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Cardiac Arrest (CA)OPEN CCTArrestNCT07388342

Diagnostic Accuracy of ECG-less Gated Cardiac CT in Resuscitated Cardiac Arrest Survivors Without ST Elevation Myocardial Infarction

A study testing ECG-less gated cardiac CT in people with Cardiac Arrest (CA) and Myocardial Infarction (MI), run by Universitair Ziekenhuis Brussel at 1 site in Belgium.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

In a significant portion of patients surviving a cardiac arrest, the event is caused by a myocardial infarction (a narrowing or blockage of one or more blood vessels that supply blood to the heart, the coronary arteries). Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
ECG-less gated cardiac CT
Type of treatment
Medical device
Could I receive a placebo?
No, everyone receives an active treatment
How many people
30 participants
Where
1 siteBelgium
Study dates
1 Sep 2025to 1 Dec 2027
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Adults (≥18 years) with sustained return of spontaneous circulation (ROSC) following in/out-of-hospital cardiac arrest.
  • Informed consent from patient or representative obtained before invasive coronary angiography.

Who cannot join

  • Patients on VA-ECMO
  • ACS STEMI or STEMI "equivalent"
  • New left/right bundle branch block
  • ST segment depression in leads V1-V3, when the terminal T wave is positive and concomitant ST-segment elevation ≥ 0,5mm recorded in leads V7-V9 (posterior MI)
  • ST-segment elevation in V7-V9 (posterior MI) or V3R-V4R (RV MI)
  • ACS NSTEMI with persistent ST depression despite optimal therapy, suggesting ongoing myocardial ischemia, with indication for an urgent ICA according to the treating physician.
Show all 16Show fewer
  • Hemodynamic/electrical instability precluding CT imaging (as perceived by the treating physician)
  • Life-threatening arrhythmia potentially caused by acute myocardial ischemia
  • Absolute contraindications to iodinated contrast
  • Patients with a known non-cardiac cause of cardiac arrest (e.g., traumatic brain injury, overt hemorrhage, asphyxia/severe hypoxia due to known lung disease, trauma, severe metabolic/electrolyte derangement, or intoxication) as perceived by the treating physician, where chest CT is considered unnecessary.
  • Known or likely pregnancy or lactation
  • Severe bleeding issue (as perceived by the treating physician) precluding heparin administration during radial access coronary angiography.
  • Prior coronary intervention (stent implantation/CABG).
  • CT findings indicating a condition that precludes coronary angiography in the short term.
  • Patients with end-of-life care pathways.
  • Participation in another intervention study interfering with the research questions in OPEN CCT Arrest.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Belgium1 site, 1 recruiting

  • Universitair Ziekenhuis Brussel (UZB)

    Brussels, Vlaams Brabant, 1090

    Bert S Popelier, MD, +32476735411, Bert.Popelier@uzbrussel.be

    Stijn Lochy, MD, +322 477 60 09, Stijn.Lochy@uzbrussel.be

    Recruiting

Other trials in Belgium

About this study

Official title: Diagnostic Accuracy of ECG-less Gated Cardiac CT in Resuscitated Cardiac Arrest Survivors

In a significant portion of patients surviving a cardiac arrest, the event is caused by a myocardial infarction (a narrowing or blockage of one or more blood vessels that supply blood to the heart, the coronary arteries). In some people, this is immediately evident from basic tests; in others, it is more difficult to predict with the currently available tests whether this (or something else) caused the cardiac arrest. We investigate a technique that allows us to also assess the coronary arteries on the CT scan that is performed in patients surviving a cardiac arrest. The coronary angiography is currently the best exam we have for examining the coronary arteries, but it has some disadvantages. Compared to the CT scan, it takes more time, needs a more complex access to the blood vessels, and has some rare but relevant possible complications. The major advantage of the coronary angiography is that there is the possibility of immediate treatment of a narrowed/blocked blood vessel of the heart. The current guidelines advice an urgent coronary angiography when a clear myocardial infarction is suggested on the electrocardiogram, but not when there is no clear indication of myocardial infarction. Nonetheless, a relevant portion (more or less 40%) of the patients without a clearly abnormal electrocardiogram, still have an important problem in the blood vessels of the heart. We aim to determine whether the CT scan provides accurate information about the condition of the blood vessels of the heart. The CT scan was already well examined for this purpose before, but in the currently conventional way it needs preparation with extra monitoring and administration of medication, which would lead to loss of precious time and potentially dangerous side effects of these drugs in this critical situation. For that reason, a new software modality was developed that allows us to examine the coronary arteries in the same CT scan, without need for additional monitoring or medication administration. It does not need additional contrast administration (the dye necessary for optimal evaluation of some diseases).

