ACL ReconstructionNCT07384780
Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training
A study testing High Load Isokinetic Training with Blood Flow Restriction and Low Load Isokinetic Training with Blood Flow Restriction in people with ACL Reconstruction and ACL Repair, run by Gulf Medical University.
Trial summary
The goal of this clinical trial is to see which type of strengthening exercise with a tight band (blood flow restriction) helps people recover better after ACL reconstruction. The study includes adults after ACL surgery who are doing physiotherapy to rebuild thigh muscle strength and knee function. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- ACL Reconstruction, ACL Repair
- What is being tested?
- High Load Isokinetic Training with Blood Flow Restriction and Low Load Isokinetic Training with Blood Flow Restriction
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- No sites listed yet
- Study dates
- Feb 2026to Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- For ACLR group:
- •Isolated unilateral ACL reconstruction 8-16 weeks post-surgery with medical clearance for moderate to high resistance training.
- For control group(healthy population):
- Healthy adults with no musculoskeletal pathology.
Who cannot join
- History of cardiovascular or metabolic diseases
- Deep vein thrombosis
- Coagulopathy
- Hypertension
- Skin lesions or infections at the site of BFR cuff administration
- Neuromuscular disorders
- Non-clearance from the surgeon or physiotherapist or resistance training.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training : A Randomized Controlled Trial in Post-ACL Reconstruction Populations
The goal of this clinical trial is to see which type of strengthening exercise with a tight band (blood flow restriction) helps people recover better after ACL reconstruction. The study includes adults after ACL surgery who are doing physiotherapy to rebuild thigh muscle strength and knee function.
The main questions are:
Read more
- Does heavy strengthening with blood flow restriction improve thigh strength, knee function, and daily activities more than light strengthening with blood flow restriction after ACL surgery?
- Can light strengthening with blood flow restriction give similar benefits to heavy strengthening while putting less strain on the knee?
Researchers will compare a heavy-exercise program plus blood flow restriction to a light-exercise program plus blood flow restriction to see which gives better strength and functional improvements.
Participants will:
- Come for supervised physiotherapy sessions and do knee exercises on a machine, using either heavy or light loads while a cuff on the thigh gently squeezes to reduce blood flow.
- Have their leg strength, and knee questionnaires checked several times during the study.
Read the detailed description
This clinical trial is testing two different ways of doing strength training with a tight leg cuff (blood flow restriction) during rehabilitation after ACL reconstruction. The aim is to find out which program helps people rebuild thigh muscle strength and knee function more effectively, while still keeping the knee joint safe after surgery.
Study purpose and questions After ACL reconstruction, many people lose muscle size and strength in the front of the thigh, which can slow down recovery and delay return to sport or full activity. Blood flow restriction training allows people to train with lighter weights but still gain strength and muscle, which may be useful when heavy loads are not yet safe.
The main questions are:
- Does a heavy-load isokinetic exercise program with blood flow restriction improve thigh strength, knee function, and patient-reported outcomes more than a low-load isokinetic program with blood flow restriction?
- Can low-load isokinetic exercise with blood flow restriction provide similar benefits in strength and function, while placing less stress on the healing knee joint? Who will take part The study will include adults who have had ACL reconstruction and are in the strengthening phase of their rehabilitation. Participants will typically be active people, cleared by their surgeon and physiotherapist to start moderate to high resistance training, with no serious heart, blood vessel, or bleeding problems that would make blood flow restriction unsafe.
What happens in the study Participants will be randomly assigned to one of two groups so that each person has an equal chance of being in either group.
- One group will do heavy-load isokinetic knee exercises with a blood flow restriction cuff on the thigh.
- The other group will do low-load isokinetic knee exercises with the same type of cuff and similar exercise schedule.
Both groups will:
- Attend supervised physiotherapy sessions several times per week for around 3-4 months.
- Perform knee extension and flexion exercises on an isokinetic machine, where the speed of movement is controlled and resistance adjusts through the range of motion.
- Wear a wide cuff around the upper thigh, which is inflated to a set pressure to partially reduce blood flow out of the leg during sets, then deflated during rest periods.
