ThyroidectomyNCT07415174
Neck Exercises After Thyroid Surgery
A study testing Postoperative Neck Exercise Program in people with Thyroidectomy and Postoperative Neck Pain, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).
Trial summary
Postoperative neck pain is common after thyroidectomy and may impair early recovery. This prospective randomized controlled study aimed to evaluate the effects of postoperative neck range-of-motion (ROM) and isometric strengthening exercises on neck pain and early-stage quality of life in patients undergoing… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Thyroidectomy, Postoperative Neck Pain, Quality of Life (QOL)
- What is being tested?
- Postoperative Neck Exercise Program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 93 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 8 Nov 2024to 30 Apr 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older
- Patients who underwent thyroidectomy for multinodular goiter, Graves' disease, or fine-needle aspiration biopsy results classified as Bethesda categories III, IV, V, or VI
- Ability to understand and comply with the study protocol
- Provision of written informed consent
Who cannot join
- Age younger than 18 years
- History of previous neck surgery
- Cervical disc herniation
- Parathyroidectomy
- Hashimoto's thyroiditis
- Refusal to provide written informed consent
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of General Surgery
Istanbul, Istanbul, 34096
About this study
Official title: Effect of Postoperative Neck Range-of-Motion and Isometric Strengthening Exercises on Neck Pain and Early-Stage Quality of Life After Thyroidectomy
Postoperative neck pain is common after thyroidectomy and may impair early recovery. This prospective randomized controlled study aimed to evaluate the effects of postoperative neck range-of-motion (ROM) and isometric strengthening exercises on neck pain and early-stage quality of life in patients undergoing thyroidectomy. Between November 2024 and April 2025, 93 patients who underwent thyroidectomy were enrolled. Surgical indications included multinodular goiter, Graves' disease, and fine-needle aspiration biopsy results classified as Bethesda categories III-VI. Patients were randomized into an intervention group (n = 48) and a control group (n = 45). Patients in the intervention group performed cervical ROM and isometric strengthening exercises from postoperative day 1 to day 10, while the control group received standard postoperative care without a structured exercise program. Both groups were evaluated on postoperative days 1 and 10. Pain severity was assessed using the Visual Analog Scale (VAS), and quality of life was assessed using the Neck Pain, Discomfort, and Early-Stage Quality of Life Questionnaire (NPDEPQ).
- Conditions
- Thyroidectomy, Postoperative Neck Pain, Quality of Life (QOL), Cervical Range of Motion, Isometric Exercises
- Being tested
- Postoperative Neck Exercise Program
- Keywords
- thyroidectomy, postoperative neck pain, quality of life, cervical range of motion, isometric exercises
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Postoperative Neck Exercise ProgramOther
A structured postoperative program including neck range-of-motion and isometric strengthening exercises, initiated on postoperative day 1 and performed for 10 consecutive days, three times daily.
| Study group | Role | What they receive |
|---|---|---|
| Postoperative Neck Exercise Program | Experimental | Patients received a structured postoperative neck range-of-motion and isometric strengthening exercise program in addition to standard postoperative care. Receives: Other: Postoperative Neck Exercise Program |
| Standard Postoperative Care | No intervention | Patients received standard postoperative care without a structured exercise program. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Neck Pain
Postoperative neck pain was assessed using the Visual Analog Scale (VAS), where scores range from 0 (no pain) to 10 (worst imaginable pain). Assessments were performed on postoperative day 1 before discharge and on postoperative day 10 during follow-up by a blinded outcome assessor.
Measured: Postoperative day 1 and postoperative day 10
Secondary outcomes (1)
Neck Discomfort and Early-Stage Quality of Life
Neck discomfort and early-stage quality of life were evaluated using the Neck Pain, Discomfort, and Early-Stage Quality of Life Questionnaire (NPDEPQ). Assessments were conducted on postoperative day 1 and postoperative day 10 by a blinded outcome assessor.
