Anterior Cruciate Ligament Rupture With LigamentoplastyReproEVONCT07389850
Evaluation of the Evolution of Proprioceptive Reweighting Abilities Following Anterior Cruciate Ligament Reconstruction Surgery
A study testing ReproEVO intervention in people with Anterior Cruciate Ligament Rupture With Ligamentoplasty, run by University Hospital, Brest at 3 sites in France.
Trial summary
Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting. ACL reconstruction (ACLR) combined with rehabilitation is the standard treatment for ACL tears in athletes, and rehabilitation is one of the keys to success. Read more about this study
- Who is it for?
- Ages 15 to 40 years
- Conditions the study is for
- Anterior Cruciate Ligament Rupture With Ligamentoplasty
- What is being tested?
- ReproEVO intervention
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 34 participants
- Where
- 3 sitesFrance
- Study dates
- 20 Feb 2026to 20 May 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 40 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Aged between 15 and 40;
- Patients with ACL rupture scheduled for ACL reconstruction surgery;
- Patients able to maintain a stable bipedal standing position without technical assistance and with their eyes closed;
- Consent of the patient, parents, legal guardians, or guardians to the recording (for minor patients) of data for research and publication purposes.
Who cannot join
- Recent osteoarticular pathology (i.e., less than three months) of the lower limbs, whether traumatic or not, other than ACL rupture;
- Proven disabling neurological pathology;
- Pain in the musculoskeletal system during exercise (excluding the operated knee);
- Fatigue assessed using the Borg scale > 6;
- Skin allergy to an adhesive product.
Trial locations and contacts
3 sites in 1 country. Contact the study team or a site near you to ask about taking part.
France3 sites
Brest University Hospital
Brest, 29609
Olivier REMY-NERIS, Professor, +33298223152, olivier.remyneris@chu-brest.fr
Olivier REMY-NERIS, Professor
Montpellier University Hospital
Montpellier, 34000
Benoît ATTALIN, Doctor, +33687643336, benoit.attalin@gmail.com
Benoît ATTALIN, Doctor
Dr. STER Clinic, Saint Clément de Rivière
Saint-Clément-de-Rivière, 34980
François FEUVRIER, Doctor, +33626467428, francois.feuvrier@cliniques-ster.fr
François FEUVRIER, Doctor
About this study
Official title: Evaluation of the Evolution of Proprioceptive Reweighting Abilities Following Anterior Cruciate Ligament Reconstruction Surgery - ReproEVO
Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting. ACL reconstruction (ACLR) combined with rehabilitation is the standard treatment for ACL tears in athletes, and rehabilitation is one of the keys to success. The overall return to sport rate is 80%, but the return to pre-injury level of sport is only 65% and the return to the same level of competition is only 55%. The recurrence rate is close to 20%.
During rehabilitation and sports practice, proprioceptive information is essential for adjusting the muscle sensorimotor loop and enabling optimal movement.
Athletes can thus be classified as plastic or rigid . Our hypothesis is to show that the proportion of "plastic" patients 9 months post-operative following ACL reconstruction is higher than that found in the same population 3 months post-operative, thus demonstrating the progression of proprioceptive integration abilities after ACL reconstruction surgery.
Read the detailed description
Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting. ACL reconstruction (ACLR) combined with rehabilitation is the standard treatment for ACL tears in athletes, and rehabilitation is one of the keys to success. The overall return to sport rate is 80%, but the return to pre-injury level of sport is only 65% and the return to the same level of competition is only 55%. The recurrence rate is close to 20%. Although the number of studies on the subject is growing, there is currently no consensus on rehabilitation protocols.
During rehabilitation and sports practice, proprioceptive information is essential for adjusting the muscle sensorimotor loop and enabling optimal movement.
We have demonstrated that athletes and athletes after ACL reconstruction show variability in the integration of proprioceptive information during a complex balance task.
Athletes can thus be classified as plastic (able to vary the source of proprioceptive information depending on conditions) or rigid (unable to do so).
Our hypothesis is to show that the proportion of "plastic" patients 9 months post-operative following ACL reconstruction is higher than that found in the same population 3 months post-operative, thus demonstrating the progression of proprioceptive integration abilities after ACL reconstruction surgery.
