Respiratory AbnormalityNCT07399119
The Study Examined the Acute Effects of Wim Hof on Aerobic Training and Cardiodynamics.
A study testing Wim Hof Breathing Method in people with Respiratory Abnormality and Pulmonary, run by Cairo University at 1 site in Lebanon.
Trial summary
Researchers will split the sixty healthy smokers in half. Thirty people will serve as a control group and will be asked to walk or jog at a controlled pace for twelve minutes as part of an aerobic exercise program. Read more about this study
- Who is it for?
- Ages 18 to 25 years
- Conditions the study is for
- Respiratory Abnormality, Pulmonary, Exercise Training
- What is being tested?
- Wim Hof Breathing Method
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteLebanon
- Study dates
- 10 Jun 2025to Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Males and females.
- Age range between 18 and 25 years.
- Adults who are healthy
Who cannot join
- If they had:
- Any systemic disorders.
- Musculoskeletal, neuromuscular, or chronic respiratory conditions.
- Females were menstruating
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: The Immediate Effect of Adding the Wim Hoff Breathing Method With Aerobic Training on Aerobic Performance and Hemodynamic Response in Smoking Adults
Researchers will split the sixty healthy smokers in half. Thirty people will serve as a control group and will be asked to walk or jog at a controlled pace for twelve minutes as part of an aerobic exercise program. Separately, 30 people participated in an aerobic exercise session that lasted 12 minutes and involved walking or running at a pace that the participants themselves controlled. WHBM will be done both prior to and subsequent to physical activity. To determine how WHBM affects the experimental group's pre- and post-WHBM heart rates, SpO2, blood pressure, and VO2 max, this study will be conducted.
Read the detailed description
The study will be a randomized single blinded control trial, sixty healthy smokers will be divided into two groups. a control group of 30 participants will performing a 12-minute aerobic exercise where it included walking/ jogging with a controlled speed by the participant. Another experimental group of 30 participants also, performing a 12-minute aerobic exercise where it included walking/ jogging with a controlled speed by the participant. WHBM will be performed before and after exercises. It will be done to assess the effect of WHBM on heart rate, SpO2, blood pressure and VO2 max that will be monitored before and after WHBM in the experimental group. In addition, Performance will be assessed by observing the difference in distance covered before and after doing the WHBM. Heart rate and SpO2 will be measured using a finger pulse oximeter (Medical Rossmax). Blood pressure will be measured using a sphygmomanometer and VO2 max will be measured using the cooper's test formula in kilometers: "VO2 max = (22.351 x distance in Km) - 11.288"
- Conditions
- Respiratory Abnormality, Pulmonary, Exercise Training
- Being tested
- aerobic exercise where it included walking/ jogging with a controlled speed by the participant, Wim Hof Breathing Method
- Keywords
- wim hoff, aerobic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
aerobic exercise where it included walking/ jogging with a controlled speed by the participantOther
participants were asked to listen attentively to the given instruction using noise cancelling headphones for the given instructions. For 11 minutes, an audio for Wim Hof breathing method that is as follow.
- Take a strong inhalation through the nose.
- Let out a relaxed exhalation through the mouth.
- Repeat for 30 breaths.
- On the 30th breath, exhale and hold your breath for 30 seconds in the first round then 1 minute in the 2nd round and 1 and a half minutes for the 3rd round.
- Take a deep breath in after the previous hold then hold it in for 15 seconds in the 3 rounds.
- Let your breathing return to normal. These steps were repeated for 3 rounds. And participants were allowed to let go of their held breath and hold it again if they couldn't keep holding it for the asked time in the audio
Wim Hof Breathing MethodOther
participants were asked to listen attentively to the given instruction using noise cancelling headphones for the given instructions. For 11 minutes, an audio for Wim Hof breathing method that is as follow.
- Take a strong inhalation through the nose.
- Let out a relaxed exhalation through the mouth.
- Repeat for 30 breaths.