The physiotherapist will adjust the load (heavy or light), cuff pressure, and number of sets and repetitions according to a fixed protocol so that each participant trains safely and progressively over time.
Measurements and outcomes
Participants will be tested at the start of the study and at follow-up visits (for example, after several weeks and at the end of the program). The main outcome is peak quadriceps strength measured on an isokinetic dynamometer. Other outcomes may include:
- Rate of torque development (how quickly the muscle can produce force).
- Functional tests such as hop tests, walking or stair tests, and timed tasks.
- Patient questionnaires about knee symptoms, daily activities, sports function, and quality of life.
- Conditions
- ACL Reconstruction, ACL Repair
- Being tested
- High Load Isokinetic Training with Blood Flow Restriction, Low Load Isokinetic Training with Blood Flow Restriction
- Keywords
- blood flow restriction training ACL, Blood flow restriction, ACL Rehab, ACLR, ACL Reconstruction, BFR therapy anterior cruciate ligament reconstruction, BFR therapy ACLR, BFR Therapy, low-load versus high-load BFR knee rehabilitation, isokinetic strength training after ACL surgery, physiotherapy rehabilitation protocol ACL isokinetic BFR, Knee physiotherapy, ACL, ACL Isokinetic, ACLٍ Isokinetic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High Load Isokinetic Training with Blood Flow RestrictionOther
Also called High Load strength training, High Load Isokinetic training, Blood Flow Restriction, BFR
High Load strength training that was administered through the use of an isokinetic device, and not conventional strength training equipment, combined with blood flow restriction.
Low Load Isokinetic Training with Blood Flow RestrictionOther
Also called Low Load strength training, Low Load Isokinetic training, Blood Flow Restriction, BFR
Low Load strength training that was administered through the use of an isokinetic device, and not conventional strength training equipment, combined with blood flow restriction.
| Study group | Role | What they receive |
|---|---|---|
| ACL Reconstruction Population | Active comparator | Not described Receives: Other: High Load Isokinetic Training with Blood Flow Restriction; Other: Low Load Isokinetic Training with Blood Flow Restriction |
| Healthy Population | Active comparator | Not described Receives: Other: High Load Isokinetic Training with Blood Flow Restriction; Other: Low Load Isokinetic Training with Blood Flow Restriction |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle Strength
Muscle strength will be measured using Biodex System 4 Pro for concentric quadriceps and hamstring strength at 60°/s and eccentric quadriceps at 60°/s.
Recorded parameters: peak torque(Nm/kg), total work(J), and average power(W).
Measured: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Muscle Girth
Muscle girth will be measured by measuring the mid-thigh circumference using an inch tape at 15cm above the superior border of the patella. The mean of two readings will be recorded
Measured: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Secondary outcomes (3)
Pain Reduction
Pain will be evaluated using the Numeric Pain Rating Scale(0-10). This refers to the pain the patient experiences in their operated knee and will observe how it changes with administration of the intervention(s).
Scale: 0-10 Minimum value: 0 Maximum value: 10 Higher is worse(more pain). Lower is better(less pain)
Measured: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Blood Flow
The blood flow to the affected knee will be assessed by using infrared thermography(IRT) using standardized imaging protocols(room temperature 20-24°C, 40-60% humidity).
Measured: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Tolerability and Perception of the Intervention(s)
This will be recorded using a Likert-type questionnaire focusing on comfort, tightness, and willingness to repeat the intervention.
Minimum value: 0 Maximum value: 10 Higher scores mean a better outcome. Lower scores mean a worse outcome.
Measured: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Feb 2026
- Study startFeb 2026 (estimated)
- Primary completionJun 2026 (estimated)
- Study completionJun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (27)Papers the sponsor has linked to this study.
- Other trials for ACL ReconstructionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Gulf Medical University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07384780
- Sponsor's protocol ID
- GulfMU
- Status last verified
- Feb 2026
- First submitted
- 27 Jan 2026
- Last updated
- 5 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
McNair PJ, Colvin M, Reid D. Predicting maximal strength of quadriceps from submaximal performance in individuals with knee joint osteoarthritis. Arthritis Care Res (Hoboken). 2011 Feb;63(2):216-22. doi: 10.1002/acr.20368.