The goal of this study is to determine whether this new technique gives us the correct information about the coronary arteries. This means we acquire the images of the heart in the same scan, and verify the results with the conventional coronary angiography. If the technique provides accurate information, it could lead to a better selection of patients we need to urgently refer for a coronary angiography and to defer the exam in those who have normal coronary arteries on the scan.

Read the detailed description

Acute coronary syndrome (ACS) is the most important treatable cause of cardiac arrest. In contrast with cardiac arrest survivors with ST elevation myocardial infarction (STEMI), current guidelines do not recommend unselected/routine urgent invasive coronary angiography (ICA) in the patients with cardiac arrest without STEMI. This recommendation reflects existing evidence indicating that immediate invasive strategies may not confer significant benefit in this population and may even be harmful, while another ongoing randomized controlled trial is investigating this. Nevertheless, in COACT, a landmark trial investigating a strategy of immediate versus delayed coronary angiography in out-of-hospital cardiac arrest patients without STEMI, one or more culprit coronary lesions responsible for triggering cardiac arrest were identified in 40% of the total patient population. The question remains pertinent whether well selected cardiac arrest survivors without STEMI can benefit from early ICA. Yet, current available clinical tools fail to identify these patients. Markers such as clinical history, echocardiographic abnormalities, arrest rhythm (shockable/non-shockable), ECG changes other than ST-segment elevation and troponin levels lack sufficient sensitivity and specificity in a cardiac arrest setting for predicting ACS requiring intervention.

The diagnostic value of ECG-gated cardiac computed tomography angiography (CCTA) for detection of both acute and chronic coronary artery syndrome is well established, with recent evidence demonstrating the additional value of fractional flow reserve (FFR)-CT in ACS. Nonetheless, the need for ECG-gating remains a limitation.

Recently an ECG-less CCTA modality was developed, but its diagnostic accuracy is still under validation. ECG-less cardiac or coronary CT angiography (CCTA) allows cardiac imaging without requiring an ECG signal from the patient. Thus, it eliminates the steps associated with using a patient-attached ECG monitor: skin preparation, attaching the ECG leads, checking impedance, and confirming that the leads provide an adequate ECG signal to the scanning system. Therefore, workflow is optimized, which is critical in an emergency setting. In situations where it is difficult to attach the ECG leads, such as patients in a resuscitation setting who already have diagnostic ECG leads in place or other instrumentation, it is also advantageous that there is no need for an ECG signal.

Cardiac arrest patients without STEMI and with no evident non-cardiac cause generally undergo CT imaging of head and chest for evaluation of potential causes of cardiac arrest (e.g. pulmonary embolism, acute aortic dissection, intracranial hemorrhage). While ECG-gated CCTA is considered the optimal modality for non-invasive coronary imaging, ECG-less CCTA might offer a highly interesting alternative with the advantages mentioned earlier. Other benefits include no substantially longer scanning time, no need for additional contrast injection or administration of betablockers.

ECG-less Cardiac software is an FDA-approved cardiac scan mode that essentially utilizes existing CT system scan technology. The system uses a wide detector coverage of 160mm to provide full heart coverage and a fast gantry speed of 0.23 seconds per rotation to perform imaging in a single cardiac cycle. An estimate of the heart rhythm has to be provided, which is often readily available because emergency patients are already monitored. Based on the heart rhythm the scanner simulates an ECG signal. This simulated ECG signal provides virtual gating of the scan. The acquisition can be performed during a full heart cycle or three-quarters or half cycle, depending on how fast the heart rhythm is. The existing cardiac software options of SmartPhase (automated phase selection) and SnapShot Freeze 2 (optimized volume registration) amplify the quality of the images and correct for motion.

Patients are scanned using a Revolution Apex Elite system (GE Healthcare, Waukesha, WI -USA). The investigators use a hyperdrive pulmonary CT angiography (523mm/s with 0.28s/rotation gantry speed). After a short delay of a few seconds (5-12 sec), allowing the contrast to leave the pulmonary circulation, and enter the aorta and coronary arteries, a coronary CT angiography is performed within the same contrast bolus. No extra contrast is given to acquire the cardiac images. No intravenous beta-blocker nor sublingual nitroglycerin is administered.

