Muscle Fatigue and Muscle OxygenationNCT07389395
Grastion and Percussion Therapy
A study testing Percussion Therapy and Instrument-Assisted Soft Tissue Mobilization (AISM) in people with Muscle Fatigue and Muscle Oxygenation, run by Karabuk University.
Trial summary
The study aims to investigate the effects of percussion therapy and instrument-assisted soft tissue mobilization (AISM), commonly used in clinical settings, on muscle fatigue, maximum muscle strength, pain threshold, and muscle oxygenation. The study will involve 20 volunteer participants. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Muscle Fatigue and Muscle Oxygenation
- What is being tested?
- Percussion Therapy and Instrument-Assisted Soft Tissue Mobilization (AISM)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- No sites listed yet
- Study dates
- 15 Feb 2026to 15 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged 18-35 years
- Healthy participants
- Sedentary lifestyle as defined by the International Physical Activity Questionnaire (IPAQ) (low physical activity category)
- Ability to understand the study procedures and provide written informed consent
Who cannot join
- Upper extremity injury or surgery within the past 6 months
- Presence of skin lesions, wounds, or dermatological diseases at the application site
- Any diagnosed musculoskeletal disorder
- History of cardiovascular, metabolic, or pulmonary disease
- Presence of neurological disorders or cognitive impairment affecting cooperation
- Use of medications affecting neuromuscular function or circulation
- Participation in any upper extremity strength training within the past 3 months
- Contraindications to percussion therapy or instrument-assisted soft tissue mobilization (Graston)
About this study
Official title: Comparison of the Effects of Pre-Exercise Instrument-Assisted Soft Tissue Mobilization and Percussion Therapy on Muscle Using a Crossover Design
The study aims to investigate the effects of percussion therapy and instrument-assisted soft tissue mobilization (AISM), commonly used in clinical settings, on muscle fatigue, maximum muscle strength, pain threshold, and muscle oxygenation.
The study will involve 20 volunteer participants. To achieve the study results, pre-exercise percussion therapy and instrument-assisted soft tissue mobilization (AISM) will be administered using a crossover design.
Results will be measured using a digital dynamometer, a moxy oxygen monitor, and a fatigue questionnaire.
- Conditions
- Muscle Fatigue and Muscle Oxygenation
- Being tested
- Percussion Therapy, Instrument-Assisted Soft Tissue Mobilization (AISM)
- Keywords
- Muscle Oxygen Saturation, Muscle Strength, Instrument-Assisted Soft Tissue Mobilization (Graston Technique), Percussion Therapy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Percussion TherapyOther
The massage gun will operate at a frequency of 30 beats per second (30 Hz), and percussion therapy will be applied to the muscle for 2 minutes. Percussion therapy will be performed using the device's standard ball head. The force applied by the device will be fixed so that it does not exceed the device's first-stage force setting (approximately 30 pounds). The biceps brachii (dominant arm) will be treated for 2 minutes at 30 Hz, moderate intensity.
Instrument-Assisted Soft Tissue Mobilization (AISM)Other
The arm will be positioned at the edge of the bed in full extension, with the shoulder in 45-degree abduction. The examiner will apply gentle pressure using a 30-degree angled instrument at a rate of 120 strokes/min, aligning the instrument's weight with the fibers of the biceps brachii muscle. The examiner will use a metronome to maintain a consistent pace during treatment, and the instrument angle will be calibrated with a protractor before each subject's treatment. The procedure will last 2 minutes, and baby oil will be used to ensure the instrument moves smoothly over the skin.
| Study group | Role | What they receive |
|---|---|---|
| instrument-assisted soft tissue mobilization | Active comparator | With the Graston method, 2 minutes of soft tissue mobilization will be performed on the biceps muscle before the exercise. Receives: Other: Instrument-Assisted Soft Tissue Mobilization (AISM) |
| percussion gun | Active comparator | A percussion gun will be applied to the biceps muscle for 2 minutes before the exercise. Receives: Other: Percussion Therapy |
| control | No intervention | A 2-minute warm-up will be performed without any application. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle Oxygen Saturation (SmO₂)
Oxygen saturation will be measured with the MOXY device. It is an infrared measuring device called "near infrared spectroscopy" that measures oxygen saturation and total hemoglobin in muscle capillaries. The device will be attached to the highest point of the muscle and secured with a black sheath and tape to prevent light exposure.
Measured: "Baseline (30 seconds before exercise)" "During the entire exercise period (from exercise onset to exercise termination)" "Post-exercise (0 to 2 minutes after exercise termination)"
Secondary outcomes (1)
Muscle Strength
Subjects will be seated with the elbow joint flexed to 90°, forearm in supination. They will be asked to contract their muscles in the direction of elbow flexion for 5 seconds, and the physiotherapist will apply force in the opposite direction to prevent movement in the elbow joint. Three measurements will be taken 30 seconds apart, and the average will be recorded.
