Carpal Tunnel SyndromeNCT07359274
Effects of Neurodynamic and Carpal Bone Mobilization in Mild-to-Moderate Carpal Tunnel Syndrome
A study testing Neurodynamic mobilization, Carpal bone mobilization and Splint in people with Carpal Tunnel Syndrome and Splints, run by Kutahya Health Sciences University at 1 site in Turkey (Türkiye).
Trial summary
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by compression of the median nerve at the wrist. Conservative interventions such as splinting and manual therapy are frequently used in individuals with mild-to-moderate CTS. Read more about this study
- Who is it for?
- Ages 20 to 55 years
- Conditions the study is for
- Carpal Tunnel Syndrome, Splints
- What is being tested?
- Neurodynamic mobilization, Carpal bone mobilization and Splint
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 93 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Jan 2026to 15 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 55 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Diagnosis of mild-to-moderate carpal tunnel syndrome confirmed by electrodiagnostic testing
- CTS symptoms for at least 3 months
- Ability to provide informed consent
Who cannot join
- Previous carpal tunnel surgery
- Diabetes mellitus or polyneuropathy
- Cervical radiculopathy
- Pregnancy or breastfeeding
- Central nervous system disorders
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Kutahya Health Sciences University Yoncalı Physical Therapy and Rehabilitation Hospital
Kütahya, Yoncalı, 43000
Merve Akdeniz Leblebicier, MD, 00902742600043 ext. 4343, merve1985akdeniz@hotmail.com
Esengül Alıcı, MD, 00902742600043 ext. 4343, essengulalici@gmail.com
About this study
Official title: Clinical and Morphological Effects of Neurodynamic Mobilization and Carpal Bone Mobilization Techniques in Patients With Mild-to-Moderate Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by compression of the median nerve at the wrist. Conservative interventions such as splinting and manual therapy are frequently used in individuals with mild-to-moderate CTS. Neurodynamic mobilization and carpal bone mobilization aim to improve neural and soft tissue mobility; however, their comparative effects on clinical outcomes and median nerve morphology are not fully understood.
This interventional, non-randomized clinical study aims to compare the clinical and ultrasonographic effects of neurodynamic mobilization plus splinting, carpal bone mobilization plus splinting, and splinting alone in patients with mild-to-moderate CTS. Ninety-three participants diagnosed with mild-to-moderate carpal tunnel syndrome based on electrodiagnostic criteria will be included. Participants will be allocated into three parallel groups without randomization. All participants will receive a neutral-position wrist splint as standard conservative care.
Read more
Two intervention groups will additionally receive either neurodynamic mobilization exercises or carpal bone mobilization techniques administered by a physiotherapist for four weeks. Clinical outcomes and median nerve morphology will be evaluated at baseline and immediately after the intervention period.
The primary outcome is the change in the Boston Carpal Tunnel Questionnaire score. Secondary outcomes include pain intensity, neuropathic pain, functional disability, muscle strength, pressure pain threshold, and ultrasonographic measurements of the median nerve.
- Conditions
- Carpal Tunnel Syndrome, Splints
- Being tested
- Neurodynamic mobilization, Carpal bone mobilization, Splint
- Medical subject headings
- Carpal Tunnel Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neurodynamic mobilizationOther
Median nerve neurodynamic mobilization exercises performed 5 sessions per week for 4 weeks.
Carpal bone mobilizationOther
Manual carpal bone mobilization techniques applied 5 sessions per week for 4 weeks.
SplintOther
Neutral-position wrist splint used during night-time for 4 weeks.
| Study group | Role | What they receive |
|---|---|---|
| neurodynamic mobs in addition splint | Experimental | Median nerve neurodynamic mobilization exercises administered by a physiotherapist for 4 weeks in addition to night-time wrist splint use Receives: Other: Neurodynamic mobilization; Other: Splint |
| Carpal Bone Mobilization + Splint | Experimental | Carpal bone mobilization techniques administered by a physiotherapist for 4 weeks in addition to night-time wrist splint use. Receives: Other: Carpal bone mobilization; Other: Splint |
| Splint only | Active comparator | Neutral-position wrist splint worn at night for 4 weeks. Receives: Other: Splint |
What is being measured
The primary outcome is the main question the study is designed to answer.