The total added exam time (assessing heart rhythm, preparing the scan parameters, the delay time and the acquisition itself) is about one to two minutes.

The dose-length product (DLP) of the ECG-less cardiac scan depends on the duration of the scan time that is chosen. The average DLP is between 150 and 200 mGy.cm. The diagnostic reference level (DRL) as set by the Federal Agency for Nuclear Controle (FANC) for a coronary CT angiography is 300 mGy.cm.

The combined pulmonary CT angiography and ECG-less cardiac scan can be used to diagnose all the pathologies that can be assessed on a conventional pulmonary CT angiography scan (including, but not limited to, pneumonia, pleural fluid, pulmonary embolism, pulmonary infarct, pulmonary mass, pneumothorax, pericardial fluid, etc.) and provides extra diagnostic information about coronary artery disease.

In case the technique is well validated, future clinical questions could include whether ECG-less CCTA can help to identify a patient population of cardiac arrest survivors without STEMI that do benefit from early invasive coronary angiography and whether earlier treatment could improve outcome.

This study aims to investigate the feasibility and diagnostic accuracy of ECG-less gated CCTA in cardiac arrest survivors without STEMI, by means of agreement with ICA.

Being tested
ECG-less gated cardiac CT
Keywords
Cardiac Arrest, Myocardial Infarction, Coronary Computed Tomography Angiography (CCTA)
Medical subject headings
Heart Arrest, Myocardial Infarction

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • ECG-less gated cardiac CTDevice

    Perform ECG-less gated cardiac CT during the CT scan routinely executed after survival of cardiac arrest in patients without STEMI.

Study groups in NCT07388342
Study groupRoleWhat they receive
Cardiac arrest survivor without STEMIExperimentalSurvivor of a cardiac arrest without STEMI, meeting inclusion criteria and no exclusion criteria, with informed consent from either the patient or his/her representative.
Receives: Device: ECG-less gated cardiac CT

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Percentage of patients correctly classified to coronary artery disease as the cause of cardiac arrest after analysis of the CT scan

    With the invasive coronary angiography as a gold standard, the investigator will assess whether the CT scan correctly allocated the patient to coronary versus non coronary cause of cardiac arrest

    Measured: Withing 24 hours after completion of the coronary angiography (which is performed within 24 hours of the CT scan) the comparative analysis will be performed

Secondary outcomes (17)

  1. Level of agreement on the estimated percentage of coronary artery stenosis between CCTA and ICA

    The degree of coronary stenosis will be estimated per-vessel (left main coronary artery, left anterior descendens, left circumflex artery and right coronary artery).

    The results will be reported as categorical variables: < 25%, 25-50%, 51-70%, 71-90%, >90% or insufficient image quality.

    Measured: Withing 24 hours after completion of the coronary angiography (which is performed within 24 hours of the CT scan) the comparative analysis will be performed

  2. Feasibility of ECG-less gated CCTA in resuscitated patients

    Percentage of patients where data on coronary stenosis based on ECG-less CCTA cannot be provided or is incompletely provided.

    Measured: Within 24 hours after completion of the coronary angiography (which is performed within 24 hours of the CT scan) the analysis will be performed

  3. Reasons for failure of ECG-less gated CCTA image acquisition

    Registrations of reasons for failure of complete CCTA reporting (eg incorrect timing, tachycardia/irregular heart rhythm...)

    Measured: Within 24 hours after completion of the coronary angiography (which is performed within 24 hours of the CT scan) the analysis will be performed

  4. Survival

    Survival status assessed by analysis of the electronic medical record

    Measured: 90 days after enrollment

  5. Severe neurologic deficit

    Severe neurologic deficit definined as Modified Rankin Scale ≥ 3, assessed by consultation of the electronic health record (Y/N).

    The Modified Rankin Scale (mRS) is a scale used to assess the degree of disability or dependence. It is a 7-point scale, ranging from 0 (no symptoms) to 6 (death), designed to evaluate how well a patient can perform daily activities and how much assistance they need.

