Chronic Ischemic StrokeSRT-ISNCT07404371
Efficacy of Sensory Reweighting Techniques for Balance and Risk of Fall in Chronic Ischemic Stroke Patients
A study testing Sensory Reweighting Balance Training and Conventional Balance Training in people with Chronic Ischemic Stroke, run by Montiha Azeem at 1 site in Pakistan.
Trial summary
This randomized controlled trial will evaluate the effectiveness of sensory reweighting techniques on balance and risk of falls in individuals with chronic ischemic stroke. A total of 46 participants will be recruited using purposive sampling and randomly assigned into two groups through the sealed envelope method. Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- Chronic Ischemic Stroke
- What is being tested?
- Sensory Reweighting Balance Training and Conventional Balance Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 46 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Feb 2026to 18 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Diagnosed case of chronic ischemic stroke (duration >6 months post-stroke)
- Both male and female patients with age range 40-60 years .
- Able to stand and walk at least 10 feet (with or without assistive devices).
- Mini-Mental State Examination (MMSE) score ≥24 (to ensure adequate cognitive ability to follow instructions).
- Medically stable and cleared by a physician to participate in balance training.
- Experiencing balance impairment and/or history of at least one fall in the past 6 months
Who cannot join
- Hemorrhagic stroke patients or mixed stroke types
- Severe visual, auditory, or vestibular impairments not correctable by aids (which would interfere with sensory reweighting assessment).
- Other neurological conditions (e.g., Parkinson's disease, multiple sclerosis, peripheral neuropathy).
- Musculoskeletal disorders significantly affecting balance (e.g., recent fracture, severe arthritis).
- On medications that severely affect balance or cause dizziness (e.g., sedatives, high-dose antiepileptic.
- Severe aphasia or communication disorders impeding participation in the intervention
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
University of Lahore Teaching Hospital, Lahore
Lahore, Punjab Province, 54000
About this study
This randomized controlled trial will evaluate the effectiveness of sensory reweighting techniques on balance and risk of falls in individuals with chronic ischemic stroke. A total of 46 participants will be recruited using purposive sampling and randomly assigned into two groups through the sealed envelope method. Balance and fall risk will be assessed using the Berg Balance Scale and the Timed Up and Go test at baseline and after completion of the intervention. Participants in the experimental group will receive sensory reweighting-based balance training three times per week for eight weeks, incorporating altered sensory conditions such as reduced visual input, unstable surfaces, and vestibular challenges. The control group will receive conventional balance training of similar duration and intensity without sensory manipulation. Both groups will also receive standard physiotherapy throughout the intervention period. Ethical approval will be obtained prior to data collection, written informed consent will be secured from all participants, and confidentiality and voluntary participation will be ensured.
Read the detailed description
This study will be conducted as a randomized controlled trial to investigate the efficacy of sensory reweighting techniques in improving balance and reducing the risk of falls among patients with chronic ischemic stroke. Following ethical approval, participants will be recruited from selected rehabilitation centers using a non-probability purposive sampling technique. A total of 46 eligible participants, including an allowance for dropout, will be enrolled and randomly allocated into experimental and control groups using the sealed envelope method to ensure unbiased group assignment. Individuals aged 40-60 years with a stroke duration of more than six months, adequate cognitive function, and the ability to stand and walk with or without assistive devices will be included.
Baseline data will be collected prior to intervention using standardized outcome measures. Balance performance will be assessed using the Berg Balance Scale, a validated tool consisting of 14 functional tasks that evaluate postural control and balance during daily activities. Risk of falls will be measured using the Timed Up and Go test, which assesses functional mobility by recording the time taken to stand from a chair, walk a short distance, turn, return, and sit down. Demographic and clinical information such as age, gender, duration of stroke, use of assistive devices, and fall history will also be documented.
Participants allocated to the experimental group will undergo a structured sensory reweighting balance training program aimed at enhancing the central nervous system's ability to integrate visual, vestibular, and somatosensory inputs for postural control. The intervention will be administered three times per week for eight weeks, with each session lasting approximately 45 minutes. Training will include balance tasks performed under progressively challenging sensory conditions, such as standing on compliant surfaces, performing tasks with eyes closed, incorporating head movements during stance and gait, and engaging in dual-task activities. Exercise intensity and task complexity will be gradually increased according to individual tolerance while maintaining participant safety.