Measured: "30, 60, and 90 seconds before the warm-up or intervention" "30, 60, and 90 seconds after the warm-up or intervention" "30, 60, and 90 seconds after exercise"
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2026
- Study start15 Feb 2026 (estimated)
- Primary completion1 Apr 2026 (estimated)
- Study completion15 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle Fatigue and Muscle OxygenationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Karabuk University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, METEHAN YANA, Karabuk University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07389395
- Sponsor's protocol ID
- Moxy
- Status last verified
- Jan 2026
- First submitted
- 18 Dec 2025
- Last updated
- 5 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Effects of Pre-Exercise Instrument-Assisted Soft Tissue Mobilization and Percussion Therapy on Muscle Using a Crossover Design
- ClinicalTrials.gov ID
- NCT07389395
- Acronym / sponsor ID
- Moxy
- Conditions
- Muscle Fatigue and Muscle Oxygenation
- Keywords
- Muscle Oxygen Saturation, Muscle Strength, Instrument-Assisted Soft Tissue Mobilization (Graston Technique), Percussion Therapy
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Karabuk UniversityUniversity, hospital or other
- Study start
- 15 Feb 2026 (estimated)
- Primary completion
- 1 Apr 2026 (estimated)
- Study completion
- 15 Jun 2026 (estimated)
- First posted
- 5 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study aims to investigate the effects of percussion therapy and instrument-assisted soft tissue mobilization (AISM), commonly used in clinical settings, on muscle fatigue, maximum muscle strength, pain threshold, and muscle oxygenation.
The study will involve 20 volunteer participants. To achieve the study results, pre-exercise percussion therapy and instrument-assisted soft tissue mobilization (AISM) will be administered using a crossover design.
Results will be measured using a digital dynamometer, a moxy oxygen monitor, and a fatigue questionnaire.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| instrument-assisted soft tissue mobilization | Active comparator | Other: Instrument-Assisted Soft Tissue Mobilization (AISM)With the Graston method, 2 minutes of soft tissue mobilization will be performed on the biceps muscle before the exercise. |
| percussion gun | Active comparator | Other: Percussion TherapyA percussion gun will be applied to the biceps muscle for 2 minutes before the exercise. |
| control | No intervention | –A 2-minute warm-up will be performed without any application. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Aged 18-35 years
- Healthy participants
- Sedentary lifestyle as defined by the International Physical Activity Questionnaire (IPAQ) (low physical activity category)
- Ability to understand the study procedures and provide written informed consent
Key exclusion criteria (8 listed)
- Upper extremity injury or surgery within the past 6 months
- Presence of skin lesions, wounds, or dermatological diseases at the application site
- Any diagnosed musculoskeletal disorder
- History of cardiovascular, metabolic, or pulmonary disease
- Presence of neurological disorders or cognitive impairment affecting cooperation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Percussion TherapyThe massage gun will operate at a frequency of 30 beats per second (30 Hz), and percussion therapy will be applied to the muscle for 2 minutes. Percussion therapy will be performed using the device's standard ball head. The force applied by the device will be fixed so that it does not exceed the device's first-stage force setting (approximately 30 pounds). The biceps brachii (dominant arm) will be treated for 2 minutes at 30 Hz, moderate intensity. | Other | percussion gun |
| Instrument-Assisted Soft Tissue Mobilization (AISM)The arm will be positioned at the edge of the bed in full extension, with the shoulder in 45-degree abduction. The examiner will apply gentle pressure using a 30-degree angled instrument at a rate of 120 strokes/min, aligning the instrument's weight with the fibers of the biceps brachii muscle. The examiner will use a metronome to maintain a consistent pace during treatment, and the instrument angle will be calibrated with a protractor before each subject's treatment. The procedure will last 2 minutes, and baby oil will be used to ensure the instrument moves smoothly over the skin. | Other | instrument-assisted soft tissue mobilization |
Primary outcome
Muscle Oxygen Saturation (SmO₂)
Time frame: "Baseline (30 seconds before exercise)" "During the entire exercise period (from exercise onset to exercise termination)" "Post-exercise (0 to 2 minutes after exercise termination)"
Oxygen saturation will be measured with the MOXY device. It is an infrared measuring device called "near infrared spectroscopy" that measures oxygen saturation and total hemoglobin in muscle capillaries. The device will be attached to the highest point of the muscle and secured with a black sheath and tape to prevent light exposure.
1 secondary outcome
Muscle Strength
Time frame: "30, 60, and 90 seconds before the warm-up or intervention" "30, 60, and 90 seconds after the warm-up or intervention" "30, 60, and 90 seconds after exercise"
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Percussion Therapy and Instrument-Assisted Soft Tissue Mobilization (AISM) in people with Muscle Fatigue and Muscle Oxygenation, run by Karabuk University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle Oxygen Saturation (SmO₂) (time frame: "Baseline (30 seconds before exercise)" "During the entire exercise period (from exercise onset to exercise termination)" "Post-exercise (0 to 2 minutes after exercise termination)"). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.