PubMed 20890972de Deus Passos M, da Rocha AF. Evaluation of infrared thermography with a portable camera as a diagnostic tool for peripheral arterial disease of the lower limbs compared with color Doppler ultrasonography. Arch Med Sci Atheroscler Dis. 2022 Aug 8;7:e66-e72. doi: 10.5114/amsad/150716. eCollection 2022.
PubMed 36158072Corte AC, Pedrinelli A, Marttos A, Souza IFG, Grava J, Jose Hernandez A. Infrared thermography study as a complementary method of screening and prevention of muscle injuries: pilot study. BMJ Open Sport Exerc Med. 2019 Jan 3;5(1):e000431. doi: 10.1136/bmjsem-2018-000431. eCollection 2019.
PubMed 30687515Alghadir AH, Anwer S, Iqbal A, Iqbal ZA. Test-retest reliability, validity, and minimum detectable change of visual analog, numerical rating, and verbal rating scales for measurement of osteoarthritic knee pain. J Pain Res. 2018 Apr 26;11:851-856. doi: 10.2147/JPR.S158847. eCollection 2018.
PubMed 29731662Cvjetkovic DD, Bijeljac S, Palija S, Talic G, Radulovic TN, Kosanovic MG, Manojlovic S. Isokinetic Testing in Evaluation Rehabilitation Outcome After ACL Reconstruction. Med Arch. 2015 Feb;69(1):21-3. doi: 10.5455/medarh.2015.69.21-23. Epub 2015 Feb 21.
PubMed 25870471Gopinatth V, Garcia JR, Reid IK, Knapik DM, Verma NN, Chahla J. Blood Flow Restriction Enhances Recovery After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arthroscopy. 2025 Apr;41(4):1048-1060. doi: 10.1016/j.arthro.2024.05.032. Epub 2024 Jun 16.
PubMed 38889851Lin Q, Zhang Y, Qin J, Wu F. Effects of Low-Load Blood Flow Restriction Training on Muscle Volume After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis. Orthop J Sports Med. 2024 Dec 13;12(12):23259671241301731. doi: 10.1177/23259671241301731. eCollection 2024 Dec.
PubMed 39678440Koc B, Jansen E, de Jong O, Ehlen T, van Rijn L, de Bie R, Schotanus M. Qualitative Evaluation of Patient Experiences with Low-Load Blood Flow Restriction and Heavy-Load Resistance Training Post-ACL Reconstruction. Int J Sports Phys Ther. 2025 Oct 1;20(10):1479-1488. doi: 10.26603/001c.143781. eCollection 2025.
PubMed 41048413Koc BB, Truyens A, Heymans MJLF, Jansen EJP, Schotanus MGM. Effect of Low-Load Blood Flow Restriction Training After Anterior Cruciate Ligament Reconstruction: A Systematic Review. Int J Sports Phys Ther. 2022 Apr 1;17(3):334-346. doi: 10.26603/001c.33151. eCollection 2022.
PubMed 35391871Norte GE, Murray AM, Rush JL, Sherman DA, Glaviano NR. Hamstrings Volumetric Adaptations to a Four-Week Nordic Hamstring Exercise Protocol in Individuals with ACL Reconstruction: A Preliminary Case Series. Int J Sports Phys Ther. 2025 Sep 2;20(9):1377-1387. doi: 10.26603/001c.143149. eCollection 2025.
PubMed 40904716Mengis N, Hoher J, Ellermann A, Eberle C, Hartner C, Keller M, Rippke JN, Sprenger N, Stein T, Stoffels T, Egloff C, Niederer D. A Guideline for Validated Return-to-Sport Testing in Everyday Clinical Practice: A Focused Review on the Validity, Reliability, and Feasibility of Tests Estimating the Risk of Reinjury After ACL Reconstruction. Orthop J Sports Med. 2025 May 5;13(5):23259671251317208. doi: 10.1177/23259671251317208. eCollection 2025 May.
