Coronary Artery Bypass Grafting (CABG)CABG QualityNCT07377149
Improving the Quality of Coronary Artery Bypass Grafting
A study testing Interventions for healthcare professionals in hospitals with low usage rates and Interventions for healthcare professionals in hospitals with high usage rates in people with Coronary Artery Bypass Grafting (CABG), run by China National Center for Cardiovascular Diseases.
Trial summary
This is a healthcare quality improvement study focused on increasing the utilization of arterial grafts in isolated coronary artery bypass grafting (CABG). Evidence indicates that arterial grafts, compared with venous grafts, provide superior long-term patency, which are recommended to use by the clinical practice… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Coronary Artery Bypass Grafting (CABG)
- What is being tested?
- Interventions for healthcare professionals in hospitals with low usage rates and Interventions for healthcare professionals in hospitals with high usage rates
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 8,700 participants
- Where
- No sites listed yet
- Study dates
- 15 Mar 2026to Jul 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged ≥ 18 years old； Indicated for CABG and undergoing CABG.
Who cannot join
- History of prior CABG; Concurrent other cardiac surgeries on the day of CABG; Malignant tumor or life expectancy < 1 year;
- 50% stenosis of left subclavian artery; Pregnant women; Individuals diagnosed with mental illness or cognitive impairment (International Classification of Diseases-10 codes F01-F99); Patients considered by the investigator to have other factors unsuitable for inclusion.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Quality Improvement Intervention on Utilization of Arterial Grafts for Coronary Artery Bypass Grafting
This is a healthcare quality improvement study focused on increasing the utilization of arterial grafts in isolated coronary artery bypass grafting (CABG). Evidence indicates that arterial grafts, compared with venous grafts, provide superior long-term patency, which are recommended to use by the clinical practice guidelines.
In hospitals where the use of the internal mammary artery as a graft is relatively low(<90%) among CABG patients, multiple interventions will be implemented to improve its adoption rate.
Read more
In hospitals where internal mammary artery graft utilization is already high(≥90%), various interventions will be introduced to promote the use of multiple arterial grafts (defined as the use of two or more arterial conduits).
The study targets healthcare professionals as the primary subjects of intervention, with no direct interventions applied to patients during the study period. Changes in the internal mammary artery graft utilization rate and the multiple arterial graft utilization rate before and after the intervention will serve as the primary endpoints for evaluating intervention effectiveness in the two types of hospitals, respectively.
- Conditions
- Coronary Artery Bypass Grafting (CABG)
- Being tested
- Interventions for healthcare professionals in hospitals with low usage rates, Interventions for healthcare professionals in hospitals with high usage rates
- Keywords
- coronary artery bypass grafting, quality improvement, arterial graft
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Interventions for healthcare professionals in hospitals with low usage ratesBehavioural
Hospitals with low usage rates aim to improve internal mammary artery graft utilization through interventions including education, theoretical training, technical training, conference exchanges, and regular feedback on quality monitoring results.
Interventions for healthcare professionals in hospitals with high usage ratesBehavioural
Hospitals with already high usage rates focus on increasing multi-arterial graft usage rates through similar intervention methods such as education, theoretical training, technical training, conference exchanges focus on multi-arterial graft use. The usage rates of multi-arterial graft for each hospital will be regular feed backed.
| Study group | Role | What they receive |
|---|---|---|
| Improving the utilization rate of arterial grafts for coronary artery bypass grafting | Other | In this stepped-wedge cluster randomized trial (SW-CRT) with a self-controlled design, hospitals were categorized into two groups according to their internal mammary artery graft usage rates, thereby forming two SW-CRT. Healthcare professionals at these hospitals will receive tailored interventions. The effectiveness of each intervention is assessed by comparing the usage rates before and after implementation within each SW-CRT. Receives: Behavioral: Interventions for healthcare professionals in hospitals with low usage rates; Behavioral: Interventions for healthcare professionals in hospitals with high usage rates |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hospitals with low usage rates of internal mammary artery: internal mammary artery graft utilization rate
Internal mammary artery graft utilization rate: the utilization rate of at least one internal mammary artery graft in patients received isolated coronary artery bypass grafting.
Measured: Duration of hospital stay(from date of admission to date of discharge)
Hospitals with high usage rates of internal mammary artery: multiple arterial graft utilization rate
Multiple arterial graft utilization rate: the utilization rate of two or more arterial conduits in patients received isolated coronary artery bypass grafting.
Measured: Duration of hospital stay(from date of admission to date of discharge)
Secondary outcomes (1)
In-hospital all-cause mortality rate
The in-hospital all-cause mortality rate of patients received isolated coronary artery bypass grafting.
Measured: Duration of hospital stay(from date of admission to date of discharge)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jan 2026
- Study start15 Mar 2026 (estimated)
- Primary completionJan 2029 (estimated)
- Study completionJul 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Coronary Artery Bypass Grafting (CABG)Studies of the same condition, open and under way.
- More trials run by China National Center for Cardiovascular DiseasesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- This is a stepped-wedge cluster randomized trial (SW-CRT) with a self-controlled design. Hospitals were categorized into two groups based on their internal mammary artery graft usage rates (low or high), forming two SW-CRT.