Participants in the control group will receive conventional balance training with the same frequency and duration as the experimental group. This program will focus on traditional static and dynamic balance exercises, including standing with a narrowed base of support, sit-to-stand practice, and forward and backward walking. No manipulation of sensory input will be included in this group, allowing comparison between standard balance rehabilitation and sensory reweighting-based training.
In addition to group-specific interventions, all participants will receive standard physiotherapy throughout the study period. This will include passive and active range of motion exercises, functional strengthening, and gait training tailored to individual needs. Standard therapy will be delivered at moderate intensity for 20-25 minutes per session, five days per week, to ensure uniform baseline rehabilitation across both groups. Written informed consent will be obtained from all participants, confidentiality will be maintained, participation will be voluntary, and individuals will be free to withdraw from the study at any time without affecting their standard care.
- Conditions
- Chronic Ischemic Stroke
- Being tested
- Sensory Reweighting Balance Training, Conventional Balance Training
- Keywords
- Sensory Reweighting, Balance Training, Fall Risk
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sensory Reweighting Balance TrainingBehavioural
Participants will receive sensory reweighting-based balance training aimed at improving postural control by enhancing the central nervous system's ability to integrate visual, vestibular, and somatosensory inputs. Training will be conducted three times per week for eight weeks, with 45-minute sessions including warm-up, core balance exercises, and cool-down. Exercises will be performed under altered sensory conditions, such as standing on foam surfaces, performing tasks with eyes closed, head movements during stance and gait, and dual-task activities. Task difficulty will be progressively increased based on individual tolerance while maintaining safety.
Conventional Balance TrainingBehavioural
Participants will receive conventional balance training without sensory reweighting components. The program will be delivered three times per week for eight weeks, with each session lasting approximately 45 minutes. Exercises will focus on static and dynamic balance tasks such as standing with a narrow base, sit-to-stand practice, and forward/backward walking. No manipulation of sensory input will be included. Training intensity and duration will be matched to the experimental group to ensure comparability of outcomes.
| Study group | Role | What they receive |
|---|---|---|
| group A Sensory Reweighting Balance Training Group | Experimental | Participants in this arm will receive sensory reweighting-based balance training aimed at enhancing integration of visual, vestibular, and somatosensory inputs for postural control. The intervention will be delivered three times per week for eight weeks, with each session lasting approximately 45 minutes. Training will include balance tasks performed under altered sensory conditions such as reduced visual input, compliant surfaces, head movements, and dual-task activities. Exercise difficulty will be progressively increased according to individual tolerance while ensuring participant safety. Receives: Behavioral: Sensory Reweighting Balance Training |
| group B Conventional Balance Training Group | Active comparator | Participants in this arm will receive conventional balance training without sensory reweighting components. The program will be delivered three times per week for eight weeks, with each session lasting approximately 45 minutes. Exercises will focus on static and dynamic balance tasks, including standing with a narrow base, sit-to-stand practice, and forward/backward walking. No manipulation of sensory input will be included. Training intensity and duration will be matched to the experimental group to allow fair comparison of outcomes. Receives: Behavioral: Conventional Balance Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Balance Performance
Balance will be measured using the Berg Balance Scale (BBS), a validated clinical tool consisting of 14 functional tasks assessing postural control, stability, and fall risk in chronic ischemic stroke patients. Each task is scored from 0 (unable to perform) to 4 (independent and safe), with a maximum total score of 56. Higher scores indicate better balance, and scores below 45 suggest increased risk of falls. Assessments will be conducted at baseline and after completion of the 8-week intervention to evaluate the efficacy of sensory reweighting balance training compared to conventional balance exercises.
Measured: Baseline and 8 weeks post-intervention
Secondary outcomes (1)
Risk of Falls
Risk of falls will be evaluated using the Timed Up and Go (TUG) test, a standardized and widely used measure of functional mobility and dynamic balance in neurological populations. The test records the time (in seconds) required for a participant to stand up from a chair, walk 3 meters, turn around, walk back, and sit down. Shorter completion times indicate better mobility and lower fall risk, while times greater than 20 seconds suggest an increased risk of falls. The TUG test will be administered at baseline and after completion of the 8-week intervention to compare changes between the sensory reweighting training group and the conventional balance training group.