PubMed 40342351Hiemstra LA, Webber S, MacDonald PB, Kriellaars DJ. Contralateral limb strength deficits after anterior cruciate ligament reconstruction using a hamstring tendon graft. Clin Biomech (Bristol). 2007 Jun;22(5):543-50. doi: 10.1016/j.clinbiomech.2007.01.009. Epub 2007 Mar 27.
PubMed 17391820Kuenze C, Hart JM. Quadriceps strength thresholds and patient-reported function after anterior cruciate ligament reconstruction: a systematic review. J Sport Rehabil. 2023 Jun 1;32(5):458-468. doi: 10.1123/jsr.2022-0362
Schwery NA, Kiely MT, Larson CM, Wulf CA, Heikes CS, Hess RW, Giveans MR, Solie BS, Doney CP. Quadriceps Strength following Anterior Cruciate Ligament Reconstruction: Normative Values based on Sex, Graft Type and Meniscal Status at 3, 6 & 9 Months. Int J Sports Phys Ther. 2022 Apr 1;17(3):434-444. doi: 10.26603/001c.32378. eCollection 2022.
PubMed 35391858Liao LR, Ng GYF, Jones AY, Lee LK, Leung HK, Ng SSM. Predicting maximal strength of quadriceps from submaximal performance in individuals with knee joint osteoarthritis. J Orthop Sports Phys Ther. 2015;45(5):408-414
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training : A Randomized Controlled Trial in Post-ACL Reconstruction Populations
- ClinicalTrials.gov ID
- NCT07384780
- Acronym / sponsor ID
- GulfMU
- Conditions
- ACL Reconstruction, ACL Repair
- Keywords
- blood flow restriction training ACL, Blood flow restriction, ACL Rehab, ACLR, ACL Reconstruction, BFR therapy anterior cruciate ligament reconstruction, BFR therapy ACLR, BFR Therapy
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Gulf Medical UniversityUniversity, hospital or other
- Study start
- Feb 2026 (estimated)
- Primary completion
- Jun 2026 (estimated)
- Study completion
- Jun 2026 (estimated)
- First posted
- 3 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to see which type of strengthening exercise with a tight band (blood flow restriction) helps people recover better after ACL reconstruction. The study includes adults after ACL surgery who are doing physiotherapy to rebuild thigh muscle strength and knee function.
The main questions are:
- Does heavy strengthening with blood flow restriction improve thigh strength, knee function, and daily activities more than light strengthening with blood flow restriction after ACL surgery?
- Can light strengthening with blood flow restriction give similar benefits to heavy strengthening while putting less strain on the knee?
Researchers will compare a heavy-exercise program plus blood flow restriction to a light-exercise program plus blood flow restriction to see which gives better strength and functional improvements.
Participants will:
- Come for supervised physiotherapy sessions and do knee exercises on a machine, using either heavy or light loads while a cuff on the thigh gently squeezes to reduce blood flow.
- Have their leg strength, and knee questionnaires checked several times during the study.
Detailed description
This clinical trial is testing two different ways of doing strength training with a tight leg cuff (blood flow restriction) during rehabilitation after ACL reconstruction. The aim is to find out which program helps people rebuild thigh muscle strength and knee function more effectively, while still keeping the knee joint safe after surgery.
Study purpose and questions After ACL reconstruction, many people lose muscle size and strength in the front of the thigh, which can slow down recovery and delay return to sport or full activity. Blood flow restriction training allows people to train with lighter weights but still gain strength and muscle, which may be useful when heavy loads are not yet safe.
The main questions are:
- Does a heavy-load isokinetic exercise program with blood flow restriction improve thigh strength, knee function, and patient-reported outcomes more than a low-load isokinetic program with blood flow restriction?
- Can low-load isokinetic exercise with blood flow restriction provide similar benefits in strength and function, while placing less stress on the healing knee joint? Who will take part The study will include adults who have had ACL reconstruction and are in the strengthening phase of their rehabilitation. Participants will typically be active people, cleared by their surgeon and physiotherapist to start moderate to high resistance training, with no serious heart, blood vessel, or bleeding problems that would make blood flow restriction unsafe.
What happens in the study Participants will be randomly assigned to one of two groups so that each person has an equal chance of being in either group.
