Respiratory FailureNCT07380607
Double Triggering Asynchrony in Mechanically Ventilated Patients.
An observational study of Respiratory Failure and Critical Illness, run by Mansoura University at 1 site in Egypt.
Trial summary
This observational study examined double triggering asynchrony in28ICU patients on mechanical ventilation. Researchers collected data on patient characteristics, health conditions, and outcomes to understand how this problem affects critically ill patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Respiratory Failure, Critical Illness, Mechanical Ventilation
- How many people
- 28 participants
- Where
- 1 siteEgypt
- Study dates
- 5 Nov 2024to 2 Nov 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients (>18 years) admitted to medical/surgical ICU at Specialized Medical Hospital, Mansoura University, receiving invasive mechanical ventilation with documented double triggering asynchrony on ventilator waveform analysis.
Who may be able to join
- Adult ICU patients aged ≥18 years receiving invasive mechanical ventilation
- Documented double triggering asynchrony on ventilator waveform analysis.
Who cannot join
- Patients with contraindications to diaphragmatic ultrasound, including thoracic or abdominal surgery.
- Patients with known diseases affecting diaphragmatic function, such as Duchenne muscular dystrophy (DMD) or myasthenia gravis (MG).
- Patients with advanced chronic liver disease (Child-Pugh class C)
- Patients with chronic increased intra-abdominal pressure.
- Patients with moderate to massive pleural effusion.
- Patient or legal guardian refusal to participate in the study.
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Specialised Medical Hospital - ICU
Al Mansurah, Dakahlia Governorate, 35516
About this study
Official title: Sensitivity of Diaphragmatic Ultrasonography in Detecting Double Triggering Asynchrony in Mechanically Ventilated ICU Patients.
This observational study examined double triggering asynchrony in28ICU patients on mechanical ventilation. Researchers collected data on patient characteristics, health conditions, and outcomes to understand how this problem affects critically ill patients. Findings may help improve ventilator care in intensive care units.
- Keywords
- Double Triggering, Patient-Ventilator Asynchrony, Diaphragmatic Ultrasound, Mechanical Ventilation
- Medical subject headings
- Respiratory Insufficiency, Critical Illness, Patient-Ventilator Asynchrony
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Double Triggering Cohort | 28mechanically ventilated ICU patients identified with double triggering asynchrony |
What is being measured
The primary outcome is the main question the study is designed to answer.
Sensitivity of diaphragmatic ultrasound for detection of double triggering asynchrony
Proportion of double triggering asynchrony events correctly identified by diaphragmatic ultrasound compared with ventilator waveform analysis as the reference standard
Measured: During ICU admission, at the time of double triggering detection by ventilator graph interpretation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Feb 2026
- Study start5 Nov 2024
- Primary completion20 Oct 2025
- Study completion2 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Respiratory FailureStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mansoura University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07380607
- Sponsor's protocol ID
- MD.24.03.838.R1
- Status last verified
- Dec 2025
- First submitted
- 17 Jan 2026
- Last updated
- 15 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Sensitivity of Diaphragmatic Ultrasonography in Detecting Double Triggering Asynchrony in Mechanically Ventilated ICU Patients.
- ClinicalTrials.gov ID
- NCT07380607
- Acronym / sponsor ID
- MD.24.03.838.R1
- Keywords
- Double Triggering, Patient-Ventilator Asynchrony, Diaphragmatic Ultrasound, Mechanical Ventilation
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Mansoura UniversityUniversity, hospital or other
- Study start
- 5 Nov 2024 (actual)
- Primary completion
- 20 Oct 2025 (actual)
- Study completion
- 2 Nov 2025 (actual)
- First posted
- 2 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This observational study examined double triggering asynchrony in28ICU patients on mechanical ventilation. Researchers collected data on patient characteristics, health conditions, and outcomes to understand how this problem affects critically ill patients. Findings may help improve ventilator care in intensive care units.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Double Triggering Cohort | – | –28mechanically ventilated ICU patients identified with double triggering asynchrony |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients (>18 years) admitted to medical/surgical ICU at Specialized Medical Hospital, Mansoura University, receiving invasive mechanical ventilation with documented double triggering asynchrony on ventilator waveform analysis.
Key inclusion criteria (2 listed)
- Adult ICU patients aged ≥18 years receiving invasive mechanical ventilation
- Documented double triggering asynchrony on ventilator waveform analysis.
Key exclusion criteria (6 listed)
- Patients with contraindications to diaphragmatic ultrasound, including thoracic or abdominal surgery.
- Patients with known diseases affecting diaphragmatic function, such as Duchenne muscular dystrophy (DMD) or myasthenia gravis (MG).
- Patients with advanced chronic liver disease (Child-Pugh class C)
- Patients with chronic increased intra-abdominal pressure.
- Patients with moderate to massive pleural effusion.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Sensitivity of diaphragmatic ultrasound for detection of double triggering asynchrony
Time frame: During ICU admission, at the time of double triggering detection by ventilator graph interpretation
Proportion of double triggering asynchrony events correctly identified by diaphragmatic ultrasound compared with ventilator waveform analysis as the reference standard
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Apr 2026.
- Individual participant dataSharing planned: No
Related trials for Respiratory Failure
Not yet recruiting
Modified Inhaled Nitric Oxide in Ventilated Patients With Acute Respiratory Failure
Acute Respiratory Failure (ARF), Nitric Oxide
Not yet recruitingObservational study
Impact of Inspiratory Effort and Patient-Ventilator Interaction During the Transition Phase
Mechanically Ventilated Patients, Acute Respiratory Failure (ARF)
Not yet recruitingObservational study
Development and Prospective Validation of the AutoEIT Foundation Model for ARDS
ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Recruiting
Humidification Effects on Airway Complications and Clinical Outcomes in Trauma ICU Patients on Mechanical Ventilation
Respiratory Insufficiency, Wounds and Injuries
Not yet recruitingObservational study
Clinical Genetics Branch Eligibility Screening Survey
Melanoma, Li-Fraumeni Syndrome
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Respiratory Failure and Critical Illness, run by Mansoura University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Sensitivity of diaphragmatic ultrasound for detection of double triggering asynchrony (time frame: During ICU admission, at the time of double triggering detection by ventilator graph interpretation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Apr 2026.