Measured: Baseline and 8 weeks post-intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Feb 2026
- Study start15 Feb 2026
- Primary completion15 Apr 2026
- Study completion18 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Ischemic StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 46 participants (actual)
Sponsor and investigators
- Lead sponsor
- Montiha Azeem
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Montiha Azeem, University of Lahore
- Investigators
- Kanwal Mirani, MSPTN, Principal investigator, The University of Lahore, Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07404371
- Sponsor's protocol ID
- UOL/IREB/25/15/03/30
- Acronym
- SRT-IS
- Status last verified
- Feb 2026
- First submitted
- 4 Feb 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy of Sensory Reweighting Techniques for Balance and Risk of Fall in Chronic Ischemic Stroke Patients
- ClinicalTrials.gov ID
- NCT07404371
- Acronym / sponsor ID
- SRT-IS / UOL/IREB/25/15/03/30
- Conditions
- Chronic Ischemic Stroke
- Keywords
- Sensory Reweighting, Balance Training, Fall Risk
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 46 participants (actual)
- Lead sponsor
- Montiha AzeemUniversity, hospital or other
- Study start
- 15 Feb 2026 (actual)
- Primary completion
- 15 Apr 2026 (actual)
- Study completion
- 18 Apr 2026 (actual)
- First posted
- 11 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial will evaluate the effectiveness of sensory reweighting techniques on balance and risk of falls in individuals with chronic ischemic stroke. A total of 46 participants will be recruited using purposive sampling and randomly assigned into two groups through the sealed envelope method. Balance and fall risk will be assessed using the Berg Balance Scale and the Timed Up and Go test at baseline and after completion of the intervention. Participants in the experimental group will receive sensory reweighting-based balance training three times per week for eight weeks, incorporating altered sensory conditions such as reduced visual input, unstable surfaces, and vestibular challenges. The control group will receive conventional balance training of similar duration and intensity without sensory manipulation. Both groups will also receive standard physiotherapy throughout the intervention period. Ethical approval will be obtained prior to data collection, written informed consent will be secured from all participants, and confidentiality and voluntary participation will be ensured.
Detailed description
This study will be conducted as a randomized controlled trial to investigate the efficacy of sensory reweighting techniques in improving balance and reducing the risk of falls among patients with chronic ischemic stroke. Following ethical approval, participants will be recruited from selected rehabilitation centers using a non-probability purposive sampling technique. A total of 46 eligible participants, including an allowance for dropout, will be enrolled and randomly allocated into experimental and control groups using the sealed envelope method to ensure unbiased group assignment. Individuals aged 40-60 years with a stroke duration of more than six months, adequate cognitive function, and the ability to stand and walk with or without assistive devices will be included.
Baseline data will be collected prior to intervention using standardized outcome measures. Balance performance will be assessed using the Berg Balance Scale, a validated tool consisting of 14 functional tasks that evaluate postural control and balance during daily activities. Risk of falls will be measured using the Timed Up and Go test, which assesses functional mobility by recording the time taken to stand from a chair, walk a short distance, turn, return, and sit down. Demographic and clinical information such as age, gender, duration of stroke, use of assistive devices, and fall history will also be documented.
Participants allocated to the experimental group will undergo a structured sensory reweighting balance training program aimed at enhancing the central nervous system's ability to integrate visual, vestibular, and somatosensory inputs for postural control. The intervention will be administered three times per week for eight weeks, with each session lasting approximately 45 minutes. Training will include balance tasks performed under progressively challenging sensory conditions, such as standing on compliant surfaces, performing tasks with eyes closed, incorporating head movements during stance and gait, and engaging in dual-task activities. Exercise intensity and task complexity will be gradually increased according to individual tolerance while maintaining participant safety.
Participants in the control group will receive conventional balance training with the same frequency and duration as the experimental group. This program will focus on traditional static and dynamic balance exercises, including standing with a narrowed base of support, sit-to-stand practice, and forward and backward walking. No manipulation of sensory input will be included in this group, allowing comparison between standard balance rehabilitation and sensory reweighting-based training.
