Meniscus TearNCT07388290
The Effect of Centralization on Medial Meniscal Extrusion for Medial Meniscus Posterior Root Tear Repair
A study testing Medial meniscus posterior root tear (MMPRT) repair with meniscus centralization and Medial meniscus posterior root tear (MMPRT) repair without meniscus centralization in people with Meniscus Tear, run by Mayo Clinic at 3 sites in United States.
Trial summary
The purpose of this research is to determine if meniscus root repair with or without centralization will have an impact on postoperative pain, function, activity levels, patient satisfaction, and incidence of revision meniscus surgery. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Meniscus Tear
- What is being tested?
- Medial meniscus posterior root tear (MMPRT) repair with meniscus centralization and Medial meniscus posterior root tear (MMPRT) repair without meniscus centralization
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 3 sitesUnited States
- Study dates
- 17 Feb 2026to Mar 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Type 2 Medial Meniscus Posterior Root Tear demonstrated on MRI
- Notable extrusion (>3 mm) on preoperative MRI
- Patient able to consent for themselves
- Patient agrees to comply with trial schedules and plan
- Pre-operative Exclusion:
- Concomitant ligamentous or meniscal procedures
Show all 26Show fewer
- Meniscal extrusion > 6 mm on pre-operative MRI
- Kellgren-Lawrence grade > 2
- Varus malalignment > 10 degrees
- Asymmetric varus alignment > 5 degrees
- Varus thrust while weightbearing
- Grade 3 bipolar medial compartment changes (isolated grade 3 changes on single articular surface with ≤ grade 2 changes on the opposing surface remains eligible)
- Previous surgery of the affected knee
- Associated fractures requiring surgery
- Concurrent Vascular injuries
- Hypermobility/Ehlers-Danlos Syndrome
- Inflammatory or autoimmune disease
- Severe mental/physical disability precluding post operative rehabilitation demands
- Contraindications to MRI
- Pregnant women
- Arthroscopy Inclusion Criteria:
- Complete radial tears within 9 mm of medial meniscus posterior root
- ICRS Grade 3 or better
- Arthroscopy Exclusion Criteria:
- Requiring concomitant procedures other than MMPRT
- ICRS Grade 4 changes
Who cannot join
None listed.
Trial locations and contacts
3 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States3 sites
Hospital for Special Surgery at Naples Comprehensive Health (HSS at NCH),
Naples, Florida, 34110
Mayo Clinic
Rochester, Minnesota, 55902
The Steadman Clinic
West Vail, Colorado, 81657
About this study
The purpose of this research is to determine if meniscus root repair with or without centralization will have an impact on postoperative pain, function, activity levels, patient satisfaction, and incidence of revision meniscus surgery.
- Conditions
- Meniscus Tear
- Being tested
- Medial meniscus posterior root tear (MMPRT) repair with meniscus centralization, Medial meniscus posterior root tear (MMPRT) repair without meniscus centralization
- Keywords
- Meniscus tear, Meniscus extrusion, Medial meniscus root repair, Meniscus centralization
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Medial meniscus posterior root tear (MMPRT) repair with meniscus centralizationProcedure or surgery
The centralization technique involves placement of 1.8-mm Knotless FiberTak suture anchors along the periphery of the tibial plateau, starting from the posteromedial corner and progressing anteriorly. The anchors are deployed using a curved drill guide, and sutures are passed in a mattress configuration to re-tension the meniscotibial ligament to centralize the meniscus.
Once centralization is complete, the posterior root tear is repaired using an anatomic suture anchor for aperture medial meniscus root fixation.
Medial meniscus posterior root tear (MMPRT) repair without meniscus centralizationProcedure or surgery
The posterior root tear is repaired using an anatomic suture anchor for aperture medial meniscus root fixation.
| Study group | Role | What they receive |
|---|---|---|
| Repair with meniscus centralization | Experimental | Medial meniscus posterior root tear (MMPRT) surgical repair with meniscus centralization Receives: Procedure: Medial meniscus posterior root tear (MMPRT) repair with meniscus centralization |
| Repair without centralization | Active comparator | Medial meniscus posterior root tear (MMPRT) surgical repair without centralization Receives: Procedure: Medial meniscus posterior root tear (MMPRT) repair without meniscus centralization |
What is being measured
The primary outcome is the main question the study is designed to answer.
Meniscus extrusion measurement
Meniscus extrusion is measured in millimeters (mm) on coronal MRI at the level of the tibial spine
Measured: Baseline (Preoperatively), 6 months
Secondary outcomes (7)
Change in Kellgren-Lawrence grade on X-ray
The Kellgren-Lawrence (KL) system is a 0-4 scale used to grade the severity of knee osteoarthritis (OA) based on X-ray. It ranges from Grade 0 (no changes) to Grade 4 (severe).
Measured: Baseline (Screening), 12 months, 24 months
Change in Tegner Activity Score
The Tegner Activity Questionnaire is a 1-item questionnaire rating physical activity from 0 (Disabled) to 10 (Elite competitive athlete). Total scores range from 0 - 10, with higher scores indicating a higher level of activity.
Measured: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Change in Visual Analog Scale (VAS) Questionnaire score
The VAS is a 2-item questionnaire assessing pain using a scale of 0 (No pain) to 10 (Worst pain). Total scores range from 0 - 10, lower scores indicating lower pain and higher scores indicating greater pain.