Measured: Postoperative day 1 and postoperative day 10
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Feb 2026
- Study start8 Nov 2024
- Primary completion30 Apr 2025
- Study completion30 Apr 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ThyroidectomyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 93 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul University - Cerrahpasa
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mertcan AK, Istanbul University - Cerrahpasa
- Investigators
- Mertcan Ak, MD, Principal investigator, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of General Surgery
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07415174
- Sponsor's protocol ID
- Cerrahpaşa Faculty of Medicine
- Status last verified
- Feb 2026
- First submitted
- 3 Feb 2026
- Last updated
- 17 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared.
Study at a glance
From the registry record, last updated by the sponsor on 17 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Postoperative Neck Range-of-Motion and Isometric Strengthening Exercises on Neck Pain and Early-Stage Quality of Life After Thyroidectomy
- ClinicalTrials.gov ID
- NCT07415174
- Acronym / sponsor ID
- Cerrahpaşa Faculty of Medicine
- Conditions
- Thyroidectomy, Postoperative Neck Pain, Quality of Life (QOL), Cervical Range of Motion, Isometric Exercises
- Keywords
- thyroidectomy, postoperative neck pain, quality of life, cervical range of motion, isometric exercises
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 93 participants (actual)
- Lead sponsor
- Istanbul University - CerrahpasaUniversity, hospital or other
- Study start
- 8 Nov 2024 (actual)
- Primary completion
- 30 Apr 2025 (actual)
- Study completion
- 30 Apr 2025 (actual)
- First posted
- 17 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Postoperative neck pain is common after thyroidectomy and may impair early recovery. This prospective randomized controlled study aimed to evaluate the effects of postoperative neck range-of-motion (ROM) and isometric strengthening exercises on neck pain and early-stage quality of life in patients undergoing thyroidectomy. Between November 2024 and April 2025, 93 patients who underwent thyroidectomy were enrolled. Surgical indications included multinodular goiter, Graves' disease, and fine-needle aspiration biopsy results classified as Bethesda categories III-VI. Patients were randomized into an intervention group (n = 48) and a control group (n = 45). Patients in the intervention group performed cervical ROM and isometric strengthening exercises from postoperative day 1 to day 10, while the control group received standard postoperative care without a structured exercise program. Both groups were evaluated on postoperative days 1 and 10. Pain severity was assessed using the Visual Analog Scale (VAS), and quality of life was assessed using the Neck Pain, Discomfort, and Early-Stage Quality of Life Questionnaire (NPDEPQ).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Postoperative Neck Exercise Program | Experimental | Other: Postoperative Neck Exercise ProgramPatients received a structured postoperative neck range-of-motion and isometric strengthening exercise program in addition to standard postoperative care. |
| Standard Postoperative Care | No intervention | –Patients received standard postoperative care without a structured exercise program. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adults aged 18 years or older
- Patients who underwent thyroidectomy for multinodular goiter, Graves' disease, or fine-needle aspiration biopsy results classified as Bethesda categories III, IV, V, or VI
- Ability to understand and comply with the study protocol
- Provision of written informed consent
Key exclusion criteria (6 listed)
- Age younger than 18 years
- History of previous neck surgery
- Cervical disc herniation
- Parathyroidectomy
- Hashimoto's thyroiditis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Postoperative Neck Exercise ProgramA structured postoperative program including neck range-of-motion and isometric strengthening exercises, initiated on postoperative day 1 and performed for 10 consecutive days, three times daily. | Other | Postoperative Neck Exercise Program |
Primary outcome
Postoperative Neck Pain
Time frame: Postoperative day 1 and postoperative day 10
Postoperative neck pain was assessed using the Visual Analog Scale (VAS), where scores range from 0 (no pain) to 10 (worst imaginable pain). Assessments were performed on postoperative day 1 before discharge and on postoperative day 10 during follow-up by a blinded outcome assessor.
1 secondary outcome
Neck Discomfort and Early-Stage Quality of Life
Time frame: Postoperative day 1 and postoperative day 10
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Feb 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared.
Related trials for Thyroidectomy
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Renovated Prediction Model for Difficult Transoral and Submental Endoscopic Thyroidectomy
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Thyroidectomy, Oxidative Stress
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mertcan Ak, MD principal investigator
Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of General Surgery
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Postoperative Neck Exercise Program in people with Thyroidectomy and Postoperative Neck Pain, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative Neck Pain (time frame: Postoperative day 1 and postoperative day 10). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Feb 2026.