Metabolism ChangesNCT07341308
Does Vitamin C Increase the Body Heat Generated By The Nervous System?
A study testing Vitamin C in people with Metabolism Changes and Vitamin D, run by Colorado State University at 1 site in United States.
Trial summary
The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for… Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Metabolism Changes, Vitamin D
- What is being tested?
- Vitamin C
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteUnited States
- Study dates
- 17 Mar 2025to 8 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age 18-40 years (inclusive)
- Body mass index greater than or equal to 25 kg/m2 and less than 30 kg/m2
- Weight stable (no change in body mass greater than 5 Lbs. within the previous 6 months.
- Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits
- Competency in English as assessed by comprehension of the Informed Consent. This is study involves invasive procedures and infusion of a systemic vasoactive agent (isoproterenol); for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.
Who cannot join
- History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
- Pregnancy or breast feeding
- Habitual use of tobacco/nicotine products or recreational drugs (2 or more uses within the previous month)
- History of a "sulfite allergy" as it is a relative contraindication to isoproteronol use.
- Has ingested vitamin supplements and/or antioxidant supplements during the previous 4-weeks (e.g. Vitamin C, Vitamin E, Multi-vitamins, etc.)
Trial locations and contacts
1 site in 1 country.
United States1 site
Colorado State University
Fort Collins, Colorado, 80523
About this study
The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for overweight based on body mass index. The main question it aims to answer are:
- By how much does body temperature increase during stimulation of beta-adrenergic receptors when vitamin C is given.
- By how much does circulating vitamin D concentration increase during stimulation of beta-adrenergic receptors when vitamin C is given.
Read more
Participants will will be asked to:
- undergo measures of body temperature
- have blood sampled on two separate occasions: once during stimulation of beta adrenergic receptors, and once during stimulation of beta-adrenergic receptors while also been given vitamin C.
Read the detailed description
Participants will be required to visit the lab twice. During each visit, beta-adrenergic receptors will be stimulated with isoproterenol. The two visits are identical in every way with one exception: during one visit the isoproterenol will be delivered with saline only, and during the other visit the isoproterenol will be delivered with saline and vitamin C. The order of the visits will be randomized. Body temperature will be measured with a thermometer and a thermal camera. venous blood will be sampled and circulating vitamin D concentration will be quantified.
- Conditions
- Metabolism Changes, Vitamin D
- Being tested
- Vitamin C
- Keywords
- isoproterenol, vitamin c, vitamin d, body temperature
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vitamin COther
Vitamin C will be co-infused with isoproterenol
| Study group | Role | What they receive |
|---|---|---|
| Response to beta-adrenergic stimulation without vitamin C | No intervention | Isoproterenol will be infused with saline only |
| Adding vitamin C to beta-adrenergic receptor stilmulation | Experimental | Isoproterenol will be infused with vitamin C Receives: Other: Vitamin C |
What is being measured
The primary outcome is the main question the study is designed to answer.
Body Temperature
Body temperature will be measured using an oral thermometer
Measured: Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.
Vitamin D
Circulating vitamin D concentration
Measured: Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jan 2026
- Study start17 Mar 2025
- Primary completion8 Jun 2026
- Study completion8 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Metabolism ChangesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Colorado State University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Christopher Bell, PhD, Principal investigator, Colorado State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07341308
- Sponsor's protocol ID
- 6115
- Status last verified
- Jul 2026
- First submitted
- 5 Dec 2025
- Last updated
- 2 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Does Vitamin C Increase the Body Heat Generated By The Nervous System?
- ClinicalTrials.gov ID
- NCT07341308
- Acronym / sponsor ID
- 6115
- Conditions
- Metabolism Changes, Vitamin D
- Keywords
- isoproterenol, vitamin c, vitamin d, body temperature
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Colorado State UniversityUniversity, hospital or other
- Study start
- 17 Mar 2025 (actual)
- Primary completion
- 8 Jun 2026 (actual)
- Study completion
- 8 Dec 2026 (estimated)
- First posted
- 14 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for overweight based on body mass index. The main question it aims to answer are:
- By how much does body temperature increase during stimulation of beta-adrenergic receptors when vitamin C is given.
- By how much does circulating vitamin D concentration increase during stimulation of beta-adrenergic receptors when vitamin C is given.
Participants will will be asked to:
- undergo measures of body temperature
- have blood sampled on two separate occasions: once during stimulation of beta adrenergic receptors, and once during stimulation of beta-adrenergic receptors while also been given vitamin C.
Detailed description
Participants will be required to visit the lab twice. During each visit, beta-adrenergic receptors will be stimulated with isoproterenol. The two visits are identical in every way with one exception: during one visit the isoproterenol will be delivered with saline only, and during the other visit the isoproterenol will be delivered with saline and vitamin C. The order of the visits will be randomized. Body temperature will be measured with a thermometer and a thermal camera. venous blood will be sampled and circulating vitamin D concentration will be quantified.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Response to beta-adrenergic stimulation without vitamin C | No intervention | –Isoproterenol will be infused with saline only |
| Adding vitamin C to beta-adrenergic receptor stilmulation | Experimental | Other: Vitamin CIsoproterenol will be infused with vitamin C |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age 18-40 years (inclusive)
- Body mass index greater than or equal to 25 kg/m2 and less than 30 kg/m2
- Weight stable (no change in body mass greater than 5 Lbs. within the previous 6 months.
- Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits
- Competency in English as assessed by comprehension of the Informed Consent. This is study involves invasive procedures and infusion of a systemic vasoactive agent (isoproterenol); for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.
Key exclusion criteria (5 listed)
- History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
- Pregnancy or breast feeding
- Habitual use of tobacco/nicotine products or recreational drugs (2 or more uses within the previous month)
- History of a "sulfite allergy" as it is a relative contraindication to isoproteronol use.
- Has ingested vitamin supplements and/or antioxidant supplements during the previous 4-weeks (e.g. Vitamin C, Vitamin E, Multi-vitamins, etc.)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vitamin CVitamin C will be co-infused with isoproterenol | Other | Adding vitamin C to beta-adrenergic receptor stilmulation |
Primary outcome
Body Temperature
Time frame: Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.
Body temperature will be measured using an oral thermometer
Vitamin D
Time frame: Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.
Circulating vitamin D concentration
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Christopher Bell, PhD principal investigator
Colorado State University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vitamin C in people with Metabolism Changes and Vitamin D, run by Colorado State University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 2 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Body Temperature (time frame: Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jul 2026; AzTrials last refreshed its copy on 31 Oct 2026.