Measured: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Change in Knee Injury and Osteoarthritis Outcome Score Jr. (KOOS, JR) Questionnaire score
The KOOS JR is a questionnaire designed to measure outcomes for patients with knee replacements. Questions focus on knee stiffness, pain, and function for daily activities and are assessed on a 5 point Likert-scale between 0 (None) and 4 (Extreme). Total scores range from 0 - 28, with higher scores indicating a greater impact of pain on daily functioning.
Measured: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Change in International Knee Documentation Committee (IKDC) Questionnaire score
The International Knee Documentation Committee (IKDC) Subjective Knee Evaluation assesses overall function over 3 domains: symptoms, athletic activity, and knee function. Higher scores indicate higher levels of function and lower levels of symptoms.
Measured: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Change in Likert Knee Questionnaire score
The Likert Knee Questionnaire is a 1-item survey asking the patient to rate knee pain post-surgery on a Likert scale where 0 (Much better than before surgery) and 5 (Much worse than before surgery).
Measured: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Surgery Satisfaction Questionnaire
The Surgery Satisfaction Questionnaire is a 1-item survey asking the patient to rate satisfaction with knee surgery on a Likert scale where 0 (Not at all) and 10 (Most Satisfied).
Measured: 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2026
- Study start17 Feb 2026
- Primary completionSep 2028 (estimated)
- Study completionMar 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Meniscus TearStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 54 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Aaron Krych, Mayo Clinic
- Investigators
- Aaron J. Krych, MD, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07388290
- Sponsor's protocol ID
- 25-011455
- Status last verified
- Apr 2026
- First submitted
- 28 Jan 2026
- Last updated
- 13 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Centralization on Medial Meniscal Extrusion for Medial Meniscus Posterior Root Tear Repair
- ClinicalTrials.gov ID
- NCT07388290
- Acronym / sponsor ID
- 25-011455
- Conditions
- Meniscus Tear
- Keywords
- Meniscus tear, Meniscus extrusion, Medial meniscus root repair, Meniscus centralization
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 54 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 17 Feb 2026 (actual)
- Primary completion
- Sep 2028 (estimated)
- Study completion
- Mar 2030 (estimated)
- First posted
- 5 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this research is to determine if meniscus root repair with or without centralization will have an impact on postoperative pain, function, activity levels, patient satisfaction, and incidence of revision meniscus surgery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Repair with meniscus centralization | Experimental | Procedure: Medial meniscus posterior root tear (MMPRT) repair with meniscus centralizationMedial meniscus posterior root tear (MMPRT) surgical repair with meniscus centralization |
| Repair without centralization | Active comparator | Procedure: Medial meniscus posterior root tear (MMPRT) repair without meniscus centralizationMedial meniscus posterior root tear (MMPRT) surgical repair without centralization |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (26 listed)
- Type 2 Medial Meniscus Posterior Root Tear demonstrated on MRI
- Notable extrusion (>3 mm) on preoperative MRI
- Patient able to consent for themselves
- Patient agrees to comply with trial schedules and plan
- Concomitant ligamentous or meniscal procedures
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Medial meniscus posterior root tear (MMPRT) repair with meniscus centralizationThe centralization technique involves placement of 1.8-mm Knotless FiberTak suture anchors along the periphery of the tibial plateau, starting from the posteromedial corner and progressing anteriorly. The anchors are deployed using a curved drill guide, and sutures are passed in a mattress configuration to re-tension the meniscotibial ligament to centralize the meniscus. Once centralization is complete, the posterior root tear is repaired using an anatomic suture anchor for aperture medial meniscus root fixation. | Procedure or surgery | Repair with meniscus centralization |
| Medial meniscus posterior root tear (MMPRT) repair without meniscus centralizationThe posterior root tear is repaired using an anatomic suture anchor for aperture medial meniscus root fixation. | Procedure or surgery | Repair without centralization |
Primary outcome
Meniscus extrusion measurement
Time frame: Baseline (Preoperatively), 6 months
Meniscus extrusion is measured in millimeters (mm) on coronal MRI at the level of the tibial spine
7 secondary outcomes
Change in Kellgren-Lawrence grade on X-ray
Time frame: Baseline (Screening), 12 months, 24 months
Change in Tegner Activity Score
Time frame: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Change in Visual Analog Scale (VAS) Questionnaire score
Time frame: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Change in Knee Injury and Osteoarthritis Outcome Score Jr. (KOOS, JR) Questionnaire score
Time frame: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Change in International Knee Documentation Committee (IKDC) Questionnaire score
Time frame: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Change in Likert Knee Questionnaire score
Time frame: Baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Surgery Satisfaction Questionnaire
Time frame: 2 weeks, 6 weeks, 3 months, 6 months, 12 months, 24 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Aaron J. Krych, MD principal investigator
Mayo Clinic
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Medial meniscus posterior root tear (MMPRT) repair with meniscus centralization and Medial meniscus posterior root tear (MMPRT) repair without meniscus centralization in people with Meniscus Tear, run by Mayo Clinic at 3 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 26 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Meniscus extrusion measurement (time frame: Baseline (Preoperatively), 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.