- Masking
- None (open label)
- Enrolment
- 8,700 participants (estimated)
Sponsor and investigators
- Sponsor type
- Other government
- Collaborators
- Chinese Academy of Medical Sciences, Fuwai Hospital, Shandong Provincial Hospital, The First Affiliated Hospital with Nanjing Medical University, Guangdong Provincial People's Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, West China Hospital, First Affiliated Hospital of Wenzhou Medical University, Ruijin Hospital, The General Hospital of Northern Theater Command, Central China Fuwai Hospital of Zhengzhou University
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07377149
- Sponsor's protocol ID
- 2025-2849
- Other IDs
- 2025ZD0546704
- Acronym
- CABG Quality
- Status last verified
- Jan 2026
- First submitted
- 23 Dec 2025
- Last updated
- 29 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Quality Improvement Intervention on Utilization of Arterial Grafts for Coronary Artery Bypass Grafting
- ClinicalTrials.gov ID
- NCT07377149
- Acronym / sponsor ID
- CABG Quality / 2025-2849
- Conditions
- Coronary Artery Bypass Grafting (CABG)
- Keywords
- coronary artery bypass grafting, quality improvement, arterial graft
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 8,700 participants (estimated)
- Lead sponsor
- China National Center for Cardiovascular DiseasesOther government
- Collaborators
- Chinese Academy of Medical Sciences, Fuwai Hospital, Shandong Provincial Hospital, The First Affiliated Hospital with Nanjing Medical University, Guangdong Provincial People's Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, West China Hospital, First Affiliated Hospital of Wenzhou Medical University, Ruijin Hospital, The General Hospital of Northern Theater Command, Central China Fuwai Hospital of Zhengzhou University
- Study start
- 15 Mar 2026 (estimated)
- Primary completion
- Jan 2029 (estimated)
- Study completion
- Jul 2029 (estimated)
- First posted
- 29 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a healthcare quality improvement study focused on increasing the utilization of arterial grafts in isolated coronary artery bypass grafting (CABG). Evidence indicates that arterial grafts, compared with venous grafts, provide superior long-term patency, which are recommended to use by the clinical practice guidelines.
In hospitals where the use of the internal mammary artery as a graft is relatively low(<90%) among CABG patients, multiple interventions will be implemented to improve its adoption rate.
In hospitals where internal mammary artery graft utilization is already high(≥90%), various interventions will be introduced to promote the use of multiple arterial grafts (defined as the use of two or more arterial conduits).
The study targets healthcare professionals as the primary subjects of intervention, with no direct interventions applied to patients during the study period. Changes in the internal mammary artery graft utilization rate and the multiple arterial graft utilization rate before and after the intervention will serve as the primary endpoints for evaluating intervention effectiveness in the two types of hospitals, respectively.
Study design
- Primary purpose
- Health services research
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- This is a stepped-wedge cluster randomized trial (SW-CRT) with a self-controlled design. Hospitals were categorized into two groups based on their internal mammary artery graft usage rates (low or high), forming two SW-CRT.
| Arm | Type | Receives |
|---|---|---|
| Improving the utilization rate of arterial grafts for coronary artery bypass grafting | Other | Behavioral: Interventions for healthcare professionals in hospitals with low usage rates, Behavioral: Interventions for healthcare professionals in hospitals with high usage ratesIn this stepped-wedge cluster randomized trial (SW-CRT) with a self-controlled design, hospitals were categorized into two groups according to their internal mammary artery graft usage rates, thereby forming two SW-CRT. Healthcare professionals at these hospitals will receive tailored interventions. The effectiveness of each intervention is assessed by comparing the usage rates before and after implementation within each SW-CRT. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Aged ≥ 18 years old； Indicated for CABG and undergoing CABG.
Key exclusion criteria (2 listed)
- History of prior CABG; Concurrent other cardiac surgeries on the day of CABG; Malignant tumor or life expectancy < 1 year;
- 50% stenosis of left subclavian artery; Pregnant women; Individuals diagnosed with mental illness or cognitive impairment (International Classification of Diseases-10 codes F01-F99); Patients considered by the investigator to have other factors unsuitable for inclusion.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Interventions for healthcare professionals in hospitals with low usage ratesHospitals with low usage rates aim to improve internal mammary artery graft utilization through interventions including education, theoretical training, technical training, conference exchanges, and regular feedback on quality monitoring results. | Behavioural | Improving the utilization rate of arterial grafts for coronary artery bypass grafting |
| Interventions for healthcare professionals in hospitals with high usage ratesHospitals with already high usage rates focus on increasing multi-arterial graft usage rates through similar intervention methods such as education, theoretical training, technical training, conference exchanges focus on multi-arterial graft use. The usage rates of multi-arterial graft for each hospital will be regular feed backed. | Behavioural | Improving the utilization rate of arterial grafts for coronary artery bypass grafting |
Primary outcome
Hospitals with low usage rates of internal mammary artery: internal mammary artery graft utilization rate
Time frame: Duration of hospital stay(from date of admission to date of discharge)
Internal mammary artery graft utilization rate: the utilization rate of at least one internal mammary artery graft in patients received isolated coronary artery bypass grafting.
Hospitals with high usage rates of internal mammary artery: multiple arterial graft utilization rate
Time frame: Duration of hospital stay(from date of admission to date of discharge)
Multiple arterial graft utilization rate: the utilization rate of two or more arterial conduits in patients received isolated coronary artery bypass grafting.
1 secondary outcome
In-hospital all-cause mortality rate
Time frame: Duration of hospital stay(from date of admission to date of discharge)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Interventions for healthcare professionals in hospitals with low usage rates and Interventions for healthcare professionals in hospitals with high usage rates in people with Coronary Artery Bypass Grafting (CABG), run by China National Center for Cardiovascular Diseases.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 29 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zhe Zheng, MD, PhD (+86 88396051, zhengzhe@fuwai.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hospitals with low usage rates of internal mammary artery: internal mammary artery graft utilization rate (time frame: Duration of hospital stay(from date of admission to date of discharge)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Jan 2026.