Boston Carpal Tunnel Questionnaire (BCTQ) Total Score
Change in Boston Carpal Tunnel Questionnaire (BCTQ) Total Score
Measured: Baseline to 4 weeks
Secondary outcomes (7)
Visual Analog Scale (VAS)
Pain intensity measured using a 10-cm visual analog scale.
Measured: Baseline to 4 weeks
Leeds Assessment of Neuropathic Symptoms and Signs (LANSS)
Change in Neuropathic Pain Score Assessed by Leeds Assessment of Neuropathic Symptoms and Signs (LANSS).
Measured: Baseline to 4 weeks
Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH)
Change in Upper Extremity Disability Assessed by Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH).
Measured: Baseline to 4 weeks
Grip Strength
Change Grip strength measured using a Jamar dynamometer.
Measured: Baseline to 4 weeks
Pinch Strength
Change in Pinch Strength measured using a Pinchmeter.
Measured: Baseline to 4 weeks
Pressure Pain Threshold
Change in pressure pain threshold assessed using J -Tech algometer.
Measured: Baseline to 4 weeks
Median Nerve Cross-Sectional Area
Change in Median Nerve Cross-Sectional Area Assessed by Ultrasonography.
Measured: Baseline to 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2026
- Study start15 Jan 2026 (estimated)
- Primary completion15 Jan 2027 (estimated)
- Study completion15 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Carpal Tunnel SyndromeStudies of the same condition, open and under way.
- More trials run by Kutahya Health Sciences UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 93 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Kutahya Health Sciences University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Merve Akdeniz Leblebicier, Kutahya Health Sciences University
- Investigators
- Merve Akdeniz Leblebicier, MD, Principal investigator, Kutahya Health Sciences University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07359274
- Sponsor's protocol ID
- Neurodynamic and Carpal Mobs
- Status last verified
- Jan 2026
- First submitted
- 13 Jan 2026
- Last updated
- 22 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical and Morphological Effects of Neurodynamic Mobilization and Carpal Bone Mobilization Techniques in Patients With Mild-to-Moderate Carpal Tunnel Syndrome
- ClinicalTrials.gov ID
- NCT07359274
- Acronym / sponsor ID
- Neurodynamic and Carpal Mobs
- Conditions
- Carpal Tunnel Syndrome, Splints
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 93 participants (estimated)
- Lead sponsor
- Kutahya Health Sciences UniversityUniversity, hospital or other
- Study start
- 15 Jan 2026 (estimated)
- Primary completion
- 15 Jan 2027 (estimated)
- Study completion
- 15 Mar 2027 (estimated)
- First posted
- 22 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by compression of the median nerve at the wrist. Conservative interventions such as splinting and manual therapy are frequently used in individuals with mild-to-moderate CTS. Neurodynamic mobilization and carpal bone mobilization aim to improve neural and soft tissue mobility; however, their comparative effects on clinical outcomes and median nerve morphology are not fully understood.
This interventional, non-randomized clinical study aims to compare the clinical and ultrasonographic effects of neurodynamic mobilization plus splinting, carpal bone mobilization plus splinting, and splinting alone in patients with mild-to-moderate CTS. Ninety-three participants diagnosed with mild-to-moderate carpal tunnel syndrome based on electrodiagnostic criteria will be included. Participants will be allocated into three parallel groups without randomization. All participants will receive a neutral-position wrist splint as standard conservative care.
Two intervention groups will additionally receive either neurodynamic mobilization exercises or carpal bone mobilization techniques administered by a physiotherapist for four weeks. Clinical outcomes and median nerve morphology will be evaluated at baseline and immediately after the intervention period.