    Measured: 90 days after enrollment

  6. Peak troponin release

    Peak high sensitivity troponin T (ng/L) level during hospitalisation

    Measured: 90 days after enrollment

  7. Length of ICU stay

    Length of ICU stay (days)

    Measured: 90 days after enrollment

  8. Duration of catecholamine support

    Duration of catecholamine support (days) assessed by analysis of the electronic medical record

    Measured: 90 days after enrollment

  9. Peak SAPS II score

    The SAP II (Simplified Acute Physiology Score II) is a scoring system used to assess the severity of illness in critically ill patients, particularly those in intensive care units (ICU). It's designed to predict the risk of mortality based on various physiological variables measured in the first 24 hours of ICU admission.

    The score is calculated using 17 different clinical parameters, which include vital signs, lab results, and other physiological data. These parameters are categorized and assigned points, and the total score provides an estimate of the patient's risk of dying in the hospital.

    The score can range from 0 to 163. Higher scores indicate more severe illness and a higher risk of death.

    Measured: 90 days after enrollment

  10. Rehospitalization for heart failure

    Rehospitalization for heart failure (Y/N), assessed by analysis of the electronic medical record

    Measured: 90 days after enrollment

  11. Acute kidney injury (AKI)

    Development of AKI according to KDIGO definition (Y/N). AKI is diagnosed when there is a sudden decline in kidney function, defined by one of the following criteria:

    Serum Creatinine Criteria:

    • Stage 1: Increase in serum creatinine by ≥ 0.3 mg/dL (≥ 26.5 µmol/L) within 48 hours, or increase to 1.5-1.9 times baseline.
    • Stage 2: Increase in serum creatinine to 2.0-2.9 times baseline.
    • Stage 3: Increase in serum creatinine to 3.0 times baseline, or serum creatinine ≥ 4.0 mg/dL (≥ 354 µmol/L), or initiation of renal replacement therapy (dialysis), or in patients less than 18 years old, a decrease in glomerular filtration rate (GFR) to < 35 mL/min/1.73 m².

    Urine Output Criteria:

    Stage 1: Urine output < 0.5 mL/kg/hour for 6-12 hours. Stage 2: Urine output < 0.5 mL/kg/hour for ≥ 12 hours. Stage 3: Urine output < 0.3 mL/kg/hour for ≥ 24 hours, or anuria for ≥ 12 hours.

    Measured: 90 days after enrollment

  12. Need for renal replacement therapy (RRT)

    Need for renal replacement therapy (RRT) (Y/N)

    Measured: 90 days after enrollment

  13. ISTH major bleeding event

    Development of ISTH Major Bleeding Definition:

    According to the International Society on Thrombosis and Haemostasis (ISTH), a major bleeding event is one that involves at least one of the following:

    • Fatal Bleeding
    • Bleeding that Requires a Transfusion: requires the administration of 2 or more units of packed red blood cells (PRBCs) or equivalent blood products to treat blood loss.
    • Bleeding that Causes a Significant Drop in Hemoglobin: A decrease in hemoglobin of 2 g/dL or more or a hematocrit drop of ≥ 6%.
    • Bleeding that Requires Surgical Intervention
    • Intracranial Hemorrhage (ICH):
    • Other Severe Bleeding: Any other bleeding that is severe, for example, bleeding into a vital organ (e.g., bleeding into the eye causing loss of vision, or into the lungs causing respiratory compromise).

    Measured: 90 days after enrollment

  14. Ischemic stroke

    Development of ischemic stroke (Y/N)

    Measured: 90 days after enrollment

  15. Need for mechanical circulatory support (MCS)

    Need for mechanical circulatory support (MCS) (Y/N) Mechanical Circulatory Support (MCS) refers to the use of devices designed to support or assist the heart's ability to pump blood, typically in patients with acute or chronic heart failure. These devices are used to maintain or improve cardiac output in cases where the heart is not functioning adequately, often as a bridge to recovery, a bridge to heart transplantation, or as a long-term solution for patients who are not candidates for a transplant.