- Being tested
- ReproEVO intervention
- Keywords
- Anterior Cruciate Ligament, Anterior Cruciate Ligament Reconstruction, Central Nervous System, Proprioceptive reweighting, Pivot-contact sport, Plastic patient, Athletes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ReproEVO interventionProcedure or surgery
After the inclusion visit, each assessment will include an examination of standing balance in two support conditions: hard floor or soft floor and two conditions of vibration of the Achilles tendons or lumbar muscles, performed randomly over five trials for each condition. The subjects stand with their eyes covered by an opaque mask. Vibrators are positioned at both locations and vibrated randomly after a trial without recording to perceive the destabilizing effect induced by the vibration. The data is recorded using a force platform on the floor.
Subjects will be seated and strapped into a rigid device attached to their leg. The device is connected to a motor that maintains a constant speed. Maximum strength will be measured at two different speeds.
Finally, at each assessment, the subjects will complete questionnaires about their fear of pain, their assessment of their knee's capabilities, and the activities they engage in.
| Study group | Role | What they receive |
|---|---|---|
| Patients with Anterior Cruciate Ligament | Experimental | Patients with Anterior Cruciate Ligament (ACL) rupture scheduled for ACL reconstruction surgery Receives: Procedure: ReproEVO intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Assessment of progress in proprioceptive reweighting after knee ligament reconstruction
Difference between the mean proprioceptive reweighting coefficient (RPw) preoperatively and 3 months postoperatively
Measured: Baseline, 3 months after surgery and 9 months after surgery
Secondary outcomes (4)
Assesment of the variation in weighting between before and after the operation
Difference between the mean proprioceptive reweighting coefficient (RPw) preoperatively and 3 months postoperatively
Measured: Baseline and 3 months postoperatively
Assess postural control
Difference in the size of the shift in the center of pressure in a static standing position, with eyes open and closed
Measured: Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess your Anterior Cruciate Ligament - Return to Sport and Injury (ACL-RSI) perception score
Assess your Anterior Cruciate Ligament - Return to Sport and Injury (ACL-RSI) perception score (0 : Not at all sure; 10: Completely safe) at the inclusion visit (preoperative); at 3 months postoperatively and at 9 months postoperatively
Measured: Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess the subjective IKDC activity score
Assess the subjective IKDC activity score (0: Never; 10: Always) at the inclusion visit (preoperative); at 3 months postoperatively and at 9 months postoperatively.
Measured: Baseline, at 3 months postoperatively and at 9 months postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2026
- Study start20 Feb 2026 (estimated)
- Primary completion20 May 2028 (estimated)
- Study completion20 May 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Anterior Cruciate Ligament Rupture With LigamentoplastyStudies of the same condition, open and under way.
- More trials run by University Hospital, BrestThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- ReproEVO is a multicenter prospective interventional study.
- Masking
- None (open label)
- Enrolment
- 34 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Brest
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07389850
- Sponsor's protocol ID
- 29BRC25.0312
- Acronym
- ReproEVO
- Status last verified
- Jan 2026
- First submitted
- 28 Jan 2026
- Last updated
- 5 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: All collected data that underlie results in a publication
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Evolution of Proprioceptive Reweighting Abilities Following Anterior Cruciate Ligament Reconstruction Surgery - ReproEVO
- ClinicalTrials.gov ID
- NCT07389850
- Acronym / sponsor ID
- ReproEVO / 29BRC25.0312
- Keywords
- Anterior Cruciate Ligament, Anterior Cruciate Ligament Reconstruction, Central Nervous System, Proprioceptive reweighting, Pivot-contact sport, Plastic patient, Athletes
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 34 participants (estimated)
- Lead sponsor
- University Hospital, BrestUniversity, hospital or other
- Study start
- 20 Feb 2026 (estimated)
- Primary completion
- 20 May 2028 (estimated)
- Study completion
- 20 May 2028 (estimated)
- First posted
- 5 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting. ACL reconstruction (ACLR) combined with rehabilitation is the standard treatment for ACL tears in athletes, and rehabilitation is one of the keys to success. The overall return to sport rate is 80%, but the return to pre-injury level of sport is only 65% and the return to the same level of competition is only 55%. The recurrence rate is close to 20%.
During rehabilitation and sports practice, proprioceptive information is essential for adjusting the muscle sensorimotor loop and enabling optimal movement.
