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Subacromial Impingement SyndromeNCT07369934

Virtual Reality Based Exercise Training Versus Mulligan Mobilization on Shoulder Posture and Function in Subacromial Impingement Syndrome

A study testing Virtual Reality and Mulligan mobilization in people with Subacromial Impingement Syndrome, run by Cairo University at 1 site in Egypt.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

The study will compare the effect of virtual reality based exercise training versus Mulligan mobilization in addition to exercise therapy added to both groups on shoulder posture and function in subacromial impingement syndrome. Read more about this study

Who is it for?
Ages 30 to 50 years
Conditions the study is for
Subacromial Impingement Syndrome
What is being tested?
Virtual Reality and Mulligan mobilization
Could I receive a placebo?
No, everyone receives an active treatment
How many people
74 participants
Where
1 siteEgypt
Study dates
13 Dec 2025to May 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 30 to 50 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Patients will be referred from the orthopedic surgeon with a diagnosis of stage II SIS with the following criteria:
  • Participants ranged in age from 30-50 years old.
  • Participants are from non-athletes from the general population.
  • Unilateral shoulder pain that is localized either anteriorly or laterally to the acromion. Pain that occurs or worsens when the affected shoulder is in flexion and/or abduction.
  • Four of the following should be present in the included patients: Neer impingement test, Hawkins' test, Pain was replicated in the supraspinatus empty-can test, a painful arc of movement from 70° to 120°, and painful greater tuberosity of the humerus.
  • BMI range 18.5- 29.9 Kg/m².

Who cannot join

  • 1) Patients who, during the previous three months, underwent shoulder physical treatment and/or an acute pain flare.
  • 2) Patients who have undergone surgeries for tendon repair. 3) Malignancy, epilepsy, pregnant women, and/or systemic conditions like chronic renal or liver failure.
  • 4) Mini-Mental State Examination test (MMSE) (< 24/30) to exclude cognitive impairment and/or significant vision impairment (if they couldn't read the introduction while wearing the Head Mounted Device (HMD).
  • 5) Corticosteroid injection during the last three months or used steroids chronically.
  • 6) Adhesive capsulitis, glenohumeral joint instability, Numbness or tingling of the upper limb, and/or full-thickness tear of the rotator cuff.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Sara M Meselhy, Demonstrator contact

+01222518092

sara.mohsen@cu.edu.eg

Afaf M Tahoon, lecturer contact

+01015401783

Afaf_tahoon@cu.edu.eg

Egypt1 site, 1 recruiting

  • Faculty of Physical Therapy, Cairo University

    Giza

    Afaf M Tahoon, lecturer, +01015401783, Afaf_tahoon@cu.edu.eg

    Sara M Meselhy, Demostrator

    Recruiting

Other trials in Egypt

About this study

The study will compare the effect of virtual reality based exercise training versus Mulligan mobilization in addition to exercise therapy added to both groups on shoulder posture and function in subacromial impingement syndrome.

Being tested
Virtual Reality, Mulligan mobilization
Keywords
subacromial impingement syndrome, Virtual reality, Mulligan mobilization, shoulder function, shoulder posture
Medical subject headings
Shoulder Impingement Syndrome

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Virtual RealityOther

    Fully immersive virtual reality mounted headset will be used

  • Mulligan mobilizationOther

    posterolateral shoulder Mulligan mobilization with movement (MWM) will be used

Study groups in NCT07369934
Study groupRoleWhat they receive
Virtual reality groupActive comparatorNot described
Receives: Other: Virtual Reality
Mulligan mobilization groupActive comparatorNot described
Receives: Other: Mulligan mobilization

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Pain intensity during shoulder elevation

    It will be measured using the Numerical Pain Rating Scale (NPRS)

    Measured: pain intensity at the start of session 1 to the end of 1 month of treatment

  2. Shoulder function

    The Shoulder Pain and Disability Index (SPADI) will be used to measure the shoulder function.

    Measured: shoulder function at the start of session 1 to the end of 1 month of treatment

  3. Shoulder flexion range of motion

    The Clinometer Application will be used to measure it.

    Measured: shoulder flexion at the start of session 1 to the end of 1 month of treatment

  4. Shoulder abduction range of motion

    The Clinometer Application will be used to measure it.

    Measured: shoulder abduction at the start of session 1 to the end of 1 month of treatment

  5. shoulder posture

    Sagittal Shoulder Angle will be used to measure the shoulder posture

    Measured: shoulder posture at the start of session 1 to the end of 1 month of treatment

Secondary outcomes (2)

  1. Patients' enjoyment

    A 7-point likert scale will be used to the evaluate the level of the patients' enjoyment at the end of the last session.

    Measured: It will be evaluated at the end of the last session (after 1 month)

  2. patients' adherence to treatment sessions

    patients' numbers of attended sessions will be calculated at the end of 1 month of treatment.

