Cardiac Arrest (CA)NCT07359313
Incidence of Colon Ischemia in Patients After Cardiopulmonary Resuscitation (CPR)
A study testing colonoscopy in people with Cardiac Arrest (CA), run by University Hospital Freiburg at 1 site in Germany.
Trial summary
Bedside colonoscopy 24-36 hours after successful CPR Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest (CA)
- What is being tested?
- colonoscopy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 1 siteGermany
- Study dates
- 7 Jan 2026to 6 Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- adult patients (≥ 18 years) admitted to the participating department AND
- in-hospital or out-of-hospital cardiac arrest (IHCA, OHCA)
Who cannot join
- resuscitation period of ≤ 5 minutes
- awake and contactable patients (GCS ≥ 13)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Germany1 site
Medical Center - University of Freiburg
Freiburg im Breisgau, 79106
Alexander Supady, MD, MPH, +49-761-270-34010, alexander.supady@uniklinik-freiburg.de
Asieb Sekandarzad, MD, +49-761-270-34010, asieb.sekandarzad@uniklinik-freiburg.de
About this study
Official title: Incidence of Colon Ischemia in Patients After Cardiopulmonary Resuscitation (CPR): a Prospective Single-center Epidemiological Incidence Study
Bedside colonoscopy 24-36 hours after successful CPR
Read the detailed description
According to previous observations, many patients after CPR develop acute non-occlusive mesenteric ischemia. However, due to the lack of established screening strategies, the number of unreported cases may be high. Routine colonoscopy at 24-36 hours after CPR may be a safe, easy and cost-effective strategy for early detection of severe mesenteric ischemia and transfer to surgical treatment. However, this strategy has not been formally evaluated in larger prospective cohorts. In our center, we perform routine colonoscopy at 24 to 36 hours after cardiac arrest in all patients who receive extracorporeal CPR (ECPR), i.e., in all patients with prolonged cardiac arrest refractory to conventional CPR measures who therefore receive venoarterial extracorporeal membrane oxygenation (VA ECMO) for cardiocirculatory support. In these patients, colonoscopy screening was feasible and safe, and our data suggest clinical benefit.
- Conditions
- Cardiac Arrest (CA)
- Being tested
- colonoscopy
- Keywords
- cardiac arrest, cardiopulmonary resuscitation, CPR, extracorporeal cardiopulmonary resuscitation, ECPR, VA ECMO, colonoscopy, mesenteric ischemia
- Medical subject headings
- Heart Arrest, Mesenteric Ischemia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
colonoscopyProcedure or surgery
bedside colonoscopy without bowel cleansing early (24-36h) after successful CPR
| Study group | Role | What they receive |
|---|---|---|
| early colonoscopy after successful CPR | Other | bedside colonoscopy 24-36 hours after successful CPR Receives: Procedure: colonoscopy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Detection of colon ischemia
Detection of colon ischemia within 30 days after return of spontaneous circulation
Measured: from baseline (0 hours) until day 30
Secondary outcomes (10)
in-hospital mortality
in-hospital mortality
Measured: from baseline (0 hours) until hospital discharge
abdominal surgery ((hemi-)colectomy)
number of patients requiring/receiving abdominal surgery ((hemi-)colectomy)
Measured: from baseline (0 hours) until hospital discharge
functional outcome
Cerebral Performance Category (CPC)
Measured: day 30, day 60 and day 90
Liver function
Liver function parameters: Quick/INR, AST, ALT, AP, g-GT
Measured: within 0-72 hours after CPR
renal function
Renal function parameters: creatinine, BUN
Measured: within 0-72 hours after CPR
Urine output
Urine output (ml)
Measured: within 0-72 hours after CPR
Renal replacement therapy
Implementation of renal replacement therapy within 30 days after return of spontaneous circulation
Measured: from baseline (day 0) until day 30
Serum lactate
Serum lactate
Measured: within 0-72 hours after CPR
SOFA score
SOFA
Measured: at 0 hours, 24 hours, 48 hours, 72 hours after CPR
SAPS II score
SAPS II
Measured: at 0 hours, 24 hours, 48 hours, 72 hours after CPR
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2026
- Study start7 Jan 2026 (estimated)
- Primary completion6 Jan 2028 (estimated)
- Study completion6 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Prospective epidemiological incidence study
