PrehabilitationPrOpENCT07394582
Preoperative Optimization Before Total Hip or Knee Replacement Surgery
A study testing Prehabilitation in people with Prehabilitation and Preoperative Care, run by Medical University Innsbruck at 1 site in Austria.
Trial summary
Preoperative Optimisation prior to Hip and Knee Arthroplasty (PrOpE) Many patients scheduled for planned hip or knee replacement surgery have health conditions that may affect recovery, such as reduced physical fitness, nutritional problems, multiple medications, or increased stress and anxiety. Read more about this study
- Who is it for?
- Ages 18 to 99 years
- Conditions the study is for
- Prehabilitation, Preoperative Care
- What is being tested?
- Prehabilitation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 180 participants
- Where
- 1 siteAustria
- Study dates
- 5 Feb 2026to 5 Feb 2034
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 99 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- American Society of Anesthesiologists (ASA) physical status classification ≥ 3
- Age between 18 and 99 years
- All sexes
- Elective total hip or knee replacement with a waiting period of ≥ 8 weeks between surgical indication and surgery
- Ability to understand the nature, content, and procedures of the study and to provide written informed consent
- Written informed consent obtained prior to any study-related procedure
Who cannot join
- Pregnancy or active breastfeeding
- Severe trauma or major blood loss within 14 days prior to enrollment
- Participation in another pharmacological or interventional clinical study
- Contraindications to physical training
- Pre-existing diagnosis of moderate to severe dementia
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Christine Eckhardt, MD, PhD contact
Austria1 site, 1 recruiting
- Recruiting
Medical University Innsbruck
Innsbruck, Tyrol, 6020
Barbara Sinner, MD, PhD, +43 50 504 28503, mui-sponsor@i-med.ac.at
About this study
Official title: Preoperative Optimization Before Total Hip or Knee Replacement Surgery - a Controlled, Randomized, Single-blind Study
Preoperative Optimisation prior to Hip and Knee Arthroplasty (PrOpE) Many patients scheduled for planned hip or knee replacement surgery have health conditions that may affect recovery, such as reduced physical fitness, nutritional problems, multiple medications, or increased stress and anxiety. These factors can increase the risk of complications and delay recovery after surgery.
The PrOpE study examines whether a structured preparation programme before surgery, known as preoperative optimization or prehabilitation, can be safely implemented and may support recovery after hip or knee replacement.
Read more
Aim of the study The main aim is to assess the feasibility of a comprehensive preoperative optimisation programme and to explore its potential effects on recovery and health outcomes. The results will help improve future care for patients undergoing major orthopaedic surgery.
Who can participate? Adult patients scheduled for elective total hip or knee replacement surgery who are classified as ASA >2, aged between 18 and 99 years old and without a severe cognitive impairment. Participation is voluntary.
Study design
A total of 180 participants will be included and randomly assigned to one of two groups:
- Standard Care Group: Participants receive usual medical care before and after surgery.
- Intervention Group:
In addition to standard care, participants receive an individualised preparation programme over several weeks before surgery. This programme may include:
- Personalised physical exercise
- Nutritional assessment and advice
- Support for stress, pain, and mental well-being
- Review of regular medications Some elements may be delivered at home or via telemedicine, depending on individual needs.
What information is collected? The study evaluates recovery after surgery, including complications, length of hospital stay, physical function, quality of life, and use of health care services. Questionnaires, physical tests, and blood samples are used to better understand health status before and after surgery.
Risks and benefits The study involves low additional risk. All measures are adapted to individual abilities and supervised by trained professionals. The main burden is the additional time required for participation. Participants in the optimisation group may benefit from improved preparation for surgery. The study also contributes to improving care for future patients.
Read the detailed description
Preoperative Optimisation prior to Hip and Knee Arthroplasty (PrOpE) Many patients scheduled for planned hip or knee replacement surgery have health conditions that may affect recovery, such as reduced physical fitness, nutritional problems, multiple medications, or increased stress and anxiety. These factors can increase the risk of complications and delay recovery after surgery.
The PrOpE study examines whether a structured preparation programme before surgery, known as preoperative optimization or prehabilitation, can be safely implemented and may support recovery after hip or knee replacement.
Aim of the study The main aim is to assess the feasibility of a comprehensive preoperative optimisation programme and to explore its potential effects on recovery and health outcomes. The results will help improve future care for patients undergoing major orthopaedic surgery.
Who can participate? Adult patients scheduled for elective total hip or knee replacement surgery who are classified as ASA >2, aged between 18 and 99 years old and without a severe cognitive impairment. Participation is voluntary.
