Physical ActivityNCT07393607
Effects of Acute Sleep Deprivation on Human Behaviours
A study testing Normal sleep and Partial sleep deprivation in people with Physical Activity and Energy Intake, run by National Taiwan Normal University.
Trial summary
This study will investigate whether acute sleep deprivation affects appetite, eating behavior, and physical activity in both regular exercisers and physically inactive individuals. Read more about this study
- Who is it for?
- Ages 20 to 45 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Physical Activity, Energy Intake, Appetite
- What is being tested?
- Normal sleep and Partial sleep deprivation
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- No sites listed yet
- Study dates
- 1 Mar 2026to 1 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 45 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between 20 and 45 years.
- Body Mass Index (BMI) between 18.5 to 27 kg/m².
- No sleep-related medical conditions and good sleep quality, defined as a Pittsburgh Sleep Quality Index (PSQI) score ≤ 5.
- Usual bedtime between 22:00 and 01:00, wake-up time between 06:00 and 09:00, with an average sleep duration of 7 to 9 hours. Chronotype classified as "definitely not evening type" (score ≥ 42 on the Morningness-Eveningness Questionnaire), with no changes in sleep patterns over the past 3 months.
- Without any metabolic or cardiovascular diseases, and not using medications that could affect metabolic responses.
- No specific dietary habits, such as intermittent fasting or a ketogenic diet.
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- Maintaining a stable weight (no self-reported weight change greater than ±3 kg) for at least 3 months.
- Resting blood pressure ≤ 130/80 mmHg.
- No smoking or excessive alcohol consumption.
- Not a shift worker.
- No international travel across time zones in the past 3 months.
Who cannot join
- Special diets (e.g., intermittent fasting, ketogenic diet)
- Recent injuries or contraindications to intense exercise.
About this study
Official title: Acute Effects of Partial Sleep Deprivation on Appetite, Energy Intake and Physical Activity
This study will investigate whether acute sleep deprivation affects appetite, eating behavior, and physical activity in both regular exercisers and physically inactive individuals.
Read the detailed description
Prior to the main trials, participants will complete assessments of V̇O2max and maximal muscle strength within 7 to 14 days before the main trials. They will also record one week of daily physical activity, sleep patterns, and diet (including two weekdays and one weekend day) to ensure they meet the inclusion criteria.
Participants will be healthy males aged 20 to 45, grouped according to their habitual activity levels.
- Sedentary: fewer than 7,000 steps/day, no regular exercise in the past 6 months.
- Regular Aerobic Exercise: Running or cycling at least 2-3 times/week for the past 6 months.
- Regular Resistance Exercise: Engaging in resistance exercise at least 2-3 times/week for the past 6 months, with minimal aerobic training.
Day 1:
Physical activity is restricted to a minimum, with no exercise permitted. Participants are allowed to eat freely before 15:00; however, all food intake will be recorded to enable replication prior to the subsequent main trial. Napping is not permitted. Participants will arrive at the laboratory between 18:30 and 19:00. Subjective appetite sensations and food preferences will be assessed. Participants will have either an 8-hour sleep opportunity in the laboratory from 23:00 to 07:00 (i.e., normal sleep trial) or a 3-hour sleep opportunity from 03:00 to 07:00 (i.e., partial sleep deprivation trial).
Day 2:
Participants will wake at 07:00. After completing personal hygiene, they will rest for 20 minutes to ensure full alertness. At 07:30, a 20-minute resting metabolic rate assessment will be conducted, alongside the collection of heart rate variability and muscle oxygen saturation data. Subsequently, pulse wave velocity measurement, cognitive function tests, subjective questionnaires, and a computerized food preference test will be administered.
After the baseline assessment, a 3-hour oral glucose tolerance test (OGTT) will be administered. Visual analogue scale assessments-including sleep, appetite, and mood-will be conducted every 30 minutes during the OGTT. Food preferences will be measured 180 minutes after the completion of the OGTT. Upon leaving the laboratory, participants will be provided with a pedometer and wearable devices and instructed to record dietary intake (using a food scale and photographic records), sleep, and glucose values on the experimental day and for the following four consecutive days.
- Conditions
- Physical Activity, Energy Intake, Appetite, Food Choice
- Being tested
- Normal sleep, Partial sleep deprivation
- Keywords
- Physical activity, Energy intake, Appetite, Food choice
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Normal sleepBehavioural
Participants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00.
Partial sleep deprivationBehavioural
Participants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00.
| Study group | Role | What they receive |
|---|---|---|
| Normal sleep | Experimental | Participants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00. Receives: Behavioral: Normal sleep |
| Partial sleep deprivation | Experimental | Participants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00. Receives: Behavioral: Partial sleep deprivation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Energy intake
Energy and macronutrients intake will be collected using pictures and via a food scale
Measured: 4 days in a free-living conditions.
Physical activity
Physical activity level and intensity will be collected using wearable devices
Measured: 4 days in a free-living conditions.
Secondary outcomes (6)
Food preference
Computerised subjective food choice
Measured: Baseline and at the end of the 3-hour oral glucose tolerance test (OGTT).
Appetite sensations
Subjective appetitive feelings will be measured using a 0-100 mm visual analog scale (VAS), with higher values indicating more intense feelings.
Measured: At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).
Mood sensations
Subjective mood feelings will be measured using a 0-100 mm visual analog scale (VAS), with higher values indicating more intense feelings.
Measured: At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).
Sleep sensations
Subjective sleep feelings will be measured using a 0-100 mm visual analog scale (VAS), with higher values indicating more intense feelings.
Measured: At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).