- On the 30th breath, exhale and hold your breath for 30 seconds in the first round then 1 minute in the 2nd round and 1 and a half minutes for the 3rd round.
- Take a deep breath in after the previous hold then hold it in for 15 seconds in the 3 rounds.
- Let your breathing return to normal. These steps were repeated for 3 rounds. And participants were allowed to let go of their held breath and hold it again if they couldn't keep holding it for the asked time in the audio
| Study group | Role | What they receive |
|---|---|---|
| CONTROL | Active comparator | Researchers took the first measurement at t=0 minutes after 5 minutes of their arrival to allow them to rest. The measurements included heart rate and SpO2 using an oximeter (Medical Rossmax) and blood pressure using a sphygmomanometer. Then they were asked to perform a 12-minute walk/jog with speed controlled by them and incline = 1. At 4 and 8 minutes, the speed was reduced to 2.0 on the treadmill, and vitals were taken again. At t= 12 minutes we stopped the treadmill, recorded the distance covered, and proceeded to measure the heart rate. SpO2, blood pressure, and VO2max were calculated using the Cooper's test formula (Alvero-Cruz et al., 2017). Participants were asked to rest for 4 minutes, and then another measurement of the vital signs (heart rate, SpO2, and blood pressure) was taken before they were dismissed. Receives: Other: aerobic exercise where it included walking/ jogging with a controlled speed by the participant |
| wim hof breathing exercises | Experimental | applying breathing interventions Receives: Other: aerobic exercise where it included walking/ jogging with a controlled speed by the participant; Other: Wim Hof Breathing Method |
What is being measured
The primary outcome is the main question the study is designed to answer.
HEART RATE
The number of heartbeats in a minute
Measured: 12 weeks
Vo2 max
oxygen consumption
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Feb 2026
- Study start10 Jun 2025
- Primary completionFeb 2026 (estimated)
- Study completionFeb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Respiratory AbnormalityStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Model description
- stop watch - blood pressure monitoring
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Khaled Takey Ahmed, Cairo University
- Investigators
- rami L abbass, professor, Study director, BAU
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07399119
- Sponsor's protocol ID
- 2025-H-0237-HSC-R-0763 - BAU.
- Status last verified
- Feb 2026
- First submitted
- 15 Jan 2026
- Last updated
- 10 Feb 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: measured data
Study at a glance
From the registry record, last updated by the sponsor on 10 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Immediate Effect of Adding the Wim Hoff Breathing Method With Aerobic Training on Aerobic Performance and Hemodynamic Response in Smoking Adults
- ClinicalTrials.gov ID
- NCT07399119
- Acronym / sponsor ID
- 2025-H-0237-HSC-R-0763 - BAU.
- Conditions
- Respiratory Abnormality, Pulmonary, Exercise Training
- Keywords
- wim hoff, aerobic
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 10 Jun 2025 (actual)
- Primary completion
- Feb 2026 (estimated)
- Study completion
- Feb 2026 (estimated)
- First posted
- 10 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Researchers will split the sixty healthy smokers in half. Thirty people will serve as a control group and will be asked to walk or jog at a controlled pace for twelve minutes as part of an aerobic exercise program. Separately, 30 people participated in an aerobic exercise session that lasted 12 minutes and involved walking or running at a pace that the participants themselves controlled. WHBM will be done both prior to and subsequent to physical activity. To determine how WHBM affects the experimental group's pre- and post-WHBM heart rates, SpO2, blood pressure, and VO2 max, this study will be conducted.