    Measured: patients' adherence at the start of session 1 to the end of 1 month of treatment

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Jan 2026
  2. Study start13 Dec 2025
  3. Primary completionMay 2026 (estimated)
  4. Study completionMay 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Participant
Enrolment
74 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07369934
Sponsor's protocol ID
Virtual reality and Mulligan M
Status last verified
Jan 2026
First submitted
12 Jan 2026
Last updated
27 Jan 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Steiner B, Elgert L, Saalfeld B, Wolf KH. Gamification in Rehabilitation of Patients With Musculoskeletal Diseases of the Shoulder: Scoping Review. JMIR Serious Games. 2020 Aug 25;8(3):e19914. doi: 10.2196/19914.

    PubMed 32840488

  • Alvarez de la Campa Crespo M, Donegan T, Amestoy-Alonso B, Just A, Combalia A, Sanchez-Vives MV. Virtual embodiment for improving range of motion in patients with movement-related shoulder pain: an experimental study. J Orthop Surg Res. 2023 Sep 26;18(1):729. doi: 10.1186/s13018-023-04158-w.

    PubMed 37752613

  • Lin HT, Li YI, Hu WP, Huang CC, Du YC. A Scoping Review of The Efficacy of Virtual Reality and Exergaming on Patients of Musculoskeletal System Disorder. J Clin Med. 2019 Jun 4;8(6):791. doi: 10.3390/jcm8060791.

    PubMed 31167435

  • Hoyek N, Di Rienzo F, Collet C, Hoyek F, Guillot A. The therapeutic role of motor imagery on the functional rehabilitation of a stage II shoulder impingement syndrome. Disabil Rehabil. 2014;36(13):1113-9. doi: 10.3109/09638288.2013.833309. Epub 2014 Feb 28.

    PubMed 24575717

  • Consigliere P, Haddo O, Levy O, Sforza G. Subacromial impingement syndrome: management challenges. Orthop Res Rev. 2018 Oct 23;10:83-91. doi: 10.2147/ORR.S157864. eCollection 2018.

    PubMed 30774463

  • Coja, D. M., Onu, I., Onu, A., Iordan, D. A., Gheorghiu, G., Ene-Voiculescu, V., & Talaghir, L. G. (2024). The Use of Virtual Reality-Assisted Therapy to Improve Shoulder function in Subacromial Impingement Syndrome: a Randomised Controlled Trial. BRAIN. Broad Research in Artificial Intelligence and Neuroscience, 15(4), 11-26. http://dx.doi.org/10.70594/brain/15.4/2

  • Chaplin E, Karatzios C, Benaim C. Clinical Applications of Virtual Reality in Musculoskeletal Rehabilitation: A Scoping Review. Healthcare (Basel). 2023 Dec 15;11(24):3178. doi: 10.3390/healthcare11243178.

    PubMed 38132067

  • Ozlu A, Ustundag S, Bulut Ozkaya D, Menekseoglu AK. Effect of Exergame on Pain, Function, and Quality of Life in Shoulder Impingement Syndrome: A Prospective Randomized Controlled Study. Games Health J. 2024 Apr;13(2):109-119. doi: 10.1089/g4h.2023.0108. Epub 2024 Feb 23.

    PubMed 38394299

  • Gumaa M, Rehan Youssef A. Is Virtual Reality Effective in Orthopedic Rehabilitation? A Systematic Review and Meta-Analysis. Phys Ther. 2019 Oct 28;99(10):1304-1325. doi: 10.1093/ptj/pzz093.

    PubMed 31343702

  • Dias D, Neto MG, Sales SDSR, Cavalcante BDS, Torrierri P Jr, Roever L, Araujo RPC. Effect of Mobilization with Movement on Pain, Disability, and Range of Motion in Patients with Shoulder Pain and Movement Impairment: A Systematic Review and Meta-Analysis. J Clin Med. 2023 Nov 29;12(23):7416. doi: 10.3390/jcm12237416.

    PubMed 38068468

  • Delgado-Gil JA, Prado-Robles E, Rodrigues-de-Souza DP, Cleland JA, Fernandez-de-las-Penas C, Alburquerque-Sendin F. Effects of mobilization with movement on pain and range of motion in patients with unilateral shoulder impingement syndrome: a randomized controlled trial. J Manipulative Physiol Ther. 2015 May;38(4):245-52. doi: 10.1016/j.jmpt.2014.12.008. Epub 2015 Apr 30.

    PubMed 25936465

Questions about this trial

What is this clinical trial studying?

A study testing Virtual Reality and Mulligan mobilization in people with Subacromial Impingement Syndrome, run by Cairo University at 1 site in Egypt.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 27 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Sara M Meselhy, Demonstrator (+01222518092, sara.mohsen@cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Pain intensity during shoulder elevation (time frame: pain intensity at the start of session 1 to the end of 1 month of treatment). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07369934, which also lists 11 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jan 2026; AzTrials last refreshed its copy on 28 Oct 2026.

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