In addition to group-specific interventions, all participants will receive standard physiotherapy throughout the study period. This will include passive and active range of motion exercises, functional strengthening, and gait training tailored to individual needs. Standard therapy will be delivered at moderate intensity for 20-25 minutes per session, five days per week, to ensure uniform baseline rehabilitation across both groups. Written informed consent will be obtained from all participants, confidentiality will be maintained, participation will be voluntary, and individuals will be free to withdraw from the study at any time without affecting their standard care.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| group A Sensory Reweighting Balance Training Group | Experimental | Behavioral: Sensory Reweighting Balance TrainingParticipants in this arm will receive sensory reweighting-based balance training aimed at enhancing integration of visual, vestibular, and somatosensory inputs for postural control. The intervention will be delivered three times per week for eight weeks, with each session lasting approximately 45 minutes. Training will include balance tasks performed under altered sensory conditions such as reduced visual input, compliant surfaces, head movements, and dual-task activities. Exercise difficulty will be progressively increased according to individual tolerance while ensuring participant safety. |
| group B Conventional Balance Training Group | Active comparator | Behavioral: Conventional Balance TrainingParticipants in this arm will receive conventional balance training without sensory reweighting components. The program will be delivered three times per week for eight weeks, with each session lasting approximately 45 minutes. Exercises will focus on static and dynamic balance tasks, including standing with a narrow base, sit-to-stand practice, and forward/backward walking. No manipulation of sensory input will be included. Training intensity and duration will be matched to the experimental group to allow fair comparison of outcomes. |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Diagnosed case of chronic ischemic stroke (duration >6 months post-stroke)
- Both male and female patients with age range 40-60 years .
- Able to stand and walk at least 10 feet (with or without assistive devices).
- Mini-Mental State Examination (MMSE) score ≥24 (to ensure adequate cognitive ability to follow instructions).
- Medically stable and cleared by a physician to participate in balance training.
Key exclusion criteria (6 listed)
- Hemorrhagic stroke patients or mixed stroke types
- Severe visual, auditory, or vestibular impairments not correctable by aids (which would interfere with sensory reweighting assessment).
- Other neurological conditions (e.g., Parkinson's disease, multiple sclerosis, peripheral neuropathy).
- Musculoskeletal disorders significantly affecting balance (e.g., recent fracture, severe arthritis).
- On medications that severely affect balance or cause dizziness (e.g., sedatives, high-dose antiepileptic.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sensory Reweighting Balance TrainingParticipants will receive sensory reweighting-based balance training aimed at improving postural control by enhancing the central nervous system's ability to integrate visual, vestibular, and somatosensory inputs. Training will be conducted three times per week for eight weeks, with 45-minute sessions including warm-up, core balance exercises, and cool-down. Exercises will be performed under altered sensory conditions, such as standing on foam surfaces, performing tasks with eyes closed, head movements during stance and gait, and dual-task activities. Task difficulty will be progressively increased based on individual tolerance while maintaining safety. | Behavioural | group A Sensory Reweighting Balance Training Group |
| Conventional Balance TrainingParticipants will receive conventional balance training without sensory reweighting components. The program will be delivered three times per week for eight weeks, with each session lasting approximately 45 minutes. Exercises will focus on static and dynamic balance tasks such as standing with a narrow base, sit-to-stand practice, and forward/backward walking. No manipulation of sensory input will be included. Training intensity and duration will be matched to the experimental group to ensure comparability of outcomes. | Behavioural | group B Conventional Balance Training Group |
Primary outcome
Balance Performance
Time frame: Baseline and 8 weeks post-intervention
Balance will be measured using the Berg Balance Scale (BBS), a validated clinical tool consisting of 14 functional tasks assessing postural control, stability, and fall risk in chronic ischemic stroke patients. Each task is scored from 0 (unable to perform) to 4 (independent and safe), with a maximum total score of 56. Higher scores indicate better balance, and scores below 45 suggest increased risk of falls. Assessments will be conducted at baseline and after completion of the 8-week intervention to evaluate the efficacy of sensory reweighting balance training compared to conventional balance exercises.
1 secondary outcome
Risk of Falls
Time frame: Baseline and 8 weeks post-intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Kanwal Mirani, MSPTN principal investigator
The University of Lahore, Lahore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sensory Reweighting Balance Training and Conventional Balance Training in people with Chronic Ischemic Stroke, run by Montiha Azeem at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Balance Performance (time frame: Baseline and 8 weeks post-intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.