    Measured: 90 days after enrollment

  16. Treatment with Dual Antiplatelet Therapy (DAPT)

    Treatment with Dual Antiplatelet Therapy (DAPT) (Y/N)

    Measured: 90 days after enrollment

  17. LV systolic function

    Left ventricular systolic function assessed by ejection fraction (LVEF) on ambulatory follow-up visit

    Measured: 90 days after enrollment

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted5 Feb 2026
  2. Study start1 Sep 2025
  3. Primary completion1 Sep 2027 (estimated)
  4. Study completion1 Dec 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Diagnosis
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
30 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07388342
Sponsor's protocol ID
1432025000122
Acronym
OPEN CCTArrest
Status last verified
Jan 2026
First submitted
15 Oct 2025
Last updated
5 Feb 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
Yes
Individual data sharing
Undecided

Publications

  • Meier D, Andreini D, Cosyns B, Skalidis I, Storozhenko T, Mahendiran T, Assanelli E, Sonck J, Roosens B, Rotzinger DC, Qanadli SD, Tzimas G, Muller O, De Bruyne B, Collet C, Fournier S. Usefulness of FFR-CT to exclude haemodynamically significant lesions in high-risk NSTE-ACS. EuroIntervention. 2025 Jan 6;21(1):73-81. doi: 10.4244/EIJ-D-24-00779.

    PubMed 39468963

  • Meijboom WB, Meijs MF, Schuijf JD, Cramer MJ, Mollet NR, van Mieghem CA, Nieman K, van Werkhoven JM, Pundziute G, Weustink AC, de Vos AM, Pugliese F, Rensing B, Jukema JW, Bax JJ, Prokop M, Doevendans PA, Hunink MG, Krestin GP, de Feyter PJ. Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective, multicenter, multivendor study. J Am Coll Cardiol. 2008 Dec 16;52(25):2135-44. doi: 10.1016/j.jacc.2008.08.058.

    PubMed 19095130

  • Budoff MJ, Dowe D, Jollis JG, Gitter M, Sutherland J, Halamert E, Scherer M, Bellinger R, Martin A, Benton R, Delago A, Min JK. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol. 2008 Nov 18;52(21):1724-32. doi: 10.1016/j.jacc.2008.07.031.

    PubMed 19007693

  • Voicu S, Sideris G, Deye N, Dillinger JG, Logeart D, Broche C, Vivien B, Brun PY, Capan DD, Manzo-Silberman S, Megarbane B, Baud FJ, Henry P. Role of cardiac troponin in the diagnosis of acute myocardial infarction in comatose patients resuscitated from out-of-hospital cardiac arrest. Resuscitation. 2012 Apr;83(4):452-8. doi: 10.1016/j.resuscitation.2011.10.008. Epub 2011 Oct 29.

    PubMed 22037386

  • Staer-Jensen H, Nakstad ER, Fossum E, Mangschau A, Eritsland J, Draegni T, Jacobsen D, Sunde K, Andersen GO. Post-Resuscitation ECG for Selection of Patients for Immediate Coronary Angiography in Out-of-Hospital Cardiac Arrest. Circ Cardiovasc Interv. 2015 Oct;8(10):e002784. doi: 10.1161/CIRCINTERVENTIONS.115.002784.

    PubMed 26453688

  • Sideris G, Voicu S, Dillinger JG, Stratiev V, Logeart D, Broche C, Vivien B, Brun PY, Deye N, Capan D, Aout M, Megarbane B, Baud FJ, Henry P. Value of post-resuscitation electrocardiogram in the diagnosis of acute myocardial infarction in out-of-hospital cardiac arrest patients. Resuscitation. 2011 Sep;82(9):1148-53. doi: 10.1016/j.resuscitation.2011.04.023. Epub 2011 May 14.

    PubMed 21632166

  • Lee SE, Uhm JS, Kim JY, Pak HN, Lee MH, Joung B. Combined ECG, Echocardiographic, and Biomarker Criteria for Diagnosing Acute Myocardial Infarction in Out-of-Hospital Cardiac Arrest Patients. Yonsei Med J. 2015 Jul;56(4):887-94. doi: 10.3349/ymj.2015.56.4.887.

    PubMed 26069108

  • Dumas F, Manzo-Silberman S, Fichet J, Mami Z, Zuber B, Vivien B, Chenevier-Gobeaux C, Varenne O, Empana JP, Pene F, Spaulding C, Cariou A. Can early cardiac troponin I measurement help to predict recent coronary occlusion in out-of-hospital cardiac arrest survivors? Crit Care Med. 2012 Jun;40(6):1777-84. doi: 10.1097/CCM.0b013e3182474d5e.