Athletes can thus be classified as plastic or rigid . Our hypothesis is to show that the proportion of "plastic" patients 9 months post-operative following ACL reconstruction is higher than that found in the same population 3 months post-operative, thus demonstrating the progression of proprioceptive integration abilities after ACL reconstruction surgery.
Detailed description
Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting. ACL reconstruction (ACLR) combined with rehabilitation is the standard treatment for ACL tears in athletes, and rehabilitation is one of the keys to success. The overall return to sport rate is 80%, but the return to pre-injury level of sport is only 65% and the return to the same level of competition is only 55%. The recurrence rate is close to 20%. Although the number of studies on the subject is growing, there is currently no consensus on rehabilitation protocols.
During rehabilitation and sports practice, proprioceptive information is essential for adjusting the muscle sensorimotor loop and enabling optimal movement.
We have demonstrated that athletes and athletes after ACL reconstruction show variability in the integration of proprioceptive information during a complex balance task.
Athletes can thus be classified as plastic (able to vary the source of proprioceptive information depending on conditions) or rigid (unable to do so).
Our hypothesis is to show that the proportion of "plastic" patients 9 months post-operative following ACL reconstruction is higher than that found in the same population 3 months post-operative, thus demonstrating the progression of proprioceptive integration abilities after ACL reconstruction surgery.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- ReproEVO is a multicenter prospective interventional study.
| Arm | Type | Receives |
|---|---|---|
| Patients with Anterior Cruciate Ligament | Experimental | Procedure: ReproEVO interventionPatients with Anterior Cruciate Ligament (ACL) rupture scheduled for ACL reconstruction surgery |
Who may qualify
- Ages
- 15 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (4 listed)
- Aged between 15 and 40;
- Patients with ACL rupture scheduled for ACL reconstruction surgery;
- Patients able to maintain a stable bipedal standing position without technical assistance and with their eyes closed;
- Consent of the patient, parents, legal guardians, or guardians to the recording (for minor patients) of data for research and publication purposes.
Key exclusion criteria (5 listed)
- Recent osteoarticular pathology (i.e., less than three months) of the lower limbs, whether traumatic or not, other than ACL rupture;
- Proven disabling neurological pathology;
- Pain in the musculoskeletal system during exercise (excluding the operated knee);
- Fatigue assessed using the Borg scale > 6;
- Skin allergy to an adhesive product.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ReproEVO interventionAfter the inclusion visit, each assessment will include an examination of standing balance in two support conditions: hard floor or soft floor and two conditions of vibration of the Achilles tendons or lumbar muscles, performed randomly over five trials for each condition. The subjects stand with their eyes covered by an opaque mask. Vibrators are positioned at both locations and vibrated randomly after a trial without recording to perceive the destabilizing effect induced by the vibration. The data is recorded using a force platform on the floor. Subjects will be seated and strapped into a rigid device attached to their leg. The device is connected to a motor that maintains a constant speed. Maximum strength will be measured at two different speeds. Finally, at each assessment, the subjects will complete questionnaires about their fear of pain, their assessment of their knee's capabilities, and the activities they engage in. | Procedure or surgery | Patients with Anterior Cruciate Ligament |
Primary outcome
Assessment of progress in proprioceptive reweighting after knee ligament reconstruction
Time frame: Baseline, 3 months after surgery and 9 months after surgery
Difference between the mean proprioceptive reweighting coefficient (RPw) preoperatively and 3 months postoperatively
4 secondary outcomes
Assesment of the variation in weighting between before and after the operation
Time frame: Baseline and 3 months postoperatively
Assess postural control
Time frame: Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess your Anterior Cruciate Ligament - Return to Sport and Injury (ACL-RSI) perception score
Time frame: Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess the subjective IKDC activity score
Time frame: Baseline, at 3 months postoperatively and at 9 months postoperatively
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2026.
- Individual participant dataSharing planned: Yes. All collected data that underlie results in a publication
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ReproEVO intervention in people with Anterior Cruciate Ligament Rupture With Ligamentoplasty, run by University Hospital, Brest at 3 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Olivier REMY-NERIS, Professor (+33298223152, olivier.remyneris@chu-brest.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Assessment of progress in proprioceptive reweighting after knee ligament reconstruction (time frame: Baseline, 3 months after surgery and 9 months after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.