Knee OsteoarthritisNCT07403383
Comparative Effects of Strain Counter Strain and Myofascial Release in Patients With Knee Osteoarthritris
A study testing Strain Counter Strain and Myofascial Release in people with Knee Osteoarthritis, run by Riphah International University at 1 site in Pakistan.
Trial summary
Osteoarthritis is a degenerative disease, the cartilage present in the joint gets damaged and the bones become hypertrophied. In US, the most commonly occuring arthritis is osteoarthritis. Myofascial release focuses on fascia. Strain counter strain is positional release Read more about this study
- Who is it for?
- Ages 40 to 65 years
- Conditions the study is for
- Knee Osteoarthritis
- What is being tested?
- Strain Counter Strain and Myofascial Release
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 sitePakistan
- Study dates
- 13 Jan 2025to 17 Nov 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Both males and females were included in the study.
- Patients aged 40 to 65 with clinical diagnosis of osteoarthritis
- Patient with Grade 2 osteoarthritis
- Patient with Grade 2 osteoarthritis
- Patients who have not undergone any surgical intervention on the Knee in the past 6 months.
- Overweight and obese people with (BMI of 25-29.9), BMI of 30 or above
Who cannot join
- Patients with history of knee surgery or joint replacement
- Patients with neurological conditions that could affect mobility or perception of pain.
- Patients with infections in the knee area
- Patients with any traumatic injury
- Pregnant Patients
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Effects of Strain Counter Strain and Myofascial Release on Pain, Function and Quality of Life in Patients With Knee Osteoarthritis
Osteoarthritis is a degenerative disease, the cartilage present in the joint gets damaged and the bones become hypertrophied. In US, the most commonly occuring arthritis is osteoarthritis. Myofascial release focuses on fascia. Strain counter strain is positional release
- Conditions
- Knee Osteoarthritis
- Being tested
- Strain Counter Strain, Myofascial Release
- Keywords
- pain, quality of life, osteoarthritis
- Medical subject headings
- Osteoarthritis, Knee, Pain, Osteoarthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Strain Counter StrainOther
Strain Counter Strain involves passive positioning of hypertonic muscles and dysfunctional joints towards position of comfort. Conventional treatment includes Hot pack, Tens 2 to 3 times per week. Isometric exercises of Quadriceps, Hamstrings, Adductors and Calf muscles
Myofascial ReleaseOther
Perform myofascial release technique 2 to 3 times per week. Time 60 seconds per area. Frequency 3 times a week. Hot packs applied 2 to 3 times per week Tens 2 to 3 times per week. Isometric contractions of Quadriceps, Hamstrings , Adductors and Calf muscles hold 10 to 15 seconds then gradually increase 30 seconds with 2 to 4 sets of each exercise
| Study group | Role | What they receive |
|---|---|---|
| experimental: Strain Counter Strain | Experimental | Strain Counter Strain involves positioning of hypertonic muscles and dysfunctional joints towards position of comfort. Initial session 2 to 3 times per week. Hot packs 2 to 3 times per week. Tens 2 to 3 times per week. Each session lasts 30 to 60 minutes holding the position for 90 seconds to 2 minutes. Exercises includes. Receives: Other: Strain Counter Strain |
| Active Comparator: Myofascial Release | Active comparator | Myofascial release focuses on the fascia , connective tissue that surrounds muscles, bones and organs which becomes tight and restrict movement. ,Myo fascial release 2 to 3 times per week. 60 seconds per area. Hot packs 2 to 3 times per week. Low frequency TENS. Foam rolling for Calves and Hamstrings. Quadriceps isometric Contraction holds for 10 to 15 seconds with 2 to 4 sets of each exercise. Hamstrings and Adductor isometric contractions. Receives: Other: Myofascial Release |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numeric Pain Rating Scale
The Numeric Pain Rating Scale is a very common tool to asses pain in clinical settings. It is 0 to 10 pain rating scale in which 0 indicates no pain and 10 indicates worse pain.
Measured: at the baseline and at the end of 4 week
Quality of Life (QoL)
QoL is 26 item tool for reliability, validity and responsiveness to changes in health.
Measured: at the baseline of 4 weeks
Secondary outcomes (1)
Time Up and Go Test TUG
In the Time Up and Go Test (TUG), Subjects are asked to rise from a standard armchair, walk from a marker 3m away, turn, walk back and sit down again. This test is reliable and valid test for quantifying functional mobility that may also be useful in following clinical change over time.