    PubMed 22488008

  • Gonzalez MR, Esposito EC, Leary M, Gaieski DF, Kolansky DM, Chang G, Becker LB, Carr BG, Grossestreuer AV, Abella BS. Initial clinical predictors of significant coronary lesions after resuscitation from cardiac arrest. Ther Hypothermia Temp Manag. 2012 Jun;2(2):73-7. doi: 10.1089/ther.2012.0012. Epub 2012 Jul 9.

    PubMed 24717160

  • Desch S, Freund A, Akin I, Behnes M, Preusch MR, Zelniker TA, Skurk C, Landmesser U, Graf T, Eitel I, Fuernau G, Haake H, Nordbeck P, Hammer F, Felix SB, Hassager C, Engstrom T, Fichtlscherer S, Ledwoch J, Lenk K, Joner M, Steiner S, Liebetrau C, Voigt I, Zeymer U, Brand M, Schmitz R, Horstkotte J, Jacobshagen C, Poss J, Abdel-Wahab M, Lurz P, Jobs A, de Waha-Thiele S, Olbrich D, Sandig F, Konig IR, Brett S, Vens M, Klinge K, Thiele H; TOMAHAWK Investigators. Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation. N Engl J Med. 2021 Dec 30;385(27):2544-2553. doi: 10.1056/NEJMoa2101909. Epub 2021 Aug 29.

    PubMed 34459570

  • Elfwen L, Lagedal R, Nordberg P, James S, Oldgren J, Bohm F, Lundgren P, Rylander C, van der Linden J, Hollenberg J, Erlinge D, Cronberg T, Jensen U, Friberg H, Lilja G, Larsson IM, Wallin E, Rubertsson S, Svensson L. Direct or subacute coronary angiography in out-of-hospital cardiac arrest (DISCO)-An initial pilot-study of a randomized clinical trial. Resuscitation. 2019 Jun;139:253-261. doi: 10.1016/j.resuscitation.2019.04.027. Epub 2019 Apr 24.

    PubMed 31028826

  • Thevathasan T, Freund A, Spoormans E, Lemkes J, Rossberg M, Skurk C, Fichtlscherer S, Akin I, Fuernau G, Hassager C, Zeymer U, Preusch MR, Graf T, Jung C, Abdel-Wahab M, Jobs A, Laufs U, Schulze PC, Linke A, de Waha S, Poss J, Thiele H, Desch S. Bayesian Reanalyses of the Trials TOMAHAWK and COACT. JACC Cardiovasc Interv. 2024 Dec 23;17(24):2879-2889. doi: 10.1016/j.jcin.2024.09.071.

    PubMed 39722271

  • Lemkes JS, Janssens GN, van der Hoeven NW, Jewbali LSD, Dubois EA, Meuwissen M, Rijpstra TA, Bosker HA, Blans MJ, Bleeker GB, Baak R, Vlachojannis GJ, Eikemans BJW, van der Harst P, van der Horst ICC, Voskuil M, van der Heijden JJ, Beishuizen A, Stoel M, Camaro C, van der Hoeven H, Henriques JP, Vlaar APJ, Vink MA, van den Bogaard B, Heestermans TACM, de Ruijter W, Delnoij TSR, Crijns HJGM, Jessurun GAJ, Oemrawsingh PV, Gosselink MTM, Plomp K, Magro M, Elbers PWG, van de Ven PM, Oudemans-van Straaten HM, van Royen N. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation. N Engl J Med. 2019 Apr 11;380(15):1397-1407. doi: 10.1056/NEJMoa1816897. Epub 2019 Mar 18.

    PubMed 30883057

  • ESC Scientific Document Group. [2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death]. G Ital Cardiol (Rome). 2023;24(3 Suppl 1):e1-e132. doi: 10.1714/3986.39669. No abstract available. Italian.

    PubMed 36880552

Questions about this trial

What is this clinical trial studying?

A study testing ECG-less gated cardiac CT in people with Cardiac Arrest (CA) and Myocardial Infarction (MI), run by Universitair Ziekenhuis Brussel at 1 site in Belgium.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 16 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Belgium. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Percentage of patients correctly classified to coronary artery disease as the cause of cardiac arrest after analysis of the CT scan (time frame: Withing 24 hours after completion of the coronary angiography (which is performed within 24 hours of the CT scan) the comparative analysis will be performed). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07388342, which also lists 14 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.

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