Study design
A total of 180 participants will be included and randomly assigned to one of two groups:
- Standard Care Group: Participants receive usual medical care before and after surgery.
- Intervention Group:
In addition to standard care, participants receive an individualised preparation programme over several weeks before surgery. This programme may include:
- Personalised physical exercise
- Nutritional assessment and advice
- Support for stress, pain, and mental well-being
- Review of regular medications Some elements may be delivered at home or via telemedicine, depending on individual needs.
What information is collected? The study evaluates recovery after surgery, including complications, length of hospital stay, physical function, quality of life, and use of health care services. Questionnaires, physical tests, and blood samples are used to better understand health status before and after surgery.
Risks and benefits The study involves low additional risk. All measures are adapted to individual abilities and supervised by trained professionals. The main burden is the additional time required for participation. Participants in the optimisation group may benefit from improved preparation for surgery. The study also contributes to improving care for future patients.
- Conditions
- Prehabilitation, Preoperative Care
- Being tested
- Prehabilitation
- Keywords
- Preoperative Optimization, orthopedic surgery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PrehabilitationOther
- Personalised physical exercise
- Nutritional assessment and advice
- Support for stress, pain, and mental well-being
- Review of regular medications Some elements may be delivered at home or via telemedicine, depending on individual needs.
| Study group | Role | What they receive |
|---|---|---|
| Standard Care Group | No intervention | Participants receive usual medical care before and after surgery. |
| Intervention Group | Experimental | In addition to standard care, participants receive an individualised preparation programme over several weeks before surgery. This programme may include:
* Personalised physical exercise
* Nutritional assessment and advice
* Support for stress, pain, and mental well-being
* Review of regular medications Receives: Other: Prehabilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Length of hospital stay
Length of hospital stay (intensive care unit, recovery room, observation unit, general ward; date of discharge readiness and actual discharge)
Measured: From enrollment to the postoperative discharge from the hospital (9 to 25 weeks).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Feb 2026
- Study start5 Feb 2026 (estimated)
- Primary completion5 Feb 2034 (estimated)
- Study completion5 Feb 2034 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PrehabilitationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Prospective, randomised, single blinded (patient-blinded) with two study groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 180 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Medical University Innsbruck
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Barbara Sinner, MD, MBA, Principal investigator, Medical University Innsbruck
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07394582
- Sponsor's protocol ID
- EK-Nr. 1193/2025
- Acronym
- PrOpE
- Status last verified
- Jan 2026
- First submitted
- 30 Jan 2026
- Last updated
- 11 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Preoperative Optimization Before Total Hip or Knee Replacement Surgery - a Controlled, Randomized, Single-blind Study
- ClinicalTrials.gov ID
- NCT07394582
- Acronym / sponsor ID
- PrOpE / EK-Nr. 1193/2025
- Conditions
- Prehabilitation, Preoperative Care
- Keywords
- Preoperative Optimization, orthopedic surgery
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 180 participants (estimated)
- Lead sponsor
- Medical University InnsbruckUniversity, hospital or other
- Study start
- 5 Feb 2026 (estimated)
- Primary completion
- 5 Feb 2034 (estimated)
- Study completion
- 5 Feb 2034 (estimated)
- First posted
- 6 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Preoperative Optimisation prior to Hip and Knee Arthroplasty (PrOpE) Many patients scheduled for planned hip or knee replacement surgery have health conditions that may affect recovery, such as reduced physical fitness, nutritional problems, multiple medications, or increased stress and anxiety. These factors can increase the risk of complications and delay recovery after surgery.
The PrOpE study examines whether a structured preparation programme before surgery, known as preoperative optimization or prehabilitation, can be safely implemented and may support recovery after hip or knee replacement.
Aim of the study The main aim is to assess the feasibility of a comprehensive preoperative optimisation programme and to explore its potential effects on recovery and health outcomes. The results will help improve future care for patients undergoing major orthopaedic surgery.
Who can participate? Adult patients scheduled for elective total hip or knee replacement surgery who are classified as ASA >2, aged between 18 and 99 years old and without a severe cognitive impairment. Participation is voluntary.
Study design
A total of 180 participants will be included and randomly assigned to one of two groups:
- Standard Care Group: Participants receive usual medical care before and after surgery.
- Intervention Group:
In addition to standard care, participants receive an individualised preparation programme over several weeks before surgery. This programme may include:
- Personalised physical exercise
- Nutritional assessment and advice
- Support for stress, pain, and mental well-being
- Review of regular medications Some elements may be delivered at home or via telemedicine, depending on individual needs.