Detailed description
The study will be a randomized single blinded control trial, sixty healthy smokers will be divided into two groups. a control group of 30 participants will performing a 12-minute aerobic exercise where it included walking/ jogging with a controlled speed by the participant. Another experimental group of 30 participants also, performing a 12-minute aerobic exercise where it included walking/ jogging with a controlled speed by the participant. WHBM will be performed before and after exercises. It will be done to assess the effect of WHBM on heart rate, SpO2, blood pressure and VO2 max that will be monitored before and after WHBM in the experimental group. In addition, Performance will be assessed by observing the difference in distance covered before and after doing the WHBM. Heart rate and SpO2 will be measured using a finger pulse oximeter (Medical Rossmax). Blood pressure will be measured using a sphygmomanometer and VO2 max will be measured using the cooper's test formula in kilometers: "VO2 max = (22.351 x distance in Km) - 11.288"
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- stop watch - blood pressure monitoring
| Arm | Type | Receives |
|---|---|---|
| CONTROL | Active comparator | Other: aerobic exercise where it included walking/ jogging with a controlled speed by the participantResearchers took the first measurement at t=0 minutes after 5 minutes of their arrival to allow them to rest. The measurements included heart rate and SpO2 using an oximeter (Medical Rossmax) and blood pressure using a sphygmomanometer. Then they were asked to perform a 12-minute walk/jog with speed controlled by them and incline = 1. At 4 and 8 minutes, the speed was reduced to 2.0 on the treadmill, and vitals were taken again. At t= 12 minutes we stopped the treadmill, recorded the distance covered, and proceeded to measure the heart rate. SpO2, blood pressure, and VO2max were calculated using the Cooper's test formula (Alvero-Cruz et al., 2017). Participants were asked to rest for 4 minutes, and then another measurement of the vital signs (heart rate, SpO2, and blood pressure) was taken before they were dismissed. |
| wim hof breathing exercises | Experimental | Other: aerobic exercise where it included walking/ jogging with a controlled speed by the participant, Other: Wim Hof Breathing Methodapplying breathing interventions |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Males and females.
- Age range between 18 and 25 years.
- Adults who are healthy
Key exclusion criteria (4 listed)
- Any systemic disorders.
- Musculoskeletal, neuromuscular, or chronic respiratory conditions.
- Females were menstruating
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| aerobic exercise where it included walking/ jogging with a controlled speed by the participantparticipants were asked to listen attentively to the given instruction using noise cancelling headphones for the given instructions. For 11 minutes, an audio for Wim Hof breathing method that is as follow. * Take a strong inhalation through the nose. * Let out a relaxed exhalation through the mouth. * Repeat for 30 breaths. * On the 30th breath, exhale and hold your breath for 30 seconds in the first round then 1 minute in the 2nd round and 1 and a half minutes for the 3rd round. * Take a deep breath in after the previous hold then hold it in for 15 seconds in the 3 rounds. * Let your breathing return to normal. These steps were repeated for 3 rounds. And participants were allowed to let go of their held breath and hold it again if they couldn't keep holding it for the asked time in the audio | Other | CONTROL, wim hof breathing exercises |
| Wim Hof Breathing Methodparticipants were asked to listen attentively to the given instruction using noise cancelling headphones for the given instructions. For 11 minutes, an audio for Wim Hof breathing method that is as follow. * Take a strong inhalation through the nose. * Let out a relaxed exhalation through the mouth. * Repeat for 30 breaths. * On the 30th breath, exhale and hold your breath for 30 seconds in the first round then 1 minute in the 2nd round and 1 and a half minutes for the 3rd round. * Take a deep breath in after the previous hold then hold it in for 15 seconds in the 3 rounds. * Let your breathing return to normal. These steps were repeated for 3 rounds. And participants were allowed to let go of their held breath and hold it again if they couldn't keep holding it for the asked time in the audio | Other | wim hof breathing exercises |
Primary outcome
HEART RATE
Time frame: 12 weeks
The number of heartbeats in a minute
Vo2 max
Time frame: 12 weeks
oxygen consumption
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Feb 2026.
- doiLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. measured data
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
rami L abbass, professor study director
BAU
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Wim Hof Breathing Method in people with Respiratory Abnormality and Pulmonary, run by Cairo University at 1 site in Lebanon.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 10 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Lebanon. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
HEART RATE (time frame: 12 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Feb 2026.