The primary outcome is the change in the Boston Carpal Tunnel Questionnaire score. Secondary outcomes include pain intensity, neuropathic pain, functional disability, muscle strength, pressure pain threshold, and ultrasonographic measurements of the median nerve.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| neurodynamic mobs in addition splint | Experimental | Other: Neurodynamic mobilization, Other: SplintMedian nerve neurodynamic mobilization exercises administered by a physiotherapist for 4 weeks in addition to night-time wrist splint use |
| Carpal Bone Mobilization + Splint | Experimental | Other: Carpal bone mobilization, Other: SplintCarpal bone mobilization techniques administered by a physiotherapist for 4 weeks in addition to night-time wrist splint use. |
| Splint only | Active comparator | Other: SplintNeutral-position wrist splint worn at night for 4 weeks. |
Who may qualify
- Ages
- 20 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Diagnosis of mild-to-moderate carpal tunnel syndrome confirmed by electrodiagnostic testing
- CTS symptoms for at least 3 months
- Ability to provide informed consent
Key exclusion criteria (5 listed)
- Previous carpal tunnel surgery
- Diabetes mellitus or polyneuropathy
- Cervical radiculopathy
- Pregnancy or breastfeeding
- Central nervous system disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neurodynamic mobilizationMedian nerve neurodynamic mobilization exercises performed 5 sessions per week for 4 weeks. | Other | neurodynamic mobs in addition splint |
| Carpal bone mobilizationManual carpal bone mobilization techniques applied 5 sessions per week for 4 weeks. | Other | Carpal Bone Mobilization + Splint |
| SplintNeutral-position wrist splint used during night-time for 4 weeks. | Other | Carpal Bone Mobilization + Splint, Splint only, neurodynamic mobs in addition splint |
Primary outcome
Boston Carpal Tunnel Questionnaire (BCTQ) Total Score
Time frame: Baseline to 4 weeks
Change in Boston Carpal Tunnel Questionnaire (BCTQ) Total Score
7 secondary outcomes
Visual Analog Scale (VAS)
Time frame: Baseline to 4 weeks
Leeds Assessment of Neuropathic Symptoms and Signs (LANSS)
Time frame: Baseline to 4 weeks
Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH)
Time frame: Baseline to 4 weeks
Grip Strength
Time frame: Baseline to 4 weeks
Pinch Strength
Time frame: Baseline to 4 weeks
Pressure Pain Threshold
Time frame: Baseline to 4 weeks
Median Nerve Cross-Sectional Area
Time frame: Baseline to 4 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jan 2026.
- Individual participant dataSharing planned: No
Related trials for Carpal Tunnel Syndrome
Not yet recruitingObservational study
Postural Control and Balance Performance in Patients With Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS), Postural Assessment
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Comparison of Wrist Splint Positions in Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS), Peripheral Neuropathies
Recruiting
Effects of Repetitive Peripheral Magnetic Stimulation(rPMS) on CTS(Carpal Tunnel Syndrome)
Carpal Tunnel Syndrome (CTS)
Recruiting
Hand Function Outcome After the Application of Transfer Energy Capacitive and Resistive on Post-burn Patients Presented With Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS) Post-burn
Not yet recruiting
Effect of Progressive Gamified Motor Rehabilitation After Carpal Tunnel Release
Carpal Tunnel Surgery
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Merve Akdeniz Leblebicier, MD principal investigator
Kutahya Health Sciences University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neurodynamic mobilization, Carpal bone mobilization and Splint in people with Carpal Tunnel Syndrome and Splints, run by Kutahya Health Sciences University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 22 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Merve Akdeniz Leblebicier, MD (00902742600043 ext. 4343, merve1985akdeniz@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Boston Carpal Tunnel Questionnaire (BCTQ) Total Score (time frame: Baseline to 4 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jan 2026.