- One group will do heavy-load isokinetic knee exercises with a blood flow restriction cuff on the thigh.
- The other group will do low-load isokinetic knee exercises with the same type of cuff and similar exercise schedule.
Both groups will:
- Attend supervised physiotherapy sessions several times per week for around 3-4 months.
- Perform knee extension and flexion exercises on an isokinetic machine, where the speed of movement is controlled and resistance adjusts through the range of motion.
- Wear a wide cuff around the upper thigh, which is inflated to a set pressure to partially reduce blood flow out of the leg during sets, then deflated during rest periods.
The physiotherapist will adjust the load (heavy or light), cuff pressure, and number of sets and repetitions according to a fixed protocol so that each participant trains safely and progressively over time.
Measurements and outcomes
Participants will be tested at the start of the study and at follow-up visits (for example, after several weeks and at the end of the program). The main outcome is peak quadriceps strength measured on an isokinetic dynamometer. Other outcomes may include:
- Rate of torque development (how quickly the muscle can produce force).
- Functional tests such as hop tests, walking or stair tests, and timed tasks.
- Patient questionnaires about knee symptoms, daily activities, sports function, and quality of life.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ACL Reconstruction Population | Active comparator | Other: High Load Isokinetic Training with Blood Flow Restriction, Other: Low Load Isokinetic Training with Blood Flow Restriction |
| Healthy Population | Active comparator | Other: High Load Isokinetic Training with Blood Flow Restriction, Other: Low Load Isokinetic Training with Blood Flow Restriction |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- •Isolated unilateral ACL reconstruction 8-16 weeks post-surgery with medical clearance for moderate to high resistance training.
- Healthy adults with no musculoskeletal pathology.
Key exclusion criteria (7 listed)
- History of cardiovascular or metabolic diseases
- Deep vein thrombosis
- Coagulopathy
- Hypertension
- Skin lesions or infections at the site of BFR cuff administration
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High Load Isokinetic Training with Blood Flow RestrictionAlso: High Load strength training, High Load Isokinetic training, Blood Flow Restriction, BFRHigh Load strength training that was administered through the use of an isokinetic device, and not conventional strength training equipment, combined with blood flow restriction. | Other | ACL Reconstruction Population, Healthy Population |
| Low Load Isokinetic Training with Blood Flow RestrictionAlso: Low Load strength training, Low Load Isokinetic training, Blood Flow Restriction, BFRLow Load strength training that was administered through the use of an isokinetic device, and not conventional strength training equipment, combined with blood flow restriction. | Other | ACL Reconstruction Population, Healthy Population |
Primary outcome
Muscle Strength
Time frame: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Muscle strength will be measured using Biodex System 4 Pro for concentric quadriceps and hamstring strength at 60°/s and eccentric quadriceps at 60°/s. Recorded parameters: peak torque(Nm/kg), total work(J), and average power(W).
Muscle Girth
Time frame: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Muscle girth will be measured by measuring the mid-thigh circumference using an inch tape at 15cm above the superior border of the patella. The mean of two readings will be recorded
3 secondary outcomes
Pain Reduction
Time frame: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Blood Flow
Time frame: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Tolerability and Perception of the Intervention(s)
Time frame: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2026.
- Background: PubMed 20890972McNair PJ, Colvin M, Reid D. Predicting maximal strength of quadriceps from submaximal performance in individuals with knee joint osteoarthritis. Arthritis Care Res (Hoboken). 2011 Feb;63(2):216-22. doi: 10.1002/acr.20368.
- Background: PubMed 36158072de Deus Passos M, da Rocha AF. Evaluation of infrared thermography with a portable camera as a diagnostic tool for peripheral arterial disease of the lower limbs compared with color Doppler ultrasonography. Arch Med Sci Atheroscler Dis. 2022 Aug 8;7:e66-e72. doi: 10.5114/amsad/150716. eCollection 2022.
- Background: PubMed 30687515Corte AC, Pedrinelli A, Marttos A, Souza IFG, Grava J, Jose Hernandez A. Infrared thermography study as a complementary method of screening and prevention of muscle injuries: pilot study. BMJ Open Sport Exerc Med. 2019 Jan 3;5(1):e000431. doi: 10.1136/bmjsem-2018-000431. eCollection 2019.