Sleep
Sleep duration will be collected via wearable device.
Measured: 4 days in a free-living conditions.
Glucose responses
Clucose responses will be collected using continuous glucose monitoring
Measured: 4 days in a free-living conditions.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Feb 2026
- Study start1 Mar 2026 (estimated)
- Primary completion1 Mar 2027 (estimated)
- Study completion1 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Physical ActivityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 48 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan Normal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yung-Chih Chen, National Taiwan Normal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07393607
- Sponsor's protocol ID
- 202412HM033-2
- Status last verified
- Feb 2026
- First submitted
- 23 Jan 2026
- Last updated
- 6 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Partial Sleep Deprivation on Appetite, Energy Intake and Physical Activity
- ClinicalTrials.gov ID
- NCT07393607
- Acronym / sponsor ID
- 202412HM033-2
- Conditions
- Physical Activity, Energy Intake, Appetite, Food Choice
- Keywords
- Physical activity, Energy intake, Appetite, Food choice
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 48 participants (estimated)
- Lead sponsor
- National Taiwan Normal UniversityUniversity, hospital or other
- Study start
- 1 Mar 2026 (estimated)
- Primary completion
- 1 Mar 2027 (estimated)
- Study completion
- 1 Mar 2027 (estimated)
- First posted
- 6 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will investigate whether acute sleep deprivation affects appetite, eating behavior, and physical activity in both regular exercisers and physically inactive individuals.
Detailed description
Prior to the main trials, participants will complete assessments of V̇O2max and maximal muscle strength within 7 to 14 days before the main trials. They will also record one week of daily physical activity, sleep patterns, and diet (including two weekdays and one weekend day) to ensure they meet the inclusion criteria.
Participants will be healthy males aged 20 to 45, grouped according to their habitual activity levels.
- Sedentary: fewer than 7,000 steps/day, no regular exercise in the past 6 months.
- Regular Aerobic Exercise: Running or cycling at least 2-3 times/week for the past 6 months.
- Regular Resistance Exercise: Engaging in resistance exercise at least 2-3 times/week for the past 6 months, with minimal aerobic training.
Day 1:
Physical activity is restricted to a minimum, with no exercise permitted. Participants are allowed to eat freely before 15:00; however, all food intake will be recorded to enable replication prior to the subsequent main trial. Napping is not permitted. Participants will arrive at the laboratory between 18:30 and 19:00. Subjective appetite sensations and food preferences will be assessed. Participants will have either an 8-hour sleep opportunity in the laboratory from 23:00 to 07:00 (i.e., normal sleep trial) or a 3-hour sleep opportunity from 03:00 to 07:00 (i.e., partial sleep deprivation trial).
Day 2:
Participants will wake at 07:00. After completing personal hygiene, they will rest for 20 minutes to ensure full alertness. At 07:30, a 20-minute resting metabolic rate assessment will be conducted, alongside the collection of heart rate variability and muscle oxygen saturation data. Subsequently, pulse wave velocity measurement, cognitive function tests, subjective questionnaires, and a computerized food preference test will be administered.
After the baseline assessment, a 3-hour oral glucose tolerance test (OGTT) will be administered. Visual analogue scale assessments-including sleep, appetite, and mood-will be conducted every 30 minutes during the OGTT. Food preferences will be measured 180 minutes after the completion of the OGTT. Upon leaving the laboratory, participants will be provided with a pedometer and wearable devices and instructed to record dietary intake (using a food scale and photographic records), sleep, and glucose values on the experimental day and for the following four consecutive days.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Normal sleep | Experimental | Behavioral: Normal sleepParticipants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00. |
| Partial sleep deprivation | Experimental | Behavioral: Partial sleep deprivationParticipants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00. |
Who may qualify
- Ages
- 20 to 45 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (11 listed)
- Age between 20 and 45 years.
- Body Mass Index (BMI) between 18.5 to 27 kg/m².
- No sleep-related medical conditions and good sleep quality, defined as a Pittsburgh Sleep Quality Index (PSQI) score ≤ 5.
- Usual bedtime between 22:00 and 01:00, wake-up time between 06:00 and 09:00, with an average sleep duration of 7 to 9 hours. Chronotype classified as "definitely not evening type" (score ≥ 42 on the Morningness-Eveningness Questionnaire), with no changes in sleep patterns over the past 3 months.
- Without any metabolic or cardiovascular diseases, and not using medications that could affect metabolic responses.
Key exclusion criteria (2 listed)
- Special diets (e.g., intermittent fasting, ketogenic diet)
- Recent injuries or contraindications to intense exercise.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Normal sleepParticipants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00. | Behavioural | Normal sleep |
| Partial sleep deprivationParticipants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00. | Behavioural | Partial sleep deprivation |
Primary outcome
Energy intake
Time frame: 4 days in a free-living conditions.
Energy and macronutrients intake will be collected using pictures and via a food scale
Physical activity
Time frame: 4 days in a free-living conditions.
Physical activity level and intensity will be collected using wearable devices
6 secondary outcomes
Food preference
Time frame: Baseline and at the end of the 3-hour oral glucose tolerance test (OGTT).
Appetite sensations
Time frame: At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).
Mood sensations
Time frame: At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).
Sleep sensations
Time frame: At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).
Sleep
Time frame: 4 days in a free-living conditions.
Glucose responses
Time frame: 4 days in a free-living conditions.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Normal sleep and Partial sleep deprivation in people with Physical Activity and Energy Intake, run by National Taiwan Normal University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 11 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 6 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Energy intake (time frame: 4 days in a free-living conditions.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Feb 2026.