
Not yet recruiting
Effects of a 50+ Toothpaste on Halitosis and Oral Comfort in Healthy Adults
Oral Malodor (Halitosis), Oral Dryness
Recruiting
The Additional Effect of Tongue Scraping on Halitosis Parameters in Initial Periodontal Therapy
Periodontitis, Halitosis
Enrolling by invitation
Investigating the Effect of Chlorine Dioxide and Chlorhexidine Mouthwash on Bad Breath
Halitosis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Propolis Containing Toothpaste, Probiotic containing toothpaste and Phosphate-based formulation toothpaste in people with Oral Malodor (Halitosis), run by Çankırı Karatekin University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in oral malodor severity (time frame: Baseline and Day 14). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jan 2026.