- Background: PubMed 29731662Alghadir AH, Anwer S, Iqbal A, Iqbal ZA. Test-retest reliability, validity, and minimum detectable change of visual analog, numerical rating, and verbal rating scales for measurement of osteoarthritic knee pain. J Pain Res. 2018 Apr 26;11:851-856. doi: 10.2147/JPR.S158847. eCollection 2018.
- Background: PubMed 25870471Cvjetkovic DD, Bijeljac S, Palija S, Talic G, Radulovic TN, Kosanovic MG, Manojlovic S. Isokinetic Testing in Evaluation Rehabilitation Outcome After ACL Reconstruction. Med Arch. 2015 Feb;69(1):21-3. doi: 10.5455/medarh.2015.69.21-23. Epub 2015 Feb 21.
- Background: PubMed 38889851Gopinatth V, Garcia JR, Reid IK, Knapik DM, Verma NN, Chahla J. Blood Flow Restriction Enhances Recovery After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arthroscopy. 2025 Apr;41(4):1048-1060. doi: 10.1016/j.arthro.2024.05.032. Epub 2024 Jun 16.
- Background: PubMed 39678440Lin Q, Zhang Y, Qin J, Wu F. Effects of Low-Load Blood Flow Restriction Training on Muscle Volume After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis. Orthop J Sports Med. 2024 Dec 13;12(12):23259671241301731. doi: 10.1177/23259671241301731. eCollection 2024 Dec.
- Background: PubMed 41048413Koc B, Jansen E, de Jong O, Ehlen T, van Rijn L, de Bie R, Schotanus M. Qualitative Evaluation of Patient Experiences with Low-Load Blood Flow Restriction and Heavy-Load Resistance Training Post-ACL Reconstruction. Int J Sports Phys Ther. 2025 Oct 1;20(10):1479-1488. doi: 10.26603/001c.143781. eCollection 2025.
- Background: PubMed 35391871Koc BB, Truyens A, Heymans MJLF, Jansen EJP, Schotanus MGM. Effect of Low-Load Blood Flow Restriction Training After Anterior Cruciate Ligament Reconstruction: A Systematic Review. Int J Sports Phys Ther. 2022 Apr 1;17(3):334-346. doi: 10.26603/001c.33151. eCollection 2022.
- Background: PubMed 40904716Norte GE, Murray AM, Rush JL, Sherman DA, Glaviano NR. Hamstrings Volumetric Adaptations to a Four-Week Nordic Hamstring Exercise Protocol in Individuals with ACL Reconstruction: A Preliminary Case Series. Int J Sports Phys Ther. 2025 Sep 2;20(9):1377-1387. doi: 10.26603/001c.143149. eCollection 2025.
- Background: PubMed 40342351Mengis N, Hoher J, Ellermann A, Eberle C, Hartner C, Keller M, Rippke JN, Sprenger N, Stein T, Stoffels T, Egloff C, Niederer D. A Guideline for Validated Return-to-Sport Testing in Everyday Clinical Practice: A Focused Review on the Validity, Reliability, and Feasibility of Tests Estimating the Risk of Reinjury After ACL Reconstruction. Orthop J Sports Med. 2025 May 5;13(5):23259671251317208. doi: 10.1177/23259671251317208. eCollection 2025 May.
- Background: PubMed 17391820Hiemstra LA, Webber S, MacDonald PB, Kriellaars DJ. Contralateral limb strength deficits after anterior cruciate ligament reconstruction using a hamstring tendon graft. Clin Biomech (Bristol). 2007 Jun;22(5):543-50. doi: 10.1016/j.clinbiomech.2007.01.009. Epub 2007 Mar 27.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing High Load Isokinetic Training with Blood Flow Restriction and Low Load Isokinetic Training with Blood Flow Restriction in people with ACL Reconstruction and ACL Repair, run by Gulf Medical University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Osman Z Khan, Bachelors of Physiotherapy (+971563292389, osman.thekhan@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle Strength (time frame: Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07384780, which also lists 27 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.