Measured: at the baseline and at the end of 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Feb 2026
- Study start13 Jan 2025
- Primary completion17 Nov 2025
- Study completion17 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Naila kanwal, TPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07403383
- Sponsor's protocol ID
- REC/RCR & AHS/24/0194
- Status last verified
- Feb 2026
- First submitted
- 4 Feb 2026
- Last updated
- 25 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effects of Strain Counter Strain and Myofascial Release on Pain, Function and Quality of Life in Patients With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT07403383
- Acronym / sponsor ID
- REC/RCR & AHS/24/0194
- Conditions
- Knee Osteoarthritis
- Keywords
- pain, quality of life, osteoarthritis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 13 Jan 2025 (actual)
- Primary completion
- 17 Nov 2025 (actual)
- Study completion
- 17 Nov 2025 (actual)
- First posted
- 11 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Osteoarthritis is a degenerative disease, the cartilage present in the joint gets damaged and the bones become hypertrophied. In US, the most commonly occuring arthritis is osteoarthritis. Myofascial release focuses on fascia. Strain counter strain is positional release
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| experimental: Strain Counter Strain | Experimental | Other: Strain Counter StrainStrain Counter Strain involves positioning of hypertonic muscles and dysfunctional joints towards position of comfort. Initial session 2 to 3 times per week. Hot packs 2 to 3 times per week. Tens 2 to 3 times per week. Each session lasts 30 to 60 minutes holding the position for 90 seconds to 2 minutes. Exercises includes. |
| Active Comparator: Myofascial Release | Active comparator | Other: Myofascial ReleaseMyofascial release focuses on the fascia , connective tissue that surrounds muscles, bones and organs which becomes tight and restrict movement. ,Myo fascial release 2 to 3 times per week. 60 seconds per area. Hot packs 2 to 3 times per week. Low frequency TENS. Foam rolling for Calves and Hamstrings. Quadriceps isometric Contraction holds for 10 to 15 seconds with 2 to 4 sets of each exercise. Hamstrings and Adductor isometric contractions. |
Who may qualify
- Ages
- 40 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Both males and females were included in the study.
- Patients aged 40 to 65 with clinical diagnosis of osteoarthritis
- Patient with Grade 2 osteoarthritis
- Patient with Grade 2 osteoarthritis
- Patients who have not undergone any surgical intervention on the Knee in the past 6 months.
Key exclusion criteria (5 listed)
- Patients with history of knee surgery or joint replacement
- Patients with neurological conditions that could affect mobility or perception of pain.
- Patients with infections in the knee area
- Patients with any traumatic injury
- Pregnant Patients
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Strain Counter StrainStrain Counter Strain involves passive positioning of hypertonic muscles and dysfunctional joints towards position of comfort. Conventional treatment includes Hot pack, Tens 2 to 3 times per week. Isometric exercises of Quadriceps, Hamstrings, Adductors and Calf muscles | Other | experimental: Strain Counter Strain |
| Myofascial ReleasePerform myofascial release technique 2 to 3 times per week. Time 60 seconds per area. Frequency 3 times a week. Hot packs applied 2 to 3 times per week Tens 2 to 3 times per week. Isometric contractions of Quadriceps, Hamstrings , Adductors and Calf muscles hold 10 to 15 seconds then gradually increase 30 seconds with 2 to 4 sets of each exercise | Other | Active Comparator: Myofascial Release |
Primary outcome
Numeric Pain Rating Scale
Time frame: at the baseline and at the end of 4 week
The Numeric Pain Rating Scale is a very common tool to asses pain in clinical settings. It is 0 to 10 pain rating scale in which 0 indicates no pain and 10 indicates worse pain.
Quality of Life (QoL)
Time frame: at the baseline of 4 weeks
QoL is 26 item tool for reliability, validity and responsiveness to changes in health.
1 secondary outcome
Time Up and Go Test TUG
Time frame: at the baseline and at the end of 4 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Naila kanwal, TPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Strain Counter Strain and Myofascial Release in people with Knee Osteoarthritis, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numeric Pain Rating Scale (time frame: at the baseline and at the end of 4 week). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Feb 2026.