What information is collected? The study evaluates recovery after surgery, including complications, length of hospital stay, physical function, quality of life, and use of health care services. Questionnaires, physical tests, and blood samples are used to better understand health status before and after surgery.
Risks and benefits The study involves low additional risk. All measures are adapted to individual abilities and supervised by trained professionals. The main burden is the additional time required for participation. Participants in the optimisation group may benefit from improved preparation for surgery. The study also contributes to improving care for future patients.
Detailed description
Preoperative Optimisation prior to Hip and Knee Arthroplasty (PrOpE) Many patients scheduled for planned hip or knee replacement surgery have health conditions that may affect recovery, such as reduced physical fitness, nutritional problems, multiple medications, or increased stress and anxiety. These factors can increase the risk of complications and delay recovery after surgery.
The PrOpE study examines whether a structured preparation programme before surgery, known as preoperative optimization or prehabilitation, can be safely implemented and may support recovery after hip or knee replacement.
Aim of the study The main aim is to assess the feasibility of a comprehensive preoperative optimisation programme and to explore its potential effects on recovery and health outcomes. The results will help improve future care for patients undergoing major orthopaedic surgery.
Who can participate? Adult patients scheduled for elective total hip or knee replacement surgery who are classified as ASA >2, aged between 18 and 99 years old and without a severe cognitive impairment. Participation is voluntary.
Study design
A total of 180 participants will be included and randomly assigned to one of two groups:
- Standard Care Group: Participants receive usual medical care before and after surgery.
- Intervention Group:
In addition to standard care, participants receive an individualised preparation programme over several weeks before surgery. This programme may include:
- Personalised physical exercise
- Nutritional assessment and advice
- Support for stress, pain, and mental well-being
- Review of regular medications Some elements may be delivered at home or via telemedicine, depending on individual needs.
What information is collected? The study evaluates recovery after surgery, including complications, length of hospital stay, physical function, quality of life, and use of health care services. Questionnaires, physical tests, and blood samples are used to better understand health status before and after surgery.
Risks and benefits The study involves low additional risk. All measures are adapted to individual abilities and supervised by trained professionals. The main burden is the additional time required for participation. Participants in the optimisation group may benefit from improved preparation for surgery. The study also contributes to improving care for future patients.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Prospective, randomised, single blinded (patient-blinded) with two study groups
| Arm | Type | Receives |
|---|---|---|
| Standard Care Group | No intervention | –Participants receive usual medical care before and after surgery. |
| Intervention Group | Experimental | Other: PrehabilitationIn addition to standard care, participants receive an individualised preparation programme over several weeks before surgery. This programme may include: * Personalised physical exercise * Nutritional assessment and advice * Support for stress, pain, and mental well-being * Review of regular medications |
Who may qualify
- Ages
- 18 to 99 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- American Society of Anesthesiologists (ASA) physical status classification ≥ 3
- Age between 18 and 99 years
- All sexes
- Elective total hip or knee replacement with a waiting period of ≥ 8 weeks between surgical indication and surgery
- Ability to understand the nature, content, and procedures of the study and to provide written informed consent
Key exclusion criteria (5 listed)
- Pregnancy or active breastfeeding
- Severe trauma or major blood loss within 14 days prior to enrollment
- Participation in another pharmacological or interventional clinical study
- Contraindications to physical training
- Pre-existing diagnosis of moderate to severe dementia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Prehabilitation* Personalised physical exercise * Nutritional assessment and advice * Support for stress, pain, and mental well-being * Review of regular medications Some elements may be delivered at home or via telemedicine, depending on individual needs. | Other | Intervention Group |
Primary outcome
Length of hospital stay
Time frame: From enrollment to the postoperative discharge from the hospital (9 to 25 weeks).
Length of hospital stay (intensive care unit, recovery room, observation unit, general ward; date of discharge readiness and actual discharge)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Christine Eckhardt, MD, PhD contact
Barbara Sinner, MD, MBA principal investigator
Medical University Innsbruck
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Prehabilitation in people with Prehabilitation and Preoperative Care, run by Medical University Innsbruck at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Helmut Raab, MD (+435050480833, helmut.raab@tirol-kliniken.at), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Length of hospital stay (time frame: From enrollment to the postoperative discharge from the hospital (9 to 25 weeks).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Feb 2026; AzTrials last refreshed its copy on 28 Oct 2026.