- Masking
- None (open label)
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital Freiburg
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, PD Dr. Alexander Supady, University Hospital Freiburg
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07359313
- Sponsor's protocol ID
- 24-1320-S1
- Status last verified
- Jan 2026
- First submitted
- 19 Dec 2025
- Last updated
- 22 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Incidence of Colon Ischemia in Patients After Cardiopulmonary Resuscitation (CPR): a Prospective Single-center Epidemiological Incidence Study
- ClinicalTrials.gov ID
- NCT07359313
- Acronym / sponsor ID
- 24-1320-S1
- Conditions
- Cardiac Arrest (CA)
- Keywords
- cardiac arrest, cardiopulmonary resuscitation, CPR, extracorporeal cardiopulmonary resuscitation, ECPR, VA ECMO, colonoscopy, mesenteric ischemia
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- University Hospital FreiburgUniversity, hospital or other
- Study start
- 7 Jan 2026 (estimated)
- Primary completion
- 6 Jan 2028 (estimated)
- Study completion
- 6 Feb 2028 (estimated)
- First posted
- 22 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Bedside colonoscopy 24-36 hours after successful CPR
Detailed description
According to previous observations, many patients after CPR develop acute non-occlusive mesenteric ischemia. However, due to the lack of established screening strategies, the number of unreported cases may be high. Routine colonoscopy at 24-36 hours after CPR may be a safe, easy and cost-effective strategy for early detection of severe mesenteric ischemia and transfer to surgical treatment. However, this strategy has not been formally evaluated in larger prospective cohorts. In our center, we perform routine colonoscopy at 24 to 36 hours after cardiac arrest in all patients who receive extracorporeal CPR (ECPR), i.e., in all patients with prolonged cardiac arrest refractory to conventional CPR measures who therefore receive venoarterial extracorporeal membrane oxygenation (VA ECMO) for cardiocirculatory support. In these patients, colonoscopy screening was feasible and safe, and our data suggest clinical benefit.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Prospective epidemiological incidence study
| Arm | Type | Receives |
|---|---|---|
| early colonoscopy after successful CPR | Other | Procedure: colonoscopybedside colonoscopy 24-36 hours after successful CPR |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- adult patients (≥ 18 years) admitted to the participating department AND
- in-hospital or out-of-hospital cardiac arrest (IHCA, OHCA)
Key exclusion criteria (2 listed)
- resuscitation period of ≤ 5 minutes
- awake and contactable patients (GCS ≥ 13)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| colonoscopybedside colonoscopy without bowel cleansing early (24-36h) after successful CPR | Procedure or surgery | early colonoscopy after successful CPR |
Primary outcome
Detection of colon ischemia
Time frame: from baseline (0 hours) until day 30
Detection of colon ischemia within 30 days after return of spontaneous circulation
10 secondary outcomes
in-hospital mortality
Time frame: from baseline (0 hours) until hospital discharge
abdominal surgery ((hemi-)colectomy)
Time frame: from baseline (0 hours) until hospital discharge
functional outcome
Time frame: day 30, day 60 and day 90
Liver function
Time frame: within 0-72 hours after CPR
renal function
Time frame: within 0-72 hours after CPR
Urine output
Time frame: within 0-72 hours after CPR
Renal replacement therapy
Time frame: from baseline (day 0) until day 30
Serum lactate
Time frame: within 0-72 hours after CPR
SOFA score
Time frame: at 0 hours, 24 hours, 48 hours, 72 hours after CPR
SAPS II score
Time frame: at 0 hours, 24 hours, 48 hours, 72 hours after CPR
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing colonoscopy in people with Cardiac Arrest (CA), run by University Hospital Freiburg at 1 site in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 22 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Alexander Supady, MD, MPH (+49-761-270-34010, alexander.supady@uniklinik-freiburg.de), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Detection of colon ischemia (time frame: from baseline (0 hours) until day 30). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jan 2026; AzTrials last refreshed its copy on 8 Nov 2026.